NO974749L - Fremgangsmåte for fremstilling av 2,2'-bipyrrolyl-pyrrometen (prodigiosiner) -derivater - Google Patents

Fremgangsmåte for fremstilling av 2,2'-bipyrrolyl-pyrrometen (prodigiosiner) -derivater

Info

Publication number
NO974749L
NO974749L NO974749A NO974749A NO974749L NO 974749 L NO974749 L NO 974749L NO 974749 A NO974749 A NO 974749A NO 974749 A NO974749 A NO 974749A NO 974749 L NO974749 L NO 974749L
Authority
NO
Norway
Prior art keywords
alkyl
phenyl
represents hydrogen
alkenyl
substituted
Prior art date
Application number
NO974749A
Other languages
English (en)
Other versions
NO974749D0 (no
Inventor
Alessio Roberto D
Arsenia Rossi
Marcellino Tibolla
Lucio Ceriani
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO974749D0 publication Critical patent/NO974749D0/no
Publication of NO974749L publication Critical patent/NO974749L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Ny fremgangsmåte for fremstilling av 5-[(2H-pyrrol-2-yliden)metyl]2,2'-bi-lH- pyrrolderivater av formel (I) (I) hvor RI representerer hydrogen, fenyl, CrC20 alkyl eller C2-C20 alkenyl, hvor alkyl- og alkenylgruppene kan være usubstituert eller substituert med l til 3 substituenter valgt uavhengig fra halogen, CrC6 alkoksy, hydroksy, aryl og aryloksy; R2 representerer hydrogen, C,-C6 alkyl, cyano, karboksy eller (C,-C6 alkoksy)karbonyl; R3 representerer halogen, hydroksy eller CrCu alkoksy usubstituert eller substituert med fenyl; R4 representerer hydrogen, CrC6 alkyl eller fenyl; hver av R5 og R6 representerer uavhengig hydrogen, C2-C20 alkanoyl, C3-C20 alkenoyl, fenyl, C,-C20 alkyl eller C2-C20 alkenyl; eller to av R4, R5 og R6 danner sammen en C4-Ci2 polymetylenkjede, som kan være usubstituert eller substituert med en C,-C|2 alkyl, med en C2-C12 alkenyl eller med en Ci-C)2 alkylidengruppe; og de farmasøytisk akseptable saltene derav.
NO974749A 1996-02-15 1997-10-14 Fremgangsmåte for fremstilling av 2,2'-bipyrrolyl-pyrrometen (prodigiosiner) -derivater NO974749L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9603212.3A GB9603212D0 (en) 1996-02-15 1996-02-15 Process for the preparation of 2,2'-bipyrrolyl-pyrromethane derivatives
PCT/EP1997/000368 WO1997030029A1 (en) 1996-02-15 1997-01-22 Process for the preparation of 2,2'-bipyrrolyl-pyrromethene (prodigiosins) derivatives

Publications (2)

Publication Number Publication Date
NO974749D0 NO974749D0 (no) 1997-10-14
NO974749L true NO974749L (no) 1997-12-12

Family

ID=10788825

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974749A NO974749L (no) 1996-02-15 1997-10-14 Fremgangsmåte for fremstilling av 2,2'-bipyrrolyl-pyrrometen (prodigiosiner) -derivater

Country Status (19)

Country Link
US (1) US5847127A (no)
EP (1) EP0825983B1 (no)
JP (1) JPH11504047A (no)
KR (1) KR19980703892A (no)
CN (1) CN1181752A (no)
AT (1) ATE204861T1 (no)
AU (1) AU719155B2 (no)
CA (1) CA2216465A1 (no)
DE (1) DE69706382T2 (no)
DK (1) DK0825983T3 (no)
ES (1) ES2163732T3 (no)
GB (1) GB9603212D0 (no)
HU (1) HUP9901176A3 (no)
IL (1) IL121809A (no)
MX (1) MX9707768A (no)
NO (1) NO974749L (no)
PT (1) PT825983E (no)
WO (1) WO1997030029A1 (no)
ZA (1) ZA97900B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705035D0 (en) * 1997-03-11 1997-04-30 Pharmacia & Upjohn Spa Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation
KR100252197B1 (ko) * 1997-09-20 2000-04-15 박호군 세라시아 마르세센스 균주의 배양액으로 부터 분리한 면역억제제용 프로디지오신
GB9802745D0 (en) 1998-02-09 1998-04-08 Pharmacia & Upjohn Spa Benzyloxy prodigiosine compounds
US6407244B1 (en) 2000-01-26 2002-06-18 Gemin X Biotechnologies Inc. Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
US20040014987A1 (en) * 2000-01-26 2004-01-22 Gemin X Biotechnologies Inc. Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases
KR20010081515A (ko) * 2000-02-15 2001-08-29 복성해 프로디지오신의 당뇨병 예방 및 치료용 조성물
KR100392225B1 (ko) * 2001-04-19 2003-07-22 한국생명공학연구원 류머티스 관절염 치료용 프로디지오신 조성물
ES2304135T3 (es) * 2001-07-18 2008-09-16 Gemin X Biotechnologies Inc. Compuestos tipo pirrol, composiciones y metodos para tratar el cancer, tratar enfermedades virales y causar inmunosupresion.
CN102731484B (zh) * 2012-06-19 2015-01-21 安徽师范大学 一种灵菌红素类似物的制备方法
CN103387529B (zh) * 2013-07-30 2016-03-30 中国农业科学院烟草研究所 抗tmv的三吡咯环类化合物及其制备方法和用途
US10111554B2 (en) 2015-03-20 2018-10-30 Meltz, LLC Systems for and methods of controlled liquid food or beverage product creation
US10314320B2 (en) 2015-03-20 2019-06-11 Meltz, LLC Systems for controlled liquid food or beverage product creation
US11484041B2 (en) 2017-04-27 2022-11-01 Cometeer, Inc. Method for centrifugal extraction and apparatus suitable for carrying out this method
US11724849B2 (en) 2019-06-07 2023-08-15 Cometeer, Inc. Packaging and method for single serve beverage product

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326284D0 (en) * 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation

Also Published As

Publication number Publication date
ES2163732T3 (es) 2002-02-01
DE69706382D1 (de) 2001-10-04
DE69706382T2 (de) 2002-05-23
IL121809A (en) 2000-07-26
EP0825983A1 (en) 1998-03-04
AU1719797A (en) 1997-09-02
MX9707768A (es) 1997-12-31
EP0825983B1 (en) 2001-08-29
ZA97900B (en) 1997-08-01
CA2216465A1 (en) 1997-08-21
DK0825983T3 (da) 2001-12-17
ATE204861T1 (de) 2001-09-15
JPH11504047A (ja) 1999-04-06
KR19980703892A (ko) 1998-12-05
GB9603212D0 (en) 1996-04-17
US5847127A (en) 1998-12-08
PT825983E (pt) 2002-02-28
NO974749D0 (no) 1997-10-14
HUP9901176A2 (hu) 1999-08-30
IL121809A0 (en) 1998-02-22
CN1181752A (zh) 1998-05-13
HUP9901176A3 (en) 2001-02-28
WO1997030029A1 (en) 1997-08-21
AU719155B2 (en) 2000-05-04

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