NO970141D0 - Konjugater av metallkomplekser og oligonukleotider, midler inneholdende konjugatene, deres anvendelse ved radiodiagnose samt fremgangsmåte for deres fremstilling - Google Patents
Konjugater av metallkomplekser og oligonukleotider, midler inneholdende konjugatene, deres anvendelse ved radiodiagnose samt fremgangsmåte for deres fremstillingInfo
- Publication number
- NO970141D0 NO970141D0 NO970141A NO970141A NO970141D0 NO 970141 D0 NO970141 D0 NO 970141D0 NO 970141 A NO970141 A NO 970141A NO 970141 A NO970141 A NO 970141A NO 970141 D0 NO970141 D0 NO 970141D0
- Authority
- NO
- Norway
- Prior art keywords
- conjugates
- oligonucleotides
- radiodiagnosis
- preparation
- metal complexes
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002184 metal Substances 0.000 title 1
- 239000008139 complexing agent Substances 0.000 abstract 2
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4424922A DE4424922A1 (de) | 1994-07-14 | 1994-07-14 | Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden |
| DE19944445078 DE4445078A1 (de) | 1994-12-05 | 1994-12-05 | Konjugate aus Metallkomplexen und Oligonucleotiden, diese enthaltende Mittel, deren Verwendung in der Radiodiagnostik sowie Verfahren zu deren Herstellung |
| PCT/EP1995/002539 WO1996002274A1 (en) | 1994-07-14 | 1995-06-30 | Conjugates made of metal complexes and oligonucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970141D0 true NO970141D0 (no) | 1997-01-13 |
| NO970141L NO970141L (no) | 1997-03-14 |
| NO318585B1 NO318585B1 (no) | 2005-04-11 |
Family
ID=25938359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970141A NO318585B1 (no) | 1994-07-14 | 1997-01-13 | Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0777498B1 (no) |
| JP (2) | JPH10503182A (no) |
| KR (1) | KR100366525B1 (no) |
| CN (1) | CN1219551C (no) |
| AT (1) | ATE265229T1 (no) |
| AU (1) | AU2979195A (no) |
| CA (1) | CA2194558A1 (no) |
| CZ (1) | CZ295930B6 (no) |
| DE (1) | DE69532958T2 (no) |
| DK (1) | DK0777498T3 (no) |
| ES (1) | ES2220933T3 (no) |
| HU (1) | HU220859B1 (no) |
| IL (1) | IL114237A (no) |
| MX (1) | MX9606443A (no) |
| NO (1) | NO318585B1 (no) |
| NZ (1) | NZ289831A (no) |
| PL (1) | PL318147A1 (no) |
| PT (1) | PT777498E (no) |
| RU (1) | RU2165771C2 (no) |
| SK (1) | SK284598B6 (no) |
| TW (1) | TW502040B (no) |
| UA (1) | UA48140C2 (no) |
| WO (1) | WO1996002274A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU739391B2 (en) * | 1996-07-03 | 2001-10-11 | President And Fellows Of Harvard College | Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides |
| US6335437B1 (en) * | 1998-09-07 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Methods for the preparation of conjugated oligomers |
| RU2244572C1 (ru) * | 2003-04-24 | 2005-01-20 | Медицинский радиологический научный центр РАМН | Способ внутритканевой лучевой терапии злокачественных опухолей |
| MX2008014005A (es) * | 2006-05-03 | 2009-01-27 | Baltic Technology Dev Ltd | Agentes antisentido que combinan un oligonucleotido modificado con base fuertemente unida y nucleasa artificial. |
| GB201012418D0 (en) * | 2010-07-23 | 2010-09-08 | Santaris Pharma As | Process |
| US10357578B2 (en) | 2014-05-13 | 2019-07-23 | Paul Scherrer Institut | Production of 43SC radionuclide and radiopharmaceuticals thereof for use in positron emission tomography |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013831A (en) * | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| WO1988009152A1 (en) * | 1985-03-19 | 1988-12-01 | Mills Randell L | Apparatus providing diagnosis and selective tissue necrosis |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| WO1989000062A1 (en) * | 1987-07-07 | 1989-01-12 | The Cancer Institute Board | Radiotherapy |
| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| KR970002255B1 (ko) * | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| IE914220A1 (en) * | 1990-12-10 | 1992-06-17 | Akzo Nv | Labelled, modified oligonucleotides |
| EP0588229A3 (en) * | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
-
1995
- 1995-06-20 IL IL11423795A patent/IL114237A/xx not_active IP Right Cessation
- 1995-06-30 JP JP8504630A patent/JPH10503182A/ja not_active Withdrawn
- 1995-06-30 HU HU9700100A patent/HU220859B1/hu not_active IP Right Cessation
- 1995-06-30 WO PCT/EP1995/002539 patent/WO1996002274A1/en not_active Ceased
- 1995-06-30 KR KR1019970700223A patent/KR100366525B1/ko not_active Expired - Fee Related
- 1995-06-30 PT PT95925792T patent/PT777498E/pt unknown
- 1995-06-30 AU AU29791/95A patent/AU2979195A/en not_active Abandoned
- 1995-06-30 DK DK95925792T patent/DK0777498T3/da active
- 1995-06-30 RU RU97102039/14A patent/RU2165771C2/ru not_active IP Right Cessation
- 1995-06-30 NZ NZ289831A patent/NZ289831A/xx not_active IP Right Cessation
- 1995-06-30 CA CA002194558A patent/CA2194558A1/en not_active Abandoned
- 1995-06-30 DE DE69532958T patent/DE69532958T2/de not_active Expired - Fee Related
- 1995-06-30 MX MX9606443A patent/MX9606443A/es not_active IP Right Cessation
- 1995-06-30 CZ CZ1997114A patent/CZ295930B6/cs not_active IP Right Cessation
- 1995-06-30 EP EP95925792A patent/EP0777498B1/en not_active Expired - Lifetime
- 1995-06-30 PL PL95318147A patent/PL318147A1/xx unknown
- 1995-06-30 AT AT95925792T patent/ATE265229T1/de not_active IP Right Cessation
- 1995-06-30 CN CNB951940007A patent/CN1219551C/zh not_active Expired - Fee Related
- 1995-06-30 ES ES95925792T patent/ES2220933T3/es not_active Expired - Lifetime
- 1995-06-30 SK SK28-97A patent/SK284598B6/sk not_active IP Right Cessation
- 1995-06-30 UA UA97020642A patent/UA48140C2/uk unknown
- 1995-10-14 TW TW084110812A patent/TW502040B/zh not_active IP Right Cessation
-
1997
- 1997-01-13 NO NO19970141A patent/NO318585B1/no not_active IP Right Cessation
-
2009
- 2009-06-04 JP JP2009134684A patent/JP2009197024A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL114237A0 (en) | 1995-10-31 |
| JPH10503182A (ja) | 1998-03-24 |
| KR100366525B1 (ko) | 2003-03-15 |
| HU9700100D0 (en) | 1997-02-28 |
| JP2009197024A (ja) | 2009-09-03 |
| HUT76329A (en) | 1997-08-28 |
| DE69532958T2 (de) | 2009-04-09 |
| SK2897A3 (en) | 1997-09-10 |
| SK284598B6 (sk) | 2005-07-01 |
| CZ11497A3 (cs) | 1998-08-12 |
| DE69532958D1 (de) | 2004-06-03 |
| NO318585B1 (no) | 2005-04-11 |
| WO1996002274A1 (en) | 1996-02-01 |
| CN1219551C (zh) | 2005-09-21 |
| TW502040B (en) | 2002-09-11 |
| ATE265229T1 (de) | 2004-05-15 |
| NZ289831A (en) | 1999-01-28 |
| CN1152879A (zh) | 1997-06-25 |
| MX9606443A (es) | 1997-12-31 |
| EP0777498A1 (en) | 1997-06-11 |
| IL114237A (en) | 2000-08-31 |
| RU2165771C2 (ru) | 2001-04-27 |
| HU220859B1 (en) | 2002-06-29 |
| CZ295930B6 (cs) | 2005-12-14 |
| DK0777498T3 (da) | 2004-08-16 |
| NO970141L (no) | 1997-03-14 |
| PT777498E (pt) | 2004-09-30 |
| EP0777498B1 (en) | 2004-04-28 |
| CA2194558A1 (en) | 1996-02-01 |
| ES2220933T3 (es) | 2004-12-16 |
| KR970704471A (ko) | 1997-09-06 |
| PL318147A1 (en) | 1997-05-12 |
| AU2979195A (en) | 1996-02-16 |
| UA48140C2 (uk) | 2002-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |