NO981392L - Substituerte pyrazolylbenzensulfonamider for anvendelse i veterinµrterapi som antiinflammatorisk middel - Google Patents
Substituerte pyrazolylbenzensulfonamider for anvendelse i veterinµrterapi som antiinflammatorisk middelInfo
- Publication number
- NO981392L NO981392L NO981392A NO981392A NO981392L NO 981392 L NO981392 L NO 981392L NO 981392 A NO981392 A NO 981392A NO 981392 A NO981392 A NO 981392A NO 981392 L NO981392 L NO 981392L
- Authority
- NO
- Norway
- Prior art keywords
- inflammatory agent
- veterinary therapy
- pyrazolylbenzenesulfonamides
- substituted
- substituted pyrazolylbenzenesulfonamides
- Prior art date
Links
- HMDUADNDMXESSJ-UHFFFAOYSA-N 2-(1h-pyrazol-5-yl)benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1C1=CC=NN1 HMDUADNDMXESSJ-UHFFFAOYSA-N 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- IGCQXMQOKRXHHN-UHFFFAOYSA-N n-(1h-pyrazol-5-yl)benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NC=1C=CNN=1 IGCQXMQOKRXHHN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/536,318 US5756529A (en) | 1995-09-29 | 1995-09-29 | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| PCT/US1996/015538 WO1997011704A1 (en) | 1995-09-29 | 1996-09-27 | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies as antiinflammatory agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981392D0 NO981392D0 (no) | 1998-03-27 |
| NO981392L true NO981392L (no) | 1998-05-25 |
| NO321157B1 NO321157B1 (no) | 2006-03-27 |
Family
ID=24138015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981392A NO321157B1 (no) | 1995-09-29 | 1998-03-27 | Anvendelse av substituerte pyrazolylbenzensulfonamider for fremstilling av et antiinflammatorisk middel til bruk innen veterinaermedisin. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5756529A (no) |
| EP (1) | EP0854723B1 (no) |
| JP (1) | JPH11514991A (no) |
| KR (1) | KR100498730B1 (no) |
| CN (1) | CN1202828A (no) |
| AT (1) | ATE238058T1 (no) |
| AU (1) | AU718300B2 (no) |
| BR (1) | BR9610974A (no) |
| CA (1) | CA2233620C (no) |
| CZ (1) | CZ297183B6 (no) |
| DE (1) | DE69627683T2 (no) |
| DK (1) | DK0854723T3 (no) |
| ES (1) | ES2197954T3 (no) |
| IL (1) | IL123635A (no) |
| NO (1) | NO321157B1 (no) |
| NZ (1) | NZ320919A (no) |
| PL (1) | PL191934B1 (no) |
| PT (1) | PT854723E (no) |
| RO (1) | RO120408B1 (no) |
| RU (1) | RU2253456C2 (no) |
| WO (1) | WO1997011704A1 (no) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492411B1 (en) * | 1993-11-30 | 2002-12-10 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
| CA2223154A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| AU7726898A (en) | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| ATE306263T1 (de) * | 1999-03-10 | 2005-10-15 | Searle Llc | Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere |
| US6376519B1 (en) | 1999-06-16 | 2002-04-23 | Temple University-Of The Commonwealth Of Higher Education | 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2 |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| DE60006057T2 (de) * | 1999-12-03 | 2004-05-27 | Pfizer Products Inc., Groton | Heteroarylphenylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| ATE245639T1 (de) | 1999-12-03 | 2003-08-15 | Pfizer Prod Inc | Acetylenderivate zur verwendung als schmerzstillendes oder entzündungshemmendes mittel |
| DE60018792T2 (de) | 1999-12-03 | 2006-01-26 | Pfizer Products Inc., Groton | Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen |
| ATE283048T1 (de) * | 1999-12-08 | 2004-12-15 | Pharmacia Corp | Cyclooxygenase-2 hemmer enthaltende zusammensetzungen mit schnellem wirkungseintritt |
| ES2236011T3 (es) * | 1999-12-08 | 2005-07-16 | Pharmacia Corporation | Formas cristalinas polimorficas de celecoxib. |
| SK9032002A3 (en) * | 1999-12-22 | 2003-03-04 | Pharmacia Corp | Dual-release compositions of a cyclooxygenase-2 inhibitor |
| US20030220371A1 (en) * | 2000-04-12 | 2003-11-27 | Kallander Lara S. | Compounds and methods |
| WO2001078724A1 (en) * | 2000-04-18 | 2001-10-25 | Pharmacia Corporation | Rapid-onset formulation of a selective cyclooxigenase-2 |
| AU2001255600A1 (en) * | 2000-04-25 | 2001-11-07 | Pharmacia Corporation | Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| US20030219461A1 (en) * | 2000-09-12 | 2003-11-27 | Britten Nancy J. | Parenteral combination therapy for infective conditions |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
| US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| ES2241964T3 (es) | 2001-07-05 | 2005-11-01 | Pfizer Products Inc. | Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos. |
| US7076539B2 (en) * | 2001-07-30 | 2006-07-11 | Hewlett-Packard Development Company, L.P. | Network connectivity establishment at user log-in |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| MXPA04002667A (es) | 2001-09-19 | 2004-06-18 | Pharmacia Corp | Compuestos de pirazolilo sustituido para el tratamiento de la inflacion. |
| ATE363473T1 (de) * | 2001-09-19 | 2007-06-15 | Pharmacia Corp | Substituierte pyrazoloverbindungen zur behandlung von entzündungen |
| GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| WO2003037330A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors |
| WO2003037351A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors |
| EP1440062A1 (en) | 2001-11-02 | 2004-07-28 | Pfizer Products Inc. | An efficient synthesis of 5-heteroatom-containing-pyrazoles |
| WO2003037335A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 5-heteroatom-substituted pyrazoles |
| CA2485679A1 (en) * | 2002-04-08 | 2003-10-23 | The Ohio State University Research Foundation | Compounds and methods for inducing apoptosis in proliferating cells |
| AU2003279622A1 (en) | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| UA79804C2 (en) | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
| US20080003258A1 (en) * | 2002-10-16 | 2008-01-03 | Marcum Frank D | Composition and Method for Treating Rheumatoid Arthritis |
| US8455458B2 (en) | 2002-10-16 | 2013-06-04 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage |
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| US20080153894A1 (en) * | 2002-12-19 | 2008-06-26 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
| US20050009931A1 (en) * | 2003-03-20 | 2005-01-13 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US20050004098A1 (en) * | 2003-03-20 | 2005-01-06 | Britten Nancy Jean | Dispersible formulation of an anti-inflammatory agent |
| US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| PL1608407T3 (pl) * | 2003-03-20 | 2006-12-29 | Pharmacia Corp | Dyspergowana kompozycja środka przeciw-zapalnego |
| EP1745791B1 (en) | 2003-05-07 | 2013-06-26 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
| US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
| JPWO2005054181A1 (ja) * | 2003-12-01 | 2007-12-06 | 株式会社リバース・プロテオミクス研究所 | 抗癌剤の新規標的タンパク質および対応する新規抗癌剤(スプナール) |
| US7250434B2 (en) | 2003-12-22 | 2007-07-31 | Janssen Pharmaceutica N.V. | CCK-1 receptor modulators |
| ITMI20041032A1 (it) * | 2004-05-24 | 2004-08-24 | Neuroscienze S C A R L | Compositi farmaceutici |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| US8128460B2 (en) * | 2006-09-14 | 2012-03-06 | The Material Works, Ltd. | Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell |
| CN102036670A (zh) * | 2007-02-01 | 2011-04-27 | 爱默思公司 | 用于减轻哺乳动物炎症和氧化应激反应的方法 |
| TW200911240A (en) * | 2007-06-11 | 2009-03-16 | Kyowa Hakko Kogyo Kk | Anti-tumor agent |
| US9186375B2 (en) | 2007-06-21 | 2015-11-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan compositions in combination with stem cells |
| RU2406505C2 (ru) * | 2007-06-29 | 2010-12-20 | Федеральное государственное образовательное учреждение высшего профессионального образования "САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ АКАДЕМИЯ ВЕТЕРИНАРНОЙ МЕДИЦИНЫ" (ФГОУ ВПО СПГАВМ) | Способ лечения воспалительного заболевания пясти и плюсны у собак |
| JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| SG192078A1 (en) * | 2011-02-03 | 2013-08-30 | Lupin Ltd | Pyrrole derivatives used as modulators of alpha7 nachr |
| CN103242233B (zh) * | 2012-02-08 | 2014-07-30 | 北京博爱汇康医药科技有限责任公司 | 制备塞来昔布的新方法 |
| WO2014012074A2 (en) * | 2012-07-12 | 2014-01-16 | Euclises Pharmaceuticals, Inc. | No-releasing nonoate (nitrogen-bound) sulfonamide-linked-coxib anti-cancer agents |
| CN110179795A (zh) | 2013-03-15 | 2019-08-30 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的多取代芳族化合物的制药用途 |
| HK1214252A1 (zh) | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| EP2886104A1 (en) | 2013-12-11 | 2015-06-24 | Patir, Suleyman | An intra-articular gel |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| CN107405333A (zh) | 2015-02-27 | 2017-11-28 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物 |
| CN107686465B (zh) * | 2017-09-02 | 2020-10-27 | 东北农业大学 | 地拉考昔的制备方法 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| CN114292235B (zh) * | 2021-12-29 | 2023-04-14 | 江苏天和制药有限公司 | 一种地拉考昔的制备和提纯方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940418A (en) * | 1972-04-07 | 1976-02-24 | G. D. Searle & Co. | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds |
| GB8814587D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US5134155A (en) * | 1991-08-08 | 1992-07-28 | Ortho Pharmaceutical Corporation | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors |
| IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
| ES2141916T3 (es) * | 1993-11-30 | 2000-04-01 | Searle & Co | Pirazolil-bencenosulfonamidas sustituidas para el tratamiento de la inflamacion. |
| US5434178A (en) * | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
-
1995
- 1995-09-29 US US08/536,318 patent/US5756529A/en not_active Expired - Lifetime
-
1996
- 1996-09-27 ES ES96936018T patent/ES2197954T3/es not_active Expired - Lifetime
- 1996-09-27 EP EP96936018A patent/EP0854723B1/en not_active Expired - Lifetime
- 1996-09-27 AU AU73768/96A patent/AU718300B2/en not_active Expired
- 1996-09-27 PL PL325952A patent/PL191934B1/pl unknown
- 1996-09-27 IL IL12363596A patent/IL123635A/xx not_active IP Right Cessation
- 1996-09-27 KR KR10-1998-0702346A patent/KR100498730B1/ko not_active Expired - Lifetime
- 1996-09-27 CN CN96198561A patent/CN1202828A/zh active Pending
- 1996-09-27 PT PT96936018T patent/PT854723E/pt unknown
- 1996-09-27 CZ CZ0089798A patent/CZ297183B6/cs not_active IP Right Cessation
- 1996-09-27 CA CA2233620A patent/CA2233620C/en not_active Expired - Lifetime
- 1996-09-27 JP JP9513685A patent/JPH11514991A/ja not_active Abandoned
- 1996-09-27 AT AT96936018T patent/ATE238058T1/de active
- 1996-09-27 NZ NZ320919A patent/NZ320919A/en not_active IP Right Cessation
- 1996-09-27 RU RU98107643/13A patent/RU2253456C2/ru active
- 1996-09-27 DE DE69627683T patent/DE69627683T2/de not_active Expired - Lifetime
- 1996-09-27 WO PCT/US1996/015538 patent/WO1997011704A1/en not_active Ceased
- 1996-09-27 DK DK96936018T patent/DK0854723T3/da active
- 1996-09-27 RO RO98-00799A patent/RO120408B1/ro unknown
-
1998
- 1998-03-27 NO NO19981392A patent/NO321157B1/no not_active IP Right Cessation
- 1998-03-30 BR BR9610974A patent/BR9610974A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ320919A (en) | 1999-10-28 |
| EP0854723A1 (en) | 1998-07-29 |
| US5756529A (en) | 1998-05-26 |
| NO321157B1 (no) | 2006-03-27 |
| CZ89798A3 (cs) | 1999-04-14 |
| DE69627683T2 (de) | 2003-12-18 |
| IL123635A0 (en) | 1998-10-30 |
| JPH11514991A (ja) | 1999-12-21 |
| KR100498730B1 (ko) | 2005-09-09 |
| PL325952A1 (en) | 1998-08-17 |
| EP0854723B1 (en) | 2003-04-23 |
| KR19990063874A (ko) | 1999-07-26 |
| RO120408B1 (ro) | 2006-01-30 |
| DK0854723T3 (da) | 2003-08-11 |
| PT854723E (pt) | 2003-08-29 |
| BR9610974A (pt) | 1999-07-13 |
| CA2233620C (en) | 2011-11-22 |
| CZ297183B6 (cs) | 2006-09-13 |
| CN1202828A (zh) | 1998-12-23 |
| CA2233620A1 (en) | 1997-04-03 |
| WO1997011704A1 (en) | 1997-04-03 |
| RU2253456C2 (ru) | 2005-06-10 |
| AU718300B2 (en) | 2000-04-13 |
| PL191934B1 (pl) | 2006-07-31 |
| ATE238058T1 (de) | 2003-05-15 |
| IL123635A (en) | 2003-06-24 |
| ES2197954T3 (es) | 2004-01-16 |
| DE69627683D1 (de) | 2003-05-28 |
| AU7376896A (en) | 1997-04-17 |
| NO981392D0 (no) | 1998-03-27 |
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