NO970892D0 - Oxazolderivater - Google Patents

Oxazolderivater

Info

Publication number: NO970892D0
Authority: NO; Norway
Prior art keywords: group; ring; integer; alkylthio; amino
Prior art date: 1994-08-30

Application number

NO970892A

Other languages

English (en)

Other versions

NO970892L (no

NO308741B1 (no

Inventor

Koichi Kojima

Junichi Sakai

Yuichi Aizawa

Naozumi Samata

Masao Kozuka

Kenji Yoshimi

Isao Kaneko

Kazuro Koyama

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-30

Filing date

1997-02-27

Publication date

1997-02-27

1997-02-27 Application filed by Sankyo Co filed Critical Sankyo Co

1997-02-27 Publication of NO970892D0 publication Critical patent/NO970892D0/no

1997-04-29 Publication of NO970892L publication Critical patent/NO970892L/no

2000-10-23 Publication of NO308741B1 publication Critical patent/NO308741B1/no

Links

125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
108010062431 Monoamine oxidase Proteins 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000002545 isoxazoles Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO970892A 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene NO308741B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP20536394		1994-08-30
JP15057195		1995-06-16
PCT/JP1995/001714 WO1996006837A1 (en)	1994-08-30	1995-08-29	Isoxazoles

Publications (3)

Publication Number	Publication Date
NO970892D0 true NO970892D0 (no)	1997-02-27
NO970892L NO970892L (no)	1997-04-29
NO308741B1 NO308741B1 (no)	2000-10-23

Family

ID=26480122

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO970892A NO308741B1 (no)	1994-08-30	1997-02-27	Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Country Status (19)

Country	Link
US (2)	US5965591A (no)
EP (1)	EP0779281B1 (no)
KR (1)	KR970705549A (no)
CN (1)	CN1098843C (no)
AT (1)	ATE253057T1 (no)
AU (1)	AU688102B2 (no)
CA (1)	CA2198457A1 (no)
CZ (1)	CZ290961B6 (no)
DE (1)	DE69532039T2 (no)
DK (1)	DK0779281T3 (no)
ES (1)	ES2208690T3 (no)
FI (1)	FI970864A7 (no)
HU (1)	HU221138B1 (no)
MX (1)	MX9701630A (no)
NO (1)	NO308741B1 (no)
NZ (1)	NZ291508A (no)
PT (1)	PT779281E (no)
RU (1)	RU2140414C1 (no)
WO (1)	WO1996006837A1 (no)

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ES2208690T3 (es) *	1994-08-30	2004-06-16	Sankyo Company Limited	Isoxazol.
RU2165415C2 (ru) *	1996-02-27	2001-04-20	Санкио Компани Лимитед	Производные изоксазола и фармацевтическая композиция на их основе
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US6497928B1 (en)	1999-05-14	2002-12-24	Canon Kabushiki Kaisha	Liquid crystal device, mesomorphic functional material and liquid crystal apparatus
DE10000577A1 (de)	2000-01-10	2001-07-26	Fumapharm Ag Muri	Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
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BRPI0706365A2 (pt)	2006-01-06	2011-03-22	Sepracor Inc	Cicloalquilaminas como inibidores da recaptação de monoamina
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DK2816024T3 (en)	2006-03-31	2017-10-30	Sunovion Pharmaceuticals Inc	CHIRALE AMINER
US7579370B2 (en) *	2006-06-30	2009-08-25	Sepracor Inc.	Fused heterocycles
US7884124B2 (en) *	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) *	2006-10-02	2008-04-03	Weyerhaeuser Co.	Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US8012955B2 (en)	2006-12-28	2011-09-06	Rigel Pharmaceuticals, Inc.	N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US7902252B2 (en) *	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
US20090099248A1 (en) *	2007-01-18	2009-04-16	Sepracor Inc.	Inhibitors of d-amino acid oxidase
AU2008259841B2 (en)	2007-05-31	2015-02-05	Sunovion Pharmaceuticals Inc.	Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
CA2716080C (en)	2008-02-20	2016-12-13	Targia Pharmaceuticals	Cns pharmaceutical compositions and methods of use
WO2010017418A1 (en) *	2008-08-07	2010-02-11	Sepracor Inc.	Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
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MX2012009377A (es)	2010-02-11	2012-09-12	Univ Vanderbilt	Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica.
US9630929B2 (en)	2011-10-31	2017-04-25	Xenon Pharmaceuticals Inc.	Benzenesulfonamide compounds and their use as therapeutic agents
JP6014155B2 (ja)	2011-10-31	2016-10-25	ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
SG11201408284VA (en)	2012-05-22	2015-02-27	Xenon Pharmaceuticals Inc	N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en)	2012-07-06	2018-09-11	Genentech, Inc.	N-substituted benzamides and methods of use thereof
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CN105492430B (zh) *	2013-03-15	2017-10-10	基因泰克公司	取代的苯并噁唑及其使用方法
MX2015010775A (es)	2013-03-15	2016-04-25	Genentech Inc	Benzoxazoles sustituidos y metodos para usarlos.
CR20160296A (es)	2013-11-27	2016-09-20	Genentech Inc	Benzamidas sustituidas y métodos para usarlas
CN106715418A (zh)	2014-07-07	2017-05-24	基因泰克公司	治疗化合物及其使用方法
JP2018520107A (ja)	2015-05-22	2018-07-26	ジェネンテック，インコーポレイテッド	置換ベンズアミド及びその使用方法
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US10899732B2 (en)	2015-11-25	2021-01-26	Genentech, Inc.	Substituted benzamides useful as sodium channel blockers
EP3854782A1 (en)	2016-03-30	2021-07-28	Genentech, Inc.	Substituted benzamides and methods of use thereof
CN105801510A (zh) *	2016-04-08	2016-07-27	李勇	一种治疗抑郁症的药物组合物
AU2017347549A1 (en)	2016-10-17	2019-05-02	Genentech, Inc.	Therapeutic compounds and methods of use thereof
JP2020511511A (ja)	2017-03-24	2020-04-16	ジェネンテック，インコーポレイテッド	ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
AR114263A1 (es)	2018-02-26	2020-08-12	Genentech Inc	Compuestos terapéuticos y métodos para utilizarlos
WO2019191702A1 (en)	2018-03-30	2019-10-03	F. Hoffmann-La Roche Ag	Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (zh)	2018-05-22	2020-01-16	瑞士商赫孚孟拉羅股份公司	治療性化合物及其使用方法
CN114349690B (zh) *	2022-02-15	2023-04-25	甘肃皓天医药科技有限责任公司	一种多拉韦林中间体合成方法

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GB1265824A (no) *	1968-03-28	1972-03-08
SU539522A3 (ru) *	1970-02-05	1976-12-15	Мерк Энд Ко. Инк. (Фирма)	Способ получени гидразин- -фенилпропионовой кислоты
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1995
- 1995-08-29 ES ES95929249T patent/ES2208690T3/es not_active Expired - Lifetime
- 1995-08-29 CN CN95195758A patent/CN1098843C/zh not_active Expired - Fee Related
- 1995-08-29 KR KR1019970701279A patent/KR970705549A/ko not_active Abandoned
- 1995-08-29 HU HU9701740A patent/HU221138B1/hu not_active IP Right Cessation
- 1995-08-29 EP EP95929249A patent/EP0779281B1/en not_active Expired - Lifetime
- 1995-08-29 MX MX9701630A patent/MX9701630A/es unknown
- 1995-08-29 RU RU97103132/04A patent/RU2140414C1/ru not_active IP Right Cessation
- 1995-08-29 PT PT95929249T patent/PT779281E/pt unknown
- 1995-08-29 WO PCT/JP1995/001714 patent/WO1996006837A1/ja not_active Ceased
- 1995-08-29 DE DE69532039T patent/DE69532039T2/de not_active Expired - Fee Related
- 1995-08-29 CA CA002198457A patent/CA2198457A1/en not_active Abandoned
- 1995-08-29 CZ CZ1997598A patent/CZ290961B6/cs not_active IP Right Cessation
- 1995-08-29 AU AU32660/95A patent/AU688102B2/en not_active Ceased
- 1995-08-29 NZ NZ291508A patent/NZ291508A/xx unknown
- 1995-08-29 AT AT95929249T patent/ATE253057T1/de not_active IP Right Cessation
- 1995-08-29 DK DK95929249T patent/DK0779281T3/da active
1997
- 1997-02-26 US US08/806,854 patent/US5965591A/en not_active Expired - Fee Related
- 1997-02-27 NO NO970892A patent/NO308741B1/no unknown
- 1997-02-28 FI FI970864A patent/FI970864A7/fi not_active IP Right Cessation
1999
- 1999-02-03 US US09/243,885 patent/US6096771A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2208690T3 (es)	2004-06-16
FI970864A0 (fi)	1997-02-28
EP0779281B1 (en)	2003-10-29
HU221138B1 (en)	2002-08-28
EP0779281A4 (en)	2000-07-26
WO1996006837A1 (en)	1996-03-07
US5965591A (en)	1999-10-12
DE69532039D1 (de)	2003-12-04
KR970705549A (ko)	1997-10-09
EP0779281A1 (en)	1997-06-18
AU688102B2 (en)	1998-03-05
HK1018878A1 (en)	2000-01-07
CZ290961B6 (cs)	2002-11-13
ATE253057T1 (de)	2003-11-15
PT779281E (pt)	2004-02-27
NZ291508A (en)	1999-07-29
NO970892L (no)	1997-04-29
FI970864A7 (fi)	1997-04-24
DE69532039T2 (de)	2004-07-08
MX9701630A (es)	1997-06-28
AU3266095A (en)	1996-03-22
NO308741B1 (no)	2000-10-23
US6096771A (en)	2000-08-01
HUT77225A (hu)	1998-03-02
CN1098843C (zh)	2003-01-15
DK0779281T3 (da)	2004-03-08
CZ59897A3 (en)	1997-07-16
CN1162957A (zh)	1997-10-22
CA2198457A1 (en)	1996-03-07
RU2140414C1 (ru)	1999-10-27

Publication	Publication Date	Title
EP0779281A4 (en)	2000-07-26	ISOXAZOLES
AU1282495A (en)	1995-07-17	Anthranilic acid derivative
DE60017115D1 (de)	2005-02-03	Amid-derivate und deren medizinische verwendung
NZ330973A (en)	2000-03-27	Azolobenzazepine derivatives as neurologically active agents
NO20020968D0 (no)	2002-02-27	Glukopyranosyloksypyrazolderivater, medisinske sammensetninger inneholdende det samme og intermediater forfremstillingen derav
AU7517400A (en)	2001-04-24	N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
AU4523797A (en)	1998-05-21	Atherosclerosis treatment
ATE231859T1 (de)	2003-02-15	Tetrahydrothiopyran-phenyloxazolidinon-s-oxide
EP0779074A4 (en)	1999-06-30	PROTECTIVE AGENT FOR ORGAN OR FABRIC
NZ334701A (en)	2001-01-26	Dihydropyrones and use in treating retrovirus infections and diseases
EP0885891A4 (en)	2001-02-21	ISOXAZOLE DERIVATIVES
EP1034783A4 (en)	2001-03-28	AMIDE DERIVATIVES
GR3036029T3 (en)	2001-09-28	Optically active thiazolidinone derivatives
DE59604901D1 (de)	2000-05-11	Carbamoylcarbonsäureamide
NO20012443D0 (no)	2001-05-18	Benzoksazolderivater og legemidler inneholdende disse som aktiv bestanddel
EP0785193A4 (en)	2000-04-19	ARYLTHIADIAZOLE DERIVATIVES AND ANTIVIRAL PRODUCTS CONTAINING THEM
ES2168119T3 (es)	2002-06-01	Derivados de quinoxalina para el tratamiento de tinnitus.
AU6118798A (en)	1998-09-22	Remedies for peripheral circulation disturbances
DE69112095D1 (de)	1995-09-21	1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.