NO961432L - Benzofiofener og beslektede forbindelser som östrogen-agonister - Google Patents

Benzofiofener og beslektede forbindelser som östrogen-agonister

Info

Publication number
NO961432L
NO961432L NO961432A NO961432A NO961432L NO 961432 L NO961432 L NO 961432L NO 961432 A NO961432 A NO 961432A NO 961432 A NO961432 A NO 961432A NO 961432 L NO961432 L NO 961432L
Authority
NO
Norway
Prior art keywords
optionally substituted
heterocycle
related compounds
estrogen agonists
benzophiophenes
Prior art date
Application number
NO961432A
Other languages
English (en)
Other versions
NO961432D0 (no
Inventor
Kimberly O Cameron
Paul Da Silva-Jardine
Eric R Larson
James R Hauske
Robert Louis Rosati
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22467873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO961432(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of NO961432L publication Critical patent/NO961432L/no
Publication of NO961432D0 publication Critical patent/NO961432D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Benzotiofener og beslektede forbindelser med formel (1), hvori A, B, Z uavhengig er -CH=, -CR4= eller =N-; X er -S-, -O-, -NH-, -NR2-, -CH2-CH2-, -CH2-CH2-CH2-, -CH2-0-; -OCH2-, -CH2-S-, -CO-, -SCH2-, -N=CR2- eller -R2C=N-; Y eventuelt er substituert fenyl, alkyl, cykloalkyl, cykloalkenyl, hetero- cyklus eller bicyklisk ringsystem; D er -CO-, -CR2R3-, -CONH-, -NHCO-, -CR2(OH)-, -CONR2, NOR1( CH-N02, N-CN, -NR2-CO-, -C-, -C-, -C-; E er en enkeltbinding, eventuelt substituert fenyl, heterocyklus; Z1 er -(CH2)p W(CH2)q-, -0(CH2)p CR5R6- eller -0(CH2)p W(CH2)q; G er -NR7R8, (a), (b), (c) en 5- eller 6- leddet mettet, umettet eller delvis umettet og eventuelt substituert heterocyklus eller et bicyklisk amin inneholdende 5 til 12 karbonatomer, enten brosammenbundet eller fusjonert, og eventuelt substituert, og R er halogen, -NR2R3, -NHCOR2/ -NHS02R2, -CR2R3OH, -CONR2R3, -S02NR2R3, OH, -OR1( -O-COR1; er østrogenagonister som er anvendelige for behandling av syndro- mer og sykdommer forårsaket av østrogenmangel.
NO961432A 1993-10-12 1996-04-11 Benzofiofener og beslektede forbindelser som östrogen-agonister NO961432D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13538693A 1993-10-12 1993-10-12
PCT/IB1994/000282 WO1995010513A1 (en) 1993-10-12 1994-09-19 Benzothiophenes and related compounds as estrogen agonists

Publications (2)

Publication Number Publication Date
NO961432L true NO961432L (no) 1996-04-11
NO961432D0 NO961432D0 (no) 1996-04-11

Family

ID=22467873

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961432A NO961432D0 (no) 1993-10-12 1996-04-11 Benzofiofener og beslektede forbindelser som östrogen-agonister

Country Status (19)

Country Link
US (1) US6756388B1 (no)
EP (1) EP0723537A1 (no)
JP (1) JPH08511273A (no)
KR (1) KR960704874A (no)
CN (1) CN1133040A (no)
AU (1) AU7545394A (no)
BR (1) BR9407790A (no)
CA (1) CA2173243A1 (no)
CO (1) CO4290353A1 (no)
CZ (1) CZ105696A3 (no)
FI (1) FI944771A7 (no)
HU (1) HUT75231A (no)
IL (1) IL111187A0 (no)
NO (1) NO961432D0 (no)
NZ (1) NZ271733A (no)
PE (1) PE22095A1 (no)
PL (1) PL313905A1 (no)
WO (1) WO1995010513A1 (no)
ZA (1) ZA947911B (no)

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