NO954072L - Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler - Google Patents

Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler

Info

Publication number: NO954072L
Authority: NO; Norway
Prior art keywords: alkyl; blend; hydrogen; antitumor agents; group
Prior art date: 1994-02-16

Application number

NO954072A

Other languages

English (en)

Norwegian (no)

Other versions

NO954072D0 (no

Inventor

Angelo Bedeschi

Franco Zarini

Walter Cabri

Ilaria Candiani

Sergio Penco

Laura Capolongo

Original Assignee

Pharmacia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-16

Filing date

1995-10-13

Publication date

1995-12-11

1995-10-13 Application filed by Pharmacia Spa filed Critical Pharmacia Spa

1995-10-13 Publication of NO954072D0 publication Critical patent/NO954072D0/no

1995-12-11 Publication of NO954072L publication Critical patent/NO954072L/no

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
239000000203 mixture Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
-1 benzoyloxy, amino, hydroxy Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO954072A 1994-02-16 1995-10-13 Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler NO954072L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9402934A GB9402934D0 (en)	1994-02-16	1994-02-16	Camptothecin derivatives and process for their preparation
PCT/EP1995/000393 WO1995022549A1 (en)	1994-02-16	1995-02-03	Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents

Publications (2)

Publication Number	Publication Date
NO954072D0 NO954072D0 (no)	1995-10-13
NO954072L true NO954072L (no)	1995-12-11

Family

ID=10750430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO954072A NO954072L (no)	1994-02-16	1995-10-13	Vannopplöselige camptotecinderivater, fremgangsmåte for deres fremstilling og deres anvendelse som antitumormidler

Country Status (20)

Country	Link
US (2)	US5602141A (de)
EP (1)	EP0694035B1 (de)
JP (1)	JPH08509244A (de)
KR (1)	KR960701878A (de)
CN (1)	CN1123548A (de)
AT (1)	ATE220681T1 (de)
AU (1)	AU681941B2 (de)
CA (1)	CA2158855C (de)
DE (1)	DE69527400T2 (de)
ES (1)	ES2180625T3 (de)
FI (1)	FI954898A0 (de)
GB (1)	GB9402934D0 (de)
HU (1)	HUT73423A (de)
IL (1)	IL112622A (de)
MX (1)	MX9504287A (de)
NO (1)	NO954072L (de)
NZ (1)	NZ279813A (de)
PL (1)	PL311122A1 (de)
WO (1)	WO1995022549A1 (de)
ZA (1)	ZA951227B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
US5965566A (en) *	1993-10-20	1999-10-12	Enzon, Inc.	High molecular weight polymer-based prodrugs
US5880131A (en) *	1993-10-20	1999-03-09	Enzon, Inc.	High molecular weight polymer-based prodrugs
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation
GB9410388D0 (en) *	1994-05-24	1994-07-13	Erba Carlo Spa	Method for the preparation of 9-amino camptothecin
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
US6096336A (en) *	1996-01-30	2000-08-01	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
GB9601779D0 (en) *	1996-01-30	1996-04-03	Pharmacia Spa	9, 10 Disubstituted camptothecin derivatives
GB9702807D0 (en)	1997-02-12	1997-04-02	Pharmacia & Upjohn Spa	Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) *	1997-07-25	1997-10-01	Pharmacia & Upjohn Spa	Amidino-camptothecin derivatives
US6043367A (en) *	1998-09-30	2000-03-28	Roffler; Steve	Proactive antitumor compounds
US6352996B1 (en)	1999-08-03	2002-03-05	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en)	1999-08-03	2001-05-08	The Stehlin Foundation For Cancer Research	Aromatic esters of camptothecins and methods to treat cancers
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
UA80409C2 (en) *	2001-11-30	2007-09-25	Chugai Pharmaceutical Co Ltd	Hexacyclic compounds
US7563810B2 (en)	2002-11-06	2009-07-21	Celgene Corporation	Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en)	2002-11-06	2011-10-11	Celgene Corporation	Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
CZ299329B6 (cs) *	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) *	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US7910593B2 (en)	2004-04-09	2011-03-22	Chugai Seiyaku Kabushiki Kaisha	Water-soluble prodrugs
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
JP5126900B2 (ja) *	2009-02-24	2013-01-23	株式会社渡辺オイスター研究所	カキ肉エキス顆粒の製造方法。
CN101555250B (zh) *	2009-05-19	2011-05-18	重庆泰濠制药有限公司	盐酸拓扑替康的制备方法
KR20240031235A (ko) *	2021-05-27	2024-03-07	자임워크스 비씨 인코포레이티드	캄프토테신 유사체, 접합체 및 사용 방법
CN117098536A (zh)	2021-10-15	2023-11-21	昆山新蕴达生物科技有限公司	包含抗肿瘤药物的组合物及其制备方法和用途
KR20240162575A (ko) *	2022-03-25	2024-11-15	자임워크스 비씨 인코포레이티드	엽산 수용체 알파를 표적화하는 항체-약물 접합체 및 사용 방법
CA3266959A1 (en) *	2022-10-19	2024-04-25	Zymeworks Bc Inc.	ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4399276A (en) *	1981-01-09	1983-08-16	Kabushiki Kaisha Yakult Honsha	7-Substituted camptothecin derivatives
JPS6019790A (ja) *	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
US5227380A (en) *	1987-03-31	1993-07-13	Research Triangle Institute	Pharmaceutical compositions and methods employing camptothecins
US5364858A (en) *	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5180722A (en) *	1987-04-14	1993-01-19	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US4943579A (en) *	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
WO1991004260A2 (en) *	1989-09-15	1991-04-04	Research Triangle Institute	10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
ES2165346T3 (es) *	1989-09-15	2002-03-16	Res Triangle Inst	Analogos de 10,11-metilendioxi-20(rs)-camptotecina y 10,11-metilendioxi-20(s)-camptotecina.
DK0547165T3 (da) *	1990-09-28	2000-03-27	Smithkline Beecham Corp	Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc
US5162532A (en) *	1990-12-20	1992-11-10	North Carolina State University	Intermediates and method of making camptothecin and camptothecin analogs
US5342947A (en) *	1992-10-09	1994-08-30	Glaxo Inc.	Preparation of water soluble camptothecin derivatives
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation

1994
- 1994-02-16 GB GB9402934A patent/GB9402934D0/en active Pending
1995
- 1995-02-03 DE DE69527400T patent/DE69527400T2/de not_active Expired - Fee Related
- 1995-02-03 JP JP7521541A patent/JPH08509244A/ja not_active Ceased
- 1995-02-03 HU HU9503273A patent/HUT73423A/hu unknown
- 1995-02-03 AT AT95908901T patent/ATE220681T1/de active
- 1995-02-03 CN CN95190093A patent/CN1123548A/zh active Pending
- 1995-02-03 MX MX9504287A patent/MX9504287A/es unknown
- 1995-02-03 EP EP95908901A patent/EP0694035B1/de not_active Expired - Lifetime
- 1995-02-03 AU AU17056/95A patent/AU681941B2/en not_active Ceased
- 1995-02-03 CA CA002158855A patent/CA2158855C/en not_active Expired - Fee Related
- 1995-02-03 WO PCT/EP1995/000393 patent/WO1995022549A1/en not_active Ceased
- 1995-02-03 KR KR1019950704455A patent/KR960701878A/ko not_active Withdrawn
- 1995-02-03 ES ES95908901T patent/ES2180625T3/es not_active Expired - Lifetime
- 1995-02-03 PL PL95311122A patent/PL311122A1/xx unknown
- 1995-02-03 NZ NZ279813A patent/NZ279813A/en unknown
- 1995-02-13 IL IL112622A patent/IL112622A/xx not_active IP Right Cessation
- 1995-02-15 US US08/389,190 patent/US5602141A/en not_active Expired - Fee Related
- 1995-02-15 ZA ZA951227A patent/ZA951227B/xx unknown
- 1995-10-13 FI FI954898A patent/FI954898A0/fi not_active Application Discontinuation
- 1995-10-13 NO NO954072A patent/NO954072L/no unknown
1996
- 1996-08-20 US US08/697,125 patent/US5801167A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MX9504287A (es)	1997-05-31
ZA951227B (en)	1996-01-19
EP0694035B1 (de)	2002-07-17
CA2158855A1 (en)	1995-08-24
JPH08509244A (ja)	1996-10-01
AU1705695A (en)	1995-09-04
EP0694035A1 (de)	1996-01-31
AU681941B2 (en)	1997-09-11
US5801167A (en)	1998-09-01
KR960701878A (ko)	1996-03-28
PL311122A1 (en)	1996-02-05
NO954072D0 (no)	1995-10-13
ES2180625T3 (es)	2003-02-16
HU9503273D0 (en)	1996-01-29
NZ279813A (en)	1996-10-28
WO1995022549A1 (en)	1995-08-24
DE69527400D1 (de)	2002-08-22
GB9402934D0 (en)	1994-04-06
IL112622A (en)	1997-09-30
IL112622A0 (en)	1995-05-26
DE69527400T2 (de)	2003-03-06
CN1123548A (zh)	1996-05-29
HUT73423A (en)	1996-07-29
US5602141A (en)	1997-02-11
FI954898A7 (fi)	1995-10-13
CA2158855C (en)	2006-01-31
ATE220681T1 (de)	2002-08-15
FI954898A0 (fi)	1995-10-13

Publication	Publication Date	Title
MX9504287A (es)	1997-05-31	Derivados de camptotecina y proceso para su preparacion.
TR200100698T2 (tr)	2001-07-23	5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri
BR0213025A (pt)	2004-10-05	Compostos de espiro-hidantoìna úteis como agentes antiinflamatórios
TR199800720T2 (xx)	1998-09-21	Farnesil transferaz inhibe eden 2-kinolon t�revleri.
CR8755A (es)	2007-01-17	Derivado de quinolina fusionada y uso del mismo
AR032453A1 (es)	2003-11-12	Derivados alquinil fenil heteroaromaticos activadores de glucoquinasa, un proceso para su preparacion, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de medicamentos
AR035548A1 (es)	2004-06-16	Compuestos organicos
BR122017028096B8 (pt)	2021-05-25	composto, composição farmacêutica, e, uso do composto
MY105402A (en)	1994-09-30	17-beta-substituted-4-aza-5alpha-androstan-3-one derivatives and process for their preparation.
HUP0303756A2 (hu)	2004-03-01	1-Aril- vagy 1-alkilszulfonil-heterociklobenzazolok és eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények
NO983970D0 (no)	1998-08-28	Tricykliske forbindelser, deres fremstilling og anvendelse
MY114679A (en)	2002-12-31	Aroyl-piperidine derivatives
BG104287A (en)	2000-11-30	Halogensubstituted tetracyclic derivatives of tetrahydrofuran
AR019788A2 (es)	2002-03-13	Compuestos derivados de la eritromicina, composiciones que los contienen, uso y procedimientos para prepararlos
DK0388948T3 (da)	1994-01-24	Acryloylsubstituerede pyrrolderivater
UY27803A1 (es)	2003-11-28	Derivados de benzoxazina y usos de los mismos.
TW333527B (en)	1998-06-11	Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
NO20052074L (no)	2005-06-01	Substituerte benzoksazinoner og anvendelser derav.
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NO964698D0 (no)	1996-11-06	Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
DK534381A (da)	1982-06-06	Fremgangsmaade til fremstilling af 2-oxoazetidinderivater
NO20054135L (no)	2005-09-23	Kipolinon/benzoksazin derivater og anvendelser derav
ES2012648A6 (es)	1990-04-01	Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina.
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
WO2002094770A3 (en)	2003-03-06	Aminoalcohol derivatives