NO974147L - Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease - Google Patents

Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease

Info

Publication number
NO974147L
NO974147L NO974147A NO974147A NO974147L NO 974147 L NO974147 L NO 974147L NO 974147 A NO974147 A NO 974147A NO 974147 A NO974147 A NO 974147A NO 974147 L NO974147 L NO 974147L
Authority
NO
Norway
Prior art keywords
retroviral
protease
retroviral protease
inhibitors
carbonylamino acid
Prior art date
Application number
NO974147A
Other languages
English (en)
Norwegian (no)
Other versions
NO974147D0 (no
Inventor
Daniel P Getman
Gary A Decrescenzo
John N Freskos
Michael L Vazquez
James A Sikorski
Balekudru Devadas
Srivivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO974147D0 publication Critical patent/NO974147D0/no
Publication of NO974147L publication Critical patent/NO974147L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO974147A 1995-03-10 1997-09-09 Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease NO974147L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
NO974147D0 NO974147D0 (no) 1997-09-09
NO974147L true NO974147L (no) 1997-11-04

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974147A NO974147L (no) 1995-03-10 1997-09-09 Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease

Country Status (20)

Country Link
US (3) US5972989A (de)
EP (1) EP0815124B1 (de)
JP (1) JP4124818B2 (de)
CN (2) CN1149223C (de)
AT (1) ATE229033T1 (de)
AU (1) AU717598B2 (de)
BR (1) BR9607625A (de)
CA (1) CA2215022A1 (de)
CZ (1) CZ297676B6 (de)
DE (1) DE69625183T2 (de)
DK (1) DK0815124T3 (de)
ES (1) ES2190793T3 (de)
HU (1) HUP9800518A3 (de)
MX (1) MX9706946A (de)
NO (1) NO974147L (de)
NZ (1) NZ306027A (de)
PL (1) PL184771B1 (de)
PT (1) PT815124E (de)
RU (1) RU2174519C2 (de)
WO (1) WO1996028465A1 (de)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU717598B2 (en) * 1995-03-10 2000-03-30 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU734302B2 (en) * 1997-05-08 2001-06-07 Smithkline Beecham Corporation Protease inhibitors
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
JP4482783B2 (ja) * 1999-01-28 2010-06-16 味の素株式会社 α−アミノケトン類の製造方法
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
BR0207862A (pt) 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
OA12464A (en) * 2001-04-09 2006-05-24 Tibotec Pharm Ltd Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
EE05307B1 (et) 2001-05-11 2010-06-15 Tibotec Pharmaceuticals Ltd. Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseks
CN100448444C (zh) 2001-12-21 2009-01-07 泰博特克药品有限公司 含杂环取代苯基的磺酰胺广谱hiv蛋白酶抑制剂
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
ATE371652T1 (de) 2002-05-17 2007-09-15 Tibotec Pharm Ltd Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
AU2003262574B2 (en) * 2002-08-14 2009-07-09 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
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DE602004021640D1 (de) 2003-12-23 2009-07-30 Tibotec Pharm Ltd Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
EP1557166A1 (de) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamidderivate für die Behandlung von Funktionsstörungen der niedrigen Harnwege
US8106090B2 (en) 2005-07-20 2012-01-31 Eli Lilly And Company 1-amino linked compounds
US8048871B2 (en) 2006-08-18 2011-11-01 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450
BRPI0819883A2 (pt) 2007-11-28 2017-05-23 Sequoia Pharmaceuticals Inc composições e métodos para inibir citocromo p450 2d6
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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Also Published As

Publication number Publication date
MX9706946A (es) 1997-11-29
CZ297676B6 (cs) 2007-03-07
WO1996028465A1 (en) 1996-09-19
PT815124E (pt) 2003-04-30
US6063795A (en) 2000-05-16
HUP9800518A3 (en) 1998-09-28
BR9607625A (pt) 1999-06-15
CN1530372A (zh) 2004-09-22
HUP9800518A2 (hu) 1998-06-29
CZ282397A3 (cs) 1998-02-18
RU2174519C2 (ru) 2001-10-10
NO974147D0 (no) 1997-09-09
EP0815124B1 (de) 2002-12-04
JPH11501920A (ja) 1999-02-16
ES2190793T3 (es) 2003-08-16
DE69625183T2 (de) 2003-10-09
PL322179A1 (en) 1998-01-19
NZ306027A (en) 1999-03-29
CN1149223C (zh) 2004-05-12
ATE229033T1 (de) 2002-12-15
JP4124818B2 (ja) 2008-07-23
CN1183102A (zh) 1998-05-27
PL184771B1 (pl) 2002-12-31
US6214861B1 (en) 2001-04-10
DK0815124T3 (da) 2003-03-17
AU717598B2 (en) 2000-03-30
DE69625183D1 (en) 2003-01-16
AU5417896A (en) 1996-10-02
US5972989A (en) 1999-10-26
CA2215022A1 (en) 1996-09-19
EP0815124A1 (de) 1998-01-07

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