NO964180L - Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer - Google Patents

Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer

Info

Publication number: NO964180L
Authority: NO; Norway
Prior art keywords: alkenyl; cycloalkyl; alkyl; alkynyl; substituted
Prior art date: 1994-04-19

Application number

NO964180A

Other languages

English (en)

Norwegian (no)

Other versions

NO964180D0 (no

Inventor

Peter Moldt

Frank Watjen

Jorgen Scheel-Krueger

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-19

Filing date

1996-10-02

Publication date

1996-12-16

1996-10-02 Application filed by Neurosearch As filed Critical Neurosearch As

1996-10-02 Publication of NO964180D0 publication Critical patent/NO964180D0/no

1996-12-16 Publication of NO964180L publication Critical patent/NO964180L/no

Links

239000003901 neurotransmitter uptake inhibitor Substances 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 7
125000000753 cycloalkyl group Chemical group 0.000 abstract 7
125000000304 alkynyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
125000001424 substituent group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

NO964180A 1994-04-19 1996-10-02 Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer NO964180L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK44794		1994-04-19
DK133894		1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en)	1994-04-19	1995-04-12	Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number	Publication Date
NO964180D0 NO964180D0 (no)	1996-10-02
NO964180L true NO964180L (no)	1996-12-16

Family

ID=26064021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964180A NO964180L (no)	1994-04-19	1996-10-02	Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer

Country Status (25)

Country	Link
US (1)	US5736556A (de)
EP (1)	EP0756596B1 (de)
JP (1)	JP2899418B2 (de)
KR (1)	KR100210417B1 (de)
CN (1)	CN1043763C (de)
AT (1)	ATE222587T1 (de)
AU (1)	AU690257B2 (de)
BG (1)	BG63259B1 (de)
BR (1)	BR9507489A (de)
CA (1)	CA2187309C (de)
CZ (1)	CZ284379B6 (de)
DE (1)	DE69527839T2 (de)
DK (1)	DK0756596T3 (de)
EE (1)	EE03877B1 (de)
FI (1)	FI965074A0 (de)
GE (1)	GEP19991749B (de)
HU (1)	HU215830B (de)
LV (1)	LV11738B (de)
NO (1)	NO964180L (de)
NZ (1)	NZ284075A (de)
PL (1)	PL183025B1 (de)
RU (1)	RU2134264C1 (de)
SK (1)	SK280875B6 (de)
UA (1)	UA49801C2 (de)
WO (1)	WO1995028401A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69637097T2 (de) *	1995-10-13	2007-09-20	Neurosearch A/S	8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
US6241963B1 (en) *	1995-10-19	2001-06-05	The Trustees Of The University Of Pennsylvania	Dopamine and serotonin transporter ligands and imaging agents
NZ321970A (en) *	1995-11-02	2000-02-28	Neurosearch As	Fused tropane-derivatives as neurotransmitter reuptake inhibitors
US5948933A (en)	1997-07-11	1999-09-07	Organix, Inc.	Tropane analogs and methods for inhibition of monoamine transport
JP3238414B2 (ja) *	1996-02-22	2001-12-17	ニューロサーチ・アクティーゼルスカブ	トロパン―誘導体、その製造方法及びその使用方法
US6232326B1 (en)	1998-07-14	2001-05-15	Jodi A. Nelson	Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) *	1999-07-13	2004-11-18	Jodi Nelson	Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
EP1261340B1 (de)	1999-07-13	2009-05-13	Alpha Research Group, LLC	Zusammensetzungen und verfahren zur behandlung der parkinson-krankheit
CN100355753C (zh) *	2000-05-26	2007-12-19	辉瑞大药厂	用于制备具有治疗作用的莨菪烷衍生物的中间体
US6667314B2 (en)	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
JP2005508872A (ja) *	2001-05-23	2005-04-07	ニューロサーチ、アクティーゼルスカブ	トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法
US6610849B2 (en) *	2001-06-28	2003-08-26	Boehringer Ingelheim Pharma Kg	Process for the manufacture of tropenol
US7381733B2 (en)	2001-11-30	2008-06-03	Neurosearch A/S	Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
DE10200943A1 (de) *	2002-01-12	2003-07-24	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Scopinestern
CA2480742A1 (en) *	2002-03-28	2003-12-04	President And Fellows Of Harvard College	Tropane compounds
KR100777885B1 (ko)	2003-10-03	2007-11-28	화이자 인코포레이티드	Ｈｉｖ 및 염증 치료를 위한 ｃｃｒ5 수용체 길항제 활성을갖는 이미다조피리딘 치환된 트로판 유도체
EP1675591B1 (de)	2003-10-16	2011-08-10	NeuroSearch A/S	Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem acetylcholinesterase-hemmer
EP1708707A1 (de) *	2004-01-22	2006-10-11	Neurosearch A/S	Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem n-methyl-d-aspartat (nmda)-rezeptorantagonisten
CA2553649A1 (en) *	2004-01-22	2005-08-04	Neurosearch A/S	Compounds for the sustained reduction of body weight
RU2352332C1 (ru) *	2005-01-14	2009-04-20	Частное Предприятие "Славянская Клиника"	Применение местного анестетика для коррекции пищевого поведения человека и способ применения
EP1779851A1 (de)	2005-10-31	2007-05-02	Boehringer Ingelheim Pharma GmbH & Co.KG	Behandlung von Diabetes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813404A (en) *	1972-11-15	1974-05-28	Sterling Drug Inc	Tropane-2-carboxylates and derivatives
SU941369A1 (ru) *	1978-12-29	1982-07-07	Научно-исследовательский институт фармакологии АМН СССР	Хлоргидраты W-аминоацильных эфиров тропан-3-ола как стимул торы центральной нервной системы
AT397962B (de) *	1985-12-27	1994-08-25	Madaus & Co Dr	Verfahren zur herstellung von azoniaspironortropanolestern
AU671163B2 (en) *	1992-12-23	1996-08-15	Neurosearch A/S	Alkyl substituted heterocyclic compounds
AU672052B2 (en) *	1992-12-23	1996-09-19	Neurosearch A/S	Antidepressant and antiparkinsonian compounds

1995
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 EP EP95915869A patent/EP0756596B1/de not_active Expired - Lifetime
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/en not_active Ceased
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 CA CA002187309A patent/CA2187309C/en not_active Expired - Fee Related
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active Expired - Fee Related
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
1996
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A0/fi active IP Right Revival

Also Published As

Publication number	Publication date
CA2187309C (en)	2000-11-21
FI965074A7 (fi)	1996-12-17
EE9600132A (et)	1997-04-15
UA49801C2 (uk)	2002-10-15
EE03877B1 (et)	2002-10-15
JP2899418B2 (ja)	1999-06-02
CN1148854A (zh)	1997-04-30
ATE222587T1 (de)	2002-09-15
PL183025B1 (pl)	2002-05-31
CZ298296A3 (en)	1997-06-11
GEP19991749B (en)	1999-09-10
US5736556A (en)	1998-04-07
BR9507489A (pt)	1997-08-12
SK280875B6 (sk)	2000-08-14
DK0756596T3 (da)	2002-12-23
NZ284075A (en)	1998-01-26
CN1043763C (zh)	1999-06-23
AU690257B2 (en)	1998-04-23
CZ284379B6 (cs)	1998-11-11
DE69527839D1 (en)	2002-09-26
HUT75865A (en)	1997-05-28
JPH09505607A (ja)	1997-06-03
DE69527839T2 (de)	2003-01-02
RU2134264C1 (ru)	1999-08-10
MX9604966A (es)	1998-05-31
AU2257595A (en)	1995-11-10
HU215830B (hu)	2001-05-28
SK128896A3 (en)	1997-04-09
FI965074A0 (fi)	1996-12-17
EP0756596B1 (de)	2002-08-21
PL316876A1 (en)	1997-02-17
LV11738B (en)	1997-12-20
HU9602707D0 (en)	1996-11-28
BG63259B1 (bg)	2001-07-31
KR100210417B1 (ko)	1999-07-15
NO964180D0 (no)	1996-10-02
LV11738A (lv)	1997-04-20
CA2187309A1 (en)	1995-10-26
WO1995028401A1 (en)	1995-10-26
BG100883A (en)	1998-03-31
EP0756596A1 (de)	1997-02-05

Legal Events

Date	Code	Title	Description
2003-09-15	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO964180L (no)	1996-12-16	Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer
NO980919D0 (no)	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse
CA2244773A1 (en)	1997-08-28	Tropane-derivatives, their preparation and use
CA2160444A1 (en)	1996-04-15	Aroyl-piperdine derivatives
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
YU40998A (sh)	1999-09-27	Derivati supstituisanog 1,2,3,4-tetrahidronaftalina
AU7206398A (en)	1998-12-08	Piperidine derivatives as neurotransmitter re-uptake inhibitors
GB9825554D0 (en)	1999-01-13	Novel Compounds
JO2235B1 (en)	2004-10-07	Derivatives of phenyl
US4840967A (en)	1989-06-20	Carbamate or urea derivatives, their preparation and pharmaceutical compositions comprising them
TH10189A (th)	1991-12-01	อนุพันธ์ของกรด (สูตรเคมี) ที่มีหมู่แทนที่ฟลูออรีน
HUP0303691A2 (hu)	2004-03-01	Uretánszármazékok, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására