DK0892802T3 - Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorer - Google Patents
Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorerInfo
- Publication number
- DK0892802T3 DK0892802T3 DK97908068T DK97908068T DK0892802T3 DK 0892802 T3 DK0892802 T3 DK 0892802T3 DK 97908068 T DK97908068 T DK 97908068T DK 97908068 T DK97908068 T DK 97908068T DK 0892802 T3 DK0892802 T3 DK 0892802T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopent
- acetylcholinesterase
- piperidines
- spiro
- indole
- Prior art date
Links
- 102000012440 Acetylcholinesterase Human genes 0.000 title 1
- 108010022752 Acetylcholinesterase Proteins 0.000 title 1
- 229940022698 acetylcholinesterase Drugs 0.000 title 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 title 1
- 239000000544 cholinesterase inhibitor Substances 0.000 title 1
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical compound C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63064196A | 1996-04-10 | 1996-04-10 | |
| PCT/US1997/003864 WO1997037992A2 (en) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indole-piperidines] and n-phenyl-hydrazon intermediates for their preparation, both being acetylcholinesterase and mao inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0892802T3 true DK0892802T3 (da) | 2003-12-01 |
Family
ID=24527997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97908068T DK0892802T3 (da) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0892802B1 (da) |
| JP (1) | JP3615225B2 (da) |
| KR (1) | KR100270145B1 (da) |
| CN (1) | CN1233249A (da) |
| AR (1) | AR006553A1 (da) |
| AT (1) | ATE252581T1 (da) |
| AU (1) | AU708124B2 (da) |
| BR (1) | BR9708563A (da) |
| CA (1) | CA2251545C (da) |
| DE (1) | DE69725713T2 (da) |
| DK (1) | DK0892802T3 (da) |
| ES (1) | ES2207718T3 (da) |
| HU (1) | HUP9902755A3 (da) |
| IL (1) | IL126003A0 (da) |
| NO (1) | NO984739L (da) |
| PT (1) | PT892802E (da) |
| WO (1) | WO1997037992A2 (da) |
| ZA (1) | ZA972984B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1604653A1 (en) | 1998-09-30 | 2005-12-14 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
| AU2011216950A1 (en) | 2010-02-16 | 2012-08-23 | Pfizer Inc. | (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors |
| JP6790094B2 (ja) | 2015-11-12 | 2020-11-25 | エーエフエーエスシーアイ，インコーポレイテッド | イオンチャネル阻害化合物、医薬製剤および使用 |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
| WO2020048829A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 3,9-diazaspiro[5.5]undecane compounds |
-
1997
- 1997-03-01 IL IL12600397A patent/IL126003A0/xx unknown
- 1997-03-10 WO PCT/US1997/003864 patent/WO1997037992A2/en not_active Ceased
- 1997-03-10 EP EP97908068A patent/EP0892802B1/en not_active Expired - Lifetime
- 1997-03-10 DE DE69725713T patent/DE69725713T2/de not_active Expired - Fee Related
- 1997-03-10 HU HU9902755A patent/HUP9902755A3/hu unknown
- 1997-03-10 AT AT97908068T patent/ATE252581T1/de not_active IP Right Cessation
- 1997-03-10 AU AU19909/97A patent/AU708124B2/en not_active Ceased
- 1997-03-10 KR KR1019980708047A patent/KR100270145B1/ko not_active Expired - Fee Related
- 1997-03-10 DK DK97908068T patent/DK0892802T3/da active
- 1997-03-10 BR BR9708563A patent/BR9708563A/pt not_active IP Right Cessation
- 1997-03-10 JP JP53619797A patent/JP3615225B2/ja not_active Expired - Fee Related
- 1997-03-10 PT PT97908068T patent/PT892802E/pt unknown
- 1997-03-10 ES ES97908068T patent/ES2207718T3/es not_active Expired - Lifetime
- 1997-03-10 CA CA002251545A patent/CA2251545C/en not_active Expired - Fee Related
- 1997-03-10 CN CN97193690A patent/CN1233249A/zh active Pending
- 1997-04-08 ZA ZA9702984A patent/ZA972984B/xx unknown
- 1997-04-08 AR ARP970101376A patent/AR006553A1/es not_active Application Discontinuation
-
1998
- 1998-10-09 NO NO984739A patent/NO984739L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU708124B2 (en) | 1999-07-29 |
| DE69725713T2 (de) | 2004-05-13 |
| WO1997037992A2 (en) | 1997-10-16 |
| ZA972984B (en) | 1997-11-03 |
| NO984739L (no) | 1998-12-09 |
| AR006553A1 (es) | 1999-09-08 |
| NO984739D0 (no) | 1998-10-09 |
| CA2251545C (en) | 2002-01-08 |
| KR20000005328A (ko) | 2000-01-25 |
| PT892802E (pt) | 2004-03-31 |
| DE69725713D1 (de) | 2003-11-27 |
| BR9708563A (pt) | 1999-08-03 |
| IL126003A0 (en) | 1999-04-11 |
| JP2002509520A (ja) | 2002-03-26 |
| HUP9902755A3 (en) | 2000-05-29 |
| ATE252581T1 (de) | 2003-11-15 |
| KR100270145B1 (ko) | 2000-11-01 |
| AU1990997A (en) | 1997-10-29 |
| EP0892802B1 (en) | 2003-10-22 |
| JP3615225B2 (ja) | 2005-02-02 |
| CN1233249A (zh) | 1999-10-27 |
| ES2207718T3 (es) | 2004-06-01 |
| CA2251545A1 (en) | 1997-10-16 |
| EP0892802A1 (en) | 1999-01-27 |
| HUP9902755A2 (hu) | 2000-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO962527L (no) | Naftalenderivater, fremgangsmåter for deres fremstilling og mellomprodukter for dem | |
| DK0740668T3 (da) | Tetracykliske derivater, fremgangsmåde til deres fremstilling og deres anvendelse | |
| NO980720D0 (no) | Pyridazin-3-on-derivater, deres anvendelse og mellomprodukter for deres fremstilling | |
| NO993003D0 (no) | Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter | |
| AU6497600A (en) | Peracid forming system, peracid forming composition, and methods for making and using | |
| DK0966454T3 (da) | Disubstituerede bicykliske heterocykler, deres fremstilling og deres anvendelse som lægemidler | |
| DK0937055T3 (da) | Fremgangsmåde til fremstilling af d,I-alfa-tocopherol | |
| DK0950657T3 (da) | Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer | |
| NO996115D0 (no) | Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister | |
| NO990246L (no) | Akryloylsubstituert distamycinderivater, fremgangsmÕte til fremstilling av disse, og deres anvendelse som antitumor- og antivirusmidler | |
| DK0912509T3 (da) | Distamycinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som antitumor- og antivirale midler | |
| DK0795547T3 (da) | (Aminoalkyl- og acylaminoalkyl-oxy)benzyloxyquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse som bradyk | |
| NO982708D0 (no) | Nye fenylamidinderivater, fremgangsmÕte for fremstilling derav og deres anvendelse som legemidler | |
| NO20010219L (no) | Polycykliske tiazolidin-2-ylidenaminer, fremgangsmÕte for deres fremstilling og deres anvendelse som legemiddel | |
| DK1015433T3 (da) | Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oler, fremgangsmåder til fremstilling af disse og deres anvendelse som lægemidler | |
| NO983860D0 (no) | Nye triazolopuriner, fremgangsmÕte for fremstilling av dem og deres anvendelse som legemidler | |
| DK0727416T3 (da) | Substituerede benzensulfonylurinstoffer og -thiourinstoffer, og fremgangsmåde til deres fremstilling, deres anvendelse som | |
| NO951418D0 (no) | Peptidderivater, deres fremstilling og anvendelse som terapeutika | |
| NO984739D0 (no) | Spiro[cyklopent[b]indolpiperidiner og N-fenyl-hydrazon-mellomprodukter for deres fremstilling, hvor begge er acetylcholinesterase og MAO-inhibitorer | |
| DK0946579T3 (da) | Nye forbindelser afledt af erythromcin, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler | |
| DK1157020T3 (da) | Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-oler, fremgangsmåder til deres fremstilling og deres anvendelse som lægemiddel | |
| TR199800068A3 (tr) | Benzofenon türevlerinin hazirlanmasina yönelik metodlar. | |
| DK0915076T3 (da) | Fremgangsmåde til fremstilling af trans-(R,R)-actinol | |
| NO970682D0 (no) | Diarylalkanderivater inneholdende en alisyklisk gruppe, deres fremstilling og deres terapeutiske og profylaktiske bruk | |
| NO20020308D0 (no) | Fremgangsmåte for fremstilling av epothiolon B og derivater, såvel som mellomprodukter for fremgangsmåten |