NO973198L - Aryl- og heteroarylpurinforbindelser - Google Patents
Aryl- og heteroarylpurinforbindelserInfo
- Publication number
- NO973198L NO973198L NO973198A NO973198A NO973198L NO 973198 L NO973198 L NO 973198L NO 973198 A NO973198 A NO 973198A NO 973198 A NO973198 A NO 973198A NO 973198 L NO973198 L NO 973198L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- halogen
- ring
- substituted
- Prior art date
Links
- -1 heteroaryl purine compounds Chemical class 0.000 title abstract 3
- 125000003118 aryl group Chemical group 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 3
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- BGCPLWWYPZAURQ-UHFFFAOYSA-N 5-[[5-chloro-2-(2,2,6,6-tetramethylmorpholin-4-yl)pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one Chemical compound ClC=1C(=NC(=NC=1)N1CC(OC(C1)(C)C)(C)C)NC1=CC2=C(N(C(N2CCC(C)(C)O)=O)C)C=C1 BGCPLWWYPZAURQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Nye bicykliske, kondenserte pyrimidinforbindelser som har den generelle formel (I) (I) hvor X er -CH2-, -NH-(CH2)n-, -0-(CH2)n- eller -S-(CH2)n- hvor n er 0 eller 1; A er en 4,5-kondensert imidazolring N-substituert med R3 som er hydrogen, C1-C4 alkyl eller benzyl, eller A er en 2,3-kondensert pyridinring C-substituert med R4 som er hydrogen, C1-C4 alkyl, C1-C4 alkoksy, halogen eller NRsR^ hvor hver av R5 og R^ uavhengig er H eller C1-C4 alkyl; B er en bicyklisk ring valgt fra tetralin, indan og 2-oksindol; hver av Rj og R2 er uavhengig hydrogen, C1-C4 alkyl, halogen, hydroksy, C]-C4 alkoksy, C1-C4 alkoksykarbonyl, niuo, cyano eller CF3; og de farmasøytisk akseptable saltene derav; og hvor, når samtidig, A er pyridin og B er en tetralinring, R4 er H, C1-C4 alkyl, C1-C4 alkoksy eller halogen og X er som definert ovenfor, så er hver av Rj og R2 forskjellig fra H; og hvor, når samtidig, A er imidazol, X er -NH-(CH2)n- som definert ovenfor, og B er en indanring usubstituert eller substi- tuert med en eller flere av halogen, hydroksy, C1-C4 alkoksy og nitro, så er R3 for- skjellig fra C]-C4 alkyl eller benzyl.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523242.7A GB9523242D0 (en) | 1995-11-14 | 1995-11-14 | Aryl and heteroaryl purine compounds |
| GBGB9524131.1A GB9524131D0 (en) | 1995-11-24 | 1995-11-24 | Pyrido-pyrimidine compounds as tyrosine kinase inhibitors |
| PCT/EP1996/004460 WO1997018212A1 (en) | 1995-11-14 | 1996-10-14 | Aryl and heteroaryl purine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO973198L true NO973198L (no) | 1997-07-09 |
| NO973198D0 NO973198D0 (no) | 1997-07-09 |
Family
ID=26308112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO973198A NO973198D0 (no) | 1995-11-14 | 1997-07-09 | Aryl- og heteroarylpurinforbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965563A (no) |
| EP (1) | EP0802914B1 (no) |
| JP (1) | JPH10512896A (no) |
| CN (1) | CN1168138A (no) |
| AR (1) | AR004320A1 (no) |
| AT (1) | ATE201873T1 (no) |
| AU (1) | AU7292096A (no) |
| BR (1) | BR9607089A (no) |
| CA (1) | CA2209598C (no) |
| DE (1) | DE69613211T2 (no) |
| EA (1) | EA000072B1 (no) |
| ES (1) | ES2159760T3 (no) |
| HU (1) | HUP9801177A3 (no) |
| IL (1) | IL121090A0 (no) |
| NO (1) | NO973198D0 (no) |
| PL (1) | PL321296A1 (no) |
| WO (1) | WO1997018212A1 (no) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| TW321649B (no) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
| EP0824525B1 (en) * | 1995-04-27 | 2001-06-13 | AstraZeneca AB | Quinazoline derivatives |
| GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
| GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
| NZ331191A (en) | 1996-03-05 | 2000-03-27 | Zeneca Ltd | 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof |
| CN100503580C (zh) | 1996-04-12 | 2009-06-24 | 沃尼尔·朗伯公司 | 酪氨酸激酶的不可逆抑制剂 |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| EP1017394B1 (en) | 1997-07-12 | 2005-12-07 | Cancer Research Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| AU3951899A (en) | 1998-06-19 | 2000-01-05 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds |
| JP2003504363A (ja) | 1999-07-09 | 2003-02-04 | グラクソ グループ リミテッド | プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類 |
| US6933299B1 (en) | 1999-07-09 | 2005-08-23 | Smithkline Beecham Corporation | Anilinoquinazolines as protein tyrosine kinase inhibitors |
| PT1244647E (pt) | 1999-11-05 | 2006-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de vegf |
| OA12118A (en) | 1999-12-10 | 2006-05-04 | Pfizer Prod Inc | PyrroloÄ2,3-dÜpyrimidine compounds. |
| OA12292A (en) | 2000-06-26 | 2003-11-11 | Pfizer Prod Inc | PyrroloÄ2,3-dÜpyrimidine compounds as immunosuppressive agents. |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| AU2002346729A1 (en) * | 2001-12-20 | 2003-07-09 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases |
| EP1352910A1 (en) * | 2002-04-10 | 2003-10-15 | Grünenthal GmbH | New analogs of nitrobenzylthioinosine |
| WO2004047843A1 (en) | 2002-11-26 | 2004-06-10 | Pfizer Products Inc. | Method of treatment of transplant rejection |
| JP2007502776A (ja) * | 2003-08-15 | 2007-02-15 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｒｔｋ阻害剤としての６−置換アニリノプリン類 |
| WO2005070891A2 (en) * | 2004-01-23 | 2005-08-04 | Amgen Inc | Compounds and methods of use |
| US7626030B2 (en) | 2004-01-23 | 2009-12-01 | Amgen Inc. | Compounds and methods of use |
| EP1612210B1 (en) * | 2004-06-29 | 2007-09-26 | Grünenthal GmbH | New analogs of nitrobenzylthioinosine |
| MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| ATE541844T1 (de) * | 2005-12-21 | 2012-02-15 | Abbott Lab | Antivirale verbindungen |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| EP2094276A4 (en) * | 2006-12-20 | 2011-01-05 | Abbott Lab | ANTIVIRAL COMPOUNDS |
| AU2008319366B2 (en) * | 2007-10-29 | 2012-03-01 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
| RS53382B (sr) | 2008-08-20 | 2014-10-31 | Zoetis Llc | Jedinjenja pirol [2,3-d]pirimidina |
| DE102011111400A1 (de) * | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| CN104470931B (zh) | 2012-05-21 | 2016-10-26 | 拜耳医药股份有限公司 | 取代的苯并噻吩并嘧啶 |
| TW201412740A (zh) * | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
| ES2686909B1 (es) | 2017-03-22 | 2019-08-16 | Consejo Superior Investigacion | Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas |
| FR3066761B1 (fr) * | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| NL2022471B1 (en) | 2019-01-29 | 2020-08-18 | Vationpharma B V | Solid state forms of oclacitinib |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB828522A (en) * | 1956-11-02 | 1960-02-17 | Geigy Ag J R | Purine derivatives and a process for the preparation thereof |
| US3112192A (en) * | 1960-09-19 | 1963-11-26 | Shell Oil Co | Preservation of cut flowers |
| AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| US4751292A (en) * | 1985-07-02 | 1988-06-14 | The Plant Cell Research Institute, Inc. | Adamantyl purines |
| DE3529497A1 (de) * | 1985-08-17 | 1987-02-26 | Boehringer Mannheim Gmbh | N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| KR910700253A (ko) * | 1989-01-31 | 1991-03-14 | 로버트 제이, 바란 | N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질 |
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| CA2124206C (en) * | 1991-11-25 | 2001-02-27 | John Eugene Macor | Indole derivatives |
| US5670501A (en) * | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
-
1996
- 1996-10-14 HU HU9801177A patent/HUP9801177A3/hu unknown
- 1996-10-14 US US08/860,717 patent/US5965563A/en not_active Expired - Fee Related
- 1996-10-14 AU AU72920/96A patent/AU7292096A/en not_active Abandoned
- 1996-10-14 IL IL12109096A patent/IL121090A0/xx unknown
- 1996-10-14 WO PCT/EP1996/004460 patent/WO1997018212A1/en not_active Ceased
- 1996-10-14 AT AT96934673T patent/ATE201873T1/de not_active IP Right Cessation
- 1996-10-14 ES ES96934673T patent/ES2159760T3/es not_active Expired - Lifetime
- 1996-10-14 EP EP96934673A patent/EP0802914B1/en not_active Expired - Lifetime
- 1996-10-14 JP JP9518527A patent/JPH10512896A/ja not_active Ceased
- 1996-10-14 PL PL96321296A patent/PL321296A1/xx unknown
- 1996-10-14 CN CN96191448A patent/CN1168138A/zh active Pending
- 1996-10-14 EA EA199700107A patent/EA000072B1/ru not_active IP Right Cessation
- 1996-10-14 DE DE69613211T patent/DE69613211T2/de not_active Expired - Fee Related
- 1996-10-14 BR BR9607089A patent/BR9607089A/pt not_active Application Discontinuation
- 1996-10-14 CA CA002209598A patent/CA2209598C/en not_active Expired - Fee Related
- 1996-11-13 AR ARP960105153A patent/AR004320A1/es unknown
-
1997
- 1997-07-09 NO NO973198A patent/NO973198D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9705010A (es) | 1997-10-31 |
| JPH10512896A (ja) | 1998-12-08 |
| EA000072B1 (ru) | 1998-06-25 |
| DE69613211D1 (de) | 2001-07-12 |
| BR9607089A (pt) | 1997-11-11 |
| CA2209598A1 (en) | 1997-05-22 |
| EA199700107A1 (ru) | 1997-12-30 |
| ES2159760T3 (es) | 2001-10-16 |
| CA2209598C (en) | 2005-06-07 |
| IL121090A0 (en) | 1997-11-20 |
| WO1997018212A1 (en) | 1997-05-22 |
| HUP9801177A2 (hu) | 1998-09-28 |
| AU7292096A (en) | 1997-06-05 |
| US5965563A (en) | 1999-10-12 |
| AR004320A1 (es) | 1998-11-04 |
| ATE201873T1 (de) | 2001-06-15 |
| DE69613211T2 (de) | 2001-11-15 |
| NO973198D0 (no) | 1997-07-09 |
| CN1168138A (zh) | 1997-12-17 |
| EP0802914B1 (en) | 2001-06-06 |
| EP0802914A1 (en) | 1997-10-29 |
| PL321296A1 (en) | 1997-12-08 |
| HUP9801177A3 (en) | 1998-11-30 |
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