NO964180L - Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer - Google Patents

Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer

Info

Publication number: NO964180L
Authority: NO; Norway
Prior art keywords: alkenyl; cycloalkyl; alkyl; alkynyl; substituted
Prior art date: 1994-04-19

Application number

NO964180A

Other languages

English (en)

Norwegian (no)

Other versions

NO964180D0 (no

Inventor

Peter Moldt

Frank Watjen

Jorgen Scheel-Krueger

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-19

Filing date

1996-10-02

Publication date

1996-12-16

1996-10-02 Application filed by Neurosearch As filed Critical Neurosearch As

1996-10-02 Publication of NO964180D0 publication Critical patent/NO964180D0/no

1996-12-16 Publication of NO964180L publication Critical patent/NO964180L/no

Links

239000003901 neurotransmitter uptake inhibitor Substances 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 7
125000000753 cycloalkyl group Chemical group 0.000 abstract 7
125000000304 alkynyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
125000001424 substituent group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

NO964180A 1994-04-19 1996-10-02 Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer NO964180L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK44794		1994-04-19
DK133894		1994-11-24
PCT/EP1995/001358 WO1995028401A1 (fr)	1994-04-19	1995-04-12	Derives de tropane-2-aldoxime en tant qu'inhibiteurs de recaptage des neurotransmetteurs

Publications (2)

Publication Number	Publication Date
NO964180D0 NO964180D0 (no)	1996-10-02
NO964180L true NO964180L (no)	1996-12-16

Family

ID=26064021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964180A NO964180L (no)	1994-04-19	1996-10-02	Tropan-2-aldoksimderivater som neurotransmitter-gjenopptaksinhibitorer

Country Status (25)

Country	Link
US (1)	US5736556A (fr)
EP (1)	EP0756596B1 (fr)
JP (1)	JP2899418B2 (fr)
KR (1)	KR100210417B1 (fr)
CN (1)	CN1043763C (fr)
AT (1)	ATE222587T1 (fr)
AU (1)	AU690257B2 (fr)
BG (1)	BG63259B1 (fr)
BR (1)	BR9507489A (fr)
CA (1)	CA2187309C (fr)
CZ (1)	CZ284379B6 (fr)
DE (1)	DE69527839T2 (fr)
DK (1)	DK0756596T3 (fr)
EE (1)	EE03877B1 (fr)
FI (1)	FI965074A7 (fr)
GE (1)	GEP19991749B (fr)
HU (1)	HU215830B (fr)
LV (1)	LV11738B (fr)
NO (1)	NO964180L (fr)
NZ (1)	NZ284075A (fr)
PL (1)	PL183025B1 (fr)
RU (1)	RU2134264C1 (fr)
SK (1)	SK280875B6 (fr)
UA (1)	UA49801C2 (fr)
WO (1)	WO1995028401A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69637097T2 (de) *	1995-10-13	2007-09-20	Neurosearch A/S	8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
US6241963B1 (en) *	1995-10-19	2001-06-05	The Trustees Of The University Of Pennsylvania	Dopamine and serotonin transporter ligands and imaging agents
AU702720B2 (en) *	1995-11-02	1999-03-04	Neurosearch A/S	Fused tropane-derivatives as neurotransmitter reuptake inhibitors
US5948933A (en)	1997-07-11	1999-09-07	Organix, Inc.	Tropane analogs and methods for inhibition of monoamine transport
BR9707636A (pt) *	1996-02-22	1999-07-27	Neurosearch As	Composto composição farmacêutica uso de um composto e processos para preparar composto e para tratar um distúrbio ou doença de um organismo animal vivo
US6232326B1 (en)	1998-07-14	2001-05-15	Jodi A. Nelson	Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) *	1999-07-13	2004-11-18	Jodi Nelson	Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
WO2001003649A2 (fr)	1999-07-13	2001-01-18	Alpha Research Group, Llc	Traitement de la maladie de parkinson et compositions a cet effet
HRP20020938B1 (en) *	2000-05-26	2011-05-31	Pfizer Inc.	Tropane derivatives useful in therapy
US6667314B2 (en)	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
JP2005508872A (ja) *	2001-05-23	2005-04-07	ニューロサーチ、アクティーゼルスカブ	トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法
US6610849B2 (en) *	2001-06-28	2003-08-26	Boehringer Ingelheim Pharma Kg	Process for the manufacture of tropenol
US7381733B2 (en)	2001-11-30	2008-06-03	Neurosearch A/S	Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
DE10200943A1 (de) *	2002-01-12	2003-07-24	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Scopinestern
CA2480742A1 (fr) *	2002-03-28	2003-12-04	President And Fellows Of Harvard College	Composes de tropane
MXPA06003749A (es)	2003-10-03	2006-06-14	Pfizer	Derivados de tropano.
EP2269608A3 (fr)	2003-10-16	2011-02-16	NeuroSearch AS	Compositions pharmaceutiques comprenants des inhibiteurs de récaptage de neurotransmitteurs monoamine et des inhibiteurs de l'acétylcholinestérase
WO2005070429A1 (fr) *	2004-01-22	2005-08-04	Neurosearch A/S	Preparation pharmaceutique contenant un inhibiteur de recapture du neurotransmetteur monoamine et un antagoniste des recepteurs du n-methyl-d-aspartate (nmda)
AU2005205880B2 (en) *	2004-01-22	2010-06-10	Neurosearch A/S	Compounds for the sustained reduction of body weight
RU2352332C1 (ru) *	2005-01-14	2009-04-20	Частное Предприятие "Славянская Клиника"	Применение местного анестетика для коррекции пищевого поведения человека и способ применения
EP1779851A1 (fr)	2005-10-31	2007-05-02	Boehringer Ingelheim Pharma GmbH & Co.KG	Traitement du diabète

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813404A (en) *	1972-11-15	1974-05-28	Sterling Drug Inc	Tropane-2-carboxylates and derivatives
SU941369A1 (ru) *	1978-12-29	1982-07-07	Научно-исследовательский институт фармакологии АМН СССР	Хлоргидраты W-аминоацильных эфиров тропан-3-ола как стимул торы центральной нервной системы
AT397962B (de) *	1985-12-27	1994-08-25	Madaus & Co Dr	Verfahren zur herstellung von azoniaspironortropanolestern
AU672052B2 (en) *	1992-12-23	1996-09-19	Neurosearch A/S	Antidepressant and antiparkinsonian compounds
AU671163B2 (en) *	1992-12-23	1996-08-15	Neurosearch A/S	Alkyl substituted heterocyclic compounds

1995
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 EP EP95915869A patent/EP0756596B1/fr not_active Expired - Lifetime
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/fr not_active Ceased
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active Expired - Fee Related
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 CA CA002187309A patent/CA2187309C/fr not_active Expired - Fee Related
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
1996
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A7/fi active IP Right Revival

Also Published As

Publication number	Publication date
FI965074A0 (fi)	1996-12-17
CA2187309C (fr)	2000-11-21
JP2899418B2 (ja)	1999-06-02
WO1995028401A1 (fr)	1995-10-26
RU2134264C1 (ru)	1999-08-10
JPH09505607A (ja)	1997-06-03
PL316876A1 (en)	1997-02-17
HU9602707D0 (en)	1996-11-28
BG63259B1 (bg)	2001-07-31
US5736556A (en)	1998-04-07
HUT75865A (en)	1997-05-28
AU2257595A (en)	1995-11-10
EE03877B1 (et)	2002-10-15
CA2187309A1 (fr)	1995-10-26
BG100883A (en)	1998-03-31
SK128896A3 (en)	1997-04-09
MX9604966A (es)	1998-05-31
NZ284075A (en)	1998-01-26
AU690257B2 (en)	1998-04-23
HU215830B (hu)	2001-05-28
EP0756596B1 (fr)	2002-08-21
CN1148854A (zh)	1997-04-30
PL183025B1 (pl)	2002-05-31
DE69527839T2 (de)	2003-01-02
NO964180D0 (no)	1996-10-02
FI965074A7 (fi)	1996-12-17
DK0756596T3 (da)	2002-12-23
CN1043763C (zh)	1999-06-23
BR9507489A (pt)	1997-08-12
GEP19991749B (en)	1999-09-10
DE69527839D1 (en)	2002-09-26
CZ298296A3 (en)	1997-06-11
EP0756596A1 (fr)	1997-02-05
LV11738A (lv)	1997-04-20
SK280875B6 (sk)	2000-08-14
CZ284379B6 (cs)	1998-11-11
EE9600132A (et)	1997-04-15
KR100210417B1 (ko)	1999-07-15
ATE222587T1 (de)	2002-09-15
LV11738B (en)	1997-12-20
UA49801C2 (uk)	2002-10-15

Legal Events

Date	Code	Title	Description
2003-09-15	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO980919D0 (no)	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse
UA49872C2 (uk)	2002-10-15	Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування
CA2187309A1 (fr)	1995-10-26	Derives de tropane-2-aldoxime en tant qu'inhibiteurs de recaptage des neurotransmetteurs
MY114679A (en)	2002-12-31	Aroyl-piperidine derivatives
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
YU40998A (sh)	1999-09-27	Derivati supstituisanog 1,2,3,4-tetrahidronaftalina
TW200724136A (en)	2007-07-01	Pharmaceutical compositions comprising PPAR modulator
AU7206398A (en)	1998-12-08	Piperidine derivatives as neurotransmitter re-uptake inhibitors
GB9825554D0 (en)	1999-01-13	Novel Compounds
ES2021261A6 (es)	1991-10-16	Procedimiento de preparacion de nuevos derivados aminopropanoles racemicos u opticamente activos, sus sales de adicion acida y sus derivados amonicos cuaternarios.
KR970042491A (ko)	1997-07-24	N- 아릴알킬호모바닐릭아미드 유도체 및 이의 제조방법