NO984445L - Tetrahydro-<beta>-karbolinforbindelser - Google Patents

Tetrahydro-<beta>-karbolinforbindelser

Info

Publication number: NO984445L
Authority: NO; Norway
Prior art keywords: beta; tetrahydro; karbolinforbindelser; compounds; carboline
Prior art date: 1996-03-25

Application number

NO984445A

Other languages

English (en)

Norwegian (no)

Other versions

NO984445D0 (no

Inventor

James E Audia

David L G Nelson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-25

Filing date

1998-09-24

Publication date

1998-11-20

1998-09-24 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1998-09-24 Publication of NO984445D0 publication Critical patent/NO984445D0/no

1998-11-20 Publication of NO984445L publication Critical patent/NO984445L/no

Links

CFTOTSJVQRFXOF-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Chemical class N1C2=CC=CC=C2C2=C1CNCC2 CFTOTSJVQRFXOF-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
102000006969 5-HT2B Serotonin Receptor Human genes 0.000 abstract 1
108010072584 5-HT2B Serotonin Receptor Proteins 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
ZXLDQJLIBNPEFJ-UHFFFAOYSA-N tetrahydro-beta-carboline Natural products C1CNC(C)C2=C1C1=CC=C(OC)C=C1N2 ZXLDQJLIBNPEFJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO984445A 1996-03-25 1998-09-24 Tetrahydro-<beta>-karbolinforbindelser NO984445L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1411996P	1996-03-25	1996-03-25
PCT/US1997/004473 WO1997035578A1 (en)	1996-03-25	1997-03-24	Tetrahydro-beta-carboline compounds

Publications (2)

Publication Number	Publication Date
NO984445D0 NO984445D0 (no)	1998-09-24
NO984445L true NO984445L (no)	1998-11-20

Family

ID=21763645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO984445A NO984445L (no)	1996-03-25	1998-09-24	Tetrahydro-<beta>-karbolinforbindelser

Country Status (20)

Country	Link
US (1)	US5886004A (de)
EP (1)	EP0942722B1 (de)
JP (1)	JP2001509130A (de)
KR (1)	KR20000004963A (de)
CN (1)	CN1225584A (de)
AT (1)	ATE267012T1 (de)
AU (1)	AU714024B2 (de)
BR (1)	BR9708347A (de)
CA (1)	CA2248874A1 (de)
CZ (1)	CZ298098A3 (de)
DE (1)	DE69729211T2 (de)
EA (1)	EA199800867A1 (de)
ES (1)	ES2221049T3 (de)
IL (1)	IL126062A0 (de)
NO (1)	NO984445L (de)
NZ (1)	NZ331827A (de)
PL (1)	PL329212A1 (de)
TR (1)	TR199801910T2 (de)
WO (1)	WO1997035578A1 (de)
YU (1)	YU41998A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings
ES2152860B1 (es) *	1998-10-23	2001-08-16	Finaf 92 Sa	Forma cristalina de la nefazodona y procedimiento para su preparacion.
WO2000069437A1 (en)	1999-05-18	2000-11-23	Synaptic Pharmaceutical Corporation	Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder
US6444477B1 (en) *	2000-11-28	2002-09-03	Pharmagene Laboratories Limited	Assay method for detecting 5-HT2B antagonists
DE10252667A1 (de) *	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
JPWO2005079845A1 (ja) *	2004-02-20	2007-08-02	アステラス製薬株式会社	片頭痛予防薬
US7550499B2 (en) *	2004-05-12	2009-06-23	Bristol-Myers Squibb Company	Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2006078621A2 (en) *	2005-01-19	2006-07-27	Bristol-Myers Squibb Company	2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders
WO2006085510A1 (ja) *	2005-02-08	2006-08-17	Astellas Pharma Inc.	過敏性腸症候群の治療薬
DE602006017694D1 (de) *	2005-06-27	2010-12-02	Bristol Myers Squibb Co	C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
ATE502924T1 (de)	2005-06-27	2011-04-15	Bristol Myers Squibb Co	Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
WO2007002634A1 (en) *	2005-06-27	2007-01-04	Bristol-Myers Squibb Company	Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
TW200726764A (en) *	2005-06-27	2007-07-16	Bristol Myers Squibb Co	N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CA2617473A1 (en) *	2005-08-08	2007-02-15	Astellas Pharma Inc.	Acylguanidine derivative or salt thereof
US7960569B2 (en) *	2006-10-17	2011-06-14	Bristol-Myers Squibb Company	Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2012051502A1 (en)	2010-10-14	2012-04-19	University Of Utah Research Foundation	Methods and compositions related to neuroactive thiazoline compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5500431A (en) *	1993-04-14	1996-03-19	Eli Lilly And Company	Tetrahydro-β-carbolines
AU679635B2 (en) *	1994-03-11	1997-07-03	Eli Lilly And Company	Method for treating 5HT-2B receptor related conditions
US5663178A (en) *	1995-02-06	1997-09-02	Eli Lilly And Company	Tetrahydro-beta carbolines
AU724646B2 (en) *	1996-03-15	2000-09-28	Eli Lilly And Company	Method of treating common cold or allergic rhinitis
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings

1997
- 1997-03-24 EP EP97916854A patent/EP0942722B1/de not_active Expired - Lifetime
- 1997-03-24 NZ NZ331827A patent/NZ331827A/en unknown
- 1997-03-24 TR TR1998/01910T patent/TR199801910T2/xx unknown
- 1997-03-24 IL IL12606297A patent/IL126062A0/xx unknown
- 1997-03-24 EA EA199800867A patent/EA199800867A1/ru unknown
- 1997-03-24 AU AU25361/97A patent/AU714024B2/en not_active Ceased
- 1997-03-24 CN CN97194732A patent/CN1225584A/zh active Pending
- 1997-03-24 AT AT97916854T patent/ATE267012T1/de not_active IP Right Cessation
- 1997-03-24 WO PCT/US1997/004473 patent/WO1997035578A1/en not_active Ceased
- 1997-03-24 CZ CZ982980A patent/CZ298098A3/cs unknown
- 1997-03-24 US US08/823,456 patent/US5886004A/en not_active Expired - Fee Related
- 1997-03-24 PL PL97329212A patent/PL329212A1/xx unknown
- 1997-03-24 DE DE69729211T patent/DE69729211T2/de not_active Expired - Fee Related
- 1997-03-24 JP JP53449297A patent/JP2001509130A/ja not_active Ceased
- 1997-03-24 BR BR9708347A patent/BR9708347A/pt not_active Application Discontinuation
- 1997-03-24 KR KR1019980707567A patent/KR20000004963A/ko not_active Withdrawn
- 1997-03-24 ES ES97916854T patent/ES2221049T3/es not_active Expired - Lifetime
- 1997-03-24 CA CA002248874A patent/CA2248874A1/en not_active Abandoned
1998
- 1998-09-24 NO NO984445A patent/NO984445L/no unknown
- 1998-09-25 YU YU41998A patent/YU41998A/sh unknown

Also Published As

Publication number	Publication date
EA199800867A1 (ru)	1999-02-25
CA2248874A1 (en)	1997-10-02
DE69729211D1 (en)	2004-06-24
JP2001509130A (ja)	2001-07-10
KR20000004963A (ko)	2000-01-25
WO1997035578A1 (en)	1997-10-02
PL329212A1 (en)	1999-03-15
AU714024B2 (en)	1999-12-16
YU41998A (sh)	1999-07-28
AU2536197A (en)	1997-10-17
CZ298098A3 (cs)	1999-02-17
IL126062A0 (en)	1999-05-09
BR9708347A (pt)	1999-08-03
EP0942722A1 (de)	1999-09-22
EP0942722A4 (de)	2002-06-05
CN1225584A (zh)	1999-08-11
TR199801910T2 (xx)	1998-12-21
NZ331827A (en)	2000-02-28
ATE267012T1 (de)	2004-06-15
US5886004A (en)	1999-03-23
DE69729211T2 (de)	2005-05-04
ES2221049T3 (es)	2004-12-16
EP0942722B1 (de)	2004-05-19
NO984445D0 (no)	1998-09-24

Publication	Publication Date	Title
NO984445L (no)	1998-11-20	Tetrahydro-<beta>-karbolinforbindelser
BG102872A (en)	1999-11-30	6-phenylpyridyl-3-amine derivatives
DK0918774T3 (da)	2002-05-21	Androgenreceptormodulatorforbindelser og fremgangsmåder
AU569310B2 (en)	1988-01-28	Leukotriene antagonists
DE69531403D1 (de)	2003-09-04	Allosterische modulatoren des nmda-rezeptors
NO972591L (no)	1997-08-14	Steroid reseptormodulator-forbindelser og fremgangsmåter
DK0729468T3 (da)	2003-05-12	Ikke-peptid tachykinin-receptor-antagonister
ES2184070T3 (es)	2003-04-01	Derivados de oximas sustituidas utiles como antagonistas de la neuroquinina.
MY141384A (en)	2010-04-30	Prevention of loss and restoration of bone mass by certain prostaglandin agonists
AU1016588A (en)	1988-07-14	Leukotriene antagonists
AP9801269A0 (en)	1999-12-18	Prostaglandin agonists.
DK0912184T3 (da)	2002-11-25	Anvendelse af K-252a-derivat til behandlingen af perifere eller centrale nervelidelser og cytokinoverproduktion
DK0556332T3 (da)	1996-06-03	Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet
AU1582197A (en)	1997-08-11	Combinatorial process for preparing substituted indane libraries
DK0852587T3 (da)	2009-06-08	Syntetiske peptider der inhiberer IL-6-aktivitet
BR9711477A (pt)	1999-08-24	Derivado de benzocicloheptapiridina substituida Úteis para inibi-Æo de transferase de farnesila
BR9712980A (pt)	2000-04-18	Compostos úteis para inibição de transferase de proteina de farnesila
FI905957A0 (fi)	1990-12-03	Foerfarande foer framstaellning av substituerade cyklohexener, som verkar pao det centrala nervsystemet.
DK0900218T3 (da)	2002-09-02	Heterocykliske forbindelser
WO2001012838A3 (en)	2001-10-04	Compounds which modulate the activity of an lpa receptor
ATE204847T1 (de)	2001-09-15	Tetracyclische aromatische retinoide verbindungen,ihre herstellung und verwendung
ECSP972315A (es)	1998-12-14	Procedimiento para la sintesis de benzotiofenos