NO982590L - Metalloproteinase-inhibitorer, farmas°ytiske blandinger inneholdende dem og deres farmas°ytiske anvendelser, og fremgangsmÕter og mellomprodukter anvendelige for deres fremstilling - Google Patents

Metalloproteinase-inhibitorer, farmas°ytiske blandinger inneholdende dem og deres farmas°ytiske anvendelser, og fremgangsmÕter og mellomprodukter anvendelige for deres fremstilling

Info

Publication number: NO982590L
Authority: NO; Norway
Prior art keywords: preparation; methods; intermediates useful; metalloproteinase inhibitors; pharmaceutical uses
Prior art date: 1995-12-08

Application number

NO982590A

Other languages

English (en)

Other versions

NO982590D0 (no

NO311360B1 (no

Inventor

Scott E Zook

Jr Raymond Dangnino

Michael E Deason

Steven L Bender

Michael J Melnick

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1998-06-05

Publication date

1998-08-05

1998-06-05 Application filed by Agouron Pharma filed Critical Agouron Pharma

1998-06-05 Publication of NO982590D0 publication Critical patent/NO982590D0/no

1998-08-05 Publication of NO982590L publication Critical patent/NO982590L/no

2001-11-19 Publication of NO311360B1 publication Critical patent/NO311360B1/no

Links

239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000003475 metalloproteinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

NO19982590A 1995-12-08 1998-06-05 Metalloproteinase-inhibitorer, farmasöytiske blandinger inneholdende dem og fremgangsmåter og mellomprodukter anvendeligefor deres fremstilling NO311360B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56976695A	1995-12-08	1995-12-08
PCT/US1996/019328 WO1997020824A1 (en)	1995-12-08	1996-12-05	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation

Publications (3)

Publication Number	Publication Date
NO982590D0 NO982590D0 (no)	1998-06-05
NO982590L true NO982590L (no)	1998-08-05
NO311360B1 NO311360B1 (no)	2001-11-19

Family

ID=24276764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19982590A NO311360B1 (no)	1995-12-08	1998-06-05	Metalloproteinase-inhibitorer, farmasöytiske blandinger inneholdende dem og fremgangsmåter og mellomprodukter anvendeligefor deres fremstilling

Country Status (39)

Country	Link
US (1)	US6153757A (no)
EP (2)	EP0874830B1 (no)
JP (1)	JP2000502330A (no)
KR (1)	KR19990072009A (no)
CN (2)	CN1207289C (no)
AP (2)	AP1288A (no)
AT (2)	ATE234291T1 (no)
AU (1)	AU725831C (no)
BG (1)	BG64279B1 (no)
BR (1)	BR9611929A (no)
CA (1)	CA2238306A1 (no)
CO (1)	CO4790150A1 (no)
CZ (1)	CZ292942B6 (no)
DE (2)	DE69633947T2 (no)
DK (1)	DK0874830T3 (no)
EA (1)	EA003294B1 (no)
ES (2)	ES2195034T3 (no)
GE (1)	GEP20012388B (no)
GT (2)	GT199700015AA (no)
HR (1)	HRP970031A2 (no)
HU (1)	HUP9902092A3 (no)
ID (1)	ID17624A (no)
IL (6)	IL124559A (no)
MX (1)	MX9804457A (no)
MY (1)	MY117290A (no)
NO (1)	NO311360B1 (no)
NZ (1)	NZ325559A (no)
OA (1)	OA10794A (no)
PA (1)	PA8431301A1 (no)
PE (1)	PE69298A1 (no)
PL (1)	PL327275A1 (no)
PT (1)	PT874830E (no)
SI (1)	SI0874830T1 (no)
SK (1)	SK73898A3 (no)
SV (1)	SV1997000008A (no)
TR (1)	TR199800990T2 (no)
TW (1)	TW546293B (no)
WO (1)	WO1997020824A1 (no)
YU (1)	YU21597A (no)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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US7115632B1 (en)	1999-05-12	2006-10-03	G. D. Searle & Co.	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6696449B2 (en)	1997-03-04	2004-02-24	Pharmacia Corporation	Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6794511B2 (en)	1997-03-04	2004-09-21	G. D. Searle	Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6362183B1 (en)	1997-03-04	2002-03-26	G. D. Searle & Company	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
ES2234103T3 (es) *	1997-03-04	2005-06-16	Pharmacia Corporation	Compuestos de acido tioarilsulfonamidohidroxamico.
WO1998039315A1 (en)	1997-03-04	1998-09-11	Monsanto Company	Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
WO1998039316A1 (en)	1997-03-04	1998-09-11	Monsanto Company	N-hydroxy 4-sulfonyl butanamide compounds
US6087359A (en) *	1997-03-04	2000-07-11	Getman; Daniel P.	Thioaryl sulfonamide hydroxamic acid compounds
WO1998038859A1 (en)	1997-03-04	1998-09-11	Monsanto Company	Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
CA2285372A1 (en) *	1997-04-01	1998-10-08	Melwyn A. Abreo	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
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JP2004137284A (ja) *	1997-06-17	2004-05-13	Kaken Pharmaceut Co Ltd	２−スルファモイル安息香酸誘導体
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US6403632B1 (en) *	2000-03-01	2002-06-11	Bristol Myers Squibb Pharma Co	Lactam metalloprotease inhibitors
JPH11199512A (ja) *	1997-10-24	1999-07-27	Pfizer Prod Inc	変形性関節症および他のｍｍｐ媒介疾患の治療のためのｍｍｐ−１３選択的阻害剤の使用
US20010039287A1 (en)	1997-11-14	2001-11-08	Thomas E Barta	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6750228B1 (en)	1997-11-14	2004-06-15	Pharmacia Corporation	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
JP2001523662A (ja)	1997-11-14	2001-11-27	ジー・ディー・サール・アンド・カンパニー	芳香族スルホンヒドロキサム酸メタロプロテアーゼ阻害剤
BR9907746A (pt) *	1998-01-27	2000-10-17	American Cyanamid Co	ácidos 2,3,4,5-tetraidro-1h[1,4]-benzodiazepina-3-hidroxâmic os como inibidores de matriz de metaloproteinase
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US6410580B1 (en)	1998-02-04	2002-06-25	Novartis Ag	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
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US6329418B1 (en) *	1998-04-14	2001-12-11	The Procter & Gamble Company	Substituted pyrrolidine hydroxamate metalloprotease inhibitors
CN1301265A (zh)	1998-05-14	2001-06-27	杜邦药品公司	新的用作金属蛋白酶抑制剂的取代的芳基异羟肟酸
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EP0965592A1 (en)	1998-06-18	1999-12-22	F. Hoffmann-La Roche Ag	Process for preparing 3-arylsulfur hydroxamic acids
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CN1398189A (zh) *	1998-12-23	2003-02-19	G.D.西尔公司	用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
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CN1349498A (zh)	1999-03-03	2002-05-15	宝洁公司	含有链烯基和炔基的金属蛋白酶抑制剂
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1996
- 1996-12-05 DE DE69633947T patent/DE69633947T2/de not_active Expired - Fee Related
- 1996-12-05 EP EP96944229A patent/EP0874830B1/en not_active Expired - Lifetime
- 1996-12-05 DK DK96944229T patent/DK0874830T3/da active
- 1996-12-05 TR TR1998/00990T patent/TR199800990T2/xx unknown
- 1996-12-05 GE GEAP19964389A patent/GEP20012388B/en unknown
- 1996-12-05 CZ CZ19981733A patent/CZ292942B6/cs not_active IP Right Cessation
- 1996-12-05 DE DE69626684T patent/DE69626684T2/de not_active Expired - Fee Related
- 1996-12-05 AP APAP/P/2001/002270A patent/AP1288A/en active
- 1996-12-05 CA CA002238306A patent/CA2238306A1/en not_active Abandoned
- 1996-12-05 KR KR1019980704301A patent/KR19990072009A/ko not_active Ceased
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- 1996-12-05 CN CNB961995831A patent/CN1207289C/zh not_active Expired - Fee Related
- 1996-12-05 JP JP9521405A patent/JP2000502330A/ja not_active Ceased
- 1996-12-05 HU HU9902092A patent/HUP9902092A3/hu unknown
- 1996-12-05 SK SK738-98A patent/SK73898A3/sk unknown
- 1996-12-05 ES ES00128719T patent/ES2233275T3/es not_active Expired - Lifetime
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- 1996-12-05 CN CNA2004100335232A patent/CN1542002A/zh active Pending
1997
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1998
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2000
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Also Published As

Publication number	Publication date
NZ325559A (en)	2000-01-28
SI0874830T1 (en)	2003-08-31
PA8431301A1 (es)	2000-05-24
WO1997020824A1 (en)	1997-06-12
IL124559A0 (en)	1998-12-06
AP2001002270A0 (en)	2001-09-30
NO982590D0 (no)	1998-06-05
IL138028A0 (en)	2001-10-31
DE69633947D1 (de)	2004-12-30
AU725831B2 (en)	2000-10-19
CZ292942B6 (cs)	2004-01-14
EP0874830A1 (en)	1998-11-04
IL138027A0 (en)	2001-10-31
CN1542002A (zh)	2004-11-03
CA2238306A1 (en)	1997-06-12
PL327275A1 (en)	1998-12-07
IL134816A0 (en)	2001-05-20
GT199700015A (es)	1998-07-23
CZ173398A3 (cs)	1998-11-11
EA199800541A1 (ru)	1998-12-24
GEP20012388B (en)	2001-03-25
SK73898A3 (en)	1999-01-11
BG64279B1 (bg)	2004-08-31
IL143674A0 (en)	2002-04-21
IL134816A (en)	2003-02-12
BG102510A (en)	1999-08-31
BR9611929A (pt)	1999-05-18
MY117290A (en)	2004-06-30
DE69626684D1 (de)	2003-04-17
TW546293B (en)	2003-08-11
PT874830E (pt)	2003-06-30
AU725831C (en)	2002-10-17
EP0874830B1 (en)	2003-03-12
EA003294B1 (ru)	2003-04-24
AU1409197A (en)	1997-06-27
HUP9902092A2 (hu)	1999-09-28
ES2195034T3 (es)	2003-12-01
NO311360B1 (no)	2001-11-19
AP9801284A0 (en)	1998-09-30
IL138027A (en)	2004-08-31
CN1207734A (zh)	1999-02-10
OA10794A (en)	2001-07-05
DK0874830T3 (da)	2003-04-22
EP1095936A1 (en)	2001-05-02
AP1288A (en)	2004-07-21
ATE283264T1 (de)	2004-12-15
IL124559A (en)	2004-07-25
DE69633947T2 (de)	2005-12-01
TR199800990T2 (xx)	1998-07-21
ID17624A (id)	1998-01-15
KR19990072009A (ko)	1999-09-27
EP1095936B1 (en)	2004-11-24
ES2233275T3 (es)	2005-06-16
SV1997000008A (es)	1999-02-15
MX9804457A (es)	1998-09-30
CN1207289C (zh)	2005-06-22
DE69626684T2 (de)	2004-04-29
HUP9902092A3 (en)	2000-12-28
AP1368A (en)	2005-04-21
HRP970031A2 (en)	1998-08-31
PE69298A1 (es)	1998-11-13
US6153757A (en)	2000-11-28
GT199700015AA (es)	1998-07-23
ATE234291T1 (de)	2003-03-15
YU21597A (en)	1999-11-22
JP2000502330A (ja)	2000-02-29
CO4790150A1 (es)	1999-05-31

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