NO953387L - Anvendelsen av 2H-1,2,4-benzotiadiazin 3 (4H)-on 1,1-dioksydderivater som ikke-kompetitive NMDA-reseptor-antagonister - Google Patents
Anvendelsen av 2H-1,2,4-benzotiadiazin 3 (4H)-on 1,1-dioksydderivater som ikke-kompetitive NMDA-reseptor-antagonisterInfo
- Publication number
- NO953387L NO953387L NO953387A NO953387A NO953387L NO 953387 L NO953387 L NO 953387L NO 953387 A NO953387 A NO 953387A NO 953387 A NO953387 A NO 953387A NO 953387 L NO953387 L NO 953387L
- Authority
- NO
- Norway
- Prior art keywords
- receptor antagonists
- benzothiadiazine
- nmda receptor
- dioxide derivatives
- competitive nmda
- Prior art date
Links
- QCHXXLQQTWUIRQ-UHFFFAOYSA-N 1,1-dioxo-4h-1$l^{6},2,4-benzothiadiazin-3-one Chemical class C1=CC=C2S(=O)(=O)NC(=O)NC2=C1 QCHXXLQQTWUIRQ-UHFFFAOYSA-N 0.000 title 1
- 229940127307 Noncompetitive NMDA Receptor Antagonists Drugs 0.000 title 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000036963 noncompetitive effect Effects 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9302439A FR2702150B1 (fr) | 1993-03-03 | 1993-03-03 | Application de dérivés de 2H-1,2-4-benzothiadiazine-3(4H)-one-1,1-dioxyde comme antagonistes non compétitifs du récepteur NMDA. |
| PCT/FR1994/000207 WO1994020109A1 (fr) | 1993-03-03 | 1994-02-25 | Application de derives de 2h-1,2,4-benzothiadiazine-3(4h)-one-1,1-dioxyde comme antagonistes non competitifs du recepteur nmda |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO953387D0 NO953387D0 (no) | 1995-08-29 |
| NO953387L true NO953387L (no) | 1995-08-29 |
Family
ID=9444603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953387A NO953387L (no) | 1993-03-03 | 1995-08-29 | Anvendelsen av 2H-1,2,4-benzotiadiazin 3 (4H)-on 1,1-dioksydderivater som ikke-kompetitive NMDA-reseptor-antagonister |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0687178A1 (de) |
| JP (1) | JPH08507303A (de) |
| AU (1) | AU6143694A (de) |
| CA (1) | CA2153951A1 (de) |
| FR (1) | FR2702150B1 (de) |
| HU (1) | HU9502572D0 (de) |
| IL (1) | IL108784A0 (de) |
| NO (1) | NO953387L (de) |
| PL (1) | PL310439A1 (de) |
| WO (1) | WO1994020109A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (de) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazolderivate als glutaminylcyclase-hemmer |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB975925A (en) * | 1961-02-21 | 1964-11-25 | Scherico Ltd | 3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides |
| US4716161A (en) * | 1984-04-17 | 1987-12-29 | Mitsubishi Chemical Industries Limited | Phenylpiperazine derivatives and their acid addition salts |
| FR2675801A1 (fr) * | 1991-04-24 | 1992-10-30 | Rhone Poulenc Rorer Sa | Piperidines, leur preparation et les medicaments les contenant. |
| FR2690160A1 (fr) * | 1992-04-15 | 1993-10-22 | Rhone Poulenc Rorer Sa | Application de dérivés d'acide 2H-1,2,4-benzothiadiazine-1,1-dioxyde-3-carboxylique à la préparation de médicaments, les produits nouveaux, leur préparation et les médicaments les contenant. |
| EP0636124A1 (de) * | 1992-04-15 | 1995-02-01 | Aventis Pharma S.A. | 3,4-dihydro-2h-1,2,4-benzothiadiazin-1,1-dioxid-3-carbosäure-derivate, ihre herstellung und diese enthaltende artzneimittel |
-
1993
- 1993-03-03 FR FR9302439A patent/FR2702150B1/fr not_active Expired - Fee Related
-
1994
- 1994-02-25 EP EP94908373A patent/EP0687178A1/de not_active Withdrawn
- 1994-02-25 WO PCT/FR1994/000207 patent/WO1994020109A1/fr not_active Ceased
- 1994-02-25 HU HU9502572A patent/HU9502572D0/hu unknown
- 1994-02-25 AU AU61436/94A patent/AU6143694A/en not_active Abandoned
- 1994-02-25 JP JP6519646A patent/JPH08507303A/ja active Pending
- 1994-02-25 CA CA002153951A patent/CA2153951A1/fr not_active Abandoned
- 1994-02-25 PL PL94310439A patent/PL310439A1/xx unknown
- 1994-02-28 IL IL10878494A patent/IL108784A0/xx unknown
-
1995
- 1995-08-29 NO NO953387A patent/NO953387L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO953387D0 (no) | 1995-08-29 |
| JPH08507303A (ja) | 1996-08-06 |
| IL108784A0 (en) | 1994-06-24 |
| FR2702150B1 (fr) | 1995-04-07 |
| FR2702150A1 (fr) | 1994-09-09 |
| PL310439A1 (en) | 1995-12-11 |
| EP0687178A1 (de) | 1995-12-20 |
| CA2153951A1 (fr) | 1994-09-15 |
| HU9502572D0 (en) | 1995-11-28 |
| WO1994020109A1 (fr) | 1994-09-15 |
| AU6143694A (en) | 1994-09-26 |
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