NO951126L - Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen - Google Patents

Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen

Info

Publication number: NO951126L
Authority: NO; Norway
Prior art keywords: weight; styrene; parts; group; isoprene
Prior art date: 1994-03-28

Application number

NO951126A

Other languages

English (en)

Norwegian (no)

Other versions

NO951126D0 (no

Inventor

Claude Mikler

Laurent Liorzou

Daniel Dhuique-Mayer

Original Assignee

Lhd Lab Hygiene Dietetique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-28

Filing date

1995-03-24

Publication date

1995-09-29

1995-03-24 Application filed by Lhd Lab Hygiene Dietetique filed Critical Lhd Lab Hygiene Dietetique

1995-03-24 Publication of NO951126D0 publication Critical patent/NO951126D0/no

1995-09-29 Publication of NO951126L publication Critical patent/NO951126L/no

Links

239000011159 matrix material Substances 0.000 title abstract 5
229920001577 copolymer Polymers 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
229940011871 estrogen Drugs 0.000 title 1
239000000583 progesterone congener Substances 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 abstract 2
229940088597 hormone Drugs 0.000 abstract 2
239000005556 hormone Substances 0.000 abstract 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 abstract 1
125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
239000000853 adhesive Substances 0.000 abstract 1
239000004840 adhesive resin Substances 0.000 abstract 1
229920006223 adhesive resin Polymers 0.000 abstract 1
229960000541 cetyl alcohol Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003338 crotamiton Drugs 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
LLRANSBEYQZKFY-UHFFFAOYSA-N dodecanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCCCCCC(O)=O LLRANSBEYQZKFY-UHFFFAOYSA-N 0.000 abstract 1
230000001076 estrogenic effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229940049964 oleate Drugs 0.000 abstract 1
229940055577 oleyl alcohol Drugs 0.000 abstract 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 abstract 1
-1 peglicolS-oleate Chemical compound 0.000 abstract 1
239000004014 plasticizer Substances 0.000 abstract 1
229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 abstract 1
230000000757 progestagenic effect Effects 0.000 abstract 1
239000003381 stabilizer Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Dermatology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Botany (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)

NO951126A 1994-03-28 1995-03-24 Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen NO951126L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9403599A FR2717689B1 (fr)	1994-03-28	1994-03-28	Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.

Publications (2)

Publication Number	Publication Date
NO951126D0 NO951126D0 (no)	1995-03-24
NO951126L true NO951126L (no)	1995-09-29

Family

ID=9461479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951126A NO951126L (no)	1994-03-28	1995-03-24	Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen

Country Status (23)

Country	Link
US (1)	US5580572A (cs)
EP (1)	EP0674901B1 (cs)
JP (1)	JPH07330609A (cs)
KR (1)	KR950031057A (cs)
CN (1)	CN1114903A (cs)
AT (1)	ATE173618T1 (cs)
AU (1)	AU691558B2 (cs)
CA (1)	CA2145584A1 (cs)
CZ (1)	CZ76795A3 (cs)
DE (1)	DE69506157T2 (cs)
DK (1)	DK0674901T3 (cs)
ES (1)	ES2128673T3 (cs)
FI (1)	FI951424A7 (cs)
FR (1)	FR2717689B1 (cs)
GR (1)	GR3029401T3 (cs)
HU (1)	HU219465B (cs)
LV (1)	LV10929B (cs)
NO (1)	NO951126L (cs)
NZ (1)	NZ270811A (cs)
PL (1)	PL178896B1 (cs)
RU (1)	RU2110282C1 (cs)
SK (1)	SK39095A3 (cs)
ZA (1)	ZA952469B (cs)

Families Citing this family (40)

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EP0394429B1 (de) *	1988-10-27	1996-01-10	Schering Aktiengesellschaft	Mittel zur transdermalen applikation enthaltend gestoden
US6148830A (en)	1994-04-19	2000-11-21	Applied Elastomerics, Inc.	Tear resistant, multiblock copolymer gels and articles
US7134236B2 (en) *	1994-04-19	2006-11-14	Applied Elastomerics, Inc.	Gelatinous elastomer compositions and articles for use as fishing bait
US7108873B2 (en)	1994-04-19	2006-09-19	Applied Elastomerics, Inc.	Gelatinous food elastomer compositions and articles
US7208184B2 (en)	2002-07-20	2007-04-24	Applied Elastomerics, Inc.	Gelatinous food elastomer compositions and articles for use as fishing bait
US7290367B2 (en)	1994-04-19	2007-11-06	Applied Elastomerics, Inc.	Tear resistant gel articles for various uses
US7226484B2 (en)	1994-04-19	2007-06-05	Applied Elastomerics, Inc.	Tear resistant gels and articles for every uses
US7234560B2 (en) *	1994-04-19	2007-06-26	Applied Elastomerics, Inc.	Inflatable restraint cushions and other uses
KR970706805A (ko) *	1994-11-18	1997-12-01	나까토미 히로타카	경피흡수첩부제(percutaneously absorbable patch)
FR2739031B1 (fr) *	1995-09-27	1997-11-21	Lhd Lab Hygiene Dietetique	Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base de copolymere styrene-isoprene-styrene, procede de preparation et utilisation en therapeutique
JP3857348B2 (ja) *	1996-02-20	2006-12-13	ソニー株式会社	テープカートリッジ
DE19700913C2 (de) *	1997-01-14	2001-01-04	Lohmann Therapie Syst Lts	Transdermales therapeutisches System zur Abgabe von Hormonen
DE19918106A1 (de) *	1999-04-22	2000-10-26	Lohmann Therapie Syst Lts	Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
WO2001001990A1 (en) *	1999-07-01	2001-01-11	Hisamitsu Pharmaceutical Co., Inc.	Adhesive preparation for percutaneous absorption
JP4648518B2 (ja) *	2000-06-01	2011-03-09	帝國製薬株式会社	４−ビフェニル酢酸含有貼付剤
DE10236319A1 (de) *	2002-08-08	2004-02-19	Beiersdorf Ag	Hautfreundliche Wirkstoffpflaster auf der Basis von SBC mit mindestens einem pharmazeutischen Wirkstoff mit einem Gehalt von mindestens 34 Gew.-% und dessen Herstellung
US20050191339A1 (en) *	2002-08-08	2005-09-01	Beiersdorf Ag	Skin friendly active ingredient plaster based on SBC, containing at least 34 WT.% of a pharmaceutical active ingredient and production thereof
JP2004224741A (ja) *	2003-01-23	2004-08-12	Hisamitsu Pharmaceut Co Inc	ツロブテロール経皮吸収型製剤
JP4422430B2 (ja) *	2003-05-14	2010-02-24	帝國製薬株式会社	エストロゲン及び／又はプロゲストゲン含有外用貼付剤
JP4311728B2 (ja) *	2003-12-10	2009-08-12	ニチバン株式会社	経皮吸収型貼付剤
DE102004028284A1 (de) *	2004-06-11	2006-01-05	Hexal Ag	Matrixkontrolliertes transdermales therapeutisches System auf Basis eines Schmelzklebstoffs zur Anwendung von Norelgestromin
US20070062884A1 (en)	2005-08-11	2007-03-22	Board Of Regents, The University Of Texas System	N-halamines compounds as multifunctional additives
MY149152A (en) *	2006-05-08	2013-07-15	Teikoku Seiyaku Kk	Percutaneous absorption preparations of antimentia drugs
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US8633178B2 (en)	2011-11-23	2014-01-21	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
EP3145489A1 (en)	2014-05-22	2017-03-29	TherapeuticsMD, Inc.	Natural combination hormone replacement formulations and therapies
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
WO2017173044A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd Inc.	Steroid hormone compositions in medium chain oils
WO2017173071A1 (en)	2016-04-01	2017-10-05	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4299501A (en) *	1979-08-10	1981-11-10	Ortho Pharmaceutical Corporation	Continuous process for the preparation of semisolid dispersions
JPS60188315A (ja) *	1984-03-07	1985-09-25	Yamanouchi Pharmaceut Co Ltd	グリチルレチン酸配合鎮痒プラスター
US4994267A (en) *	1988-03-04	1991-02-19	Noven Pharmaceuticals, Inc.	Transdermal acrylic multipolymer drug delivery system
US5032402A (en) *	1988-10-27	1991-07-16	The University Of Kentucky Research Foundation	3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer
US5248676A (en) *	1990-05-17	1993-09-28	Hisamitsu Pharmaceutical Co., Inc.	Estradiol percutaneous administration preparations
US5232702A (en) *	1991-07-22	1993-08-03	Dow Corning Corporation	Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices
JPH05331064A (ja) *	1992-05-26	1993-12-14	Sekisui Chem Co Ltd	消炎鎮痛貼付剤

1994
- 1994-03-28 FR FR9403599A patent/FR2717689B1/fr not_active Expired - Fee Related
1995
- 1995-03-15 DK DK95400574T patent/DK0674901T3/da active
- 1995-03-15 DE DE69506157T patent/DE69506157T2/de not_active Expired - Fee Related
- 1995-03-15 AT AT95400574T patent/ATE173618T1/de not_active IP Right Cessation
- 1995-03-15 ES ES95400574T patent/ES2128673T3/es not_active Expired - Lifetime
- 1995-03-15 EP EP95400574A patent/EP0674901B1/fr not_active Expired - Lifetime
- 1995-03-21 AU AU14978/95A patent/AU691558B2/en not_active Ceased
- 1995-03-21 LV LVP-95-76A patent/LV10929B/en unknown
- 1995-03-24 FI FI951424A patent/FI951424A7/fi unknown
- 1995-03-24 NO NO951126A patent/NO951126L/no not_active Application Discontinuation
- 1995-03-27 HU HU9500880A patent/HU219465B/hu not_active IP Right Cessation
- 1995-03-27 ZA ZA952469A patent/ZA952469B/xx unknown
- 1995-03-27 CA CA002145584A patent/CA2145584A1/en not_active Abandoned
- 1995-03-27 NZ NZ270811A patent/NZ270811A/en unknown
- 1995-03-27 SK SK390-95A patent/SK39095A3/sk unknown
- 1995-03-27 PL PL95307891A patent/PL178896B1/pl unknown
- 1995-03-27 RU RU95104225A patent/RU2110282C1/ru active
- 1995-03-27 CZ CZ95767A patent/CZ76795A3/cs unknown
- 1995-03-28 JP JP7069493A patent/JPH07330609A/ja active Pending
- 1995-03-28 US US08/413,216 patent/US5580572A/en not_active Expired - Fee Related
- 1995-03-28 KR KR1019950006675A patent/KR950031057A/ko not_active Withdrawn
- 1995-03-28 CN CN95103637A patent/CN1114903A/zh active Pending
1999
- 1999-02-15 GR GR980403030T patent/GR3029401T3/el unknown

Also Published As

Publication number	Publication date
EP0674901B1 (fr)	1998-11-25
CN1114903A (zh)	1996-01-17
GR3029401T3 (en)	1999-05-28
KR950031057A (ko)	1995-12-18
SK39095A3 (en)	1995-10-11
LV10929A (lv)	1995-12-20
US5580572A (en)	1996-12-03
NZ270811A (en)	1995-12-21
PL178896B1 (pl)	2000-06-30
DE69506157T2 (de)	1999-07-01
AU691558B2 (en)	1998-05-21
HU9500880D0 (en)	1995-05-29
JPH07330609A (ja)	1995-12-19
FI951424A7 (fi)	1995-09-29
FR2717689A1 (fr)	1995-09-29
DE69506157D1 (de)	1999-01-07
ATE173618T1 (de)	1998-12-15
LV10929B (en)	1996-08-20
HU219465B (hu)	2001-04-28
NO951126D0 (no)	1995-03-24
AU1497895A (en)	1995-10-05
RU2110282C1 (ru)	1998-05-10
FR2717689B1 (fr)	1996-07-05
DK0674901T3 (da)	1999-08-09
HUT75238A (en)	1997-05-28
FI951424A0 (fi)	1995-03-24
ES2128673T3 (es)	1999-05-16
PL307891A1 (en)	1995-10-02
CA2145584A1 (en)	1995-09-29
ZA952469B (en)	1995-12-19
CZ76795A3 (en)	1995-10-18
EP0674901A1 (fr)	1995-10-04

Legal Events

Date	Code	Title	Description
2001-03-05	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO951126L (no)	1995-09-29	Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen
NO951125D0 (no)	1995-03-24	Transdermalt matriks-system basert på EVA for administrasjon av et östrogen og/eller et progestogen
NO981315L (no)	1998-03-24	Transdermalt matrikssystem
BR9808330A (pt)	2000-05-16	Sìntese de 2-alcoxiestradióis e composto de estradiol
DE3650265D1 (de)	1995-04-20	Makrolide Antibiotika und Verfahren zu deren Herstellung.
NO954681L (no)	1995-11-20	Kjemiske forbindelser
NO981252L (no)	1998-03-19	Transdermalt matrikssystem
AU1517088A (en)	1988-12-01	Agents for repelling insects and mites
PT79839A (en)	1985-02-01	Process for the preparation of 6,6-ethylene-15,16-methylene-3-oxi-17alpha-pregn-4-ene-21,17-carbolactones and pharmaceutical compositions therewith
WO1995018821A3 (en)	1995-08-31	Novel antiandrogenic agents and related pharmaceutical compositions and methods of use
CA2080459A1 (en)	1992-10-09	Compositions for moisture curing hot melt adhesives
NO932277L (no)	1993-08-20	6,7-modifiserte 11beta-aryl-4-oestrener
ES8502700A1 (es)	1985-01-16	Procedimiento para la fabricacion de derivados de tetrahidrobenzotiazol.
EP0239527A3 (en)	1988-01-07	Composition adopted for use as a transdermal formulation
JPS5522632A (en)	1980-02-18	Preparation of stable composition comprising prenyl ketone compound
KR960000882A (ko)	1996-01-25	신규한 피리돈 카르본산 유도체 및 그의 제조방법