NO960370L - Markörreagens, samt anvendelse derav i assay - Google Patents

Markörreagens, samt anvendelse derav i assay

Info

Publication number
NO960370L
NO960370L NO960370A NO960370A NO960370L NO 960370 L NO960370 L NO 960370L NO 960370 A NO960370 A NO 960370A NO 960370 A NO960370 A NO 960370A NO 960370 L NO960370 L NO 960370L
Authority
NO
Norway
Prior art keywords
analyte
marker
unit
reagents
library
Prior art date
Application number
NO960370A
Other languages
English (en)
Norwegian (no)
Other versions
NO960370D0 (no
Inventor
Edwin Southern
William Jonathan Cummins
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Publication of NO960370D0 publication Critical patent/NO960370D0/no
Publication of NO960370L publication Critical patent/NO960370L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6872Methods for sequencing involving mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/911Microorganisms using fungi
    • Y10S435/912Absidia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
NO960370A 1993-07-30 1996-01-29 Markörreagens, samt anvendelse derav i assay NO960370L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939315847A GB9315847D0 (en) 1993-07-30 1993-07-30 Tag reagent and assay method
PCT/GB1994/001675 WO1995004160A1 (fr) 1993-07-30 1994-08-01 Reactif de marquage et methode de dosage

Publications (2)

Publication Number Publication Date
NO960370D0 NO960370D0 (no) 1996-01-29
NO960370L true NO960370L (no) 1996-03-28

Family

ID=10739735

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960370A NO960370L (no) 1993-07-30 1996-01-29 Markörreagens, samt anvendelse derav i assay

Country Status (16)

Country Link
US (4) US5770367A (fr)
EP (2) EP0778280B1 (fr)
JP (1) JP3289911B2 (fr)
CN (1) CN1088758C (fr)
AT (2) ATE230409T1 (fr)
AU (1) AU695349B2 (fr)
CA (1) CA2168010C (fr)
DE (2) DE69406544T2 (fr)
DK (1) DK0711362T3 (fr)
ES (1) ES2108479T3 (fr)
FI (1) FI960403A7 (fr)
GB (1) GB9315847D0 (fr)
HU (1) HU220967B1 (fr)
NO (1) NO960370L (fr)
RU (1) RU2158310C2 (fr)
WO (1) WO1995004160A1 (fr)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
EP0834575B1 (fr) 1990-12-06 2001-11-28 Affymetrix, Inc. (a Delaware Corporation) Identification d'acides nucléiques dans des échantillons
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
AU694146B2 (en) * 1993-09-27 1998-07-16 Arch Development Corporation Methods and compositions for efficient nucleic acid sequencing
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
EP0776330B1 (fr) * 1994-06-23 2003-08-20 Affymax Technologies N.V. Compose photolabiles et procedes pour leur utilisation
US5679773A (en) * 1995-01-17 1997-10-21 Affymax Technologies N.V Reagants and methods for immobilized polymer synthesis and display
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5891742A (en) * 1995-01-19 1999-04-06 Chiron Corporation Affinity selection of ligands by mass spectroscopy
GB9504598D0 (en) 1995-03-03 1995-04-26 Imp Cancer Res Tech Method of nucleic acid analysis
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5750341A (en) * 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
GB9517661D0 (en) * 1995-08-30 1995-11-01 Smithkline Beecham Plc Novel compounds
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
DE69701671T3 (de) * 1996-01-23 2006-08-17 Qiagen Genomics, Inc., Bothell Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekülen
EP0992511B1 (fr) 1996-01-23 2009-03-11 Operon Biotechnologies, Inc. Méthodes et compositions de détermination de la séquence de molécules d'acides nucléiques
DK0840804T3 (da) * 1996-01-23 2000-07-17 Rapigene Inc Fremgangsmåder og sammensætninger til analyse af nukleinsyremolekyler ved anvendelse af størrelsesseparationsteknikker
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
DE69700902T2 (de) * 1996-01-23 2000-07-20 Rapigene, Inc. Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
EP0962464A3 (fr) * 1996-01-23 2004-02-11 Qiagen Genomics, Inc. Procédés et compositions pour détecter une paire de ligands par marquage non fluorescent
AU2069597A (en) * 1996-03-04 1997-09-22 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
ES2213823T3 (es) * 1996-04-08 2004-09-01 Glaxo Group Limited Codificacion y analisis cualitativo de bibliotecas combinatorias basadas en masa.
CA2255599C (fr) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Assemblage electrocinetique de particules proches des surfaces regule par la lumiere
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5965363A (en) * 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
AU4428497A (en) 1996-09-20 1998-04-14 James P. Demers Spatially addressable combinatorial chemical arrays in cd-rom format
EP1164203B1 (fr) 1996-11-06 2007-10-10 Sequenom, Inc. Diagnostics de l'ADN fondés sur la spectrométrie de masse
EP0963443B1 (fr) * 1996-12-10 2006-03-08 Sequenom, Inc. Molecules d'etiquetage massique, non volatiles et liberables
US6699668B1 (en) 1997-01-15 2004-03-02 Xzillion Gmbh & Co. Mass label linked hybridisation probes
JP3884087B2 (ja) * 1997-01-15 2007-02-21 イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 質量標識結合ハイブリダイゼーションプローブ
EP0960215A1 (fr) * 1997-01-15 1999-12-01 Brax Genomics Limited Dechiffrement de sequences nucleotidiques
GB9707980D0 (en) 1997-04-21 1997-06-11 Brax Genomics Ltd Characterising DNA
US6312904B1 (en) 1997-07-11 2001-11-06 Xzillion Gmbh & Co. Kg Characterizing nucleic acid
GB9714716D0 (en) 1997-07-11 1997-09-17 Brax Genomics Ltd Characterising nucleic acids
EP1002128A1 (fr) 1997-07-11 2000-05-24 Brax Genomics Limited Caracterisation des acides nucleiques
EP1000176A1 (fr) * 1997-07-22 2000-05-17 Rapigene, Inc. Procede et systeme informatiques pour la mise en correlation de donnees de sequen age par spectometre de masse
HUP0003296A3 (en) 1997-07-22 2001-09-28 Qiagen Genomics Inc Bothell Apparatus and methods for arraying solution onto a solid support
CA2297158C (fr) * 1997-07-22 2009-12-22 Rapigene Inc. Methodes et composes d'analyse des acides nucleiques par spectrometrie de masse
CN1265156A (zh) 1997-07-22 2000-08-30 拉普吉恩公司 核酸阵列上进行的扩增及其它酶反应
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
DK1036202T3 (da) * 1997-12-05 2002-08-12 Max Planck Gesellschaft Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri
EP2241542A1 (fr) 1998-01-05 2010-10-20 Neogenesis, Inc. Appareil pour la production de bibliothèques combinatoires codées en masse
EP1728776A3 (fr) * 1998-01-05 2006-12-13 Neogenesis, Inc. Procédé de production de bibliothèques combinatoires codées en masse
US6207861B1 (en) * 1998-01-05 2001-03-27 Neogenesis, Inc. Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
US6265163B1 (en) * 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
US6562567B2 (en) 1998-01-27 2003-05-13 California Institute Of Technology Method of detecting a nucleic acid
ATE256142T1 (de) 1998-05-15 2003-12-15 Isis Innovation Bibliotheken von unterschiedlich markierten oligomeren
US6104028A (en) 1998-05-29 2000-08-15 Genetrace Systems Inc. Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US7399844B2 (en) 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6218118B1 (en) * 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6423493B1 (en) * 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US20040242521A1 (en) * 1999-10-25 2004-12-02 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
WO2000056937A2 (fr) * 1999-03-25 2000-09-28 Hyseq, Inc. Procedes et materiaux permettant l'analyse des sequences par hybridation dans un environnement en solution
AU4051300A (en) * 1999-04-02 2000-10-23 Tropix, Inc. High throughput and high sensitivity detection assays
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP3668075B2 (ja) * 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたSNPs高速スコアリング方法
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
AU6291301A (en) 2000-02-22 2001-09-03 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
CN1404415A (zh) 2000-02-22 2003-03-19 基因谱公司 微阵列制造技术及设备
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
DE10021204A1 (de) * 2000-04-25 2001-11-08 Epigenomics Ag Verfahren zur hochparallelen Analyse von Polymorphismen
US20030190609A1 (en) * 2000-06-08 2003-10-09 White P. Scott Address/capture tags for flow-cytometery based minisequencing
DE60137722D1 (de) 2000-06-13 2009-04-02 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
DE60117556T2 (de) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
US6627748B1 (en) 2000-09-11 2003-09-30 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
US20060057565A1 (en) * 2000-09-11 2006-03-16 Jingyue Ju Combinatorial fluorescence energy transfer tags and uses thereof
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
AU2001296645A1 (en) 2000-10-06 2002-04-15 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
AU2001296718A1 (en) 2000-10-06 2002-04-15 Novozymes A/S Methods for monitoring multiple gene expression
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
RU2195668C2 (ru) * 2001-02-12 2002-12-27 Мешандин Алексей Гаврилович Способ постановки реакции агглютинационного иммунологического анализа
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7718354B2 (en) * 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121310A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in forensic studies
WO2004060278A2 (fr) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Procedes d'identification rapide de pathogenes chez l'homme et les betes
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
EP1423400B2 (fr) * 2001-03-19 2013-05-22 President and Fellows of Harvard College Evolution d'une nouvelle fonction moleculaire
WO2002081752A2 (fr) * 2001-04-03 2002-10-17 Thermo Finnigan Corporation Methodes et materiels utiles pour la simplification de melanges de peptides complexes
EP1401850A1 (fr) 2001-06-20 2004-03-31 Nuevolution A/S Derives nucleosidiques pour elaboration de bibliotheque combinatoire
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
WO2003004690A2 (fr) * 2001-07-06 2003-01-16 454$m(3) CORPORATION Methode utilisant un filtre poreux pour isoler en parallele des micro-reactions chimiques independantes
US20030087309A1 (en) * 2001-08-27 2003-05-08 Shiping Chen Desktop drug screening system
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
PT1425586E (pt) * 2001-09-14 2007-12-31 Electrophoretics Ltd Marcadores de massa
CA2497740C (fr) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Analyse multiplexee de loci polymorphes par une methode de detection basee sur le prolongement de la sonde
US20080138800A1 (en) * 2001-10-15 2008-06-12 Alice Xiang Li Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
GB0129012D0 (en) * 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0131014D0 (en) 2001-12-28 2002-02-13 James Peter Method for molecule-mlecule analysis
AU2003214031A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
US8048623B1 (en) 2002-04-24 2011-11-01 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US7214492B1 (en) 2002-04-24 2007-05-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
US8383342B2 (en) 2002-04-24 2013-02-26 The University Of North Carolina At Greensboro Compositions, products, methods and systems to monitor water and other ecosystems
US9126165B1 (en) 2002-04-24 2015-09-08 The University Of North Carolina At Greensboro Nucleic acid arrays to monitor water and other ecosystems
GB0210535D0 (en) * 2002-05-08 2002-06-19 Novartis Ag Organic compounds
EP1520040A2 (fr) * 2002-06-20 2005-04-06 Nuevolution A/S Microreseaux presentant des molecules codees
US7074597B2 (en) * 2002-07-12 2006-07-11 The Trustees Of Columbia University In The City Of New York Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
EP1539980B1 (fr) 2002-08-01 2016-02-17 Nuevolution A/S Synthese en plusieurs etapes de molecules synthetisees
WO2004016767A2 (fr) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Developpement d'une nouvelle fonction moleculaire
WO2004018497A2 (fr) * 2002-08-23 2004-03-04 Solexa Limited Nucleotides modifies
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
CA2749227A1 (fr) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Banques combinatoires d'aptameres a groupes phosphorothioate et phosphorodithioate oligonucleotidiques lies a des billes
EP2348124B1 (fr) 2002-10-30 2013-12-11 Nuevolution A/S Synthése de complexes bifonctionnels
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
WO2004055160A2 (fr) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Methodes de couplage biomoleculaire par cycloaddition 1,3-dipolaire
WO2004056994A2 (fr) 2002-12-19 2004-07-08 Nuevolution A/S Procedes de synthese guidee a fonction et structure quasi-selectives
CA2513899C (fr) 2003-01-29 2013-03-26 454 Corporation Procede d'amplification et de sequencage d'acides nucleiques
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
JP2004235111A (ja) * 2003-01-31 2004-08-19 Ebara Corp イオン伝導体及びその製造方法
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
GB0306756D0 (en) 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US20050233390A1 (en) * 2003-04-09 2005-10-20 Allen John W Device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
WO2004101808A2 (fr) * 2003-05-09 2004-11-25 Sigma-Aldrich Co. Approches genomique et proteomique en vue du developpement de milieux de culture de cellules
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
WO2005032455A2 (fr) * 2003-05-23 2005-04-14 Board Of Regents Oligonucleoside phosphorothioate selectionnes de maniere combinatoire et a base structurelle et facteurs de transcription ap-1 ciblant un phosphorodithioate aptamere
US20060121489A1 (en) * 2003-05-23 2006-06-08 Board Of Regents, The University Of Texas System High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens
WO2005003778A2 (fr) * 2003-07-02 2005-01-13 Nuevolution A/S Procede d'identification d'une molecule synthetique ayant une affinite pour une cible
US20050118611A1 (en) * 2003-07-24 2005-06-02 Board Of Regents, The University Of Texas System Thioaptamers enable discovery of physiological pathways and new therapeutic strategies
GB0320059D0 (en) * 2003-08-27 2003-10-01 Solexa Ltd A method of sequencing
US20050048498A1 (en) * 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
US20050069895A1 (en) * 2003-08-29 2005-03-31 Applera Corporation Compositions, methods, and kits for fabricating coded molecular tags
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (fr) 2003-09-22 2015-02-03 Xinwen Wang Polyelectrolyte immobilise en surface a plusieurs groupes fonctionnels pouvant se lier de maniere covalente a des biomolecules
CA2544041C (fr) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimisation de l'analyse de l'expression genique a l'aide de sondes de capture immobilisees
CA2544202C (fr) 2003-10-29 2012-07-24 Bioarray Solutions Ltd. Analyse multiplexee d'acide nucleique par fragmentation d'adn bicatenaire
US20050239102A1 (en) * 2003-10-31 2005-10-27 Verdine Gregory L Nucleic acid binding oligonucleotides
EP1694693A2 (fr) * 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Procedes de synthese de bibliotheques codees
EP2284185A3 (fr) 2004-01-09 2011-05-18 Novozymes A/S Inactivation de protéine de Bacillus licheniformis
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP2436778A3 (fr) * 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Nucleotides fluorescents photoclivables destinés à séquencer de l'ADN sur une puce construite par chimie de couplage specifique au site
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
DE602005017370D1 (de) 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
US20050239134A1 (en) * 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
WO2006073436A2 (fr) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Pcr a marqueur de masse permettant de proceder a un diagnostic multiplex
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
JP2008514900A (ja) 2004-07-30 2008-05-08 アデザ・バイオメデイカル・コーポレイシヨン 疾病および他の状態のマーカーとしての癌胎児性フィブロネクチンならびに癌胎児性フィブロネクチンの検出のための方法
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
WO2006135400A2 (fr) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Procedes pour l'identification rapide d'organismes recombinants
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
EP2230316A1 (fr) 2005-02-01 2010-09-22 AB Advanced Genetic Analysis Corporation Sequencage nucléotidique comprenant des cycles sucessifs de fromation duplex
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20070034513A1 (en) * 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007000669A2 (fr) 2005-06-07 2007-01-04 Centre National De La Recherche Scientifique (Cnrs) Utilisation de conjugues avec des lieurs clivables par photodissociation ou par fragmentation a des fins d'analyse par spectrometrie de masse des parties du tissu
US9169510B2 (en) * 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
JP2009502137A (ja) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド 核酸変種の迅速な同定および定量のための方法
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
GB0518585D0 (en) 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
WO2007062105A2 (fr) * 2005-11-21 2007-05-31 The Trustees Of Columbia University In The City Of New York Immunocapture numerique multiplex utilisant une bibliotheque de marqueurs de masse photoclivable
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
DK1991694T3 (da) 2006-02-13 2016-08-01 Fluidigm Canada Inc Genekspressionsanalyse med grundstoftagget oligonukleotid
CN101495654A (zh) * 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
WO2007146158A1 (fr) * 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Séquençage d'adn par nanopore au moyen de nucléotides modifiés
US9149473B2 (en) 2006-09-14 2015-10-06 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2008042067A2 (fr) 2006-09-28 2008-04-10 Illumina, Inc. Compositions et procédés de séquencage nucléotidique
US20100064393A1 (en) 2006-11-29 2010-03-11 Novozymes, Inc. Bacillus liceniformis chromosome
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US7902345B2 (en) * 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7893227B2 (en) * 2006-12-05 2011-02-22 Lasergen, Inc. 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
US7897737B2 (en) 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
EP2126132B1 (fr) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Procédé d'analyse d'adn médico-légale rapide
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
WO2008151023A2 (fr) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009032781A2 (fr) 2007-08-29 2009-03-12 Sequenom, Inc. Méthodes et compositions s'appliquant à une amplification en chaîne par polymèrase universelle spécifique de la taille
DK2725107T3 (da) 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
WO2009051807A1 (fr) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Conception et synthèse de nucléotides fluorescents clivables en tant que terminateurs réversibles pour le séquençage de l'adn par synthèse
GB0809488D0 (en) 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
NZ590265A (en) 2008-06-11 2012-11-30 Lasergen Inc Nucleotides and nucleosides and methods for their use in dna sequencing
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033625A1 (fr) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Systèmes de manipulation de microplaques et produits-programmes informatiques et procédés connexes
EP2396803A4 (fr) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ensembles sonde d'ionisation
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
CA2755615A1 (fr) * 2009-03-18 2010-09-23 Sequenom, Inc. Utilisation d'endonucleases thermostables pour generer des molecules rapporteuses
EP2454000A4 (fr) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systèmes pour l'identification d'un bioagent
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
CN102858995B (zh) * 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
US10174368B2 (en) * 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
EP2488656B1 (fr) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Amplification par déplacement multiple
WO2011090793A2 (fr) 2010-01-20 2011-07-28 Customarray, Inc. Microréseau multiplex de molécules biologiques déposées en série sur un microréseau
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
EP3540059A1 (fr) 2010-04-16 2019-09-18 Nuevolution A/S Complexes bifonctionnels et procédés de fabrication et d'utilisation de tels complexes
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
WO2012083249A2 (fr) 2010-12-17 2012-06-21 The Trustees Of Columbia University In The City Of New York Séquençage d'adn par une synthèse utilisant des nucléotides modifiés et une détection par nanopores
GB2500360B (en) 2010-12-22 2019-10-23 Genia Tech Inc Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
IN2014CN02574A (fr) 2011-09-07 2015-06-26 Chem Inc X
WO2013040257A1 (fr) 2011-09-13 2013-03-21 Lasergen, Inc. 5-méthoxy-nucléotides à terminaison rapidement photoclivable non bloqués en 3'oh et procédés de séquençage d'acide nucléique
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
WO2013154999A2 (fr) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Procédé de préparation de nanopore, et utilisations de celui-ci
WO2013188841A1 (fr) 2012-06-15 2013-12-19 Genia Technologies, Inc. Configuration de puce et séquençage d'acide nucléique à haute précision
EP3674412A1 (fr) 2012-06-20 2020-07-01 The Trustees of Columbia University in the City of New York Séquençage d'acide nucléique par détection de nanopores de molécules d'étiquettes
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
WO2014144883A1 (fr) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Molecules marquees par des amas de raman destinees a l'imagerie biologique
US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
WO2014139596A1 (fr) 2013-03-15 2014-09-18 Illumina Cambridge Limited Nucléosides ou nucléotides modifiés
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
JP6461943B2 (ja) 2013-10-23 2019-01-30 ジェニア・テクノロジーズ・インコーポレイテッド ナノポアを備えた高速分子検知
MA39774A (fr) 2014-03-24 2021-05-12 Roche Sequencing Solutions Inc Procédés chimiques pour produire des nucléotides étiquetés
CN105131035B (zh) * 2015-08-05 2017-03-22 延边大学 氨基官能团化合物及糖链标记带正电荷质谱衍生化试剂
JP6657721B2 (ja) 2015-09-30 2020-03-04 ソニー株式会社 細胞の分析方法、細胞分析用チップ、細胞分析用試薬、細胞分析用キット及び細胞分析用装置
KR102873902B1 (ko) * 2024-04-03 2025-10-20 건국대학교 산학협력단 질량 변환이 용이한 광분해성 질량 태그 물질 및 이를 이용한 분자진단 방법
EP4667939A1 (fr) 2024-06-21 2025-12-24 Commissariat à l'Energie Atomique et aux Energies Alternatives Profilage multiplex de cellules cancéreuses à l'aide de sondes étiquetées ms contenant un lieur clivable par iminosydénone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258506A (en) * 1984-10-16 1993-11-02 Chiron Corporation Photolabile reagents for incorporation into oligonucleotide chains
IL86164A0 (en) * 1987-04-28 1988-11-15 Tamir Biotechnology Ltd Improved dna probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5003059A (en) * 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
EP0473984A1 (fr) * 1990-09-07 1992-03-11 The Board Of Governors Of Wayne State University Dérivés de 1,2-dioxetane comme marqueurs chimiluminescents pour les molécules organiques et biologiques
WO1993005183A1 (fr) * 1991-09-09 1993-03-18 Baylor College Of Medicine Procede et dispositif pour la determination rapide du sequençage d'adn ou d'arn au moyen d'une methode de sequençage par addition de base
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
WO2002092128A1 (fr) 2001-05-11 2002-11-21 Genzyme Corporation Compositions et procedes permettant de reguler le phosphate de serum

Also Published As

Publication number Publication date
AU7269194A (en) 1995-02-28
EP0778280B1 (fr) 2003-01-02
ES2108479T3 (es) 1997-12-16
DE69431967D1 (de) 2003-02-06
HU220967B1 (hu) 2002-07-29
DK0711362T3 (da) 1997-12-22
ATE159767T1 (de) 1997-11-15
ATE230409T1 (de) 2003-01-15
US20010031472A1 (en) 2001-10-18
US5770367A (en) 1998-06-23
HUT73802A (en) 1996-09-30
GB9315847D0 (en) 1993-09-15
HU9600027D0 (en) 1996-03-28
EP0778280A2 (fr) 1997-06-11
CN1088758C (zh) 2002-08-07
US20020115091A1 (en) 2002-08-22
EP0778280A3 (fr) 1999-01-27
EP0711362B1 (fr) 1997-10-29
CN1131440A (zh) 1996-09-18
DE69406544T2 (de) 1998-02-26
DE69406544D1 (de) 1997-12-04
JP3289911B2 (ja) 2002-06-10
NO960370D0 (no) 1996-01-29
FI960403A0 (fi) 1996-01-29
FI960403A7 (fi) 1996-01-29
EP0711362A1 (fr) 1996-05-15
US6218111B1 (en) 2001-04-17
JPH09501830A (ja) 1997-02-25
AU695349B2 (en) 1998-08-13
CA2168010C (fr) 2002-10-01
RU2158310C2 (ru) 2000-10-27
CA2168010A1 (fr) 1995-02-09
WO1995004160A1 (fr) 1995-02-09
US6576426B2 (en) 2003-06-10

Similar Documents

Publication Publication Date Title
NO960370L (no) Markörreagens, samt anvendelse derav i assay
PT100724A (pt) Processo de determinacao da quantidade de grupos tiol ligados em proteinas e conjunto para a deteccao de estados isquemicos
HK1040547A1 (zh) 自動化分析儀
DE69433816D1 (de) Die bestimmung von nukleinsäuremutationen durch analyse des sputum
KR930004478A (ko) 핵산의 정량법
DE69429770D1 (de) Verfahren und analytisches system zur genauen schnellen und einfachen ausführung von fibrinogen-assays
ATE72584T1 (de) Homogenes testsystem fuer spezifische polynukleotide und kit dafuer.
DE69330608D1 (de) Positionelle sequenzierung durch hybridisierung
DK463089A (da) Fremgangsmaade og reagenssaet til detektion af en specifik nucleinsyresekvens i en proeve indeholdende en nucleinsyre
ATE181576T1 (de) Nachweis einer nukleinsäuresequenz oder einer änderung darin
GB8827160D0 (en) Detection & quantitative determination of rna & dna
TW326074B (en) Methods, kits and diagnostic systems for performing an affinity assay
ATE253645T1 (de) Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
WO2004019000A3 (fr) Reactifs chimiques et procedes de detection de quantification de proteines presentes dans des melanges complexes
BR8901136A (pt) Processo para detectar a presenca ou ausencia de pelo menos um nucleotidio variante em um ou mais acidos nucleicos,sequencia de nucleotideos para uso no processo e estojo para realizar a dita deteccao
AU2001282920A1 (en) Methods for detecting and assaying nucleic acid sequences
WO1998041650A3 (fr) Procede et trousse de quantification et de sequençage d'acide nucleique d'analytes d'acide nucleique dans un echantillon
DE3474305D1 (en) Probe containing a modified nucleic acid recognizable by specific antibodies and the use to detect and characterize a homologous dna sequence
ES543660A0 (es) Un metodo para determinar una secuencia particular de poli- nucleotidos en un medio de ensayo que contiene acidos nu- cleicos monocatenarios
ATE553216T1 (de) Sonden, bibliotheken und kits zur analyse von nukleinsäuregemischen und verfahren zu deren konstruktion
ES2052607T3 (es) Metodos y kits para detectar secuencias de acidos nucleicos.
ES2081991T3 (es) Deteccion o cuantificacion de varios analitos utilizando tecnicas de marcacion.
ES2118062T3 (es) Composiciones reactivas, metodos y reactivos para la valoracion cuantitativa de magnesio o de calcio y magnesio.
Jalali-Heravi et al. Artificial neural network modeling of peptide mobility and peptide mapping in capillary zone electrophoresis
JP2000125900A5 (fr)