NO954441L - Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler - Google Patents
Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidlerInfo
- Publication number
- NO954441L NO954441L NO954441A NO954441A NO954441L NO 954441 L NO954441 L NO 954441L NO 954441 A NO954441 A NO 954441A NO 954441 A NO954441 A NO 954441A NO 954441 L NO954441 L NO 954441L
- Authority
- NO
- Norway
- Prior art keywords
- complexes
- derivatives
- contrast agents
- tricyclopolyazamacrocyclophosphonic
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Luminescent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Tri- og tetracyklopolyazamakrocyklofosfonsyreforbindelser og deres derivater er beskrevet som kan danne inerte komplek-ser med Gd-, Mn- eller Fe-ioner. Den totale ladning av kom-plekset kan varieres for å forandre in vivo biolokaliseringen. Kompleksene er anvendelige som kontrastmidler for diagnostiske formål.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/058,622 US5385893A (en) | 1993-05-06 | 1993-05-06 | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| PCT/US1994/005071 WO1994026276A1 (en) | 1993-05-06 | 1994-05-06 | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO954441D0 NO954441D0 (no) | 1995-11-06 |
| NO954441L true NO954441L (no) | 1996-01-05 |
Family
ID=22017946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO954441A NO954441L (no) | 1993-05-06 | 1995-11-06 | Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5385893A (no) |
| EP (1) | EP0697872B1 (no) |
| JP (1) | JP3553940B2 (no) |
| KR (1) | KR960702462A (no) |
| CN (1) | CN1125906A (no) |
| AT (1) | ATE316377T1 (no) |
| AU (1) | AU687400B2 (no) |
| BG (1) | BG100194A (no) |
| CA (1) | CA2162172A1 (no) |
| DE (1) | DE69434618T2 (no) |
| FI (1) | FI955336L (no) |
| HU (1) | HUT72649A (no) |
| LV (1) | LV11429B (no) |
| NO (1) | NO954441L (no) |
| PL (1) | PL311649A1 (no) |
| SG (1) | SG46496A1 (no) |
| WO (1) | WO1994026276A1 (no) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5714604A (en) * | 1993-05-06 | 1998-02-03 | The Dow Chemical Company | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| US6207826B1 (en) * | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| US6107482A (en) | 1995-03-27 | 2000-08-22 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
| DE19546234C1 (de) * | 1995-12-04 | 1997-08-28 | Schering Ag | Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| KR20000010533A (ko) * | 1996-04-19 | 2000-02-15 | 텍사스 테크 유니버시티 | 시각적 조직 특이성 조영제로서의 형광 킬레이트 |
| CA2333649C (en) | 1998-06-15 | 2010-04-06 | Unilever Plc | Bleach catalysts and formulations containing them |
| WO2001028567A2 (en) * | 1999-10-18 | 2001-04-26 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
| US6794371B1 (en) * | 1999-10-18 | 2004-09-21 | The Dow Chemical Company | Aminoalkylenephosphonates for treatment of bone disorders |
| WO2006020779A2 (en) * | 2004-08-10 | 2006-02-23 | Dow Global Technologies Inc. | Targeting chelants and chelates |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| WO2007140371A2 (en) | 2006-05-30 | 2007-12-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| AU2007308792B2 (en) | 2006-10-27 | 2013-01-24 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| BRPI0806403A2 (pt) | 2007-02-09 | 2011-09-06 | Genentech Inc | anticorpo anti-robo4, usode um anticorpo e método de obtenção de imagem |
| ATE543835T1 (de) | 2007-07-16 | 2012-02-15 | Genentech Inc | Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren |
| ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| PT2247620T (pt) | 2008-01-31 | 2016-08-23 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| CA2757382A1 (en) | 2009-04-01 | 2010-10-21 | Kristi Elkins | Anti-fcrh5 antibodies and immunoconjugates |
| PT2437785E (pt) | 2009-06-04 | 2015-04-20 | Novartis Ag | Método de identificação de sítios para conjugação de igg |
| ES2533072T3 (es) * | 2009-09-18 | 2015-04-07 | Weylchem Switzerland Ag | Procedimiento para la preparación de compuestos complejos de manganeso puenteados del triazaciclononano |
| RU2016105962A (ru) | 2009-12-04 | 2018-11-23 | Дженентек, Инк. | Мультиспецифические антитела, аналоги антител, композиции и способы |
| BR112012029866A2 (pt) | 2010-06-03 | 2017-03-07 | Genentech Inc | método para a determinação da presença de uma proteína steap-1 |
| SG185428A1 (en) | 2010-06-08 | 2012-12-28 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| BR112014029403A2 (pt) | 2012-07-04 | 2018-10-09 | F. Hoffmann-La Roche Ag | conjugados, anticorpo e formulação farmacêutica |
| JP6324376B2 (ja) | 2012-07-04 | 2018-05-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗テオフィリン抗体および使用方法 |
| BR112014030844A2 (pt) | 2012-07-04 | 2019-10-15 | Hoffmann La Roche | anticorpo anti-biotina humanizado, formulação farmacêutica e uso do anticorpo |
| EP3089759B1 (en) | 2014-01-03 | 2018-12-05 | F. Hoffmann-La Roche AG | Covalently linked polypeptide toxin-antibody conjugates |
| EP3089758B1 (en) | 2014-01-03 | 2021-01-27 | F.Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
| ES2895752T3 (es) | 2014-01-03 | 2022-02-22 | Hoffmann La Roche | Anticuerpos biespecíficos anti-hapteno/anti-receptor de la barrera hematoencefálica, complejos de los mismos y su uso como lanzaderas a través de la barrera hematoencefálica |
| TW201625688A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 經半胱胺酸改造之抗體及接合物 |
| JP6618539B2 (ja) | 2014-12-17 | 2019-12-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ソルターゼを使用した酵素媒介性のポリペプチドコンジュゲーションのための方法 |
| EP3353314A1 (en) | 2015-09-25 | 2018-08-01 | H. Hoffnabb-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| JP6998862B2 (ja) | 2015-09-25 | 2022-02-04 | エフ.ホフマン-ラ ロシュ アーゲー | 可溶性ソルターゼa |
| JP6895953B2 (ja) | 2015-09-25 | 2021-06-30 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ソルターゼaを利用してチオエステルを作製するための方法 |
| EP3353201B1 (en) | 2015-09-25 | 2021-09-08 | F. Hoffmann-La Roche AG | Recombinant immunoglobulin heavy chains comprising a sortase conjugation loop and conjugates thereof |
| US10494379B2 (en) | 2015-11-26 | 2019-12-03 | Debreceni Egyetem | 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents |
| EP3380472A1 (en) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca- 1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| EP3380473A1 (en) * | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents |
| FR3045053B1 (fr) * | 2015-12-09 | 2018-01-05 | Cisbio Bioassays | Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants |
| CN109072212B (zh) | 2016-03-30 | 2022-10-04 | 豪夫迈·罗氏有限公司 | 改善的分选酶 |
| WO2018191389A1 (en) | 2017-04-12 | 2018-10-18 | Roche Sequencing Solutions, Inc. | A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction |
| EP4707307A2 (en) | 2017-07-13 | 2026-03-11 | Roche Diagnostics GmbH | New binding agent and assay for pivka |
| EP3697813A1 (en) | 2017-10-20 | 2020-08-26 | H. Hoffnabb-La Roche Ag | Copy protection for antibodies |
| CN111918876B (zh) | 2017-11-30 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 抗pd-l1抗体及使用其检测pd-l1的方法 |
| WO2019175127A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Novel anti-troponint antibodies |
| WO2019175131A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
| WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
| CN112639475A (zh) | 2018-08-31 | 2021-04-09 | 豪夫迈·罗氏有限公司 | Dlbcl的预后指数中的胸苷激酶(tk-1) |
| CN116271117A (zh) | 2018-09-28 | 2023-06-23 | 伊麦吉纳博公司 | Cd8成像构建体及其使用方法 |
| JP2022542056A (ja) | 2019-07-22 | 2022-09-29 | エフ.ホフマン-ラ ロシュ アーゲー | 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのs100a6 |
| WO2021013781A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
| EP4004552A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis |
| EP4004553A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis |
| EP4004554A1 (en) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis |
| BR112022002376A2 (pt) | 2019-08-09 | 2022-04-26 | Hoffmann La Roche | Anticorpos que se ligam especificamente à troponina t cardíaca humana, anticorpos, moléculas de ácido nucleico, vetor, composição e método para determinar a troponina t cardíaca humana |
| JP7783809B2 (ja) | 2019-11-15 | 2025-12-10 | エフ. ホフマン-ラ ロシュ アーゲー | 患者試料における質量分析測定のためのβ-ラクタム抗生物質の誘導体化 |
| EP4237855A1 (en) | 2020-10-30 | 2023-09-06 | F. Hoffmann-La Roche AG | Timp1 as a marker for cholangiocarcinoma |
| WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN117337394A (zh) | 2021-05-17 | 2024-01-02 | 豪夫迈·罗氏有限公司 | sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断 |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| CN118382636A (zh) | 2021-12-17 | 2024-07-23 | 豪夫迈·罗氏有限公司 | 一种用于检测淀粉样蛋白β42(Aβ42)的新抗体 |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| US20260036596A1 (en) | 2022-07-22 | 2026-02-05 | Roche Diagnostics Operations, Inc. | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| CN119585618A (zh) | 2022-07-22 | 2025-03-07 | 豪夫迈·罗氏有限公司 | 成纤维细胞生长因子结合蛋白1(fgfbp1)作为(血液)生物标志物用于诊断多囊卵巢综合征 |
| EP4558825A1 (en) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2609390A (en) * | 1950-06-01 | 1952-09-02 | Frederick C Bersworth | Phosphonic alkylene polyamino acids and method of producing same |
| US3336221A (en) * | 1964-11-05 | 1967-08-15 | Calgon Corp | Method of inhibiting precipitation and scale formation |
| US3331773A (en) * | 1966-07-22 | 1967-07-18 | Grace W R & Co | Process for inhibiting precipitation in water |
| US3434969A (en) * | 1967-08-11 | 1969-03-25 | Calgon Corp | Scale inhibiting |
| GB1441081A (en) * | 1974-01-09 | 1976-06-30 | Ici Ltd | Tetra-aza-macrocycles and their metal complexes |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5247077A (en) * | 1989-06-23 | 1993-09-21 | Celltech Limited | Tri-aza macrocycles and processes for their preparation |
| DK0570575T3 (da) * | 1991-12-10 | 1998-08-24 | Dow Chemical Co | Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf |
| DE69230970T2 (de) * | 1991-12-10 | 2001-01-04 | The Dow Chemical Co., Midland | Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| ZA929578B (en) * | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates processes for their preparation and use as radiopharmaceuticals |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
-
1993
- 1993-05-06 US US08/058,622 patent/US5385893A/en not_active Expired - Lifetime
-
1994
- 1994-05-06 HU HU9502023A patent/HUT72649A/hu unknown
- 1994-05-06 WO PCT/US1994/005071 patent/WO1994026276A1/en not_active Ceased
- 1994-05-06 KR KR1019950704947A patent/KR960702462A/ko not_active Withdrawn
- 1994-05-06 JP JP52558694A patent/JP3553940B2/ja not_active Expired - Fee Related
- 1994-05-06 CA CA002162172A patent/CA2162172A1/en not_active Abandoned
- 1994-05-06 AU AU67849/94A patent/AU687400B2/en not_active Ceased
- 1994-05-06 EP EP94916043A patent/EP0697872B1/en not_active Expired - Lifetime
- 1994-05-06 FI FI955336A patent/FI955336L/fi unknown
- 1994-05-06 SG SG1996005135A patent/SG46496A1/en unknown
- 1994-05-06 CN CN94192528A patent/CN1125906A/zh active Pending
- 1994-05-06 PL PL94311649A patent/PL311649A1/xx unknown
- 1994-05-06 AT AT94916043T patent/ATE316377T1/de not_active IP Right Cessation
- 1994-05-06 DE DE69434618T patent/DE69434618T2/de not_active Expired - Fee Related
-
1995
- 1995-11-06 NO NO954441A patent/NO954441L/no unknown
- 1995-12-05 BG BG100194A patent/BG100194A/xx unknown
- 1995-12-06 LV LVP-95-361A patent/LV11429B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69434618D1 (de) | 2006-04-13 |
| FI955336A7 (fi) | 1995-12-22 |
| FI955336A0 (fi) | 1995-11-06 |
| EP0697872A4 (en) | 2003-04-02 |
| EP0697872B1 (en) | 2006-01-25 |
| PL311649A1 (en) | 1996-03-04 |
| EP0697872A1 (en) | 1996-02-28 |
| BG100194A (bg) | 1996-12-31 |
| NO954441D0 (no) | 1995-11-06 |
| AU687400B2 (en) | 1998-02-26 |
| LV11429A (lv) | 1996-08-20 |
| JP3553940B2 (ja) | 2004-08-11 |
| LV11429B (en) | 1997-04-20 |
| DE69434618T2 (de) | 2006-08-10 |
| US5385893A (en) | 1995-01-31 |
| ATE316377T1 (de) | 2006-02-15 |
| CN1125906A (zh) | 1996-07-03 |
| SG46496A1 (en) | 1998-02-20 |
| HU9502023D0 (en) | 1995-09-28 |
| KR960702462A (ko) | 1996-04-27 |
| HUT72649A (en) | 1996-05-28 |
| WO1994026276A1 (en) | 1994-11-24 |
| JPH08511003A (ja) | 1996-11-19 |
| FI955336L (fi) | 1995-12-22 |
| AU6784994A (en) | 1994-12-12 |
| CA2162172A1 (en) | 1994-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO954441D0 (no) | Tricyklopolyazamakrocyklofosfonsyrer, komplekser og derivater derav for anvendelse som kontrastmidler | |
| SG46458A1 (en) | 2-Pyridylmethyenepolyazamacrocyclophosphonic acids complexes and derivatives thereof for use as contrast agents | |
| AU2118488A (en) | Improvements in or relating to methods of treating damaged skin | |
| EP2767291A3 (en) | Treatment of glycogen storage disease type II | |
| CA2255951A1 (en) | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators | |
| BG103947A (en) | Derivatives of 9-oxymerythromycin | |
| AU1937395A (en) | Pharmaceutical compositions containing alkylthioalkanoic acids or derivatives thereof and their use in the treatment of mycobacterial infections and as antiseptic | |
| AU628095B2 (en) | Chelants possessing ortho ligating functionality and complexes thereof | |
| WO2000040583A3 (de) | Imidazo[4,5-c]-pyridin-4-on-derivate | |
| MY133785A (en) | Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias | |
| CA2103554A1 (en) | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents | |
| IL104060A0 (en) | Bicyclopolyazamacrocyclophosphonic acids,their complexes and conjugates,for use as contrast agents,and processes for their preparation | |
| WO1999011256A8 (en) | L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof | |
| EP0194901A3 (en) | Isoprenoidamine derivatives, compositions containing them, their preparation, and their use | |
| IL118218A (en) | Pharmaceutical compositions containing sarcodictyins | |
| IE880628L (en) | Substituted pyridine-2,4-dicarboxylic acid derivatives,¹processes for their preparation, the use thereof and¹medicaments based on these compounds | |
| NO954442L (no) | Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling | |
| EP0342617A3 (en) | Use of pyrimido-(6,1-a)isoquinolin-4-one derivatives, and medical preparations based on same | |
| PL355113A1 (en) | Novel fusidic acid derivatives | |
| ES469840A1 (es) | Procedimiento para la obtencion de nuevos derivados de tria-zolotiadiacinas. | |
| AU2001292498A1 (en) | 1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain | |
| MY141501A (en) | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents and processes for their preparation |