NO990227L - Heterocykliske forbindelser som farmas°ytika - Google Patents

Heterocykliske forbindelser som farmas°ytika

Info

Publication number
NO990227L
NO990227L NO990227A NO990227A NO990227L NO 990227 L NO990227 L NO 990227L NO 990227 A NO990227 A NO 990227A NO 990227 A NO990227 A NO 990227A NO 990227 L NO990227 L NO 990227L
Authority
NO
Norway
Prior art keywords
group
substituted
compound
alkyl
unsubstituted
Prior art date
Application number
NO990227A
Other languages
English (en)
Other versions
NO990227D0 (no
Inventor
David Haigh
John Thomas Sime
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929214185A external-priority patent/GB9214185D0/en
Priority claimed from GB929227030A external-priority patent/GB9227030D0/en
Priority claimed from GB939311027A external-priority patent/GB9311027D0/en
Publication of NO990227L publication Critical patent/NO990227L/no
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO990227D0 publication Critical patent/NO990227D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En forbindelse med formel (I): A1-/- (CH2) n-A2-A3-Y.R2 eller en tautomer form derav og/eller et farmasøytisk aksepta- belt salt derav, og/eller et farmasøytisk akseptabelt solvat derav, hvori: A1 representerer en substituert eller ikke- substituert aromatisk heterocyklylgruppe; A2 representerer en benzenring som har tre eventuelle substituenter; A3 represente- rer en gruppe med formelen - (CH^-CHfOR1) - hvor R1 represente- rer substituert eller usubstituert alkyl, aryl, aralkyl eller alkylkarbonyl og m representerer et helt tall i området fra l til 5, eller A3 representerer en gruppe med formelen - (CH ) -CH=C(OR1}- hvor R1 og m er som definert ovenfor; R2 representerer OR3 hvor R3 representerer hydrogen, alkyl, aryl eller aralkyl eller R2 representerer en aromatisk hetero- cyklylgruppe eller -NR4R5 hvor R4 og R5 begge uavhengig repre- senterer hydrogen, alkyl eller alkylkarbonyl eller R4 og R5 sammen med det nitrogenatom som de er bundet til, danner en heterocyklisk ring, under forutsetning av at R2 representerer en aromatisk heterocyklylgruppe bare når Y som definert neden- for representerer en binding; X representerer NR hvor R repre- senterer et hydrogenatom, en alkylgruppe, en acylgruppe, en aralkylgruppe, hvor arylgruppen kan være substituert eller usubstituert, eller en substituert eller usubstituert aryl- gruppe; Y representerer CO eller CS eller en binding forut- satt at Y representerer en binding bare når R2 representerer den ovenfornevnte aromatiske heterocyklylgruppe; og n representerer et helt tall i området fra 2 til 6; en frem- gangsmåte for fremstilling av en slik forbindelse, et preparat omfattende en slik forbindelse og anvendelse av en slik for- bindelse og preparat i medisinen.
NO990227A 1992-07-03 1999-01-19 Heterocykliske forbindelser som farmas°ytika NO990227D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929214185A GB9214185D0 (en) 1992-07-03 1992-07-03 Novel compounds
GB929227030A GB9227030D0 (en) 1992-12-29 1992-12-29 Novel compounds
GB939311027A GB9311027D0 (en) 1993-05-28 1993-05-28 Novel compounds
PCT/GB1993/001363 WO1994001420A1 (en) 1992-07-03 1993-06-29 Heterocyclic compounds as pharmaceutical

Publications (2)

Publication Number Publication Date
NO990227L true NO990227L (no) 1995-03-02
NO990227D0 NO990227D0 (no) 1999-01-19

Family

ID=27266276

Family Applications (2)

Application Number Title Priority Date Filing Date
NO950009A NO305318B1 (no) 1992-07-03 1995-01-02 Heterocykliske forbindelser og anvendelser derav
NO990227A NO990227D0 (no) 1992-07-03 1999-01-19 Heterocykliske forbindelser som farmas°ytika

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO950009A NO305318B1 (no) 1992-07-03 1995-01-02 Heterocykliske forbindelser og anvendelser derav

Country Status (19)

Country Link
US (2) US6048883A (no)
EP (2) EP0648212B1 (no)
JP (1) JPH07508747A (no)
KR (1) KR950702545A (no)
CN (2) CN1042532C (no)
AT (1) ATE207470T1 (no)
AU (1) AU678974B2 (no)
CA (1) CA2139442A1 (no)
CZ (1) CZ1095A3 (no)
DE (1) DE69331010D1 (no)
FI (1) FI950016A7 (no)
HU (1) HUT71247A (no)
MX (1) MX9303981A (no)
NO (2) NO305318B1 (no)
NZ (1) NZ253742A (no)
PL (2) PL176885B1 (no)
RU (1) RU2134686C1 (no)
SK (1) SK695A3 (no)
WO (1) WO1994001420A1 (no)

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Also Published As

Publication number Publication date
PL174610B1 (pl) 1998-08-31
PL307087A1 (en) 1995-05-02
ATE207470T1 (de) 2001-11-15
RU2134686C1 (ru) 1999-08-20
JPH07508747A (ja) 1995-09-28
NO990227D0 (no) 1999-01-19
CN1095716A (zh) 1994-11-30
FI950016A7 (fi) 1995-03-02
PL176885B1 (pl) 1999-08-31
HU9500006D0 (en) 1995-03-28
WO1994001420A1 (en) 1994-01-20
US6048883A (en) 2000-04-11
HUT71247A (en) 1995-11-28
CN1042532C (zh) 1999-03-17
EP1000938A1 (en) 2000-05-17
US5869495A (en) 1999-02-09
KR950702545A (ko) 1995-07-29
AU678974B2 (en) 1997-06-19
NZ253742A (en) 1997-06-24
NO950009L (no) 1995-03-02
CZ1095A3 (en) 1995-10-18
EP0648212A1 (en) 1995-04-19
MX9303981A (es) 1994-04-29
AU4506893A (en) 1994-01-31
FI950016A0 (fi) 1995-01-02
DE69331010D1 (de) 2001-11-29
CA2139442A1 (en) 1994-01-20
SK695A3 (en) 1995-07-11
RU94046169A (ru) 1996-10-27
NO305318B1 (no) 1999-05-10
CN1215724A (zh) 1999-05-05
EP0648212B1 (en) 2001-10-24
NO950009D0 (no) 1995-01-02

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