NO985979L - 1,2,4-benzotiadiazinderivater, deres fremstilling og anvendelse - Google Patents

1,2,4-benzotiadiazinderivater, deres fremstilling og anvendelse

Info

Publication number
NO985979L
NO985979L NO985979A NO985979A NO985979L NO 985979 L NO985979 L NO 985979L NO 985979 A NO985979 A NO 985979A NO 985979 A NO985979 A NO 985979A NO 985979 L NO985979 L NO 985979L
Authority
NO
Norway
Prior art keywords
preparation
benzothiadiazine derivatives
compounds
benzothiadiazine
derivatives
Prior art date
Application number
NO985979A
Other languages
English (en)
Other versions
NO985979D0 (no
Inventor
Bernard Pirotte
Philippe Lebrun
Pascal De Tullio
Fabian Somers
Jacques Delarge
John Bondo Hansen
Flemming Elmelund Nielsen
Holger Claus Hansen
John Patrick Mogensen
Tina M Ller Tagmose
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO985979D0 publication Critical patent/NO985979D0/no
Publication of NO985979L publication Critical patent/NO985979L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1,2,4-benzotiadiazinderivater som har formel (I) b 12 hvor D, R1, R2, R3, R4, R5, R12, R13, R14 og R15 er definert i beskrivelsen, pre- parater derav og fremgangsmåter for fremstilling av forbindelsene er be- skrevet. Forbindelsene kan anvendes ved behandlingen av sykdommer i sentralner- vesystemet, det kardiovaskulære system, det pulmonale system, det gastrointes- tinale system og det endokrinologiske system.
NO985979A 1996-06-21 1998-12-18 1,2,4-benzotiadiazinderivater, deres fremstilling og anvendelse NO985979L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK69396 1996-06-21
DK145196 1996-12-19
PCT/DK1997/000266 WO1997049692A1 (en) 1996-06-21 1997-06-19 1,2,4-benzothiadiazine derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
NO985979D0 NO985979D0 (no) 1998-12-18
NO985979L true NO985979L (no) 1999-02-19

Family

ID=26064470

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985979A NO985979L (no) 1996-06-21 1998-12-18 1,2,4-benzotiadiazinderivater, deres fremstilling og anvendelse

Country Status (18)

Country Link
US (1) US6242443B1 (no)
EP (1) EP0906297B1 (no)
JP (1) JP2000512641A (no)
KR (1) KR20000022087A (no)
CN (1) CN1081633C (no)
AT (1) ATE260266T1 (no)
AU (1) AU737920B2 (no)
BR (1) BR9709858A (no)
CA (1) CA2258100A1 (no)
CZ (1) CZ413198A3 (no)
DE (1) DE69727806T2 (no)
ES (1) ES2216155T3 (no)
HU (1) HUP9904032A3 (no)
IL (1) IL127368A0 (no)
MX (1) MXPA98010773A (no)
NO (1) NO985979L (no)
PL (1) PL330815A1 (no)
WO (1) WO1997049692A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69832374D1 (de) * 1997-04-28 2005-12-22 Us Health Cyclin abhängige kinase(cdk)4 hemmer und deren verwendung zur behandlung von krebs
WO1999032467A1 (en) * 1997-12-19 1999-07-01 Novo Nordisk A/S 1,2,4-benzothiadiazine derivatives, their preparation and use
US6943159B1 (en) 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators
WO2002000223A1 (en) * 2000-06-26 2002-01-03 Novo Nordisk A/S Use of potassium channel agonists for reducing fat food comsumption
BR0207865A (pt) * 2001-02-14 2004-03-23 Warner Lambert Co Benzotiadiazinas inibidores de metaloproteinases de matriz
CA2536975A1 (en) 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
WO2006091716A2 (en) 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
JP5306194B2 (ja) * 2006-06-22 2013-10-02 アナディス ファーマシューティカルズ インク ピロ［１，２−ｂ］ピリダジノン化合物
WO2009134616A2 (en) * 2008-04-15 2009-11-05 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
EP2395987A1 (en) 2009-02-12 2011-12-21 Coöperatieve Mirzorg U.A., Arnhem Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
US20120100229A1 (en) * 2009-03-27 2012-04-26 Yale University Treatment and Prevention of White Matter Injury with KATP Channel Activators
TW201121968A (en) * 2009-11-09 2011-07-01 Intermune Inc Novel inhibitors of hepatitis C virus replication
WO2015117024A1 (en) 2014-01-31 2015-08-06 Mayo Foundation For Medical Education And Research Novel therapeutics for the treatment of glaucoma
WO2017098421A1 (en) * 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
EP3813824B1 (en) * 2018-05-11 2025-07-02 University of Florida Research Foundation, Incorporated Use of myelination stimulator compounds
NL2022291B1 (en) * 2018-12-21 2020-07-21 Academisch Ziekenhuis Leiden Compound for Use in Treatment and Prevention of Type I Diabetes
AU2020266529B2 (en) 2019-04-29 2026-01-29 Solent Therapeutics, Llc 3-amino-4H-benzo[E][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2
CA3159771A1 (en) 2019-12-12 2021-06-17 Thurein M. Htoo Controlled-delivery cromakalim prodrugs
CN110903264B (zh) * 2019-12-26 2021-06-18 苏州大学 一种制备二氮嗪的方法
US20230219912A1 (en) * 2020-05-19 2023-07-13 Board Of Regents Of The University Of Nebraska Halogenated benzothiadiazines for the treatment of cancer
CN120530097A (zh) * 2022-10-18 2025-08-22 节奏制药公司 新颖的atp敏感性钾通道增效剂、其制备和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3269906A (en) 1966-08-30 Imino-j,x-dihydro-l,z,x-benzothiadiazine- i,i-dioxides
GB847176A (en) * 1958-06-20 1960-09-07 Lepetit Spa Benzothiadiazine compounds
DE2548283A1 (de) * 1974-10-29 1976-05-06 Dainippon Pharmaceutical Co 1,2,4-benzothiadiazin-1,1-dioxidderivate
SE402773B (sv) 1976-04-20 1978-07-17 Dainippon Pharmaceutical Co Forfarande for framstellning av 1,2,4-bensotiadiazin-1,1-dioxid-derivat
DE2757925A1 (de) * 1977-12-24 1979-06-28 Bayer Ag Diazacyclo-1.2.4-benzothiadizine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2757922A1 (de) * 1977-12-24 1979-06-28 Bayer Ag Substituierte alkylenamino-1.2.4- benzothiadizine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
ES2216155T3 (es) 2004-10-16
JP2000512641A (ja) 2000-09-26
CN1222910A (zh) 1999-07-14
PL330815A1 (en) 1999-06-07
DE69727806D1 (de) 2004-04-01
IL127368A0 (en) 1999-10-28
ATE260266T1 (de) 2004-03-15
AU3166497A (en) 1998-01-14
NO985979D0 (no) 1998-12-18
HUP9904032A3 (en) 2001-11-28
CZ413198A3 (cs) 1999-06-16
DE69727806T2 (de) 2005-01-13
CA2258100A1 (en) 1997-12-31
HUP9904032A2 (hu) 2000-03-28
BR9709858A (pt) 1999-08-10
MXPA98010773A (es) 2002-06-11
KR20000022087A (ko) 2000-04-25
EP0906297A1 (en) 1999-04-07
CN1081633C (zh) 2002-03-27
AU737920B2 (en) 2001-09-06
WO1997049692A1 (en) 1997-12-31
US6242443B1 (en) 2001-06-05
EP0906297B1 (en) 2004-02-25

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