NO963358L - Vertsvektor-system til anvendelse i genterapi - Google Patents

Vertsvektor-system til anvendelse i genterapi

Info

Publication number
NO963358L
NO963358L NO963358A NO963358A NO963358L NO 963358 L NO963358 L NO 963358L NO 963358 A NO963358 A NO 963358A NO 963358 A NO963358 A NO 963358A NO 963358 L NO963358 L NO 963358L
Authority
NO
Norway
Prior art keywords
sequence
transgene
recombinant virus
gene therapy
vector system
Prior art date
Application number
NO963358A
Other languages
English (en)
Other versions
NO963358D0 (no
Inventor
David Klatzmann
Jean-Loup Salzmann
Original Assignee
Univ Paris Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9401994A external-priority patent/FR2716461A1/fr
Application filed by Univ Paris Curie filed Critical Univ Paris Curie
Publication of NO963358D0 publication Critical patent/NO963358D0/no
Publication of NO963358L publication Critical patent/NO963358L/no

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13061—Methods of inactivation or attenuation
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6045—RNA rev transcr viruses
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Plant Pathology (AREA)
  • Biophysics (AREA)
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  • Virology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Devices For Executing Special Programs (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

System for ekspressjon av et transgen i en målcelle eller humant eller animalt vev kjennetegnet ved at det består av en linjeetablert eukaryotisk celle, hvori det er transfektert: a) en rekombinant virussekvens hvori et gen har vært slettet enten fullstendig eller delvis og erstattet med transgenet; b) en nukleinsyresekvens hvilken inkluderer en sekens som koder det slettede protein, idet sekvensen styres av en promotor og, om nødvendig, er assosiert med transgenet, og ved sin 3' ende er flankert av et polyadenyleringspunkt. Det rekombinante virusgenom og sekvensen som bæres av en eller to plasmidformede bærere tenderer til å være transkomplimentære og gjøre det mulig for vertcellen å frembringe defekte infektuøse vimser.
NO963358A 1994-02-22 1996-08-13 Vertsvektor-system til anvendelse i genterapi NO963358L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9401994A FR2716461A1 (fr) 1994-02-22 1994-02-22 Système hôte-vecteur utilisable en thérapie génique.
FR9415135A FR2716459B1 (fr) 1994-02-22 1994-12-15 Système hôte-vecteur utilisable en thérapie génique.
PCT/FR1995/000208 WO1995022617A1 (fr) 1994-02-22 1995-02-22 Systeme hote-vecteur utilisable en therapie genique

Publications (2)

Publication Number Publication Date
NO963358D0 NO963358D0 (no) 1996-08-13
NO963358L true NO963358L (no) 1996-09-02

Family

ID=26230967

Family Applications (1)

Application Number Title Priority Date Filing Date
NO963358A NO963358L (no) 1994-02-22 1996-08-13 Vertsvektor-system til anvendelse i genterapi

Country Status (14)

Country Link
US (2) US5948675A (no)
EP (2) EP0738327B1 (no)
JP (1) JP3681752B2 (no)
AT (1) ATE172496T1 (no)
AU (1) AU1851895A (no)
CA (1) CA2183151C (no)
DE (1) DE69505493T2 (no)
DK (1) DK0738327T3 (no)
ES (1) ES2124532T3 (no)
FI (1) FI963246A7 (no)
FR (1) FR2716459B1 (no)
IL (1) IL112736A0 (no)
NO (1) NO963358L (no)
WO (1) WO1995022617A1 (no)

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FI963246L (fi) 1996-10-16
EP0738327B1 (fr) 1998-10-21
FR2716459B1 (fr) 1996-05-10
JP3681752B2 (ja) 2005-08-10
EP0855185A2 (fr) 1998-07-29
FR2716459A1 (fr) 1995-08-25
WO1995022617A1 (fr) 1995-08-24
EP0738327A1 (fr) 1996-10-23
US20020051763A1 (en) 2002-05-02
IL112736A0 (en) 1995-05-26
FI963246A7 (fi) 1996-10-16
ES2124532T3 (es) 1999-02-01
ATE172496T1 (de) 1998-11-15
DE69505493T2 (de) 1999-04-22
AU1851895A (en) 1995-09-04
CA2183151C (fr) 2008-12-09
CA2183151A1 (fr) 1995-08-24
NO963358D0 (no) 1996-08-13
JPH09509060A (ja) 1997-09-16
DK0738327T3 (da) 1999-06-28
EP0855185A3 (fr) 1998-11-18
DE69505493D1 (de) 1998-11-26
US5948675A (en) 1999-09-07
FI963246A0 (fi) 1996-08-19

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