NO984739L - Spiro[cyklopent[b]indolpiperidiner og N-fenyl-hydrazon-mellomprodukter for deres fremstilling, hvor begge er acetylcholinesterase og MAO-inhibitorer - Google Patents
Spiro[cyklopent[b]indolpiperidiner og N-fenyl-hydrazon-mellomprodukter for deres fremstilling, hvor begge er acetylcholinesterase og MAO-inhibitorerInfo
- Publication number
- NO984739L NO984739L NO984739A NO984739A NO984739L NO 984739 L NO984739 L NO 984739L NO 984739 A NO984739 A NO 984739A NO 984739 A NO984739 A NO 984739A NO 984739 L NO984739 L NO 984739L
- Authority
- NO
- Norway
- Prior art keywords
- cyclopent
- piperidines
- indole
- spiro
- preparation
- Prior art date
Links
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical compound C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 125000003003 spiro group Chemical group 0.000 title abstract 3
- XVTILWLVPDMCSO-UHFFFAOYSA-N 1h-indole;piperidine Chemical class C1CCNCC1.C1=CC=C2NC=CC2=C1 XVTILWLVPDMCSO-UHFFFAOYSA-N 0.000 title 1
- 102000012440 Acetylcholinesterase Human genes 0.000 title 1
- 108010022752 Acetylcholinesterase Proteins 0.000 title 1
- 229940022698 acetylcholinesterase Drugs 0.000 title 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 title 1
- 239000000544 cholinesterase inhibitor Substances 0.000 title 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000007857 hydrazones Chemical class 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63064196A | 1996-04-10 | 1996-04-10 | |
| PCT/US1997/003864 WO1997037992A2 (en) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indole-piperidines] and n-phenyl-hydrazon intermediates for their preparation, both being acetylcholinesterase and mao inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO984739D0 NO984739D0 (no) | 1998-10-09 |
| NO984739L true NO984739L (no) | 1998-12-09 |
Family
ID=24527997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO984739A NO984739L (no) | 1996-04-10 | 1998-10-09 | Spiro[cyklopent[b]indolpiperidiner og N-fenyl-hydrazon-mellomprodukter for deres fremstilling, hvor begge er acetylcholinesterase og MAO-inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0892802B1 (de) |
| JP (1) | JP3615225B2 (de) |
| KR (1) | KR100270145B1 (de) |
| CN (1) | CN1233249A (de) |
| AR (1) | AR006553A1 (de) |
| AT (1) | ATE252581T1 (de) |
| AU (1) | AU708124B2 (de) |
| BR (1) | BR9708563A (de) |
| CA (1) | CA2251545C (de) |
| DE (1) | DE69725713T2 (de) |
| DK (1) | DK0892802T3 (de) |
| ES (1) | ES2207718T3 (de) |
| HU (1) | HUP9902755A3 (de) |
| IL (1) | IL126003A0 (de) |
| NO (1) | NO984739L (de) |
| PT (1) | PT892802E (de) |
| WO (1) | WO1997037992A2 (de) |
| ZA (1) | ZA972984B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891954A3 (de) | 1998-09-30 | 2009-01-14 | Takeda Pharmaceutical Company Limited | Wirkstoffe zur Verbesserung der Exkretionskraft der Harnblase |
| JP2013519722A (ja) | 2010-02-16 | 2013-05-30 | ファイザー・インク | （ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト |
| WO2017083867A1 (en) | 2015-11-12 | 2017-05-18 | Afasci, Inc. | Ion channel inhibitory compounds, pharmaceutical formulations and uses |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048829A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 3,9-diazaspiro[5.5]undecane compounds |
-
1997
- 1997-03-01 IL IL12600397A patent/IL126003A0/xx unknown
- 1997-03-10 HU HU9902755A patent/HUP9902755A3/hu unknown
- 1997-03-10 JP JP53619797A patent/JP3615225B2/ja not_active Expired - Fee Related
- 1997-03-10 DK DK97908068T patent/DK0892802T3/da active
- 1997-03-10 WO PCT/US1997/003864 patent/WO1997037992A2/en not_active Ceased
- 1997-03-10 DE DE69725713T patent/DE69725713T2/de not_active Expired - Fee Related
- 1997-03-10 AU AU19909/97A patent/AU708124B2/en not_active Ceased
- 1997-03-10 PT PT97908068T patent/PT892802E/pt unknown
- 1997-03-10 ES ES97908068T patent/ES2207718T3/es not_active Expired - Lifetime
- 1997-03-10 KR KR1019980708047A patent/KR100270145B1/ko not_active Expired - Fee Related
- 1997-03-10 BR BR9708563A patent/BR9708563A/pt not_active IP Right Cessation
- 1997-03-10 CA CA002251545A patent/CA2251545C/en not_active Expired - Fee Related
- 1997-03-10 AT AT97908068T patent/ATE252581T1/de not_active IP Right Cessation
- 1997-03-10 CN CN97193690A patent/CN1233249A/zh active Pending
- 1997-03-10 EP EP97908068A patent/EP0892802B1/de not_active Expired - Lifetime
- 1997-04-08 ZA ZA9702984A patent/ZA972984B/xx unknown
- 1997-04-08 AR ARP970101376A patent/AR006553A1/es not_active Application Discontinuation
-
1998
- 1998-10-09 NO NO984739A patent/NO984739L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9902755A2 (hu) | 2000-03-28 |
| IL126003A0 (en) | 1999-04-11 |
| ZA972984B (en) | 1997-11-03 |
| ES2207718T3 (es) | 2004-06-01 |
| CN1233249A (zh) | 1999-10-27 |
| KR20000005328A (ko) | 2000-01-25 |
| DE69725713D1 (de) | 2003-11-27 |
| PT892802E (pt) | 2004-03-31 |
| AU1990997A (en) | 1997-10-29 |
| HUP9902755A3 (en) | 2000-05-29 |
| DK0892802T3 (da) | 2003-12-01 |
| CA2251545C (en) | 2002-01-08 |
| AR006553A1 (es) | 1999-09-08 |
| NO984739D0 (no) | 1998-10-09 |
| JP2002509520A (ja) | 2002-03-26 |
| EP0892802A1 (de) | 1999-01-27 |
| WO1997037992A2 (en) | 1997-10-16 |
| EP0892802B1 (de) | 2003-10-22 |
| DE69725713T2 (de) | 2004-05-13 |
| AU708124B2 (en) | 1999-07-29 |
| KR100270145B1 (ko) | 2000-11-01 |
| JP3615225B2 (ja) | 2005-02-02 |
| ATE252581T1 (de) | 2003-11-15 |
| CA2251545A1 (en) | 1997-10-16 |
| BR9708563A (pt) | 1999-08-03 |
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