ATE151423T1 - Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen - Google Patents

Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen

Info

Publication number: ATE151423T1
Authority: AT; Austria
Prior art keywords: alkyl; compounds; substituent; agents useful; selective inhibitors
Prior art date: 1993-06-21

Application number

AT94918130T

Other languages

English (en)

Inventor

Carl K Edwards Iii

David R Borcherding

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-21

Filing date

1994-05-25

Publication date

1997-04-15

1994-05-25 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-04-15 Application granted granted Critical

1997-04-15 Publication of ATE151423T1 publication Critical patent/ATE151423T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT94918130T 1993-06-21 1994-05-25 Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen ATE151423T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8024993A	1993-06-21	1993-06-21

Publications (1)

Publication Number	Publication Date
ATE151423T1 true ATE151423T1 (de)	1997-04-15

Family

ID=22156170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94918130T ATE151423T1 (de)	1993-06-21	1994-05-25	Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen

Country Status (20)

Country	Link
US (1)	US6541482B2 (de)
EP (1)	EP0705263B1 (de)
JP (1)	JP3479077B2 (de)
KR (1)	KR100337720B1 (de)
CN (1)	CN1041631C (de)
AT (1)	ATE151423T1 (de)
AU (1)	AU677851B2 (de)
CA (1)	CA2165779C (de)
DE (1)	DE69402548T2 (de)
DK (1)	DK0705263T3 (de)
ES (1)	ES2103131T3 (de)
FI (1)	FI956142A7 (de)
GR (1)	GR3023373T3 (de)
HU (1)	HUT73412A (de)
IL (1)	IL110041A0 (de)
NO (1)	NO312836B1 (de)
NZ (1)	NZ267322A (de)
TW (1)	TW356471B (de)
WO (1)	WO1995000514A1 (de)
ZA (1)	ZA944256B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0111497D0 (en) *	2001-05-11	2001-07-04	Medical Res Council	Therapeutic methods
GB0114286D0 (en) *	2001-06-12	2001-08-01	Hoffmann La Roche	Nucleoside Derivatives
WO2004056868A2 (en) *	2002-12-19	2004-07-08	Endocube Sas	Nf-hev compositions and methods of use
US7196093B2 (en)	2003-04-09	2007-03-27	General Atomics	Reversible inhibitors of SAH hydrolase and uses thereof
US7868011B2 (en)	2003-04-09	2011-01-11	General Atomics	Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus
US7517887B2 (en)	2003-04-09	2009-04-14	General Atomics	Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof
US11033821B2 (en)	2003-09-02	2021-06-15	Jeffrey D. Mullen	Systems and methods for location based games and employment of the same on location enabled devices
BRPI0511768A (pt) *	2004-06-02	2008-01-08	Takeda Pharmaceutical	composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN164556B (de)	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4931559A (en)	1988-01-20	1990-06-05	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
US4916224A (en)	1988-01-20	1990-04-10	Regents Of The University Of Minnesota	Dideoxycarbocyclic nucleosides
GB8815265D0 (en)	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
AU647822B2 (en) *	1990-09-14	1994-03-31	Marion Merrell Dow Inc.	Novel carbocyclic adenosine analogs useful as immunosuppressants
AU642526B2 (en)	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5332814A (en) *	1991-11-12	1994-07-26	Ciba-Geigy Corporation	Process for the preparation of carbacyclic nucleosides, and intermediates
AU658698B2 (en)	1991-12-06	1995-04-27	Aventis Pharmaceuticals Inc.	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
GB9204015D0 (en) *	1992-02-25	1992-04-08	Wellcome Found	Therapeutic nucleosides
SK285228B6 (sk) *	1997-05-13	2006-09-07	Lonza Ag	Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
JPH11255768A (ja) *	1998-03-09	1999-09-21	Ajinomoto Co Inc	抗ウイルス剤の製造方法

1994
- 1994-05-25 FI FI956142A patent/FI956142A7/fi not_active Application Discontinuation
- 1994-05-25 DE DE69402548T patent/DE69402548T2/de not_active Expired - Lifetime
- 1994-05-25 CN CN94192526A patent/CN1041631C/zh not_active Expired - Fee Related
- 1994-05-25 AU AU69583/94A patent/AU677851B2/en not_active Ceased
- 1994-05-25 EP EP94918130A patent/EP0705263B1/de not_active Expired - Lifetime
- 1994-05-25 AT AT94918130T patent/ATE151423T1/de not_active IP Right Cessation
- 1994-05-25 WO PCT/US1994/005916 patent/WO1995000514A1/en not_active Ceased
- 1994-05-25 DK DK94918130.9T patent/DK0705263T3/da active
- 1994-05-25 HU HU9503689A patent/HUT73412A/hu unknown
- 1994-05-25 JP JP50282295A patent/JP3479077B2/ja not_active Expired - Lifetime
- 1994-05-25 KR KR1019950705826A patent/KR100337720B1/ko not_active Expired - Fee Related
- 1994-05-25 ES ES94918130T patent/ES2103131T3/es not_active Expired - Lifetime
- 1994-05-25 NZ NZ267322A patent/NZ267322A/en unknown
- 1994-05-25 CA CA002165779A patent/CA2165779C/en not_active Expired - Fee Related
- 1994-06-15 ZA ZA944256A patent/ZA944256B/xx unknown
- 1994-06-16 TW TW083105476A patent/TW356471B/zh active
- 1994-06-17 IL IL11004194A patent/IL110041A0/xx unknown
1995
- 1995-02-03 US US08/383,339 patent/US6541482B2/en not_active Expired - Fee Related
- 1995-12-20 NO NO19955197A patent/NO312836B1/no unknown
1997
- 1997-05-09 GR GR970401026T patent/GR3023373T3/el unknown

Also Published As

Publication number	Publication date
US6541482B2 (en)	2003-04-01
JPH08511558A (ja)	1996-12-03
CN1041631C (zh)	1999-01-13
EP0705263B1 (de)	1997-04-09
ZA944256B (en)	1995-02-08
KR100337720B1 (ko)	2002-11-02
HU9503689D0 (en)	1996-02-28
CA2165779A1 (en)	1995-01-05
GR3023373T3 (en)	1997-08-29
FI956142A0 (fi)	1995-12-20
IL110041A0 (en)	1994-10-07
NZ267322A (en)	1997-09-22
TW356471B (en)	1999-04-21
NO312836B1 (no)	2002-07-08
ES2103131T3 (es)	1997-08-16
CN1125946A (zh)	1996-07-03
HUT73412A (en)	1996-07-29
JP3479077B2 (ja)	2003-12-15
NO955197L (no)	1996-02-16
AU6958394A (en)	1995-01-17
WO1995000514A1 (en)	1995-01-05
DE69402548D1 (de)	1997-05-15
FI956142L (fi)	1995-12-20
DE69402548T2 (de)	1997-07-17
KR960703122A (ko)	1996-06-19
NO955197D0 (no)	1995-12-20
DK0705263T3 (da)	1997-05-05
EP0705263A1 (de)	1996-04-10
FI956142A7 (fi)	1995-12-20
US20020004508A1 (en)	2002-01-10
AU677851B2 (en)	1997-05-08
CA2165779C (en)	1998-06-16

Legal Events

Date	Code	Title	Description
1997-10-15	UEP	Publication of translation of european patent specification
2006-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
HUP0001446A2 (hu)	2001-05-28	HIV reverz transzkriptáz inhibitor hatású 4,4-diszubsztituált-3,4-dihidro-2(1H)-kinazolinon-származékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
ES2188280T3 (es)	2003-06-16	Acetales heteroaril-ciclicos.
EA200400886A1 (ru)	2005-02-24	Макроциклические пептиды, обладающие активностью в отношении вируса гепатита c
CY1846A (en)	1996-03-08	1-Indolylalkyl-4-(substituted-pyridinyl) piperazines
DK0861242T3 (da)	2001-08-06	Hetorocycliske fungicider
HUP9802304A2 (hu)	1999-01-28	Piridazin-3-on-származékok, intermedierjeik, alkalmazásuk, a vegyületeket hatóanyagként tartalmazó herbicid készítmények
ES2189968T3 (es)	2003-07-16	Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS.
EP0363085A3 (de)	1991-03-27	Chemische Verbindungen
KR910007883A (ko)	1991-05-30	퀴놀린 유도체, 그의 제조방법 및 용도
EA200000320A1 (ru)	2000-10-30	Изохинолины в качестве ингибиторов урокиназы
ATE151423T1 (de)	1997-04-15	Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen
TW345577B (en)	1998-11-21	A substituted tertiary amino compound or the salt thereof
DK0686142T3 (da)	1999-08-30	Polyaminderivater som radioprotektive midler
FI964463A0 (fi)	1996-11-06	Bisykliset amidiinijohdannaiset typpioksidinsyntetaasin inhibiittoreina
RU96114993A (ru)	1998-10-20	Производные n-замещенного 3-азабицикло[3.2.0]гептана
HUP0203275A2 (hu)	2003-01-28	1-(Gyűrűs amino)-alkilciklohexán-származékok, ezeket tartalmazó görcsoldó hatású gyógyszerkészítmények, valamint ezek alkalmazása
TW333532B (en)	1998-06-11	Benzopyrans
UA41281C2 (uk)	2001-09-17	Тіоксантенонові сполуки, фармацевтична композиція на їх основі з протипухлинною активністю
GB2334032B (en)	2000-11-08	Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumour agents
HUP9902316A2 (hu)	1999-11-29	Endotelin-antagonista hatású 4-(benzo-1,3-dioxolil)-pirrolidin-3-karbonsav-származékok és az ezeket tartalmazó gyógyszerkészítmények
MY131365A (en)	2007-08-30	Carbamic acid derivatives
DK0475413T3 (da)	1996-07-15	Carbocycliske nukleosidanaloge, der kan anvendes som immunsuppressorer
HUP9700558A2 (hu)	1998-03-02	Mikrobicid készítmények