NO982712L - FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin - Google Patents

FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin

Info

Publication number: NO982712L
Authority: NO; Norway
Prior art keywords: alkyl; compound; formula; trifluoromethyl; alkoxy
Prior art date: 1995-12-15

Application number

NO982712A

Other languages

English (en)

Norwegian (no)

Other versions

NO982712D0 (no

Inventor

Keith M Devries

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1998-06-12

Publication date

1998-06-12

1998-06-12 Application filed by Pfizer filed Critical Pfizer

1998-06-12 Publication of NO982712D0 publication Critical patent/NO982712D0/no

1998-06-12 Publication of NO982712L publication Critical patent/NO982712L/no

Links

239000000543 intermediate Substances 0.000 title abstract 2
PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 title 1
IHMQOBPGHZFGLC-UHFFFAOYSA-N 5,6-dimethoxy-2,3-dihydroinden-1-one Chemical compound C1=C(OC)C(OC)=CC2=C1C(=O)CC2 IHMQOBPGHZFGLC-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 benzyl halide Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

NO982712A 1995-12-15 1998-06-12 FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin NO982712L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US875395P	1995-12-15	1995-12-15
PCT/IB1996/001076 WO1997022584A1 (fr)	1995-12-15	1996-10-11	Procedes de preparation de 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine et intermediaires utilises a cet effet

Publications (2)

Publication Number	Publication Date
NO982712D0 NO982712D0 (no)	1998-06-12
NO982712L true NO982712L (no)	1998-06-12

Family

ID=21733469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO982712A NO982712L (no)	1995-12-15	1998-06-12	FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin

Country Status (33)

Country	Link
EP (1)	EP0883607A1 (fr)
JP (1)	JP3066083B2 (fr)
KR (1)	KR20000064387A (fr)
AP (1)	AP708A (fr)
AR (1)	AR004368A1 (fr)
AU (1)	AU716462B2 (fr)
BG (1)	BG102525A (fr)
BR (1)	BR9612018A (fr)
CA (1)	CA2237647A1 (fr)
CO (1)	CO4750831A1 (fr)
CZ (1)	CZ180898A3 (fr)
DZ (1)	DZ2141A1 (fr)
GT (1)	GT199600092A (fr)
HN (1)	HN1996000065A (fr)
HR (1)	HRP960592A2 (fr)
HU (1)	HUP9904275A3 (fr)
IL (3)	IL136421A0 (fr)
IS (1)	IS4752A (fr)
MA (1)	MA24032A1 (fr)
NO (1)	NO982712L (fr)
NZ (1)	NZ318843A (fr)
OA (1)	OA10694A (fr)
PE (1)	PE25698A1 (fr)
PL (1)	PL197306B1 (fr)
RO (1)	RO121382B1 (fr)
RU (1)	RU2160731C2 (fr)
SK (1)	SK75498A3 (fr)
TN (1)	TNSN96153A1 (fr)
TW (1)	TW414787B (fr)
UY (1)	UY24401A1 (fr)
WO (1)	WO1997022584A1 (fr)
YU (1)	YU49486B (fr)
ZA (1)	ZA9610533B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE292116T1 (de)	1998-01-16	2005-04-15	Eisai Co Ltd	Verfahren zur herstellung von donepezilderivaten
IL125809A (en)	1998-08-17	2005-08-31	Finetech Lab Ltd	Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) *	2002-07-24	2006-12-12	Dr. Reddy's Laboratories Limited	Process for preparation of donepezil
IL150982A (en)	2002-07-30	2007-02-11	Ori Lerman	Process for making Donafzil
IL151253A0 (en) *	2002-08-14	2003-04-10	Finetech Lab Ltd	Process for production of highly pure donepezil hydrochloride
US6649765B1 (en)	2003-02-12	2003-11-18	Usv Limited, Bsd Marg.	Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en)	2003-02-12	2005-10-11	Usv, Limited	Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
EP1608371A1 (fr) *	2003-03-21	2005-12-28	Ranbaxy Laboratories, Ltd.	Procede de preparation de donepezil et de ses derives
WO2004099142A1 (fr) *	2003-05-05	2004-11-18	Ranbaxy Laboratories Limited	Sel de bromhydrate de benzyl-piperidylmethyl-indanone et ses polymorphes
US7446203B2 (en)	2003-07-01	2008-11-04	Hetero Drugs Limited	Preparation of intermediates for acetycholinesterase inhibitors
CN1280273C (zh)	2003-11-05	2006-10-18	天津和美生物技术有限公司	合成多奈哌齐及其衍生物的方法
WO2006035433A2 (fr)	2004-09-29	2006-04-06	Chemagis Ltd.	Utilisation de maleate de donepezil purifie pour preparer un hydrochlorure de donepezil amorphe pharmaceutiquement pur
CN100436416C (zh) *	2005-07-29	2008-11-26	西南合成制药股份有限公司	盐酸多奈哌齐合成工艺
GB0515803D0 (en) *	2005-07-30	2005-09-07	Pliva Hrvatska D O O	Intermediate compounds
AR057910A1 (es)	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar donepezilo
NZ569532A (en)	2006-01-04	2010-11-26	Cipla Ltd	Process and intermediate for preparation of donepezil
AU2007333586A1 (en)	2006-12-11	2008-06-19	Reviva Pharmaceuticals, Inc.	Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
WO2013078608A1 (fr)	2011-11-29	2013-06-06	Ziqiang Gu	Pamoate de donepezil et ses procédés de fabrication et d'utilisation
AU2014307803A1 (en)	2013-08-16	2016-03-10	Universiteit Maastricht	Treatment of cognitive impairment with PDE4 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) *	1989-01-20	1991-04-12	Rhone Poulenc Sante	Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) *	1994-11-08	1996-08-29	Bayer Ag	Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

1996
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 EP EP96931937A patent/EP0883607A1/fr not_active Withdrawn
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/fr not_active Ceased
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 CA CA002237647A patent/CA2237647A1/fr not_active Abandoned
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Ceased
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU7092596A (en)	1997-07-14
IL136421A0 (en)	2001-06-14
MX9804820A (es)	1998-10-31
NZ318843A (en)	2000-01-28
EP0883607A1 (fr)	1998-12-16
AP708A (en)	1998-12-04
OA10694A (en)	2001-05-04
NO982712D0 (no)	1998-06-12
JP3066083B2 (ja)	2000-07-17
CA2237647A1 (fr)	1997-06-26
HRP960592A2 (en)	1998-06-30
HUP9904275A2 (hu)	2000-05-28
PE25698A1 (es)	1998-05-21
IL124452A0 (en)	1998-12-06
CO4750831A1 (es)	1999-03-31
KR20000064387A (ko)	2000-11-06
MA24032A1 (fr)	1997-07-01
PL197306B1 (pl)	2008-03-31
HN1996000065A (es)	1997-06-26
YU66096A (en)	1999-11-22
ZA9610533B (en)	1998-06-15
AP9600892A0 (en)	1997-01-31
PL327512A1 (en)	1998-12-21
AR004368A1 (es)	1998-11-04
BG102525A (en)	1999-05-31
IL136420A0 (en)	2001-06-14
BR9612018A (pt)	1999-02-17
WO1997022584A1 (fr)	1997-06-26
HUP9904275A3 (en)	2001-05-28
CZ180898A3 (cs)	1999-05-12
JPH11500756A (ja)	1999-01-19
AU716462B2 (en)	2000-02-24
RU2160731C2 (ru)	2000-12-20
UY24401A1 (es)	1997-06-09
GT199600092A (es)	1998-05-12
IS4752A (is)	1998-05-22
TW414787B (en)	2000-12-11
DZ2141A1 (fr)	2002-07-23
RO121382B1 (ro)	2007-04-30
YU49486B (sh)	2006-08-17
TNSN96153A1 (fr)	2005-03-15
SK75498A3 (en)	1999-08-06

Legal Events

Date	Code	Title	Description
2001-12-27	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO982712L (no)	1998-06-12	FremgangsmÕter og mellomprodukter for fremstilling av 1-benzyl-4-((5,6-dimetoksy-1-indanon)-2-yl)metylpiperidin
EA200001135A1 (ru)	2001-06-25	Способ получения изоксазолин-3-ил-ацилбензолов
CA2161542A1 (fr)	1995-08-31	Nouveaux derives de 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazole
YU48446B (sh)	1998-07-10	Postupak za dobijanje novih derivata 1-(cikloheksil)-4- aril-4-piperidinkarboksilne kiseline
NO20002490D0 (no)	2000-05-12	FremgangsmÕte for fremstilling av 1,4-dihydropyridiner og forbindelser anvendt ved denne fremgangsmÕten
DE60133288D1 (de)	2008-04-30	Verfahren zur herstellung von fexofenadinen
EE05398B1 (et)	2011-04-15	Amlodipiinbenseensulfonaadi valmistamise meetod
RU96120212A (ru)	1998-12-27	Производное простого эфира, его применение, и промежуточные соединения, используемые при его получении
ES474081A1 (es)	1980-01-16	Un procedimiento para la preparacion de 1-(4,4-bis(4-fluoro-fenil)butil-4-fenoxi-1,2,3,6-tetrahidropiridinas y piperidi-nas afinas
ES2016017A6 (es)	1990-10-01	Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
HUP9800511A2 (hu)	1999-03-29	Eljárás 4-(4-(4-(hidroxi-difenil)-1-piperidinil)-1-hidroxi-butil)-alfa, alfa-dimetil-fenil-ecetsav és foszforilezett származékai előállítására
FI974435A0 (fi)	1997-12-05	Menetelmä 2,4-diklooripyridiinien muuttamiseksi 2-aryylioksi-4-klooripyridiineiksi
EP0881215A4 (fr)	1999-01-20	Procede d'elaboration de 4-methylenepiperidines
SU718011A3 (ru)	1980-02-25	Способ получени производных 4-фенилтиено-(2,3-с)пиперидина или их солей
ATE30718T1 (de)	1987-11-15	Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
MY105529A (en)	1994-10-31	Preparation of glutaric acid derivatives.
DK571284D0 (da)	1984-11-30	Indolderivater, laegemiddel indeholdende disse derivater og fremgangsmaade til deres fremstilling
NO20000344L (no)	2000-03-22	FremgangsmÕte for fremstilling av 1,3-diaza-spiro (4,4) non-1- en-4-on-derivater og 1-cyano-1-acylaminsyklopentanintermediater
NO20010801L (no)	2001-08-20	Nye 6-amino- eller 6-hydroazino-sulfonyl-3- kinolynylfosfonsyreforbindelse, fremgangsmåte ved deresfremstilling og farmasöytiske sammensetninger inneholdende dem
SU845776A3 (ru)	1981-07-07	Способ получени 2,2-диарил-4-/4 -ОКСипипЕРидиНО/-буТиРАМидОВ илииХ СОлЕй
YU45942B (sh)	1992-09-07	Postupak za dobivanje hidrohlorida 2(n-benzil-n-metilamino)-etil-metil-1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridin-dikarbok sil
ATE19629T1 (de)	1986-05-15	N-substituierte derivate des tetrahydroisophthalimids.
JPS57118565A (en)	1982-07-23	Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation
DK0557519T3 (da)	1997-06-23	Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
KR880000396A (ko)	1988-03-25	2-(N-벤질-N-메틸아미노)에틸메틸 2,6-디메틸-4-(m-니트로페닐)-1,4-디히드로피리딘-3,5-디카르복실레이트 및 그의 염산염의 제조방법