NO952253L - Tropon-substituerte, fenyloksazolidinon-antibakterielle midler - Google Patents

Tropon-substituerte, fenyloksazolidinon-antibakterielle midler

Info

Publication number
NO952253L
NO952253L NO952253A NO952253A NO952253L NO 952253 L NO952253 L NO 952253L NO 952253 A NO952253 A NO 952253A NO 952253 A NO952253 A NO 952253A NO 952253 L NO952253 L NO 952253L
Authority
NO
Norway
Prior art keywords
tropon
antibacterial agents
group
substituted
agents
Prior art date
Application number
NO952253A
Other languages
English (en)
Other versions
NO952253D0 (no
Inventor
Michael Robert Barbachyn
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO952253D0 publication Critical patent/NO952253D0/no
Publication of NO952253L publication Critical patent/NO952253L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En ny klasse av fenyloxazolidi- non-antibakterielle midler som har, som deres iøynefallende strukturelle trekk, en vedhengende substituert tropongruppe, er beskrevet. Mellom- produkter og fremgangsmåter for fremstilling av disse antibiotikaer er også beskrevet. Disse forbindel- ser er anvendbare aritibakterielle midler for å utrydde eller regulere ømfintlige organismer. I formel (I) (I) har R , R og R de samme betydnin- 4 ger som i krav l, og R er valgt fra gruppen bestående av (a), (b), (c) og (d) hvori R og Ra er like eller for- skjellige og er valgtfra gruppen bestående av (C,-C0)-alkyl eventu- 1 o elt substituert med klor, fluor, hydroxy, (C1,-CR8)-alkoxy, amino, (C,-Ca)-alkylamino, (C1-C8)- dialkylamino.
NO952253A 1992-12-08 1995-06-07 Tropon-substituerte, fenyloksazolidinon-antibakterielle midler NO952253L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98858992A 1992-12-08 1992-12-08
US377893A 1993-01-13 1993-01-13
US6635693A 1993-05-21 1993-05-21
PCT/US1993/009589 WO1994013649A1 (en) 1992-12-08 1993-10-14 Tropone-substituted phenyloxazolidinone antibacterial agents

Publications (2)

Publication Number Publication Date
NO952253D0 NO952253D0 (no) 1995-06-07
NO952253L true NO952253L (no) 1995-08-08

Family

ID=27357482

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952253A NO952253L (no) 1992-12-08 1995-06-07 Tropon-substituerte, fenyloksazolidinon-antibakterielle midler

Country Status (20)

Country Link
US (1) US5523403A (no)
EP (1) EP0673370B1 (no)
JP (1) JP3558088B2 (no)
KR (1) KR100276382B1 (no)
AT (1) ATE161833T1 (no)
AU (1) AU670842B2 (no)
CA (1) CA2147753C (no)
CZ (1) CZ288788B6 (no)
DE (1) DE69316240T2 (no)
DK (1) DK0673370T3 (no)
ES (1) ES2111188T3 (no)
FI (1) FI952798A7 (no)
GR (1) GR3026228T3 (no)
HU (1) HUT74099A (no)
NO (1) NO952253L (no)
NZ (1) NZ257031A (no)
PL (1) PL175782B1 (no)
RU (1) RU2119484C1 (no)
SK (1) SK282453B6 (no)
WO (1) WO1994013649A1 (no)

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US5708169A (en) * 1995-09-15 1998-01-13 Pharmacia & Upjohn Company 5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US5990136A (en) * 1996-08-21 1999-11-23 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials
US5998414A (en) * 1996-08-22 1999-12-07 Hoechst Marion Roussel, Inc. Troponyl piperazines as dopamine D4 receptor ligands
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
CA2304100A1 (en) * 1997-11-07 1999-05-20 Pharmacia & Upjohn Company Process to produce oxazolidinones
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6083967A (en) * 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
WO1999037630A1 (en) * 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
KR20010052615A (ko) 1998-06-05 2001-06-25 다비드 에 질레스 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
EP1147422A1 (en) 1999-01-27 2001-10-24 Pharmacia & Upjohn Company Assays for modulators of "elongation factor p" activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
DE60206154T2 (de) * 2001-04-17 2006-06-29 Merck & Co., Inc. Bicyclo[3,1,0]hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
JP2005519931A (ja) * 2002-02-05 2005-07-07 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 細菌感染症治療に有用な抗微生物性チアジアジノン誘導体
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
WO2003084534A1 (en) * 2002-03-29 2003-10-16 Pharmacia & Upjohn Company Llc Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
WO2004014897A1 (en) * 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
WO2004045616A1 (en) * 2002-11-21 2004-06-03 Pharmacia & Upjohn Company Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
US8813142B2 (en) * 2003-01-31 2014-08-19 Qwest Communications International Inc. Methods, systems and apparatus for providing video transmissions over multiple media
US8050281B2 (en) * 2003-01-31 2011-11-01 Qwest Communications International Inc. Alert gateway, systems and methods
US7474742B2 (en) * 2003-01-31 2009-01-06 Qwest Communications International Inc. Environmentally-controlled network interface device and methods
EP1594865A2 (en) * 2003-02-07 2005-11-16 Warner-Lambert Company LLC Antibacterial agents
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AU2004267007C1 (en) 2003-06-03 2010-04-29 Melinta Subsidiary Corp. Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
JP2007521284A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド オキサゾリジノン系抗生物質及びその誘導体
EP1646629B1 (en) * 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
US20060247286A1 (en) * 2003-07-02 2006-11-02 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
BRPI0413838A (pt) * 2003-08-25 2006-10-24 Warner Lambert Co compostos de ariloxazolidinona antimicrobianos
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
EP2181994B1 (en) 2006-03-31 2014-05-28 Research Foundation Itsuu Laboratory Antimicrobial compounds
JPWO2007116960A1 (ja) * 2006-04-06 2009-08-20 財団法人乙卯研究所 炭素環を有するオキサゾリジノン誘導体
US8530646B2 (en) * 2007-10-02 2013-09-10 Research Foundation Itsuu Laboratory Oxazolidinone derivative having 7-membered hetero ring
WO2010042887A2 (en) * 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
BRPI1008829A2 (pt) 2009-02-03 2016-03-15 Trius Therapeutics forma cristalina de dihidrogenofosfato de (r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofenil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2025134688A1 (ja) * 2023-12-22 2025-06-26 東亞合成株式会社 トロポロン誘導体

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LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
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Also Published As

Publication number Publication date
KR100276382B1 (ko) 2000-12-15
ATE161833T1 (de) 1998-01-15
ES2111188T3 (es) 1998-03-01
AU670842B2 (en) 1996-08-01
AU5323994A (en) 1994-07-04
HU9501670D0 (en) 1995-08-28
NO952253D0 (no) 1995-06-07
NZ257031A (en) 1996-07-26
HUT74099A (en) 1996-11-28
SK282453B6 (sk) 2002-02-05
GR3026228T3 (en) 1998-05-29
JP3558088B2 (ja) 2004-08-25
US5523403A (en) 1996-06-04
RU95114378A (ru) 1997-06-10
DE69316240T2 (de) 1998-05-20
JPH08504205A (ja) 1996-05-07
DE69316240D1 (de) 1998-02-12
SK74695A3 (en) 1995-10-11
CA2147753A1 (en) 1994-06-23
RU2119484C1 (ru) 1998-09-27
CA2147753C (en) 2004-08-03
FI952798A0 (fi) 1995-06-07
EP0673370A1 (en) 1995-09-27
PL175782B1 (pl) 1999-02-26
FI952798L (fi) 1995-06-07
CZ136695A3 (en) 1995-10-18
PL309283A1 (en) 1995-10-02
CZ288788B6 (cs) 2001-09-12
DK0673370T3 (da) 1998-09-07
EP0673370B1 (en) 1998-01-07
FI952798A7 (fi) 1995-06-07
WO1994013649A1 (en) 1994-06-23

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