NO952482L - Peptider av borsyre, samt fremstilling derav - Google Patents

Peptider av borsyre, samt fremstilling derav

Info

Publication number: NO952482L
Authority: NO; Norway
Prior art keywords: hydrogen atom; phenyl; preparation; boric acid; acid peptides
Prior art date: 1994-06-22

Application number

NO952482A

Other languages

English (en)

Norwegian (no)

Other versions

NO952482D0 (no

Inventor

Guillaume De Nanteuil

Christine Lila

Philippe Gloanec

Michel Laubie

Tony Verbeuren

Serge Simonet

Alain Rubin

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-22

Filing date

1995-06-21

Publication date

1995-12-27

1995-06-21 Application filed by Adir filed Critical Adir

1995-06-21 Publication of NO952482D0 publication Critical patent/NO952482D0/no

1995-12-27 Publication of NO952482L publication Critical patent/NO952482L/no

Links

KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
239000004327 boric acid Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
-1 (pyridyl) methyl Chemical group 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
MOILFCKRQFQVFS-BDNRQGISSA-N (1r,3s,4r,5r)-4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1[C@@H]2C(C)(C)[C@H]1C[C@H](O)[C@@]2(O)C MOILFCKRQFQVFS-BDNRQGISSA-N 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO952482A 1994-06-22 1995-06-21 Peptider av borsyre, samt fremstilling derav NO952482L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9407589A FR2721611B1 (fr)	1994-06-22	1994-06-22	Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .

Publications (2)

Publication Number	Publication Date
NO952482D0 NO952482D0 (no)	1995-06-21
NO952482L true NO952482L (no)	1995-12-27

Family

ID=9464456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO952482A NO952482L (no)	1994-06-22	1995-06-21	Peptider av borsyre, samt fremstilling derav

Country Status (13)

Country	Link
US (1)	US5585360A (de)
EP (1)	EP0688788B1 (de)
JP (1)	JP2862496B2 (de)
CN (1)	CN1121077A (de)
AT (1)	ATE199910T1 (de)
AU (1)	AU686365B2 (de)
CA (1)	CA2152205A1 (de)
DE (1)	DE69520389D1 (de)
FI (1)	FI953089A7 (de)
FR (1)	FR2721611B1 (de)
NO (1)	NO952482L (de)
NZ (1)	NZ272401A (de)
ZA (1)	ZA955176B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6825169B1 (en)	1991-10-22	2004-11-30	Trustees Of Tufts College	Inhibitors of dipeptidyl-aminopeptidase type IV
US5726159A (en) *	1994-03-04	1998-03-10	Eli Lilly And Company	Antithrombotic agents
US5602101A (en) *	1994-03-04	1997-02-11	Eli Lilly And Company	Antithrombotic agents
US5707966A (en) *	1994-03-04	1998-01-13	Eli Lilly And Company	Antithrombotic agents
CA2143533A1 (en) *	1994-03-04	1995-09-05	Kenneth D. Kurz	Antithrombotic agents
ZA951618B (en) *	1994-03-04	1996-08-27	Lilly Co Eli	Antithrombotic agents
US5705487A (en) *	1994-03-04	1998-01-06	Eli Lilly And Company	Antithrombotic agents
US5885967A (en) *	1994-03-04	1999-03-23	Eli Lilly And Company	Antithrombotic agents
US5710130A (en) *	1995-02-27	1998-01-20	Eli Lilly And Company	Antithrombotic agents
US5914319A (en) *	1995-02-27	1999-06-22	Eli Lilly And Company	Antithrombotic agents
US5811402A (en) *	1996-03-22	1998-09-22	Eli Lilly And Company	Antithrombotic diamides
US5965532A (en)	1996-06-28	1999-10-12	Trustees Of Tufts College	Multivalent compounds for crosslinking receptors and uses thereof
US6063794A (en)	1996-10-11	2000-05-16	Cor Therapeutics Inc.	Selective factor Xa inhibitors
US6194435B1 (en)	1996-10-11	2001-02-27	Cor Therapeutics, Inc.	Lactams as selective factor Xa inhibitors
US6262047B1 (en)	1996-10-11	2001-07-17	Cor Therapeutics, Inc.	Selective factor Xa inhibitors
US6369080B2 (en)	1996-10-11	2002-04-09	Cor Therapeutics, Inc.	Selective factor Xa inhibitors
EP0975659A1 (de) *	1997-04-14	2000-02-02	Cor Therapeutics, Inc.	Selektive faktor xa-inhibitoren
WO1998046626A1 (en)	1997-04-14	1998-10-22	Cor Therapeutics, Inc.	SELECTIVE FACTOR Xa INHIBITORS
AU6896398A (en)	1997-04-14	1998-11-11	Cor Therapeutics, Inc.	Selective factor xa inhibitors
US6100234A (en) *	1997-05-07	2000-08-08	Tufts University	Treatment of HIV
US6040145A (en)	1997-05-07	2000-03-21	Tufts University	Potentiation of the immune response
US6228854B1 (en)	1997-08-11	2001-05-08	Cor Therapeutics, Inc.	Selective factor Xa inhibitors
US6218382B1 (en)	1997-08-11	2001-04-17	Cor Therapeutics, Inc	Selective factor Xa inhibitors
US6333321B1 (en)	1997-08-11	2001-12-25	Cor Therapeutics, Inc.	Selective factor Xa inhibitors
BR9813233A (pt)	1997-09-29	2000-08-22	Point Therapeutics Inc	Estimulação de células hematopoéticas in vitro
JP2002513762A (ja)	1998-05-04	2002-05-14	ポイントセラピューティクス，インコーポレイテッド	造血刺激
US6979697B1 (en)	1998-08-21	2005-12-27	Point Therapeutics, Inc.	Regulation of substrate activity
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
ATE317850T1 (de) *	2001-05-30	2006-03-15	Novartis Pharma Gmbh	2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate
US20050119226A1 (en) *	2003-09-09	2005-06-02	Trigen Limited	Methods for synthesizing organoboronic compounds and products thereof
US7371729B2 (en) *	2002-09-09	2008-05-13	Trigen Limited	Boronic acid salts useful in parenteral formulations
KR20050057295A (ko)	2002-09-09	2005-06-16	트라이젠 리미티드	혈전증 치료를 위한 보론산의 다가 금속염
US20050176651A1 (en) *	2002-09-09	2005-08-11	Trigen Limited	Peptide boronic acids useful in making salts thereof
US20050282757A1 (en) *	2002-09-09	2005-12-22	Trigen Limited	Peptide boronic acid compounds useful in anticoagulation
US20060084592A1 (en) *	2002-09-09	2006-04-20	Trigen Limited	Peptide boronic acid inhibitors
GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) *	1990-08-13	1990-09-26	Sandoz Ltd	Improvements in or relating to organic chemistry
US5288707A (en) *	1990-08-13	1994-02-22	Sandoz Ltd.	Borolysine peptidomimetics
GB9024129D0 (en) *	1990-11-06	1990-12-19	Thrombosis Research Trust	Inhibitors and substrates of thrombin
FR2701951B1 (fr) *	1993-02-24	1995-06-09	Adir	Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5384410A (en)	1993-03-24	1995-01-24	The Du Pont Merck Pharmaceutical Company	Removal of boronic acid protecting groups by transesterification
IL109319A0 (en) *	1993-04-27	1994-07-31	Du Pont Merck Pharma	Amidino and guanidino substituted boronic acid compounds
IL111175A0 (en) *	1993-10-07	1994-12-29	Du Pont Merck Pharma	Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them

1994
- 1994-06-22 FR FR9407589A patent/FR2721611B1/fr not_active Expired - Lifetime
1995
- 1995-06-02 US US08/458,504 patent/US5585360A/en not_active Expired - Fee Related
- 1995-06-20 AU AU21801/95A patent/AU686365B2/en not_active Ceased
- 1995-06-20 CA CA002152205A patent/CA2152205A1/fr not_active Abandoned
- 1995-06-21 FI FI953089A patent/FI953089A7/fi unknown
- 1995-06-21 AT AT95401462T patent/ATE199910T1/de not_active IP Right Cessation
- 1995-06-21 JP JP7154218A patent/JP2862496B2/ja not_active Expired - Lifetime
- 1995-06-21 NZ NZ272401A patent/NZ272401A/en unknown
- 1995-06-21 NO NO952482A patent/NO952482L/no not_active Application Discontinuation
- 1995-06-21 DE DE69520389T patent/DE69520389D1/de not_active Expired - Lifetime
- 1995-06-21 EP EP95401462A patent/EP0688788B1/de not_active Expired - Lifetime
- 1995-06-21 CN CN95106659A patent/CN1121077A/zh active Pending
- 1995-06-22 ZA ZA955176A patent/ZA955176B/xx unknown

Also Published As

Publication number	Publication date
EP0688788B1 (de)	2001-03-21
AU686365B2 (en)	1998-02-05
FR2721611B1 (fr)	1996-09-27
DE69520389D1 (de)	2001-04-26
FI953089A7 (fi)	1995-12-23
NO952482D0 (no)	1995-06-21
NZ272401A (en)	1996-05-28
FI953089A0 (fi)	1995-06-21
US5585360A (en)	1996-12-17
ATE199910T1 (de)	2001-04-15
JP2862496B2 (ja)	1999-03-03
JPH083187A (ja)	1996-01-09
FR2721611A1 (fr)	1995-12-29
CN1121077A (zh)	1996-04-24
EP0688788A1 (de)	1995-12-27
ZA955176B (en)	1996-02-08
CA2152205A1 (fr)	1995-12-23
AU2180195A (en)	1996-01-04

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Legal Events

Date	Code	Title	Description
2002-04-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application