NO980919L - 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel - Google Patents

8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Info

Publication number: NO980919L
Authority: NO; Norway
Prior art keywords: heteroaryl; alkynyl; cycloalkyl; alkenyl; alkyl
Prior art date: 1995-10-13

Application number

NO19980919A

Other languages

English (en)

Other versions

NO980919D0 (no

Inventor

Peter Moldt

Jorgen Scheel-Krueger

Gunnar M Olsen

Elsebet Ostergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1998-03-03

Publication date

1998-06-08

1998-03-03 Application filed by Neurosearch As filed Critical Neurosearch As

1998-03-03 Publication of NO980919D0 publication Critical patent/NO980919D0/no

1998-06-08 Publication of NO980919L publication Critical patent/NO980919L/no

Links

239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO19980919A 1995-10-13 1998-03-03 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel NO980919L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK115695		1995-10-13
PCT/EP1996/004449 WO1997013770A1 (en)	1995-10-13	1996-10-11	8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Publications (2)

Publication Number	Publication Date
NO980919D0 NO980919D0 (no)	1998-03-03
NO980919L true NO980919L (no)	1998-06-08

Family

ID=8101642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19980919A NO980919L (no)	1995-10-13	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Country Status (24)

Country	Link
US (1)	US6100275A (no)
EP (1)	EP0859777B1 (no)
JP (1)	JP3462505B2 (no)
KR (1)	KR100274829B1 (no)
CN (1)	CN1083840C (no)
AT (1)	ATE362931T1 (no)
AU (1)	AU709327B2 (no)
BR (1)	BR9610960A (no)
CA (1)	CA2233541C (no)
CZ (1)	CZ285093B6 (no)
DE (1)	DE69637097T2 (no)
DK (1)	DK0859777T3 (no)
EE (1)	EE03446B1 (no)
HU (1)	HUP9802433A3 (no)
IL (1)	IL123583A (no)
IS (1)	IS4681A (no)
NO (1)	NO980919L (no)
NZ (1)	NZ320216A (no)
PL (1)	PL185357B1 (no)
RU (1)	RU2157372C2 (no)
SK (1)	SK283425B6 (no)
TR (1)	TR199800628T2 (no)
UA (1)	UA63894C2 (no)
WO (1)	WO1997013770A1 (no)

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DE69728531T2 (de) *	1996-05-13	2004-09-30	Syngenta Ltd., Guildford	Bicyclische amine als insektizide
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
GB9624611D0 (en)	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
CA2271749A1 (en)	1996-11-26	1998-06-18	Christopher Richard Ayles Godfrey	8-azabicyclo¬3.2.1\|octane-, 8-azabicyclo¬3.2.1\|oct-6-ene-, 9-azabicyclo¬3.3.1\|nonane-, 9-aza-3-oxabicyclo¬3.3.1\|nonane- and 9-aza-3-thiabicyclo¬3.3.1\|nonane derivatives, their preparation and their use as insecticides
GB9706222D0 (en) *	1997-03-26	1997-05-14	Zeneca Ltd	Bicyclic amine derivatives
KR100589872B1 (ko)	1997-05-30	2006-06-15	뉴로서치 에이/에스	8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
GB9726033D0 (en)	1997-12-09	1998-02-04	Zeneca Ltd	Chemical process
TWI221842B (en) *	1997-12-11	2004-10-11	Syngenta Ltd	Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
JP2002501921A (ja) *	1998-01-28	2002-01-22	ニューロサーチ、アクティーゼルスカブ	標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法
US6403605B1 (en)	1998-05-29	2002-06-11	Queen's University At Kingston	Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
WO1999065492A1 (en) *	1998-06-19	1999-12-23	Eli Lilly And Company	Inhibition of serotonin reuptake
ATE259804T1 (de) *	1998-11-27	2004-03-15	Neurosearch As	8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate
RU2211216C2 (ru) *	1998-12-22	2003-08-27	Мерк Патент Гмбх	Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d
AU2278700A (en)	1999-01-28	2000-08-18	Neurosearch A/S	Novel azabicyclo derivatives and their use
CA2365032A1 (en) *	1999-03-01	2000-09-08	Pfizer Limited	1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy
EP1671628B1 (en)	1999-09-03	2012-10-03	APBI Holdings, LLC	Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction
AU2049501A (en) *	1999-12-20	2001-07-03	Eli Lilly And Company	Benzofuran derivatives
JP2003534344A (ja)	2000-05-25	2003-11-18	ターガセプト，インコーポレイテッド	ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン
US6667314B2 (en)	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
US6579878B1 (en)	2000-07-07	2003-06-17	Targacept, Inc.	Pharmaceutical compositions and methods for use
US6624167B1 (en)	2000-08-04	2003-09-23	Targacept, Inc.	Pharmaceutical compositions and methods for use
CN100398103C (zh) *	2000-10-13	2008-07-02	神经研究公司	通过烟碱性受体激动剂和单胺能物质的联合作用治疗情感性精神障碍
DE60231386D1 (de)	2001-04-09	2009-04-16	Neurosearch As	Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
AR035898A1 (es)	2001-05-25	2004-07-21	Wyeth Corp	Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
RU2203044C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Антидепрессант амитриптилин-ферейн
CN100522976C (zh) *	2002-05-07	2009-08-05	神经研究公司	氮杂环乙炔基衍生物
BRPI0411608A (pt) *	2003-06-24	2006-08-08	Neurosearch As	derivado de 8-aza-biciclo [3.2.1] octano, composição farmacêutica, uso do composto, e, método de tratamento, prevenção ou alìvio de uma doença, um distúrbio ou uma condição de um organismo animal vivo
BRPI0515261A (pt) *	2004-09-30	2008-07-15	Neurosearch As	composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso do composto quìmico ou de qualquer um de seus isÈmeros ou de qualquer mistura de seus isÈmeros, ou um sal farmaceuticamente aceitável do mesmo, e, método para o tratamento, a prevenção ou o alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo de animal vivo
EP2272847A1 (en)	2005-04-08	2011-01-12	NeuroSearch A/S	Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) *	2005-09-01	2007-12-16	Neurosearch As	Novel compounds
RU2315047C1 (ru) *	2006-09-04	2008-01-20	Институт нефтехимии и катализа РАН	Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана
KR100812499B1 (ko) *	2006-10-16	2008-03-11	이도훈	항경련제
TWI415850B (zh) *	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
AU2009221310A1 (en) *	2008-03-05	2009-09-11	Neurosearch A/S	Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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DK198590D0 (da) *	1990-08-21	1990-08-21	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse
GB9019973D0 (en) *	1990-09-12	1990-10-24	Wyeth John & Brother Ltd	Azabicyclic derivatives
FI111367B (fi) *	1991-02-04	2003-07-15	Aventis Pharma Inc	Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet
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1996
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 EP EP96934662A patent/EP0859777B1/en not_active Expired - Lifetime
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown

Also Published As

Publication number	Publication date
CZ285093B6 (cs)	1999-05-12
EE03446B1 (et)	2001-06-15
NO980919D0 (no)	1998-03-03
AU709327B2 (en)	1999-08-26
PL326195A1 (en)	1998-08-31
PL185357B1 (pl)	2003-04-30
DE69637097T2 (de)	2007-09-20
CN1199400A (zh)	1998-11-18
CZ75898A3 (cs)	1998-11-11
KR100274829B1 (ko)	2000-12-15
UA63894C2 (en)	2004-02-16
IL123583A0 (en)	1998-10-30
DK0859777T3 (da)	2007-09-03
IS4681A (is)	1998-03-04
NZ320216A (en)	1999-05-28
ATE362931T1 (de)	2007-06-15
BR9610960A (pt)	1999-03-02
EP0859777B1 (en)	2007-05-23
CA2233541A1 (en)	1997-04-17
EP0859777A1 (en)	1998-08-26
HUP9802433A3 (en)	2000-03-28
TR199800628T2 (xx)	1998-07-21
HUP9802433A2 (hu)	1999-04-28
US6100275A (en)	2000-08-08
JP3462505B2 (ja)	2003-11-05
CN1083840C (zh)	2002-05-01
CA2233541C (en)	2002-04-30
KR19990063651A (ko)	1999-07-26
DE69637097D1 (de)	2007-07-05
EE9800062A (et)	1998-08-17
IL123583A (en)	2003-07-31
RU2157372C2 (ru)	2000-10-10
SK283425B6 (sk)	2003-07-01
WO1997013770A1 (en)	1997-04-17
JPH10512589A (ja)	1998-12-02
SK28798A3 (en)	1998-09-09
AU7291796A (en)	1997-04-30

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Publication	Publication Date	Title
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