IS4031A - Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja - Google Patents

Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja

Info

Publication number: IS4031A
Authority: IS; Iceland
Prior art keywords: acid derivatives; hydroxamic acid; pharmaceuticals; manufacture; heterocyclic ring
Prior art date: 1992-06-11

Application number

IS4031A

Other languages

English (en)

Inventor

John Broadhurst Michael

Anthony Brown Paul

Henry Johnson William

Lawton Geoffrey

Original Assignee

F.Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-11

Filing date

1993-06-10

Publication date

1993-12-12

1992-06-11 Priority claimed from GB929212421A external-priority patent/GB9212421D0/en

1993-06-10 Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag

1993-12-12 Publication of IS4031A publication Critical patent/IS4031A/is

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
201000008482 osteoarthritis Diseases 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000002442 collagenase inhibitor Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

IS4031A 1992-06-11 1993-06-10 Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja IS4031A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929212421A GB9212421D0 (en)	1992-06-11	1992-06-11	Hydroxamic acid derivatives
GB939305720A GB9305720D0 (en)	1992-06-11	1993-03-19	Hydroxamic acid derivatives

Publications (1)

Publication Number	Publication Date
IS4031A true IS4031A (is)	1993-12-12

Family

ID=26301054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4031A IS4031A (is)	1992-06-11	1993-06-10	Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja

Country Status (21)

Country	Link
US (2)	US5318964A (is)
EP (1)	EP0574758B1 (is)
JP (1)	JPH0776210B2 (is)
CN (1)	CN1035616C (is)
AT (1)	ATE170840T1 (is)
AU (1)	AU659555B2 (is)
BG (1)	BG61724B1 (is)
CA (1)	CA2098168A1 (is)
CZ (1)	CZ283373B6 (is)
DE (1)	DE69320869T2 (is)
DK (1)	DK0574758T3 (is)
ES (1)	ES2121896T3 (is)
FI (1)	FI109535B (is)
HU (1)	HU9301645D0 (is)
IL (1)	IL105921A (is)
IS (1)	IS4031A (is)
MY (1)	MY108798A (is)
NO (1)	NO932117L (is)
NZ (1)	NZ247765A (is)
PH (1)	PH30245A (is)
SK (1)	SK57393A3 (is)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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US5892112A (en) *	1990-11-21	1999-04-06	Glycomed Incorporated	Process for preparing synthetic matrix metalloprotease inhibitors
US5530161A (en) *	1991-07-08	1996-06-25	British Bio-Technology Limited	Hydroxamic acid based collagenase inhibitors
PT822186E (pt) *	1994-01-20	2000-08-31	British Biotech Pharm	L-tert-leucina-2-piridilamida
GB9501737D0 (en) *	1994-04-25	1995-03-22	Hoffmann La Roche	Hydroxamic acid derivatives
WO1995029892A1 (en) *	1994-04-28	1995-11-09	The Du Pont Merck Pharmaceutical Company	Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9411598D0 (en) *	1994-06-09	1994-08-03	Hoffmann La Roche	Hydroxamic acid derivatives
GB9423914D0 (en) *	1994-11-26	1995-01-11	British Biotech Pharm	Polyether derivatives as metalloproteinase inhibitors
US5919940A (en) *	1995-01-20	1999-07-06	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
US5703092A (en) *	1995-04-18	1997-12-30	The Dupont Merck Pharmaceutical Company	Hydroxamic acid compounds as metalloprotease and TNF inhibitors
US5691381A (en) *	1995-04-18	1997-11-25	The Dupont Merck Pharmaceutical Company	Hydroxamic and carbocyclic acids as metalloprotease inhibitors
US5917090A (en) *	1995-06-30	1999-06-29	British Biotech Pharmaceuticals Ltd.	Matrix metalloproteinase inhibitors
US6281352B1 (en)	1995-11-14	2001-08-28	Dupont Pharmaceuticals Company	Macrocyclic compounds as metalloprotease inhibitors
US5665777A (en) *	1995-11-14	1997-09-09	Abbott Laboratories	Biphenyl hydroxamate inhibitors of matrix metalloproteinases
ATE205184T1 (de)	1995-11-23	2001-09-15	British Biotech Pharm	Metalloproteinase inhibitoren
TW448172B (en) *	1996-03-08	2001-08-01	Pharmacia & Upjohn Co Llc	Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
PT1021424E (pt) *	1996-06-21	2003-06-30	Upjohn Co	Amidas de tiadiazolo como inibidores da metaloproteinase de matriz
US6462023B1 (en)	1996-09-10	2002-10-08	British Biotech Pharmaceuticals, Ltd.	Cytostatic agents
IL128337A0 (en)	1996-09-10	2000-01-31	British Biotech Pharm	Cytostatic hydroxamic acid derivatives
US5840974A (en) *	1996-12-04	1998-11-24	Britisch Biotech Pharmaceuticals, Ltd.	Metalloproteinase inhibitors
AU5577498A (en) *	1997-01-31	1998-08-25	Shionogi & Co., Ltd.	Compounds having metalloprotease inhibitory activity
US5847148A (en) *	1997-04-10	1998-12-08	Pharmacia & Upjohn Company	Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation
US6576664B1 (en)	1997-08-18	2003-06-10	Bristol-Myers Squibb Pharma Company	Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
US6403632B1 (en)	2000-03-01	2002-06-11	Bristol Myers Squibb Pharma Co	Lactam metalloprotease inhibitors
ZA988967B (en) *	1997-10-03	2000-04-03	Du Pont Pharm Co	Lactam metalloprotease inhibitors.
WO1999041246A1 (en)	1998-02-11	1999-08-19	Du Pont Pharmaceuticals Company	Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
AU6843598A (en) *	1998-03-25	1999-10-18	British Biotech Pharmaceuticals Limited	Metalloproteinase inhibitors
US6329418B1 (en)	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
FR2780402B1 (fr) *	1998-06-30	2001-04-27	Adir	Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000017162A1 (en) *	1998-09-21	2000-03-30	Takeda Chemical Industries, Ltd.	Novel thiol derivatives, process for producing the same and utilization thereof
EP1004578B1 (en) *	1998-11-05	2004-02-25	Pfizer Products Inc.	5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
GB9903598D0 (en)	1999-02-18	1999-04-07	Univ Manchester	Connective tissue healing
EP1165500A1 (en)	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
EP1165546A2 (en)	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US6696456B1 (en)	1999-10-14	2004-02-24	The Procter & Gamble Company	Beta disubstituted metalloprotease inhibitors
US6797820B2 (en) *	1999-12-17	2004-09-28	Vicuron Pharmaceuticals Inc.	Succinate compounds, compositions and methods of use and preparation
GB9929979D0 (en) *	1999-12-17	2000-02-09	Darwin Discovery Ltd	Hydroxamic acid derivatives
WO2001070693A2 (en) *	2000-03-21	2001-09-27	The Procter & Gamble Company	Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
NZ520657A (en) *	2000-03-21	2004-11-26	Procter & Gamble	Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
WO2001070682A2 (en) *	2000-03-21	2001-09-27	The Procter & Gamble Company	Carbocyclic side chain containing metalloprotease inhibitors
US6620823B2 (en)	2000-07-11	2003-09-16	Bristol-Myers Squibb Pharme Company	Lactam metalloprotease inhibitors
DE60129442T2 (de)	2000-07-19	2008-04-17	Mitsubishi Pharma Corp.	Sulphonsäurederivate von hydroxamsäuren und deren verwendung in medizinischen produkten
EP1406893B1 (en)	2001-06-15	2007-04-18	Vicuron Pharmaceuticals, Inc.	Pyrrolidine bicyclic compounds
AR036053A1 (es)	2001-06-15	2004-08-04	Versicor Inc	Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
ITMI20011733A1 (it) *	2001-08-07	2003-02-07	Italfarmaco Spa	Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
NZ536116A (en)	2002-04-03	2007-01-26	Topotarget Uk Ltd	Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
EP1583736A1 (en)	2003-01-17	2005-10-12	TopoTarget UK Limited	Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors
CN101282962A (zh)	2005-08-12	2008-10-08	先灵公司	用于治疗炎性疾病的化合物

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US4743587A (en) *	1985-09-10	1988-05-10	G. D. Searle & Co.	Hydroxamic acid based collagenase inhibitors
GB8827308D0 (en) *	1988-11-23	1988-12-29	British Bio Technology	Compounds

1993
- 1993-05-24 US US08/066,832 patent/US5318964A/en not_active Expired - Fee Related
- 1993-05-26 AU AU39816/93A patent/AU659555B2/en not_active Ceased
- 1993-05-28 EP EP93108628A patent/EP0574758B1/en not_active Expired - Lifetime
- 1993-05-28 AT AT93108628T patent/ATE170840T1/de not_active IP Right Cessation
- 1993-05-28 ES ES93108628T patent/ES2121896T3/es not_active Expired - Lifetime
- 1993-05-28 DK DK93108628T patent/DK0574758T3/da active
- 1993-05-28 DE DE69320869T patent/DE69320869T2/de not_active Expired - Fee Related
- 1993-06-02 NZ NZ247765A patent/NZ247765A/en unknown
- 1993-06-04 HU HU9301645A patent/HU9301645D0/hu unknown
- 1993-06-04 CZ CZ931081A patent/CZ283373B6/cs unknown
- 1993-06-07 IL IL105921A patent/IL105921A/en not_active IP Right Cessation
- 1993-06-08 SK SK573-93A patent/SK57393A3/sk unknown
- 1993-06-09 MY MYPI93001124A patent/MY108798A/en unknown
- 1993-06-09 BG BG97857A patent/BG61724B1/bg unknown
- 1993-06-10 NO NO932117A patent/NO932117L/no unknown
- 1993-06-10 CA CA002098168A patent/CA2098168A1/en not_active Abandoned
- 1993-06-10 CN CN93107239A patent/CN1035616C/zh not_active Expired - Fee Related
- 1993-06-10 IS IS4031A patent/IS4031A/is unknown
- 1993-06-10 PH PH46328A patent/PH30245A/en unknown
- 1993-06-10 JP JP5165228A patent/JPH0776210B2/ja not_active Expired - Fee Related
- 1993-06-11 FI FI932692A patent/FI109535B/fi active
1994
- 1994-03-17 US US08/214,895 patent/US5447929A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SK57393A3 (en)	1994-05-11
CN1083062A (zh)	1994-03-02
US5447929A (en)	1995-09-05
IL105921A (en)	1998-01-04
NO932117D0 (no)	1993-06-10
FI932692L (fi)	1993-12-12
ATE170840T1 (de)	1998-09-15
CN1035616C (zh)	1997-08-13
PH30245A (en)	1997-02-05
JPH0665196A (ja)	1994-03-08
DE69320869T2 (de)	1999-04-29
IL105921A0 (en)	1993-10-20
CZ283373B6 (cs)	1998-04-15
FI932692A0 (fi)	1993-06-11
DE69320869D1 (de)	1998-10-15
FI109535B (fi)	2002-08-30
HU9301645D0 (en)	1993-09-28
AU3981693A (en)	1993-12-16
BG61724B1 (bg)	1998-04-30
BG97857A (bg)	1994-12-02
US5318964A (en)	1994-06-07
NO932117L (no)	1993-12-13
EP0574758B1 (en)	1998-09-09
DK0574758T3 (da)	1999-06-07
NZ247765A (en)	1995-11-27
MY108798A (en)	1996-11-30
AU659555B2 (en)	1995-05-18
EP0574758A1 (en)	1993-12-22
ES2121896T3 (es)	1998-12-16
JPH0776210B2 (ja)	1995-08-16
CA2098168A1 (en)	1993-12-12
CZ108193A3 (en)	1994-02-16

Publication	Publication Date	Title
IS4031A (is)	1993-12-12	Hydroxamicsýruafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja
NO307215B1 (no)	2000-02-28	Hydroxamsyre-derivater med tricyklisk substitusjon, medikamenter inneholdende dem, anvendelse av dem og mellomprodukter i fremstilling av dem
DE69018908D1 (de)	1995-06-01	N-aryl und N-Heteroarylamide und Harnstoffderivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase.
ATE253546T1 (de)	2003-11-15	Chalcon-derivate und medikamente die diese enthalten
ATE255106T1 (de)	2003-12-15	Bicyclische, heterocyclische sulfonamide und sulfonsäureester
DK0734383T3 (da)	2002-10-14	Cykliske amidderivater som neurokinin-A-antagonister
HUT52059A (en)	1990-06-28	Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
HU9400250D0 (en)	1994-05-30	Quinoline-or quinazoine derivatives process fop producing them and pharmaceutical compositions containing them
PL305457A1 (en)	1995-04-18	Galantamine derivatives, method of obtaining them and their application as drugs
DE69706386D1 (de)	2001-10-04	2-Aryl-3-Aminoaryloxynaphthylverbindungen, Zwischenverbindungen, Zusammensetzungen und Verfahren
DE69629838D1 (de)	2003-10-09	Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate
AU7276291A (en)	1991-09-12	Urea derivatives and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same
WO2001022951A3 (en)	2001-10-11	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis
TW375525B (en)	1999-12-01	Inhibitors for morphine-like drug induced emesis containing active components (R)-1-ethyl-4-methyl hexahydro-1H-1,4-diazepine derivatives
MX9303391A (es)	1994-06-30	Derivados de acido hidroxamico, procedimiento para su preparcion y medicamento que los contiene.
RU95105969A (ru)	1997-01-10	Производные диоксциклобутена, способ получения, фармацевтическая композиция, способ лечения гипертонии