NO960467L - Bicyklo(2.2.2)oktanderivatcholecystokinin og/eller gastrin-antagonister - Google Patents

Bicyklo(2.2.2)oktanderivatcholecystokinin og/eller gastrin-antagonister

Info

Publication number
NO960467L
NO960467L NO960467A NO960467A NO960467L NO 960467 L NO960467 L NO 960467L NO 960467 A NO960467 A NO 960467A NO 960467 A NO960467 A NO 960467A NO 960467 L NO960467 L NO 960467L
Authority
NO
Norway
Prior art keywords
carboxy
alkyl
halo
group
carboxymethyl
Prior art date
Application number
NO960467A
Other languages
English (en)
Other versions
NO960467D0 (no
Inventor
Sarkis Barret Kalindjian
Katherine Isobel Mary Steel
Matthew John Tozer
Martin Lyn Hudson
Original Assignee
Black James Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Black James Foundation filed Critical Black James Foundation
Publication of NO960467L publication Critical patent/NO960467L/no
Publication of NO960467D0 publication Critical patent/NO960467D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings
    • C07C2603/88—Ethanoanthracenes; Hydrogenated ethanoanthracenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Det blir beskrevet forbindelser med formel (1), hvor R1 og R2 uavhengig er H, metyl, halo, karboksy, esterlflsert karboksy, amldert karboksy, karboksymetyl, esterlfisert karboksymetyl eller amidert karboksymetyl; R3 og R4 (eller hver R3- og R4-gruppe når m eller n er 2 eller flere) er uavhengig valgt fra halo, amino, nitro, cyano, sulfamoyl, sulfonyl, trifluormetyl, Cj til C3 alkyl, Cj til C3 alkoksy, hydroksy, G! til C3 hydroksyalkyl, C1 til C3 alkylkarboksyamino, karboksy, esterifisert karboksy og amldert karboksy; R5 og R6 er uavhengig valgt fra H og gruppene angitt ovenfor for R3; m er fra O til 4, forutsatt at m ikke er mer enn 2, dersom R3 ikke eksklusivt er halo; n er fra O til 4, forutsatt at n Ikke er mer enn 2 dersom ikke R4 eksklusivt er halo; R7, R9 og R10 er uavhengig H eller G! til C3 alkyl; R8 er H eller Cx til C15 hydrokarbyl, hvor en eller flere hydrogenatomer i hydrokarbylgruppen kan bli erstattet med et halogenatom, og opptil to av karbonatomene kan være erstattet av et nitrogen, oksygen eller sovevelatom, forutsatt at R8 ikke inneholder en -0-0-gruppe; U er aryl, substituert aryl, heterocyklisk, substituert heterocyklisk eller cykloalkyl, og Z er en gruppe med formel (II) eller (III) (hvor R er H eller C1 til C3 alkyl; X er -C02H eller tetrazolyl: Y er H, -C02H, tetrazolyl, -CH2OH, -C020H, -C02Me eller -COKH2. og a er fra O til 2); og farmasøytisk akseptable salter derav, som har høy affinitet for CCK og/eller gastrinreseptorer.
NO960467A 1993-08-12 1996-02-05 Bicyklo(2.2.2)oktanderivatcholecystokinin og/eller gastrin-antagonister NO960467D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939316722A GB9316722D0 (en) 1993-08-12 1993-08-12 Bicyclo (2.2.2)octane derivatives
PCT/GB1994/001740 WO1995005359A1 (en) 1993-08-12 1994-08-09 Bicyclo (2.2.2) octane derivatives cholecystokinin and/or gastrin antagonists

Publications (2)

Publication Number Publication Date
NO960467L true NO960467L (no) 1996-02-05
NO960467D0 NO960467D0 (no) 1996-02-05

Family

ID=10740353

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960467A NO960467D0 (no) 1993-08-12 1996-02-05 Bicyklo(2.2.2)oktanderivatcholecystokinin og/eller gastrin-antagonister

Country Status (15)

Country Link
EP (1) EP0719251B1 (no)
JP (1) JPH09501438A (no)
AT (1) ATE174327T1 (no)
AU (1) AU689788B2 (no)
CA (1) CA2167156A1 (no)
DE (1) DE69415165D1 (no)
FI (1) FI960571A0 (no)
GB (1) GB9316722D0 (no)
HU (1) HUT74570A (no)
NO (1) NO960467D0 (no)
NZ (1) NZ269826A (no)
PL (1) PL312959A1 (no)
SG (1) SG49638A1 (no)
WO (1) WO1995005359A1 (no)
ZA (1) ZA946087B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3459497A (en) * 1996-07-12 1998-02-09 Chugai Seiyaku Kabushiki Kaisha Cancer cell proliferation inhibitors
EP1534273A4 (en) * 2002-07-18 2007-08-22 Bristol Myers Squibb Co MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD
US7253283B2 (en) 2004-01-16 2007-08-07 Bristol-Myers Squibb Company Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7605264B2 (en) * 2004-01-16 2009-10-20 Bristol-Myers Squibb Company Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7625921B2 (en) 2004-01-16 2009-12-01 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7326728B2 (en) 2004-01-16 2008-02-05 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
US7569689B2 (en) * 2004-01-16 2009-08-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7317024B2 (en) 2005-01-13 2008-01-08 Bristol-Myers Squibb Co. Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7642273B2 (en) 2005-01-13 2010-01-05 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7361654B2 (en) 2005-01-13 2008-04-22 Bristol-Myers Squibb Co. Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7411071B2 (en) 2005-01-13 2008-08-12 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
WO1993008175A1 (en) * 1991-10-24 1993-04-29 Glaxo Group Limited Benzodiazepine derivatives as antagonists of gastrin and/or cholecystokinin
NZ249202A (en) * 1992-02-20 1996-06-25 Black James Foundation Bicyclo[2.2.2.]octane derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
JPH09501438A (ja) 1997-02-10
GB9316722D0 (en) 1993-09-29
SG49638A1 (en) 1998-06-15
NZ269826A (en) 1996-10-28
CA2167156A1 (en) 1995-02-23
EP0719251A1 (en) 1996-07-03
ATE174327T1 (de) 1998-12-15
DE69415165D1 (de) 1999-01-21
WO1995005359A1 (en) 1995-02-23
HU9600069D0 (en) 1996-03-28
NO960467D0 (no) 1996-02-05
AU689788B2 (en) 1998-04-09
FI960571A7 (fi) 1996-02-07
ZA946087B (en) 1996-02-12
AU7347794A (en) 1995-03-14
HUT74570A (en) 1997-01-28
PL312959A1 (en) 1996-05-27
EP0719251B1 (en) 1998-12-09
FI960571A0 (fi) 1996-02-07

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