NO974890L - Radicicolderivater - Google Patents

Radicicolderivater

Info

Publication number
NO974890L
NO974890L NO974890A NO974890A NO974890L NO 974890 L NO974890 L NO 974890L NO 974890 A NO974890 A NO 974890A NO 974890 A NO974890 A NO 974890A NO 974890 L NO974890 L NO 974890L
Authority
NO
Norway
Prior art keywords
hydrogen
alkenoyl
alkanoyl
same
derivatives
Prior art date
Application number
NO974890A
Other languages
English (en)
Other versions
NO974890D0 (no
Inventor
Tsutomu Agatsuma
Yutaka Saitoh
Yoshinori Yamashita
Tamio Mizukami
Shiro Akinaga
Kasushige Gomi
Kazuhito Akasaka
Isami Takahashi
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of NO974890D0 publication Critical patent/NO974890D0/no
Publication of NO974890L publication Critical patent/NO974890L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Radicicolderivater representert ved generell formel (I) eller farmakologisk akseptable salter derav: (I) hvori R1 og R2 kan være like eller forskjellige og hver repre- senterer hydrogen, alkanoyl, alkenoyl eller tert-butyldi- metylsilyl, og (1) når X representerer halogen, da represen- terer Y et oksygenatom eller R4-O-N (idet R4 er hydrogen eller (u)substituert lavere alkyl) og R3 representerer hydrogen, alkanoyl, alkenoyl etc., mens (2) når X er kombinert med R3 til å representere en enkeltbinding, representerer Y R4B-O-N (idet R4B er det samme som R4) . Derivatene har en tyrosin- kinase-inhiberende aktivitet og har således ulike farmako- logiske aktiviteter slik som antitumor-, antibakterielle og immunundertrykkende effekter.
NO974890A 1995-04-26 1997-10-23 Radicicolderivater NO974890L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10262695 1995-04-26
PCT/JP1996/001158 WO1996033989A1 (en) 1995-04-26 1996-04-26 Radicicol derivatives

Publications (2)

Publication Number Publication Date
NO974890D0 NO974890D0 (no) 1997-10-23
NO974890L true NO974890L (no) 1997-12-29

Family

ID=14332458

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974890A NO974890L (no) 1995-04-26 1997-10-23 Radicicolderivater

Country Status (13)

Country Link
US (1) US5977165A (no)
EP (1) EP0823429B1 (no)
JP (1) JP3938936B2 (no)
KR (1) KR19990008051A (no)
AT (1) ATE194610T1 (no)
AU (1) AU700840B2 (no)
CA (1) CA2218981C (no)
DE (1) DE69609325T2 (no)
ES (1) ES2149468T3 (no)
HU (1) HUP9901344A3 (no)
NO (1) NO974890L (no)
NZ (1) NZ311790A (no)
WO (1) WO1996033989A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE266017T1 (de) 1996-10-25 2004-05-15 Kyowa Hakko Kogyo Kk Radicicolderivate
US6353019B1 (en) * 1997-07-25 2002-03-05 United States Of America As Represented By The Department Of Health And Human Services Macrocyclic lactones, compositions, and methods of use
AU3534499A (en) * 1998-04-24 1999-11-16 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
CA2356622A1 (en) 1998-12-24 2000-07-06 Novation Pharmaceuticals Inc. Compounds which affect mrna stability and uses therefor
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
ES2278778T3 (es) 2000-07-26 2007-08-16 Smithkline Beecham Plc Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana.
EP1315732B1 (en) * 2000-08-25 2006-06-07 Sloan-Kettering Institute For Cancer Research Radicicol and monocillin and their analogues and uses thereof
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
CA2447066A1 (en) * 2001-05-23 2002-11-28 Sloan Kettering Institute For Cancer Research Method of treatment for cancers associated with elevated
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US20040192638A1 (en) * 2001-07-02 2004-09-30 Oaks John A. Method and composition for prolonging the residence time of drugs in the gut
TW200406410A (en) 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
JP4508650B2 (ja) 2002-01-29 2010-07-21 グラクソ グループ リミテッド アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物
JP4575294B2 (ja) 2003-06-27 2010-11-04 協和発酵キリン株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
US20070004674A1 (en) * 2003-08-22 2007-01-04 Kyowa Hakko Kogyo Co. Ltd. Remedy for diseases associated with immunoglobulin gene translocation
US20080108694A1 (en) * 2003-12-19 2008-05-08 Samuel J Danishefsky Novel Macrocycles and Uses Thereof
WO2008021213A1 (en) * 2006-08-11 2008-02-21 Nicolas Winssinger Macrocyclic compounds useful as inhibitors of kinases and hsp90
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
MX2010007755A (es) * 2008-01-15 2010-12-21 Univ Strasbourg Sintesis de lactonas de acido resorcilico utiles como agentes terapeuticos.
EP2254880B8 (en) * 2008-02-21 2016-09-21 OncoSynergy, Inc. Macrocyclic prodrug compounds useful as therapeutics
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228079A (en) * 1978-10-30 1980-10-14 W. R. Grace & Co. Dialkoxy monorden derivatives
IE911915A1 (en) * 1990-06-06 1991-12-18 Sankyo Co Radicicol derivatives, their preparation and their¹anti-tumor activity
GB9225396D0 (en) * 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
DE69609325D1 (de) 2000-08-17
KR19990008051A (ko) 1999-01-25
HUP9901344A3 (en) 2001-05-28
NO974890D0 (no) 1997-10-23
NZ311790A (en) 1999-04-29
EP0823429A1 (en) 1998-02-11
CA2218981C (en) 2007-01-16
ES2149468T3 (es) 2000-11-01
HUP9901344A2 (hu) 2001-04-28
DE69609325T2 (de) 2000-11-23
EP0823429B1 (en) 2000-07-12
ATE194610T1 (de) 2000-07-15
EP0823429A4 (en) 1998-07-08
CA2218981A1 (en) 1996-10-31
AU700840B2 (en) 1999-01-14
AU6292796A (en) 1996-11-18
US5977165A (en) 1999-11-02
WO1996033989A1 (en) 1996-10-31
JP3938936B2 (ja) 2007-06-27

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application