ES2111188T3 - Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona. - Google Patents

Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona.

Info

Publication number
ES2111188T3
ES2111188T3 ES93923304T ES93923304T ES2111188T3 ES 2111188 T3 ES2111188 T3 ES 2111188T3 ES 93923304 T ES93923304 T ES 93923304T ES 93923304 T ES93923304 T ES 93923304T ES 2111188 T3 ES2111188 T3 ES 2111188T3
Authority
ES
Spain
Prior art keywords
antibacterial agents
tropone
substituted
phenyloxazolidinone
agents derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923304T
Other languages
English (en)
Inventor
Michael Robert Barbachyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2111188T3 publication Critical patent/ES2111188T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UNA NUEVA CLASE DE AGENTES ANTIBACTERIALES DE FENILIDOXAZOLIDINONA QUE TIENEN, COMO PRINCIPAL CARACTERISTICA ESTRUCTURAL, UNA MITAD DE TROPONA SUSTITUIDA AÑADIDA. TAMBIEN SE HAN DESCUBIERTO INTERMEDIARIOS Y PROCESOS PARA LA PREPARACION DE ESTOS ANTIBIOTICOS. ESTOS COMPUESTOS SON AGENTES ANTIBACTERIALES UTILES PARA ERRADICAR O CONTROLAR ORGANISMOS SUSCEPTIBLES. EN LA FORMULA (I), R1, R2 Y R3 SON LO MISMO COMO 1 Y R4 ESTA SELECCIONADO DE UN GRUPO FORMADO POR (A),(B),(C),(D) DONDE R Y RA SON LO MISMO O DIFERENTE Y ESTAN SELECCIONADOS DEL GRUPO DE ALQUILO (C1-C8) OPCIONALMENTE SUSTITUIDO CON CLORO, FLUORO, HIDROXI, ALKOXI (C1-C8), AMINO, ALQUILAMINO (C1-C8), DIALQUILALMINO (C1-C8).
ES93923304T 1992-12-08 1993-10-14 Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona. Expired - Lifetime ES2111188T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98858992A 1992-12-08 1992-12-08
US377893A 1993-01-13 1993-01-13
US6635693A 1993-05-21 1993-05-21

Publications (1)

Publication Number Publication Date
ES2111188T3 true ES2111188T3 (es) 1998-03-01

Family

ID=27357482

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923304T Expired - Lifetime ES2111188T3 (es) 1992-12-08 1993-10-14 Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona.

Country Status (20)

Country Link
US (1) US5523403A (es)
EP (1) EP0673370B1 (es)
JP (1) JP3558088B2 (es)
KR (1) KR100276382B1 (es)
AT (1) ATE161833T1 (es)
AU (1) AU670842B2 (es)
CA (1) CA2147753C (es)
CZ (1) CZ288788B6 (es)
DE (1) DE69316240T2 (es)
DK (1) DK0673370T3 (es)
ES (1) ES2111188T3 (es)
FI (1) FI952798L (es)
GR (1) GR3026228T3 (es)
HU (1) HUT74099A (es)
NO (1) NO952253L (es)
NZ (1) NZ257031A (es)
PL (1) PL175782B1 (es)
RU (1) RU2119484C1 (es)
SK (1) SK282453B6 (es)
WO (1) WO1994013649A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
WO1997010235A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
JP2000516245A (ja) * 1996-08-21 2000-12-05 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤として有用なイソオキサゾリン誘導体類
US5998414A (en) * 1996-08-22 1999-12-07 Hoechst Marion Roussel, Inc. Troponyl piperazines as dopamine D4 receptor ligands
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
NZ504372A (en) * 1997-11-07 2002-12-20 Upjohn Co Process to produce N-[3-fluoro-4(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinones
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6083967A (en) * 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
CA2318969A1 (en) * 1998-01-23 1999-07-29 Mikhail F. Gordeev Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1082323A2 (en) * 1998-06-05 2001-03-14 AstraZeneca UK Limited Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
EP1349853B1 (en) 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
TW200302095A (en) * 2002-01-25 2003-08-01 Upjohn Co Oxazolidinone cotherapy
MXPA04007468A (es) * 2002-02-05 2004-11-10 Upjohn Co Derivados de tiadiazinona antimicrobianos y su aplicacion para el tratamiento de infecciones bacterianas.
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
PL372661A1 (en) * 2002-03-29 2005-07-25 Pharmacia & Upjohn Company Llc. Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
MXPA05001558A (es) * 2002-08-12 2005-09-08 Pharmacia & Upjohn Co Llc N-aril-2-oxazolidinonas y sus derivados.
ATE344036T1 (de) * 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
US7474742B2 (en) * 2003-01-31 2009-01-06 Qwest Communications International Inc. Environmentally-controlled network interface device and methods
US8050281B2 (en) * 2003-01-31 2011-11-01 Qwest Communications International Inc. Alert gateway, systems and methods
US8813142B2 (en) * 2003-01-31 2014-08-19 Qwest Communications International Inc. Methods, systems and apparatus for providing video transmissions over multiple media
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
TWI378092B (en) 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
MXPA06000228A (es) 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
US20070293493A1 (en) * 2003-07-02 2007-12-20 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
CA2529292A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
MXPA06002188A (es) * 2003-08-25 2006-04-27 Warner Lambert Co Nuevos compuestos antimicrobianos de ariloxazolidinona.
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (ja) * 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1904489B1 (en) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
CN101460495B (zh) 2006-03-31 2013-08-14 财团法人乙卯研究所 具有杂环的化合物
JPWO2007116960A1 (ja) * 2006-04-06 2009-08-20 財団法人乙卯研究所 炭素環を有するオキサゾリジノン誘導体
EP2669283A1 (en) 2007-10-02 2013-12-04 Shionogi&Co., Ltd. Oxazolidinone derivative having 7-membered hetero ring
RU2659792C1 (ru) 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Оксазолидиноны и способ их очистки
MX384300B (es) 2009-02-03 2025-03-14 Merck Sharp & Dohme Llc Forma cristalina del fosfato de dihidrogeno r) -3- (4- (2- (2-metiltetrazol-5-il) piridin-5-il) -3-fluorofenil) -5-hidroximetil oxazolidin-2-ona.
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2025134688A1 (ja) * 2023-12-22 2025-06-26 東亞合成株式会社 トロポロン誘導体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE29607E (en) * 1969-03-18 1978-04-11 Delalande S. A. Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
DE3149608A1 (de) * 1981-12-15 1983-08-04 Dr. Madaus & Co, 5000 Köln Substituierte tropolone, verfahren zur herstellung derselben und diese enthaltende pharmazeutische zubereitungen
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
ATE95176T1 (de) * 1987-10-21 1993-10-15 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones

Also Published As

Publication number Publication date
JP3558088B2 (ja) 2004-08-25
RU2119484C1 (ru) 1998-09-27
CA2147753A1 (en) 1994-06-23
DE69316240T2 (de) 1998-05-20
FI952798A0 (fi) 1995-06-07
DE69316240D1 (de) 1998-02-12
NO952253D0 (no) 1995-06-07
US5523403A (en) 1996-06-04
KR100276382B1 (ko) 2000-12-15
DK0673370T3 (da) 1998-09-07
EP0673370A1 (en) 1995-09-27
SK74695A3 (en) 1995-10-11
EP0673370B1 (en) 1998-01-07
NO952253L (no) 1995-08-08
CZ136695A3 (en) 1995-10-18
CZ288788B6 (cs) 2001-09-12
PL309283A1 (en) 1995-10-02
GR3026228T3 (en) 1998-05-29
NZ257031A (en) 1996-07-26
JPH08504205A (ja) 1996-05-07
PL175782B1 (pl) 1999-02-26
AU670842B2 (en) 1996-08-01
AU5323994A (en) 1994-07-04
FI952798A7 (fi) 1995-06-07
RU95114378A (ru) 1997-06-10
HUT74099A (en) 1996-11-28
CA2147753C (en) 2004-08-03
FI952798L (fi) 1995-06-07
WO1994013649A1 (en) 1994-06-23
ATE161833T1 (de) 1998-01-15
HU9501670D0 (en) 1995-08-28
SK282453B6 (sk) 2002-02-05

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