NO942553L - Ny humanproteaseinhibitor av Kunitz-type og varianter derav - Google Patents

Ny humanproteaseinhibitor av Kunitz-type og varianter derav

Info

Publication number
NO942553L
NO942553L NO942553A NO942553A NO942553L NO 942553 L NO942553 L NO 942553L NO 942553 A NO942553 A NO 942553A NO 942553 A NO942553 A NO 942553A NO 942553 L NO942553 L NO 942553L
Authority
NO
Norway
Prior art keywords
phe
cys
gly
protease inhibitor
asn
Prior art date
Application number
NO942553A
Other languages
English (en)
Norwegian (no)
Other versions
NO942553D0 (no
Inventor
Fanny Norris
Kjeld Norris
Soeren Erik Bjoern
Lars Christian Petersen
Ole Hvilsted Olsen
Donald Cameron Foster
Cindy Ann Sprecher
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO942553D0 publication Critical patent/NO942553D0/no
Publication of NO942553L publication Critical patent/NO942553L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
NO942553A 1992-01-07 1994-07-06 Ny humanproteaseinhibitor av Kunitz-type og varianter derav NO942553L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200003 1992-01-07
PCT/DK1993/000006 WO1993014123A1 (en) 1992-01-07 1993-01-07 A novel human kunitz-type protease inhibitor and variants thereof

Publications (2)

Publication Number Publication Date
NO942553D0 NO942553D0 (no) 1994-07-06
NO942553L true NO942553L (no) 1994-09-07

Family

ID=8153772

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942553A NO942553L (no) 1992-01-07 1994-07-06 Ny humanproteaseinhibitor av Kunitz-type og varianter derav

Country Status (17)

Country Link
US (1) US5618696A (cs)
EP (1) EP0621873B1 (cs)
JP (1) JP3345420B2 (cs)
KR (1) KR940703860A (cs)
AT (1) ATE171712T1 (cs)
AU (1) AU670059B2 (cs)
CA (1) CA2127247A1 (cs)
CZ (1) CZ164894A3 (cs)
DE (1) DE69321342T2 (cs)
ES (1) ES2123635T3 (cs)
FI (1) FI943235L (cs)
HU (1) HUT70291A (cs)
IL (1) IL104314A0 (cs)
NO (1) NO942553L (cs)
NZ (1) NZ246571A (cs)
WO (1) WO1993014123A1 (cs)
ZA (1) ZA9394B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
ES2348230T3 (es) * 2002-06-07 2010-12-01 Dyax Corp. Prevención y reducción de la isquemia.
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK1587907T3 (da) * 2003-01-07 2011-04-04 Dyax Corp Kunitz-domænebibliotek
CN101014611A (zh) * 2004-07-13 2007-08-08 拜尔药品公司 改良的抑酶肽变体
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
PL1981519T3 (pl) 2005-12-29 2018-07-31 Dyax Corp. Hamowanie proteaz
US20090075887A1 (en) * 2007-08-21 2009-03-19 Genzyme Corporation Treatment with Kallikrein Inhibitors
CN101952309A (zh) * 2007-12-21 2011-01-19 Ifxa有限公司 蛋白酶抑制剂
KR101792032B1 (ko) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Ｔｆｐｉ 억제제 및 사용 방법
US8637454B2 (en) * 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
SMT201800552T1 (it) 2010-01-06 2018-11-09 Dyax Corp Proteine che legano la callicreina plasmatica
DK2547355T3 (en) 2010-03-19 2017-03-20 Baxalta GmbH TFPI INHIBITORS AND METHODS OF USE
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
BR112014022435B1 (pt) 2012-03-21 2023-02-14 Takeda Pharmaceutical Company Limited Inibidores de tfpi e métodos de uso
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
EP3387018A1 (en) 2015-12-11 2018-10-17 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
JP7034951B2 (ja) 2016-06-08 2022-03-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する
JP2021502381A (ja) 2017-11-08 2021-01-28 プレジデント アンド フェローズ オブ ハーバード カレッジ ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
EP4090427A1 (en) 2020-01-13 2022-11-23 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
DK225488D0 (da) 1988-04-26 1988-04-26 Novo Industri As Polypeptid
JPH07102137B2 (ja) * 1988-07-19 1995-11-08 塩野義製薬株式会社 修飾ヒトｐｓｔｉ

Also Published As

Publication number Publication date
FI943235A0 (fi) 1994-07-06
ZA9394B (en) 1993-08-10
US5618696A (en) 1997-04-08
CA2127247A1 (en) 1993-07-22
AU3346193A (en) 1993-08-03
AU670059B2 (en) 1996-07-04
JPH07504652A (ja) 1995-05-25
FI943235A7 (fi) 1994-07-06
EP0621873B1 (en) 1998-09-30
HUT70291A (en) 1995-09-28
EP0621873A1 (en) 1994-11-02
NO942553D0 (no) 1994-07-06
ES2123635T3 (es) 1999-01-16
HU9401989D0 (en) 1994-09-28
NZ246571A (en) 1996-09-25
DE69321342T2 (de) 1999-04-01
WO1993014123A1 (en) 1993-07-22
DE69321342D1 (de) 1998-11-05
CZ164894A3 (en) 1994-12-15
JP3345420B2 (ja) 2002-11-18
FI943235L (fi) 1994-07-06
IL104314A0 (en) 1993-05-13
KR940703860A (ko) 1994-12-12
ATE171712T1 (de) 1998-10-15

Similar Documents

Publication Publication Date Title
NO942553L (no) Ny humanproteaseinhibitor av Kunitz-type og varianter derav
DE60333758D1 (de) Prevention und Verringerung von Ischemia
NL300013I1 (nl) Nieuwe protein met TNF-remmende werking en hun ber
NO942551L (no) Humanproteaseinhibitorvariant av Kunitz-type
PT883687E (pt) Receptores de quimiocinas c-c, ckr-5, cc, os seus derivados e as suas utilizacoes
RU94036776A (ru) Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы
DK0573538T3 (da) Peptider til behandling
YU29596A (sh) Genski proizvodi koji regulišu gojaznost
ATE42308T1 (de) Pharmakologisch aktive peptide.
AU682638B2 (en) Peptide, bronchodilator and blood flow ameliorant
DE3751398D1 (de) Substrat-Peptide.
DE60038310D1 (de) Menschliche antithrombin-varianten
NO941562L (no) Anvendelse av brandykinin-anatgonister for fremstilling av et medikament for profylakse eller forbehandling av arteriosklerose
PT789761E (pt) Scf humano, uma respectiva variante de processamento, sua utilizacao farmaceutica
RU94036002A (ru) Ингибитор протеазы, днк, вектор, клетка, способ получения ингибитора, фармацевтическая композиция
AR009805A1 (es) Peptidos que contienen cisteina
ATE305478T1 (de) Topoisomerase-ii inhibitoren
ECSP972344A (es) Proteinas antiobesidad
CY1115911T1 (el) Τροποποιημενα πολυπεπτιδια περιοχης kunitz και η χρηση τους στην μειωση της ισχαιμιας ή της εκκινησης μιας συστημικης φλεγμονωδους ανταποκρισης που σχετιζεται με μια χειρουργικη επεμβαση