NO953146D0 - Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler - Google Patents

Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler

Info

Publication number: NO953146D0
Authority: NO; Norway
Prior art keywords: hydrogen; alkyl; halogen; tetralin; isoquinoline
Prior art date: 1993-12-22

Application number

NO953146A

Other languages

English (en)

Norwegian (no)

Other versions

NO953146L (no

Inventor

Franco Buzzetti

Antonio Longo

Maria Gabriella Brasca

Fabrizio Orzi

Angelo Crugnola

Dario Ballinari

Mariangela Mariani

Original Assignee

Pharmacia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-22

Filing date

1995-08-10

Publication date

1995-08-10

1995-08-10 Application filed by Pharmacia Spa filed Critical Pharmacia Spa

1995-08-10 Publication of NO953146L publication Critical patent/NO953146L/no

1995-08-10 Publication of NO953146D0 publication Critical patent/NO953146D0/no

Links

239000004037 angiogenesis inhibitor Substances 0.000 title abstract 2
125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 12
239000001257 hydrogen Substances 0.000 abstract 12
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 10
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 8
150000002431 hydrogen Chemical group 0.000 abstract 8
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 8
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 7
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 4
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
125000002619 bicyclic group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000001624 naphthyl group Chemical group 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
-1 cyano, carboxy Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO953146A 1993-12-22 1995-08-10 Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler NO953146D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939326136A GB9326136D0 (en)	1993-12-22	1993-12-22	Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents
PCT/EP1994/003664 WO1995017181A1 (en)	1993-12-22	1994-11-08	Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents

Publications (2)

Publication Number	Publication Date
NO953146L NO953146L (no)	1995-08-10
NO953146D0 true NO953146D0 (no)	1995-08-10

Family

ID=10746990

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO953146A NO953146D0 (no)	1993-12-22	1995-08-10	Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler

Country Status (17)

Country	Link
US (1)	US5576330A (de)
EP (1)	EP0684820B1 (de)
JP (1)	JPH08507089A (de)
KR (1)	KR960700707A (de)
AT (1)	ATE204168T1 (de)
AU (1)	AU676958B2 (de)
CA (1)	CA2155098A1 (de)
DE (1)	DE69427962T2 (de)
ES (1)	ES2162871T3 (de)
GB (1)	GB9326136D0 (de)
HU (1)	HUT73176A (de)
IL (1)	IL112010A (de)
NO (1)	NO953146D0 (de)
PL (1)	PL310379A1 (de)
TW (1)	TW273510B (de)
WO (1)	WO1995017181A1 (de)
ZA (1)	ZA9410204B (de)

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GB9613021D0 (en) *	1996-06-21	1996-08-28	Pharmacia Spa	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
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US6797825B2 (en)	2001-12-13	2004-09-28	Abbott Laboratories	Protein kinase inhibitors
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
EP1572078A4 (de) *	2002-03-08	2006-08-09	Univ Emory	NEUE CURCUMINOID-FAKTOR-VIIa-KONSTRUKTE ALS MITTEL ZUR UNTERDRÜCKUNG VON TUMORWACHSTUM UND ANGIOGENESE
KR20120068769A (ko)	2002-07-15	2012-06-27	더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템	음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
ATE508747T1 (de)	2003-03-10	2011-05-15	Eisai R&D Man Co Ltd	C-kit kinase-hemmer
US7683172B2 (en)	2003-11-11	2010-03-23	Eisai R&D Management Co., Ltd.	Urea derivative and process for preparing the same
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CN103402519B (zh)	2011-04-18	2015-11-25	卫材R&D管理有限公司	肿瘤治疗剂
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KR20150098605A (ko)	2012-12-21	2015-08-28	에자이 알앤드디 매니지먼트 가부시키가이샤	퀴놀린 유도체의 비정질 형태 및 그의 제조방법
NZ714049A (en)	2013-05-14	2020-05-29	Eisai R&D Man Co Ltd	Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
EP2837626A1 (de) *	2013-08-16	2015-02-18	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Indolinon-Derivate als GRK5-Modulatoren
PT3524595T (pt)	2014-08-28	2022-09-19	Eisai R&D Man Co Ltd	Derivado de quinolina altamente puro e método para produção do mesmo
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1993
- 1993-12-22 GB GB939326136A patent/GB9326136D0/en active Pending
1994
- 1994-11-08 CA CA002155098A patent/CA2155098A1/en not_active Abandoned
- 1994-11-08 ES ES94931583T patent/ES2162871T3/es not_active Expired - Lifetime
- 1994-11-08 KR KR1019950703524A patent/KR960700707A/ko not_active Withdrawn
- 1994-11-08 HU HU9502761A patent/HUT73176A/hu unknown
- 1994-11-08 PL PL94310379A patent/PL310379A1/xx unknown
- 1994-11-08 WO PCT/EP1994/003664 patent/WO1995017181A1/en not_active Ceased
- 1994-11-08 AU AU80612/94A patent/AU676958B2/en not_active Ceased
- 1994-11-08 JP JP7517121A patent/JPH08507089A/ja active Pending
- 1994-11-08 AT AT94931583T patent/ATE204168T1/de not_active IP Right Cessation
- 1994-11-08 EP EP94931583A patent/EP0684820B1/de not_active Expired - Lifetime
- 1994-11-08 DE DE69427962T patent/DE69427962T2/de not_active Expired - Fee Related
- 1994-11-15 TW TW083110552A patent/TW273510B/zh active
- 1994-12-12 US US08/354,215 patent/US5576330A/en not_active Expired - Fee Related
- 1994-12-12 ZA ZA9410204A patent/ZA9410204B/xx unknown
- 1994-12-16 IL IL11201094A patent/IL112010A/en not_active IP Right Cessation
1995
- 1995-08-10 NO NO953146A patent/NO953146D0/no unknown

Also Published As

Publication number	Publication date
KR960700707A (ko)	1996-02-24
GB9326136D0 (en)	1994-02-23
NO953146L (no)	1995-08-10
ZA9410204B (en)	1995-11-10
AU8061294A (en)	1995-07-10
US5576330A (en)	1996-11-19
ATE204168T1 (de)	2001-09-15
DE69427962D1 (de)	2001-09-20
CA2155098A1 (en)	1995-06-29
EP0684820A1 (de)	1995-12-06
WO1995017181A1 (en)	1995-06-29
HU9502761D0 (en)	1995-11-28
JPH08507089A (ja)	1996-07-30
ES2162871T3 (es)	2002-01-16
PL310379A1 (en)	1995-12-11
IL112010A0 (en)	1995-03-15
HUT73176A (en)	1996-06-28
IL112010A (en)	1998-10-30
EP0684820B1 (de)	2001-08-16
AU676958B2 (en)	1997-03-27
DE69427962T2 (de)	2002-04-04
TW273510B (de)	1996-04-01

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NO953146L (no)	1995-08-10	Biologisk aktive 3-substituerte oksindolderivater som er nyttige som antiangiogeniske midler
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