NO951646L - Nye merkaptoacetylamid-bisykliske laktamderivater som er anvendbare som inhibitorer av enkefalinase og ACE - Google Patents

Nye merkaptoacetylamid-bisykliske laktamderivater som er anvendbare som inhibitorer av enkefalinase og ACE

Info

Publication number: NO951646L
Authority: NO; Norway
Prior art keywords: enkephalinase; ace; inhibitors; derivatives useful; biscyclic
Prior art date: 1992-10-30

Application number

NO951646A

Other languages

English (en)

Norwegian (no)

Other versions

NO951646D0 (no

Inventor

Gary Alan Flynn

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-30

Filing date

1995-04-28

Publication date

1995-06-23

1995-04-28 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-04-28 Publication of NO951646D0 publication Critical patent/NO951646D0/no

1995-06-23 Publication of NO951646L publication Critical patent/NO951646L/no

Links

102000003729 Neprilysin Human genes 0.000 title abstract 2
108090000028 Neprilysin Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical compound NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title 1
150000003951 lactams Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000005869 (methoxyethoxy)methanyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])* 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
-1 mercaptoacetylamide bicyclic lactam Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO951646A 1992-10-30 1995-04-28 Nye merkaptoacetylamid-bisykliske laktamderivater som er anvendbare som inhibitorer av enkefalinase og ACE NO951646L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96877092A	1992-10-30	1992-10-30
PCT/US1993/009001 WO1994010193A1 (en)	1992-10-30	1993-09-23	Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace

Publications (2)

Publication Number	Publication Date
NO951646D0 NO951646D0 (no)	1995-04-28
NO951646L true NO951646L (no)	1995-06-23

Family

ID=25514751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951646A NO951646L (no)	1992-10-30	1995-04-28	Nye merkaptoacetylamid-bisykliske laktamderivater som er anvendbare som inhibitorer av enkefalinase og ACE

Country Status (21)

Country	Link
US (1)	US5635502A (de)
EP (1)	EP0669936B1 (de)
JP (1)	JP3420766B2 (de)
KR (1)	KR100311166B1 (de)
AT (1)	ATE197714T1 (de)
AU (1)	AU673857B2 (de)
CA (1)	CA2146238C (de)
DE (1)	DE69329701T2 (de)
DK (1)	DK0669936T3 (de)
ES (1)	ES2155852T3 (de)
FI (1)	FI110263B (de)
GR (1)	GR3035416T3 (de)
HU (1)	HUT71243A (de)
IL (1)	IL107413A (de)
MX (1)	MX9306758A (de)
NO (1)	NO951646L (de)
NZ (1)	NZ256589A (de)
PT (1)	PT669936E (de)
TW (1)	TW327172B (de)
WO (1)	WO1994010193A1 (de)
ZA (1)	ZA937912B (de)

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US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
JP3563738B2 (ja) *	1993-06-11	2004-09-08	エーザイ株式会社	アミノ酸誘導体
US5508272A (en) *	1993-06-15	1996-04-16	Bristol-Myers Squibb Company	Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
CA2183314C (en) *	1994-02-14	1999-08-31	Gary A. Flynn	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
JPH09508906A (ja) *	1994-02-14	1997-09-09	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
CA2183313C (en) *	1994-02-14	2001-01-02	Gary A. Flynn	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
JP3444666B2 (ja)	1994-08-24	2003-09-08	エーザイ株式会社	（２ｓ，３ｓ）−３− メチル−２− チオペンタン酸誘導体の製造方法
DE69532155T2 (de) *	1994-07-18	2004-08-19	Eisai Co., Ltd.	Substituierte thiazolo [3,2-alpha]azepinderivate
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US6699869B1 (en)	1995-03-24	2004-03-02	Myriad Genetics Inc.	β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6245764B1 (en)	1995-03-24	2001-06-12	Molecumetics Ltd.	β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) *	1995-03-24	2000-02-01	Molecumetics, Ltd.	β-sheet mimetics and use thereof as protease inhibitors
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US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
WO1999065500A1 (en)	1998-06-17	1999-12-23	Bristol-Myers Squibb Company	Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
WO2000056724A1 (en) *	1999-03-22	2000-09-28	The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations	Oxazole and thiazole combinatorial libraries
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
AU2003219809A1 (en)	2002-02-14	2003-09-04	Myriad Genetics, Inc.	Beta-sheet mimetics and composition and methods relating thereto
FR2984716B1 (fr)	2011-12-22	2013-12-27	Essilor Int	Dispositif et procede de determination d'au moins un parametre de refraction oculaire objective d'un sujet en fonction d'une pluralite de directions de regard
CA2896577C (en)	2012-11-30	2024-01-23	Sanford-Burnham Medical Research Institute	Inhibitor of apoptosis protein (iap) antagonists
JP6768522B2 (ja)	2014-06-04	2020-10-14	サンフォード−バーンハムメディカルリサーチインスティテュート	Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用
US10513515B2 (en)	2017-08-25	2019-12-24	Biotheryx, Inc.	Ether compounds and uses thereof
WO2020023782A1 (en)	2018-07-27	2020-01-30	Biotheryx, Inc.	Bifunctional compounds as cdk modulators
US12678509B2 (en)	2019-11-08	2026-07-14	Sanford Burnham Prebys Medical Discovery Institute	Inhibitor of apoptosis (IAP) protein antagonists
EP4143329A4 (de)	2020-04-28	2024-10-16	Anwita Biosciences, Inc.	Interleukin-2-polypeptide und fusionsproteine davon sowie deren pharmazeutische zusammensetzungen und therapeutische anwendungen

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US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
ATE158303T1 (de) *	1990-12-21	1997-10-15	Merrell Pharma Inc	Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften
FR2679564A1 (fr) *	1991-07-23	1993-01-29	Inst Nat Sante Rech Med	Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
EP0605589A1 (de) *	1991-09-16	1994-07-13	Schering Corporation	Natriuretische peptide oder neutrale endopeptidaseinhibitoren enthaltene pharmazeutische zusammensetzungen (arznei) der behandlung oder vorbeugung myointimaler wucherung
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US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds

1993
- 1993-09-23 PT PT94914243T patent/PT669936E/pt unknown
- 1993-09-23 WO PCT/US1993/009001 patent/WO1994010193A1/en not_active Ceased
- 1993-09-23 HU HU9501239A patent/HUT71243A/hu unknown
- 1993-09-23 AU AU51362/93A patent/AU673857B2/en not_active Expired
- 1993-09-23 JP JP51105294A patent/JP3420766B2/ja not_active Expired - Fee Related
- 1993-09-23 AT AT94914243T patent/ATE197714T1/de active
- 1993-09-23 EP EP94914243A patent/EP0669936B1/de not_active Expired - Lifetime
- 1993-09-23 DK DK94914243T patent/DK0669936T3/da active
- 1993-09-23 ES ES94914243T patent/ES2155852T3/es not_active Expired - Lifetime
- 1993-09-23 DE DE69329701T patent/DE69329701T2/de not_active Expired - Lifetime
- 1993-09-23 US US08/406,979 patent/US5635502A/en not_active Expired - Lifetime
- 1993-09-23 CA CA002146238A patent/CA2146238C/en not_active Expired - Lifetime
- 1993-09-23 KR KR1019950701668A patent/KR100311166B1/ko not_active Expired - Fee Related
- 1993-09-23 NZ NZ256589A patent/NZ256589A/en not_active IP Right Cessation
- 1993-10-25 ZA ZA937912A patent/ZA937912B/xx unknown
- 1993-10-26 TW TW082108885A patent/TW327172B/zh not_active IP Right Cessation
- 1993-10-27 IL IL10741393A patent/IL107413A/en not_active IP Right Cessation
- 1993-10-29 MX MX9306758A patent/MX9306758A/es unknown
1995
- 1995-04-27 FI FI952014A patent/FI110263B/fi not_active IP Right Cessation
- 1995-04-28 NO NO951646A patent/NO951646L/no not_active Application Discontinuation
2001
- 2001-02-14 GR GR20010400246T patent/GR3035416T3/el unknown

Also Published As

Publication number	Publication date
HUT71243A (en)	1995-11-28
NZ256589A (en)	1996-05-28
KR950704349A (ko)	1995-11-20
FI110263B (fi)	2002-12-31
HU9501239D0 (en)	1995-06-28
FI952014L (fi)	1995-04-27
JP3420766B2 (ja)	2003-06-30
ES2155852T3 (es)	2001-06-01
EP0669936A1 (de)	1995-09-06
DE69329701D1 (de)	2000-12-28
ZA937912B (en)	1994-06-01
TW327172B (en)	1998-02-21
IL107413A0 (en)	1994-01-25
DK0669936T3 (da)	2001-02-05
ATE197714T1 (de)	2000-12-15
NO951646D0 (no)	1995-04-28
CA2146238A1 (en)	1994-05-11
MX9306758A (es)	1994-07-29
US5635502A (en)	1997-06-03
FI952014A0 (fi)	1995-04-27
IL107413A (en)	1999-08-17
PT669936E (pt)	2001-04-30
KR100311166B1 (ko)	2002-02-28
WO1994010193A1 (en)	1994-05-11
AU673857B2 (en)	1996-11-28
GR3035416T3 (en)	2001-05-31
JPH08502746A (ja)	1996-03-26
DE69329701T2 (de)	2001-05-10
EP0669936B1 (de)	2000-11-22
CA2146238C (en)	2001-03-13
AU5136293A (en)	1994-05-24

Legal Events

Date	Code	Title	Description
2003-10-13	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
FI952014A0 (fi)	1995-04-27	Uusia bisyklisiä merkaptoasetyyliamidilaktaamijohdannaisia, jotka ovat hyödyllisiä enkefalinaasin ja ACE:n inhibiittoreina
AU563683C (en)	2001-12-20	Substituted acyl derivative of 1,2,3,4-tetrahydroiso- quinoline-3-carboxylic acid
FI881446A0 (fi)	1988-03-25	Menetelmä fenyyliryhmällä ja heterobisyklisellä ryhmällä disubstituoituneiden asetyleenien valmistamiseksi, joilla on retiinihapon kaltaista aktiivisuutta
ES2186672T3 (es)	2003-05-16	Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.
HUT52059A (en)	1990-06-28	Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
CA2053340A1 (en)	1992-04-19	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
IE43847L (en)	1976-11-16	N-substituted phenylpiperidine derivatives.
NO933837L (no)	1993-10-25	4-aryl-3-(heteroarylureido)kinolin-derivater
UA43338C2 (uk)	2001-12-17	Похідні бензолу
MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
TW340844B (en)	1998-09-21	Amide derivatives
TW336232B (en)	1998-07-11	Indol-3-yl propenoic acid derivatives for antagonizing NMDA(N-methyl-D-aspartate) and pharmaceutical compositions thereof
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