NO981165L - Mikroemulsjon - Google Patents

Mikroemulsjon

Info

Publication number
NO981165L
NO981165L NO981165A NO981165A NO981165L NO 981165 L NO981165 L NO 981165L NO 981165 A NO981165 A NO 981165A NO 981165 A NO981165 A NO 981165A NO 981165 L NO981165 L NO 981165L
Authority
NO
Norway
Prior art keywords
microemulsion
Prior art date
Application number
NO981165A
Other languages
English (en)
Other versions
NO316590B1 (no
NO981165D0 (no
Inventor
Kurt Bauer
Clarissa Neuber
Axel Schmid
Lker Karl Manfred V
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO981165D0 publication Critical patent/NO981165D0/no
Publication of NO981165L publication Critical patent/NO981165L/no
Publication of NO316590B1 publication Critical patent/NO316590B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/062Oil-in-water emulsions
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/02Other edible oils or fats, e.g. shortenings or cooking oils characterised by the production or working-up
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40Colouring or decolouring of foods
    • A23L5/42Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/068Microemulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
NO981165A 1997-03-17 1998-03-16 Mikroemulsjon, anvendelse derav som sammensetning i farmasøytiske preparater og i kosmetikk samt matvare, farmasøytisk blanding eller kosmetikk inneholdende samme NO316590B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH62897 1997-03-17

Publications (3)

Publication Number Publication Date
NO981165D0 NO981165D0 (no) 1998-03-16
NO981165L true NO981165L (no) 1998-09-18
NO316590B1 NO316590B1 (no) 2004-03-01

Family

ID=4191447

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981165A NO316590B1 (no) 1997-03-17 1998-03-16 Mikroemulsjon, anvendelse derav som sammensetning i farmasøytiske preparater og i kosmetikk samt matvare, farmasøytisk blanding eller kosmetikk inneholdende samme

Country Status (16)

Country Link
US (1) US6426078B1 (no)
EP (1) EP0866117B1 (no)
JP (1) JPH10263385A (no)
KR (1) KR100583480B1 (no)
CN (1) CN1085048C (no)
AR (1) AR012053A1 (no)
AU (1) AU729818B2 (no)
BR (1) BR9800890A (no)
CA (1) CA2231719C (no)
DE (1) DE59811302D1 (no)
DK (1) DK0866117T3 (no)
ES (1) ES2219800T3 (no)
ID (1) ID20039A (no)
MX (1) MX212055B (no)
NO (1) NO316590B1 (no)
TW (1) TW522022B (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
ATE355854T1 (de) * 2000-08-03 2007-03-15 Antares Pharma Ipl Ag Neue zusammensetzung zur transdermalen und/oder transmukosalen wirkstoffanwendung mit geeignetem therapeutischen spiegel
KR100654060B1 (ko) * 2001-01-15 2006-12-05 주식회사 코리아나화장품 레티놀과 카로티노이드 성분을 함유하는 화장료 조성물
WO2002058586A2 (en) * 2001-01-26 2002-08-01 Steven Baranowitz Systemic formulations containing beta-carotene and derivatives thereof
US6902756B2 (en) 2001-04-02 2005-06-07 Firmenich Sa Transparent high oil loaded microemulsions
ES2282338T3 (es) * 2001-03-22 2007-10-16 Firmenich Sa Microemulsiones transparentes con alta carga de aceite.
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
US20030095990A1 (en) * 2001-06-19 2003-05-22 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Microemulsion facial washes comprising specific oils
JP4065841B2 (ja) 2001-10-26 2008-03-26 太陽化学株式会社 油状泡沫性エアゾール用組成物
BR0214679A (pt) * 2001-12-03 2004-12-14 Novacea Inc Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
US20030228395A1 (en) * 2002-01-31 2003-12-11 Archer-Daniels Midland Company Isotropic transparent structured fluids
GB0218932D0 (en) * 2002-08-14 2002-09-25 Zoolife Internat Ltd Composition for dietary enrichment
WO2004023900A1 (en) * 2002-09-10 2004-03-25 Pepsico, Inc. Use of surfactants to solubilize water-insoluble solids in beverages
AU2003284633B2 (en) * 2002-11-22 2008-07-10 Nippon Suisan Kaisha, Ltd. External composition containing polyunsaturated fatty acid or its salt or ester
US20050026877A1 (en) * 2002-12-03 2005-02-03 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
GB0229811D0 (en) 2002-12-20 2003-01-29 Unilever Plc Compound delivery systems
US20040219274A1 (en) * 2003-04-29 2004-11-04 Cook Phillip Michael Beverages containing water-soluble vitamin E
KR20040098887A (ko) * 2003-05-16 2004-11-26 주식회사 마린프로덕트테크 지용성 아스타산틴 등의 수용화 조제 방법
US20050020546A1 (en) * 2003-06-11 2005-01-27 Novacea, Inc. Pharmaceutical compositions comprising active vitamin D compounds
US7387788B1 (en) 2003-10-10 2008-06-17 Antares Pharma Ipl Ag Pharmaceutical compositions of nicotine and methods of use thereof
DK1670433T3 (da) 2003-10-10 2012-03-12 Ferring Bv Transdermal farmaceutisk formulering til mindskelse af hudrester
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
GB0428515D0 (en) * 2004-12-30 2005-02-09 Unilever Plc Edible compositions and their preparation
WO2006088102A1 (ja) * 2005-02-17 2006-08-24 Kaneka Corporation 赤色酵母由来の乳化剤
KR101332869B1 (ko) * 2005-04-15 2013-11-25 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 항-egfr 치료법에 속발된 피부 발진의 예방 및 치료를위한 비타민 k
US7595171B2 (en) * 2005-05-03 2009-09-29 Sinotrade Technology Limited Ketocarotenoids from Adonis palaestina
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
KR100699582B1 (ko) 2005-07-11 2007-03-23 삼성전기주식회사 출력 버퍼회로
US9743680B2 (en) 2005-10-14 2017-08-29 Wild Flavors, Inc. Microemulsions for use in food and beverage products
JP2007112744A (ja) * 2005-10-20 2007-05-10 Toyo Seikan Kaisha Ltd β−クリプトキサンチン成分含有抽出物液およびこの抽出物液を添加してなる飲食物および石鹸または化粧品
WO2007083707A1 (ja) * 2006-01-19 2007-07-26 Kaneka Corporation 乳化剤
JP5273633B2 (ja) * 2006-01-19 2013-08-28 株式会社カネカ 乳化剤
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
EP2043685B1 (en) * 2006-07-03 2015-12-23 Genmab A/S Prevention of rash in patients undergoing anti-egfr therapy
US20080058418A1 (en) * 2006-09-06 2008-03-06 The Coca-Cola Company Stable polyunsaturated fatty acid emulsions and methods for inhibiting, suppressing, or reducing degradation of polyunsaturated fatty acids in an emulsion
JP2008142588A (ja) * 2006-12-06 2008-06-26 Fujifilm Corp 水中油滴型エマルション及びその製造方法、並びに機能性粉末及びその製造方法
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
EP2052727A3 (en) * 2007-10-02 2010-06-02 Unilever N.V. Hoodia extract oil compositions comprising unsaturated monoacylglycerides
JP5393123B2 (ja) * 2007-12-12 2014-01-22 富士フイルム株式会社 皮膚外用剤及びその製造方法
US8815953B2 (en) * 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
JP5680275B2 (ja) * 2009-01-20 2015-03-04 富士フイルム株式会社 エマルション組成物、該エマルション組成物を含む食品及び化粧品
EP2531263B1 (en) * 2010-02-03 2016-06-22 Unilever N.V. A photostable sunscreen composition
JP5936234B2 (ja) * 2010-04-09 2016-06-22 ディーエスエム アイピー アセッツ ビー.ブイ. 多価不飽和脂肪酸を含有する油を含有する熱安定性水中油エマルジョン
EP3245875B1 (en) 2010-12-29 2021-05-26 Abbott Laboratories Nutritional product for use in reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child
CN102525923B (zh) * 2012-02-16 2014-09-10 中国农业大学 类胡萝卜素乳液及微胶囊的制备方法
JP5952382B2 (ja) * 2012-02-24 2016-07-13 富士フイルム株式会社 水中油型エマルション組成物
JP5889220B2 (ja) * 2012-03-30 2016-03-22 富士フイルム株式会社 水性分散組成物
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
US20140221500A1 (en) * 2013-02-01 2014-08-07 Wade Cheng Highly concentrated astaxanthin for topical application
EP2777402A1 (en) * 2013-03-15 2014-09-17 DSM IP Assets B.V. Solid lipid nanoparticles (I)
CN103262931B (zh) * 2013-05-23 2015-09-30 云南瑞宝生物科技有限公司 水溶性叶黄素酯、其制备方法以及含水溶性叶黄素酯的硬糖
MX382072B (es) * 2014-06-06 2025-03-12 Archer Daniels Midland Co Microemulsiones y sus usos.
JP6100227B2 (ja) * 2014-11-26 2017-03-22 長谷川香料株式会社 β−カロテン結晶の水分散性組成物
JP6078043B2 (ja) * 2014-11-26 2017-02-08 長谷川香料株式会社 リコペン結晶の水分散性組成物
CN106261451A (zh) * 2016-08-31 2017-01-04 金寨县劲春银杏树种植专业合作社 一种银杏果油乳液的制备方法
JP6533003B1 (ja) * 2018-12-26 2019-06-19 株式会社ファンケル カロテン含有油性組成物
JP2022165020A (ja) * 2021-04-19 2022-10-31 学校法人 名城大学 シス型環状カロテンを含む機能性食品用組成物及び機能性食品

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5951214A (ja) * 1982-09-16 1984-03-24 Taiho Yakuhin Kogyo Kk バイオアベイラビリテイの高い薬剤の製造方法
JPS60137260A (ja) * 1983-12-26 1985-07-20 Kunoole Shokuhin Kk O/w型乳化食品の製造方法
JPS61103536A (ja) * 1984-10-26 1986-05-22 Pola Chem Ind Inc 可溶化方法
JPS62419A (ja) * 1985-06-26 1987-01-06 Shiseido Co Ltd 脂溶性ビタミン含有水溶性剤
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5045337A (en) 1990-04-19 1991-09-03 The Procter & Gamble Company Food microemulsion
DE4100490C1 (no) * 1991-01-10 1992-03-05 Goldwell Ag, 6100 Darmstadt, De
JP3534199B2 (ja) * 1993-11-10 2004-06-07 株式会社薬研 界面活性剤組成物
DE69527624T2 (de) * 1994-05-20 2003-04-03 Novavax, Inc. Antimikrobielle öl-in-wasser-emulsionen
GB2297759A (en) 1995-02-13 1996-08-14 Nestle Sa Microemulsions containing functional substances
JPH09157159A (ja) * 1995-12-11 1997-06-17 Lion Corp カロチノイド含有組成物

Also Published As

Publication number Publication date
US6426078B1 (en) 2002-07-30
BR9800890A (pt) 1999-12-07
KR19980080310A (ko) 1998-11-25
CN1085048C (zh) 2002-05-22
CN1193465A (zh) 1998-09-23
MX9801863A (es) 1998-11-25
CA2231719A1 (en) 1998-09-17
CA2231719C (en) 2006-08-22
EP0866117A1 (de) 1998-09-23
EP0866117B1 (de) 2004-05-06
TW522022B (en) 2003-03-01
KR100583480B1 (ko) 2006-08-30
JPH10263385A (ja) 1998-10-06
AU5844998A (en) 1998-09-17
NO316590B1 (no) 2004-03-01
NO981165D0 (no) 1998-03-16
DE59811302D1 (de) 2004-06-09
AR012053A1 (es) 2000-09-27
ID20039A (id) 1998-09-17
ES2219800T3 (es) 2004-12-01
DK0866117T3 (da) 2004-08-30
MX212055B (es) 2002-12-13
AU729818B2 (en) 2001-02-08

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