NO983439L - 1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet - Google Patents

1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet

Info

Publication number
NO983439L
NO983439L NO983439A NO983439A NO983439L NO 983439 L NO983439 L NO 983439L NO 983439 A NO983439 A NO 983439A NO 983439 A NO983439 A NO 983439A NO 983439 L NO983439 L NO 983439L
Authority
NO
Norway
Prior art keywords
indol
pyrazol
medicine
ethyl
acts
Prior art date
Application number
NO983439A
Other languages
English (en)
Other versions
NO983439D0 (no
Inventor
Henning Boettcher
Joachim Maerz
Gerd Bartoszyk
Hartmut Greiner
Juergen Harting
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO983439D0 publication Critical patent/NO983439D0/no
Publication of NO983439L publication Critical patent/NO983439L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen vedrører nye 1- pyrazol-3-yletyl-4-indol-3-ylpiperidin- derivater med formel (I) hvor R1 er H eller A; R2 er H, fenyl substituert 1-3 ganger med Hal, N02, CON(R4)2, S02N(R4)2, cyan, A eller R4-O; R3 er H, Hal, A, A-O-, amino, cyan, karboksamid, NO2, SO2N(R4)2; R4 er H eller A; R5 er H eller A; A er (C-^-C^- alkyl eller (C^-CgJ-alkyl substituert 1-3 ganger med fluor; Hal er F, Cl, Br eller J. Oppfinnelsen vedrører også saltene av derivatene. Det er blitt påvist at disse forbindelsene har en interessant farmasøytisk aktivitet.
NO983439A 1996-01-25 1998-07-24 1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet NO983439L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
PCT/EP1997/000187 WO1997027186A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel

Publications (2)

Publication Number Publication Date
NO983439D0 NO983439D0 (no) 1998-07-24
NO983439L true NO983439L (no) 1998-09-25

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983439A NO983439L (no) 1996-01-25 1998-07-24 1-(pyrazol-3-yl-etyl)-4-(indol-3-yl)-piperidin anvendt som medisin som virker på sentralnervesystemet

Country Status (16)

Country Link
EP (1) EP0879234A1 (no)
JP (1) JP2000503972A (no)
KR (1) KR19990081970A (no)
CN (1) CN1209807A (no)
AR (1) AR005549A1 (no)
AU (1) AU715785B2 (no)
BR (1) BR9707467A (no)
CA (1) CA2244136A1 (no)
CZ (1) CZ231898A3 (no)
DE (1) DE19602505A1 (no)
HU (1) HUP9900980A2 (no)
NO (1) NO983439L (no)
PL (1) PL328228A1 (no)
SK (1) SK99298A3 (no)
WO (1) WO1997027186A1 (no)
ZA (1) ZA97572B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003509509A (ja) * 1999-09-09 2003-03-11 ハー・ルンドベック・アクチエゼルスカベット ５−アミノアルキル及び５−アミノカルボニル置換されたインドール類
CA2390923A1 (en) 1999-11-10 2001-05-31 Takeda Chemical Industries, Ltd. 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7589202B2 (en) 2000-08-14 2009-09-15 Ortho Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
MXPA04004443A (es) * 2001-11-14 2004-08-11 Merck Patent Gmbh Derivados de pirazol.
JP4885967B2 (ja) 2005-10-11 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジアゼピン誘導体
WO2007050381A2 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
CA3194595A1 (en) * 2020-11-04 2022-05-12 Seok Ju Lee Method for preparing crystalline particles of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid, and pharmaceutical composition comprising same
KR20260040647A (ko) * 2023-07-24 2026-03-25 이노웨이스톤 테라퓨틱스 리미티드 5-ht2a 수용체 효능제, 그리고 그것을 위한 제조 방법 및 그것의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Also Published As

Publication number Publication date
ZA97572B (en) 1997-08-04
DE19602505A1 (de) 1997-07-31
PL328228A1 (en) 1999-01-18
SK99298A3 (en) 1999-01-11
JP2000503972A (ja) 2000-04-04
AU1443297A (en) 1997-08-20
KR19990081970A (ko) 1999-11-15
CA2244136A1 (en) 1997-07-31
AU715785B2 (en) 2000-02-10
WO1997027186A1 (de) 1997-07-31
AR005549A1 (es) 1999-06-23
CN1209807A (zh) 1999-03-03
EP0879234A1 (de) 1998-11-25
HUP9900980A2 (hu) 1999-07-28
CZ231898A3 (cs) 1998-10-14
BR9707467A (pt) 1999-07-20
NO983439D0 (no) 1998-07-24

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