NO951277L - Desulfatohirudin med höy molekylvekt - Google Patents

Desulfatohirudin med höy molekylvekt

Info

Publication number
NO951277L
NO951277L NO951277A NO951277A NO951277L NO 951277 L NO951277 L NO 951277L NO 951277 A NO951277 A NO 951277A NO 951277 A NO951277 A NO 951277A NO 951277 L NO951277 L NO 951277L
Authority
NO
Norway
Prior art keywords
desulfatohirudin
molecular weight
high molecular
desulfato
thrombin
Prior art date
Application number
NO951277A
Other languages
English (en)
Other versions
NO951277D0 (no
Inventor
Hugo Grossenbacher
Jui Yoa Chang
Walter Marki
Original Assignee
Ciba Geigy Ag
Upc Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag, Upc Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of NO951277D0 publication Critical patent/NO951277D0/no
Publication of NO951277L publication Critical patent/NO951277L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Thrombininhibitorer og produksjon av modifiserte desulfatohlrudlner ved hjelp av genetisk omkonstruerlng samt en fremgangsmåte for denaturerlng og renaturerlng av et modifisert desulfatohlrudln til en biologisk aktiv thromblnlnhibitor og kombinasjonen av to eller flere desulfatohlrudlner for å danne thrmombin- inhlbltorer med høyere molekylvekt, er beskrevet.
NO951277A 1993-08-04 1995-04-03 Desulfatohirudin med höy molekylvekt NO951277L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810552 1993-08-04
PCT/EP1994/002438 WO1995004823A1 (en) 1993-08-04 1994-07-23 High molecular weight desulphatohirudin

Publications (2)

Publication Number Publication Date
NO951277D0 NO951277D0 (no) 1995-04-03
NO951277L true NO951277L (no) 1995-04-03

Family

ID=8215008

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951277A NO951277L (no) 1993-08-04 1995-04-03 Desulfatohirudin med höy molekylvekt

Country Status (15)

Country Link
US (1) US5661001A (no)
EP (1) EP0663009A1 (no)
JP (1) JPH08502661A (no)
KR (1) KR950703645A (no)
CN (1) CN1113389A (no)
AU (1) AU685835B2 (no)
CA (1) CA2144523A1 (no)
FI (1) FI951541L (no)
HU (1) HUT72926A (no)
IL (1) IL110540A0 (no)
NO (1) NO951277L (no)
NZ (1) NZ271088A (no)
SG (1) SG49862A1 (no)
WO (1) WO1995004823A1 (no)
ZA (1) ZA945775B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2370235T3 (es) * 2001-02-23 2011-12-13 Immunex Corporation Recuperación eficaz de proteínas replegadas correctamente.
CN1328380C (zh) * 2001-09-24 2007-07-25 天津天士力制药股份有限公司 高效表达水蛭素及其生产方法
US20090317329A2 (en) * 2005-07-05 2009-12-24 Baker Idi Heart & Diabetes Institute Holdings Limited Anticoagulation agent and uses thereof
US7803762B1 (en) * 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
CN101993489B (zh) * 2009-08-20 2013-10-23 重庆富进生物医药有限公司 可逆转水蛭素
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
CN114292765B (zh) * 2021-09-24 2023-04-07 江西康之康中药科技有限公司 枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
DE3479520D1 (en) * 1983-11-21 1989-09-28 Ciba Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
AU622860B2 (en) * 1987-05-11 1992-04-30 Novartis Vaccines And Diagnostics, Inc. Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
CA2067224C (en) * 1989-12-01 2001-02-13 Manfred Kurfuerst Hirudin/polyalkylene glycol conjugates
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
IT1248565B (it) * 1991-06-27 1995-01-19 Erba Carlo Spa Anticorpi policlonali anti-irudina e loro utilizzo per la identificazione, l`immunopurificazione e la determinazione quantitativa dell`uridina.

Also Published As

Publication number Publication date
CA2144523A1 (en) 1995-02-16
SG49862A1 (en) 2002-03-19
KR950703645A (ko) 1995-09-20
EP0663009A1 (en) 1995-07-19
ZA945775B (en) 1995-02-06
AU7460594A (en) 1995-02-28
FI951541A0 (fi) 1995-03-31
AU685835B2 (en) 1998-01-29
JPH08502661A (ja) 1996-03-26
NO951277D0 (no) 1995-04-03
NZ271088A (en) 1996-10-28
US5661001A (en) 1997-08-26
WO1995004823A1 (en) 1995-02-16
IL110540A0 (en) 1994-11-11
CN1113389A (zh) 1995-12-13
HUT72926A (en) 1996-06-28
FI951541A7 (fi) 1995-03-31
HU9500689D0 (en) 1995-06-28
FI951541L (fi) 1995-03-31

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application