NO990472D0 - Fluorholdige 1,4-disubstituerte piperidinderivater - Google Patents

Fluorholdige 1,4-disubstituerte piperidinderivater

Info

Publication number
NO990472D0
NO990472D0 NO990472A NO990472A NO990472D0 NO 990472 D0 NO990472 D0 NO 990472D0 NO 990472 A NO990472 A NO 990472A NO 990472 A NO990472 A NO 990472A NO 990472 D0 NO990472 D0 NO 990472D0
Authority
NO
Norway
Prior art keywords
fluorine
piperidine derivatives
disubstituted piperidine
disubstituted
derivatives
Prior art date
Application number
NO990472A
Other languages
English (en)
Norwegian (no)
Other versions
NO990472L (no
Inventor
Yoshimi Tsuchiya
Takashi Nomoto
Hirokazu Ohsawa
Kumiko Kawakami
Kenji Ohwaki
Masaru Nishikibe
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of NO990472L publication Critical patent/NO990472L/no
Publication of NO990472D0 publication Critical patent/NO990472D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO990472A 1996-08-01 1999-02-01 Fluorholdige 1,4-disubstituerte piperidinderivater NO990472D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21943696 1996-08-01
JP5397997 1997-02-21
PCT/JP1997/002600 WO1998005641A1 (fr) 1996-08-01 1997-07-28 Derives de piperidine fluores a disubstitution en position 1,4

Publications (2)

Publication Number Publication Date
NO990472L NO990472L (no) 1999-02-01
NO990472D0 true NO990472D0 (no) 1999-02-01

Family

ID=26394715

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990472A NO990472D0 (no) 1996-08-01 1999-02-01 Fluorholdige 1,4-disubstituerte piperidinderivater

Country Status (29)

Country Link
US (2) US5948792A (fr)
EP (1) EP0930298B1 (fr)
JP (1) JP3063164B2 (fr)
KR (1) KR20000022214A (fr)
CN (1) CN1226888A (fr)
AR (3) AR008272A1 (fr)
AT (1) ATE229941T1 (fr)
AU (1) AU716050B2 (fr)
BG (1) BG103114A (fr)
BR (1) BR9711108A (fr)
CA (1) CA2261680C (fr)
CO (1) CO4960641A1 (fr)
CZ (1) CZ33199A3 (fr)
DE (1) DE69718026T2 (fr)
EE (1) EE9900038A (fr)
ES (1) ES2188961T3 (fr)
HR (1) HRP970426A2 (fr)
HU (1) HUP9902381A3 (fr)
ID (1) ID17259A (fr)
IL (1) IL127685A0 (fr)
IS (1) IS4960A (fr)
NO (1) NO990472D0 (fr)
NZ (1) NZ333842A (fr)
PE (1) PE92198A1 (fr)
PL (1) PL331431A1 (fr)
SK (1) SK12299A3 (fr)
TR (2) TR199900204T2 (fr)
WO (1) WO1998005641A1 (fr)
YU (1) YU1299A (fr)

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WO2000061572A1 (fr) * 1999-04-08 2000-10-19 Merck & Co., Inc. Preparation diastereoselective d'adduits de michael
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WO2001013918A1 (fr) * 1999-08-23 2001-03-01 H. Lundbeck A/S Traitement de l'incontinence urinaire
DE60021282T2 (de) 1999-12-07 2006-05-18 Theravance, Inc., South San Francisco Carbamat-derivate als muscarin-rezeptor antonisten
UA73543C2 (uk) 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
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US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
US6469172B2 (en) 2000-03-08 2002-10-22 Merck & Co., Inc. Process for the preparation of chemical compounds
US6403584B1 (en) * 2000-06-22 2002-06-11 Merck & Co., Inc. Substituted nipecotyl derivatives as inhibitors of cell adhesion
EP1302458A4 (fr) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd Derives d'ester
NZ526580A (en) 2000-12-22 2005-04-29 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
DE60121813T2 (de) * 2000-12-28 2007-09-20 Almirall Ag Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
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ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh) 2002-07-31 2006-04-13 Ranbaxy Laboratories Limited 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
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EP1534675B1 (fr) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Derives d'azabicyclo(3.1.0)hexanes 3,6-disubstitues contenant fluoro et sulfonylamino, utilises comme antagonistes des recepteurs de muscarine
JP2006506392A (ja) * 2002-10-29 2006-02-23 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ムスカリン受容体アンタゴニストとしての第四級アンモニウム化合物
TWI295669B (en) 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
ATE400553T1 (de) * 2002-12-10 2008-07-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
AU2003303041B2 (en) 2002-12-13 2008-07-24 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
DE60225195T2 (de) 2002-12-23 2009-02-26 Ranbaxy Laboratories, Ltd. Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) * 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1618091A1 (fr) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EA009059B1 (ru) 2003-04-10 2007-10-26 Рэнбакси Лабораториз Лимитед Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
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BRPI0418212A (pt) * 2003-12-29 2007-04-27 Banyu Pharma Co Ltd composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidade
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US20080262075A1 (en) * 2004-08-19 2008-10-23 Ranbaxy Laboratories Limited Pyrrolidine Derivatives as Muscarinic Receptor Antagonists
WO2006032994A2 (fr) * 2004-09-24 2006-03-30 Ranbaxy Laboratories Limited Antagonistes des recepteurs muscariniques
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WO2007037534A1 (fr) * 2005-09-30 2007-04-05 Banyu Pharmaceutical Co., Ltd. Derive indole substitue en position 2 par un groupe heteroaryle
WO2007039884A1 (fr) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited Dérivés de 3 -azabicyclooctane en tant qu’antagonistes de récepteurs muscariniques
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JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US20090010923A1 (en) * 2007-04-24 2009-01-08 University Of Maryland, Baltimore Treatment of cancer with anti-muscarinic receptor agents
JP5656288B2 (ja) * 2007-09-07 2015-01-21 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物
BRPI0820819B1 (pt) * 2007-12-21 2021-06-08 F. Hoffmann-La Roche Ag formulação de anticorpos humanizados b-ly 1 e seu uso
CN104876854B (zh) * 2015-04-16 2017-03-01 御盛隆堂药业有限责任公司 羟基乙酸酯衍生物及其用途

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Also Published As

Publication number Publication date
AR016877A2 (es) 2001-08-01
EP0930298B1 (fr) 2002-12-18
AU3635197A (en) 1998-02-25
HUP9902381A2 (hu) 1999-11-29
AR017021A1 (es) 2001-08-22
DE69718026T2 (de) 2003-07-10
CA2261680C (fr) 2005-03-08
EE9900038A (et) 1999-08-16
NO990472L (no) 1999-02-01
PE92198A1 (es) 1999-01-09
AR008272A1 (es) 1999-12-29
TR199900204T2 (xx) 2000-01-21
PL331431A1 (en) 1999-07-19
WO1998005641A1 (fr) 1998-02-12
HUP9902381A3 (en) 2000-06-28
CN1226888A (zh) 1999-08-25
IL127685A0 (en) 1999-10-28
HRP970426A2 (en) 1998-08-31
YU1299A (sh) 2002-03-18
SK12299A3 (en) 2000-05-16
BG103114A (en) 1999-11-30
IS4960A (is) 1999-01-29
AU716050B2 (en) 2000-02-17
JP3063164B2 (ja) 2000-07-12
BR9711108A (pt) 1999-08-17
US6040449A (en) 2000-03-21
NZ333842A (en) 2001-05-25
TR200001482T2 (tr) 2000-11-21
US5948792A (en) 1999-09-07
ES2188961T3 (es) 2003-07-01
CO4960641A1 (es) 2000-09-25
ID17259A (id) 1997-12-11
EP0930298A4 (fr) 2000-06-07
ATE229941T1 (de) 2003-01-15
DE69718026D1 (de) 2003-01-30
CZ33199A3 (cs) 1999-07-14
EP0930298A1 (fr) 1999-07-21
KR20000022214A (ko) 2000-04-25
CA2261680A1 (fr) 1998-02-12

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