NO980919L - 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel - Google Patents

8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Info

Publication number: NO980919L
Authority: NO; Norway
Prior art keywords: heteroaryl; alkynyl; cycloalkyl; alkenyl; alkyl
Prior art date: 1995-10-13

Application number

NO19980919A

Other languages

English (en)

Other versions

NO980919D0 (no

Inventor

Peter Moldt

Jorgen Scheel-Krueger

Gunnar M Olsen

Elsebet Ostergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1998-03-03

Publication date

1998-06-08

1998-03-03 Application filed by Neurosearch As filed Critical Neurosearch As

1998-03-03 Publication of NO980919D0 publication Critical patent/NO980919D0/no

1998-06-08 Publication of NO980919L publication Critical patent/NO980919L/no

Links

239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 5
125000000753 cycloalkyl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000001561 neurotransmitter reuptake Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO19980919A 1995-10-13 1998-03-03 8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel NO980919L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK115695		1995-10-13
PCT/EP1996/004449 WO1997013770A1 (en)	1995-10-13	1996-10-11	8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use

Publications (2)

Publication Number	Publication Date
NO980919D0 NO980919D0 (no)	1998-03-03
NO980919L true NO980919L (no)	1998-06-08

Family

ID=8101642

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19980919A NO980919L (no)	1995-10-13	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, og deres anvendelse til fremstilling av et legemiddel

Country Status (24)

Country	Link
US (1)	US6100275A (no)
EP (1)	EP0859777B1 (no)
JP (1)	JP3462505B2 (no)
KR (1)	KR100274829B1 (no)
CN (1)	CN1083840C (no)
AT (1)	ATE362931T1 (no)
AU (1)	AU709327B2 (no)
BR (1)	BR9610960A (no)
CA (1)	CA2233541C (no)
CZ (1)	CZ285093B6 (no)
DE (1)	DE69637097T2 (no)
DK (1)	DK0859777T3 (no)
EE (1)	EE03446B1 (no)
HU (1)	HUP9802433A3 (no)
IL (1)	IL123583A (no)
IS (1)	IS4681A (no)
NO (1)	NO980919L (no)
NZ (1)	NZ320216A (no)
PL (1)	PL185357B1 (no)
RU (1)	RU2157372C2 (no)
SK (1)	SK283425B6 (no)
TR (1)	TR199800628T2 (no)
UA (1)	UA63894C2 (no)
WO (1)	WO1997013770A1 (no)

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GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
TW370451B (en)	1996-11-26	1999-09-21	Zeneca Ltd	Bicyclic amine derivatives
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
GB9706222D0 (en) *	1997-03-26	1997-05-14	Zeneca Ltd	Bicyclic amine derivatives
KR100589872B1 (ko)	1997-05-30	2006-06-15	뉴로서치 에이/에스	8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법
GB9726033D0 (en)	1997-12-09	1998-02-04	Zeneca Ltd	Chemical process
TWI221842B (en) *	1997-12-11	2004-10-11	Syngenta Ltd	Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
JP2002501921A (ja) *	1998-01-28	2002-01-22	ニューロサーチ、アクティーゼルスカブ	標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法
US6403605B1 (en)	1998-05-29	2002-06-11	Queen's University At Kingston	Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
WO1999065492A1 (en) *	1998-06-19	1999-12-23	Eli Lilly And Company	Inhibition of serotonin reuptake
DE69914935T2 (de) *	1998-11-27	2009-10-01	Neurosearch A/S	8-azabicyclo[3.2.1]okt-2-en- und -oktanderivate
RU2211216C2 (ru) *	1998-12-22	2003-08-27	Мерк Патент Гмбх	Производные амидов и мочевины в качестве ингибиторов вторичного поглощения 5-ht и лигандов 5-ht1b/1d
EP1149095B1 (en) *	1999-01-28	2004-01-21	Neurosearch A/S	Novel azabicyclo derivatives and their use
ES2245639T3 (es) *	1999-03-01	2006-01-16	Pfizer Inc.	Compuestos 1,2,3,4-tetrahidro-1-naftalenamina utiles en terapia.
EP1671628B1 (en)	1999-09-03	2012-10-03	APBI Holdings, LLC	Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction
WO2001046186A1 (en) *	1999-12-20	2001-06-28	Eli Lilly And Company	Benzofuran derivatives
EP1289996B1 (en)	2000-05-25	2005-04-06	Targacept, Inc.	Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands
US6667314B2 (en)	2000-05-26	2003-12-23	Pfizer, Inc.	Tropane derivatives useful in therapy
US6579878B1 (en)	2000-07-07	2003-06-17	Targacept, Inc.	Pharmaceutical compositions and methods for use
US6624167B1 (en)	2000-08-04	2003-09-23	Targacept, Inc.	Pharmaceutical compositions and methods for use
EP1358177B1 (en) *	2000-10-13	2006-08-02	NeuroSearch A/S	Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
ATE424194T1 (de)	2001-04-09	2009-03-15	Neurosearch As	Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
TW589312B (en)	2001-05-25	2004-06-01	Wyeth Corp	Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
RU2203044C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Антидепрессант амитриптилин-ферейн
AU2003222738B2 (en)	2002-05-07	2009-09-17	Neurosearch A/S	Novel azacyclic ethynyl derivatives
WO2004113334A1 (en) *	2003-06-24	2004-12-29	Neurosearch A/S	Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7696350B2 (en) *	2004-09-30	2010-04-13	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2006108789A1 (en) *	2005-04-08	2006-10-19	Neurosearch A/S	Novel enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) *	2005-09-01	2007-12-16	Neurosearch As	Novel compounds
RU2315047C1 (ru) *	2006-09-04	2008-01-20	Институт нефтехимии и катализа РАН	Способ получения 8-этил-6,7-фуллеро[60]-3-окса-8-азабицикло[3.2.1]октана
KR100812499B1 (ko) *	2006-10-16	2008-03-11	이도훈	항경련제
TWI415850B (zh) *	2007-07-20	2013-11-21	Theravance Inc	製備ｍｕ類鴉片受體拮抗劑之中間物的方法
CA2717367A1 (en) *	2008-03-05	2009-09-11	Neurosearch A/S	Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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NZ241481A (en) *	1991-02-04	1994-06-27	Hoechst Roussel Pharma	Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof
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1996
- 1996-10-11 HU HU9802433A patent/HUP9802433A3/hu unknown
- 1996-10-11 BR BR9610960A patent/BR9610960A/pt not_active Application Discontinuation
- 1996-10-11 CN CN96197566A patent/CN1083840C/zh not_active Expired - Fee Related
- 1996-10-11 AU AU72917/96A patent/AU709327B2/en not_active Ceased
- 1996-10-11 IL IL12358396A patent/IL123583A/xx not_active IP Right Cessation
- 1996-10-11 TR TR1998/00628T patent/TR199800628T2/xx unknown
- 1996-10-11 US US09/043,294 patent/US6100275A/en not_active Expired - Fee Related
- 1996-10-11 DE DE69637097T patent/DE69637097T2/de not_active Expired - Lifetime
- 1996-10-11 NZ NZ320216A patent/NZ320216A/xx not_active IP Right Cessation
- 1996-10-11 CA CA002233541A patent/CA2233541C/en not_active Expired - Fee Related
- 1996-10-11 EE EE9800062A patent/EE03446B1/xx not_active IP Right Cessation
- 1996-10-11 EP EP96934662A patent/EP0859777B1/en not_active Expired - Lifetime
- 1996-10-11 DK DK96934662T patent/DK0859777T3/da active
- 1996-10-11 RU RU98105169/04A patent/RU2157372C2/ru not_active IP Right Cessation
- 1996-10-11 KR KR1019980702103A patent/KR100274829B1/ko not_active Expired - Fee Related
- 1996-10-11 JP JP51472697A patent/JP3462505B2/ja not_active Expired - Fee Related
- 1996-10-11 PL PL96326195A patent/PL185357B1/pl not_active IP Right Cessation
- 1996-10-11 AT AT96934662T patent/ATE362931T1/de active
- 1996-10-11 CZ CZ98758A patent/CZ285093B6/cs not_active IP Right Cessation
- 1996-10-11 SK SK287-98A patent/SK283425B6/sk unknown
- 1996-10-11 WO PCT/EP1996/004449 patent/WO1997013770A1/en not_active Ceased
- 1996-11-10 UA UA98031543A patent/UA63894C2/uk unknown
1998
- 1998-03-03 NO NO19980919A patent/NO980919L/no not_active Application Discontinuation
- 1998-03-04 IS IS4681A patent/IS4681A/is unknown

Also Published As

Publication number	Publication date
PL185357B1 (pl)	2003-04-30
NO980919D0 (no)	1998-03-03
CN1083840C (zh)	2002-05-01
EE9800062A (et)	1998-08-17
PL326195A1 (en)	1998-08-31
BR9610960A (pt)	1999-03-02
EE03446B1 (et)	2001-06-15
JP3462505B2 (ja)	2003-11-05
ATE362931T1 (de)	2007-06-15
IL123583A0 (en)	1998-10-30
AU709327B2 (en)	1999-08-26
JPH10512589A (ja)	1998-12-02
SK28798A3 (en)	1998-09-09
CZ285093B6 (cs)	1999-05-12
HUP9802433A3 (en)	2000-03-28
IL123583A (en)	2003-07-31
RU2157372C2 (ru)	2000-10-10
DE69637097D1 (de)	2007-07-05
KR19990063651A (ko)	1999-07-26
US6100275A (en)	2000-08-08
AU7291796A (en)	1997-04-30
UA63894C2 (en)	2004-02-16
IS4681A (is)	1998-03-04
CN1199400A (zh)	1998-11-18
HUP9802433A2 (hu)	1999-04-28
WO1997013770A1 (en)	1997-04-17
NZ320216A (en)	1999-05-28
CZ75898A3 (cs)	1998-11-11
KR100274829B1 (ko)	2000-12-15
EP0859777A1 (en)	1998-08-26
CA2233541C (en)	2002-04-30
DK0859777T3 (da)	2007-09-03
EP0859777B1 (en)	2007-05-23
SK283425B6 (sk)	2003-07-01
CA2233541A1 (en)	1997-04-17
TR199800628T2 (xx)	1998-07-21
DE69637097T2 (de)	2007-09-20

Legal Events

Date	Code	Title	Description
2007-12-03	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO980919D0 (no)	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse
UA49872C2 (uk)	2002-10-15	Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
CA2187309A1 (en)	1995-10-26	Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors
ES2141688A1 (es)	2000-05-16	Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
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