NO955197L - Nye carbosykliske nukleoside midler som er anvendbare som selektive inhibitorer av pro-inflammatoriske cytokiner - Google Patents

Nye carbosykliske nukleoside midler som er anvendbare som selektive inhibitorer av pro-inflammatoriske cytokiner

Info

Publication number: NO955197L
Authority: NO; Norway
Prior art keywords: pro; inflammatory cytokines; agents useful; selective inhibitors; alkyl
Prior art date: 1993-06-21

Application number

NO955197A

Other languages

English (en)

Other versions

NO955197D0 (no

NO312836B1 (no

Inventor

Iii Carl Keith Edwards

David Roger Borcherding

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-21

Filing date

1995-12-20

Publication date

1996-02-16

1995-12-20 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-12-20 Publication of NO955197D0 publication Critical patent/NO955197D0/no

1996-02-16 Publication of NO955197L publication Critical patent/NO955197L/no

2002-07-08 Publication of NO312836B1 publication Critical patent/NO312836B1/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO19955197A 1993-06-21 1995-12-20 Forbindelser anvendelige som selektive inhibitorer av pro- inflammatoriske cytokiner og farmasöytisk preparat inneholdendenevnte forbindelser NO312836B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8024993A	1993-06-21	1993-06-21
PCT/US1994/005916 WO1995000514A1 (en)	1993-06-21	1994-05-25	Novel carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines

Publications (3)

Publication Number	Publication Date
NO955197D0 NO955197D0 (no)	1995-12-20
NO955197L true NO955197L (no)	1996-02-16
NO312836B1 NO312836B1 (no)	2002-07-08

Family

ID=22156170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19955197A NO312836B1 (no)	1993-06-21	1995-12-20	Forbindelser anvendelige som selektive inhibitorer av pro- inflammatoriske cytokiner og farmasöytisk preparat inneholdendenevnte forbindelser

Country Status (20)

Country	Link
US (1)	US6541482B2 (no)
EP (1)	EP0705263B1 (no)
JP (1)	JP3479077B2 (no)
KR (1)	KR100337720B1 (no)
CN (1)	CN1041631C (no)
AT (1)	ATE151423T1 (no)
AU (1)	AU677851B2 (no)
CA (1)	CA2165779C (no)
DE (1)	DE69402548T2 (no)
DK (1)	DK0705263T3 (no)
ES (1)	ES2103131T3 (no)
FI (1)	FI956142A7 (no)
GR (1)	GR3023373T3 (no)
HU (1)	HUT73412A (no)
IL (1)	IL110041A0 (no)
NO (1)	NO312836B1 (no)
NZ (1)	NZ267322A (no)
TW (1)	TW356471B (no)
WO (1)	WO1995000514A1 (no)
ZA (1)	ZA944256B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0111497D0 (en) *	2001-05-11	2001-07-04	Medical Res Council	Therapeutic methods
GB0114286D0 (en) *	2001-06-12	2001-08-01	Hoffmann La Roche	Nucleoside Derivatives
AU2003299441A1 (en) *	2002-12-19	2004-07-14	Centre National De La Recherche Scientifique - Cnrs	Nf-hev compositions and methods of use
US7868011B2 (en) *	2003-04-09	2011-01-11	General Atomics	Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
US7196093B2 (en) *	2003-04-09	2007-03-27	General Atomics	Reversible inhibitors of SAH hydrolase and uses thereof
US7517887B2 (en)	2003-04-09	2009-04-14	General Atomics	Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US11033821B2 (en)	2003-09-02	2021-06-15	Jeffrey D. Mullen	Systems and methods for location based games and employment of the same on location enabled devices
MEP8409A (en) *	2004-06-02	2011-12-20		Fused heterocyclic compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN164556B (no)	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4916224A (en)	1988-01-20	1990-04-10	Regents Of The University Of Minnesota	Dideoxycarbocyclic nucleosides
US4931559A (en)	1988-01-20	1990-06-05	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en)	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
AU642526B2 (en)	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
CA2051012C (en) *	1990-09-14	2002-04-02	David R. Borcherding	Carbocyclic adenosine analogs useful as immunosupressants
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates
CA2084222C (en)	1991-12-06	2004-04-06	David R. Borcherding	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
GB9204015D0 (en) *	1992-02-25	1992-04-08	Wellcome Found	Therapeutic nucleosides
SK285228B6 (sk) *	1997-05-13	2006-09-07	Lonza Ag	Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
JPH11255768A (ja) *	1998-03-09	1999-09-21	Ajinomoto Co Inc	抗ウイルス剤の製造方法

1994
- 1994-05-25 AU AU69583/94A patent/AU677851B2/en not_active Ceased
- 1994-05-25 FI FI956142A patent/FI956142A7/fi not_active Application Discontinuation
- 1994-05-25 ES ES94918130T patent/ES2103131T3/es not_active Expired - Lifetime
- 1994-05-25 JP JP50282295A patent/JP3479077B2/ja not_active Expired - Lifetime
- 1994-05-25 HU HU9503689A patent/HUT73412A/hu unknown
- 1994-05-25 KR KR1019950705826A patent/KR100337720B1/ko not_active Expired - Fee Related
- 1994-05-25 DE DE69402548T patent/DE69402548T2/de not_active Expired - Lifetime
- 1994-05-25 NZ NZ267322A patent/NZ267322A/en unknown
- 1994-05-25 WO PCT/US1994/005916 patent/WO1995000514A1/en not_active Ceased
- 1994-05-25 CN CN94192526A patent/CN1041631C/zh not_active Expired - Fee Related
- 1994-05-25 EP EP94918130A patent/EP0705263B1/en not_active Expired - Lifetime
- 1994-05-25 AT AT94918130T patent/ATE151423T1/de not_active IP Right Cessation
- 1994-05-25 CA CA002165779A patent/CA2165779C/en not_active Expired - Fee Related
- 1994-05-25 DK DK94918130.9T patent/DK0705263T3/da active
- 1994-06-15 ZA ZA944256A patent/ZA944256B/xx unknown
- 1994-06-16 TW TW083105476A patent/TW356471B/zh active
- 1994-06-17 IL IL11004194A patent/IL110041A0/xx unknown
1995
- 1995-02-03 US US08/383,339 patent/US6541482B2/en not_active Expired - Fee Related
- 1995-12-20 NO NO19955197A patent/NO312836B1/no unknown
1997
- 1997-05-09 GR GR970401026T patent/GR3023373T3/el unknown

Also Published As

Publication number	Publication date
DE69402548D1 (de)	1997-05-15
KR100337720B1 (ko)	2002-11-02
ATE151423T1 (de)	1997-04-15
KR960703122A (ko)	1996-06-19
DE69402548T2 (de)	1997-07-17
EP0705263B1 (en)	1997-04-09
CN1125946A (zh)	1996-07-03
DK0705263T3 (da)	1997-05-05
NO955197D0 (no)	1995-12-20
GR3023373T3 (en)	1997-08-29
CA2165779C (en)	1998-06-16
WO1995000514A1 (en)	1995-01-05
AU6958394A (en)	1995-01-17
JP3479077B2 (ja)	2003-12-15
US6541482B2 (en)	2003-04-01
HUT73412A (en)	1996-07-29
US20020004508A1 (en)	2002-01-10
ZA944256B (en)	1995-02-08
TW356471B (en)	1999-04-21
NZ267322A (en)	1997-09-22
FI956142A0 (fi)	1995-12-20
CN1041631C (zh)	1999-01-13
JPH08511558A (ja)	1996-12-03
IL110041A0 (en)	1994-10-07
FI956142L (fi)	1995-12-20
EP0705263A1 (en)	1996-04-10
FI956142A7 (fi)	1995-12-20
NO312836B1 (no)	2002-07-08
ES2103131T3 (es)	1997-08-16
AU677851B2 (en)	1997-05-08
HU9503689D0 (en)	1996-02-28
CA2165779A1 (en)	1995-01-05

Publication	Publication Date	Title
HUP0001446A2 (hu)	2001-05-28	HIV reverz transzkriptáz inhibitor hatású 4,4-diszubsztituált-3,4-dihidro-2(1H)-kinazolinon-származékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
HRP20040977B1 (hr)	2008-04-30	Derivati n-[fenil(piperidin-2-il)metil]benzamida,postupak njihovog pripravljanja i primjena istih u terapiji
ES2188280T3 (es)	2003-06-16	Acetales heteroaril-ciclicos.
YU17092A (sh)	1994-12-28	Derivati 2,4-diaminohinazolina
NO892381L (no)	1989-12-11	1-indolylalkyl-4-(substituert-pyridinyl)piperaziner.
YU46787B (sh)	1994-06-10	Derivati heteroaril 3-okso-propan-nitrila i postupak za njihovo dobijanje
NO964698D0 (no)	1996-11-06	Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
DK0686142T3 (da)	1999-08-30	Polyaminderivater som radioprotektive midler
NO955197D0 (no)	1995-12-20	Nye karbosykliske nucleoside midler som er anvendbare som inhibitorer av pro-inflammatoriske cytokiner
TR200001010T2 (tr)	2000-09-21	Ürokinaz önleyicileri olan izokinolinler.
NO177995C (no)	1996-01-03	Analogifremgangsmåte for fremstilling av terapeutisk aktive 1,3-dioksanderivater
DK0861250T3 (da)	2002-04-29	Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase
HUP0203275A2 (hu)	2003-01-28	1-(Gyűrűs amino)-alkilciklohexán-származékok, ezeket tartalmazó görcsoldó hatású gyógyszerkészítmények, valamint ezek alkalmazása
CA2209422A1 (en)	1997-01-30	4-amino-3-acylnaphthyridine derivatives
RU94037965A (ru)	1996-08-10	Производные бензоксазола в виде рацемата или отдельных энантиомеров и их фармацевтически приемлемые соли и фармацевтические композиции с ингибирующей биосинтез лейкотриенов активностью
AU4713797A (en)	1998-05-15	Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
MY131365A (en)	2007-08-30	Carbamic acid derivatives
NO922523L (no)	1992-12-28	Aminopyrimidinkarboksamiddrivater med terapeutisk virkning
FI955680A0 (fi)	1995-11-24	Psoraleenijohdannaiset, niiden valmistus ja käyttö