DK0892802T3 - Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorer - Google Patents
Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorerInfo
- Publication number
- DK0892802T3 DK0892802T3 DK97908068T DK97908068T DK0892802T3 DK 0892802 T3 DK0892802 T3 DK 0892802T3 DK 97908068 T DK97908068 T DK 97908068T DK 97908068 T DK97908068 T DK 97908068T DK 0892802 T3 DK0892802 T3 DK 0892802T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclopent
- acetylcholinesterase
- piperidines
- spiro
- indole
- Prior art date
Links
- 102000012440 Acetylcholinesterase Human genes 0.000 title 1
- 108010022752 Acetylcholinesterase Proteins 0.000 title 1
- 229940022698 acetylcholinesterase Drugs 0.000 title 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 title 1
- 239000000544 cholinesterase inhibitor Substances 0.000 title 1
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical compound C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 title 1
- 125000003003 spiro group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63064196A | 1996-04-10 | 1996-04-10 | |
| PCT/US1997/003864 WO1997037992A2 (en) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indole-piperidines] and n-phenyl-hydrazon intermediates for their preparation, both being acetylcholinesterase and mao inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0892802T3 true DK0892802T3 (da) | 2003-12-01 |
Family
ID=24527997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97908068T DK0892802T3 (da) | 1996-04-10 | 1997-03-10 | Spiro[cyclopent[b]indol-piperidiner] og N-phenyl-hydrazon-mellemprodukter til deres fremstilling, begge som acetylcholinesterase- og mao-inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0892802B1 (da) |
| JP (1) | JP3615225B2 (da) |
| KR (1) | KR100270145B1 (da) |
| CN (1) | CN1233249A (da) |
| AR (1) | AR006553A1 (da) |
| AT (1) | ATE252581T1 (da) |
| AU (1) | AU708124B2 (da) |
| BR (1) | BR9708563A (da) |
| CA (1) | CA2251545C (da) |
| DE (1) | DE69725713T2 (da) |
| DK (1) | DK0892802T3 (da) |
| ES (1) | ES2207718T3 (da) |
| HU (1) | HUP9902755A3 (da) |
| IL (1) | IL126003A0 (da) |
| NO (1) | NO984739L (da) |
| PT (1) | PT892802E (da) |
| WO (1) | WO1997037992A2 (da) |
| ZA (1) | ZA972984B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891954A3 (en) | 1998-09-30 | 2009-01-14 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
| JP2013519722A (ja) | 2010-02-16 | 2013-05-30 | ファイザー・インク | （ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト |
| WO2017083867A1 (en) | 2015-11-12 | 2017-05-18 | Afasci, Inc. | Ion channel inhibitory compounds, pharmaceutical formulations and uses |
| WO2020048827A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 1, 3, 9-triazaspiro[5.5] undecan-2-one compounds |
| WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
| WO2020048829A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 3,9-diazaspiro[5.5]undecane compounds |
-
1997
- 1997-03-01 IL IL12600397A patent/IL126003A0/xx unknown
- 1997-03-10 HU HU9902755A patent/HUP9902755A3/hu unknown
- 1997-03-10 JP JP53619797A patent/JP3615225B2/ja not_active Expired - Fee Related
- 1997-03-10 DK DK97908068T patent/DK0892802T3/da active
- 1997-03-10 WO PCT/US1997/003864 patent/WO1997037992A2/en not_active Ceased
- 1997-03-10 DE DE69725713T patent/DE69725713T2/de not_active Expired - Fee Related
- 1997-03-10 AU AU19909/97A patent/AU708124B2/en not_active Ceased
- 1997-03-10 PT PT97908068T patent/PT892802E/pt unknown
- 1997-03-10 ES ES97908068T patent/ES2207718T3/es not_active Expired - Lifetime
- 1997-03-10 KR KR1019980708047A patent/KR100270145B1/ko not_active Expired - Fee Related
- 1997-03-10 BR BR9708563A patent/BR9708563A/pt not_active IP Right Cessation
- 1997-03-10 CA CA002251545A patent/CA2251545C/en not_active Expired - Fee Related
- 1997-03-10 AT AT97908068T patent/ATE252581T1/de not_active IP Right Cessation
- 1997-03-10 CN CN97193690A patent/CN1233249A/zh active Pending
- 1997-03-10 EP EP97908068A patent/EP0892802B1/en not_active Expired - Lifetime
- 1997-04-08 ZA ZA9702984A patent/ZA972984B/xx unknown
- 1997-04-08 AR ARP970101376A patent/AR006553A1/es not_active Application Discontinuation
-
1998
- 1998-10-09 NO NO984739A patent/NO984739L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9902755A2 (hu) | 2000-03-28 |
| IL126003A0 (en) | 1999-04-11 |
| ZA972984B (en) | 1997-11-03 |
| ES2207718T3 (es) | 2004-06-01 |
| CN1233249A (zh) | 1999-10-27 |
| KR20000005328A (ko) | 2000-01-25 |
| NO984739L (no) | 1998-12-09 |
| DE69725713D1 (de) | 2003-11-27 |
| PT892802E (pt) | 2004-03-31 |
| AU1990997A (en) | 1997-10-29 |
| HUP9902755A3 (en) | 2000-05-29 |
| CA2251545C (en) | 2002-01-08 |
| AR006553A1 (es) | 1999-09-08 |
| NO984739D0 (no) | 1998-10-09 |
| JP2002509520A (ja) | 2002-03-26 |
| EP0892802A1 (en) | 1999-01-27 |
| WO1997037992A2 (en) | 1997-10-16 |
| EP0892802B1 (en) | 2003-10-22 |
| DE69725713T2 (de) | 2004-05-13 |
| AU708124B2 (en) | 1999-07-29 |
| KR100270145B1 (ko) | 2000-11-01 |
| JP3615225B2 (ja) | 2005-02-02 |
| ATE252581T1 (de) | 2003-11-15 |
| CA2251545A1 (en) | 1997-10-16 |
| BR9708563A (pt) | 1999-08-03 |
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