NO991230L - Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer - Google Patents

Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer

Info

Publication number: NO991230L
Authority: NO; Norway
Prior art keywords: inhibition; treatment; proliferative diseases; protein function; tricyclic compounds
Prior art date: 1996-09-13

Application number

NO991230A

Other languages

English (en)

Norwegian (no)

Other versions

NO991230D0 (no

Inventor

Dinanath F Rane

Alan K Mallams

Arthur G Taveras

F George Njoroge

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1999-03-12

Publication date

1999-05-14

1999-03-12 Application filed by Schering Corp filed Critical Schering Corp

1999-03-12 Publication of NO991230D0 publication Critical patent/NO991230D0/no

1999-05-14 Publication of NO991230L publication Critical patent/NO991230L/no

Links

150000001875 compounds Chemical class 0.000 title abstract 3
108091006027 G proteins Proteins 0.000 title 1
102000030782 GTP binding Human genes 0.000 title 1
108091000058 GTP-Binding Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
230000002062 proliferating effect Effects 0.000 title 1
230000004853 protein function Effects 0.000 title 1
102000007317 Farnesyltranstransferase Human genes 0.000 abstract 1
108010007508 Farnesyltranstransferase Proteins 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940121649 protein inhibitor Drugs 0.000 abstract 1
239000012268 protein inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO991230A 1996-09-13 1999-03-12 Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer NO991230L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71332696A	1996-09-13	1996-09-13
PCT/US1997/015900 WO1998011096A1 (fr)	1996-09-13	1997-09-11	Composes tricycliques inhibant la fonction de la proteine g et traitant les maladies proliferantes

Publications (2)

Publication Number	Publication Date
NO991230D0 NO991230D0 (no)	1999-03-12
NO991230L true NO991230L (no)	1999-05-14

Family

ID=24865700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO991230A NO991230L (no)	1996-09-13	1999-03-12	Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer

Country Status (20)

Country	Link
EP (1)	EP0927178B1 (fr)
JP (1)	JP3152438B2 (fr)
KR (1)	KR20000036059A (fr)
CN (1)	CN1237169A (fr)
AT (1)	ATE213736T1 (fr)
AU (1)	AU729810B2 (fr)
BR (1)	BR9712819A (fr)
CA (1)	CA2264569C (fr)
CZ (1)	CZ83499A3 (fr)
DE (1)	DE69710741T2 (fr)
ES (1)	ES2169420T3 (fr)
HU (1)	HUP9904067A2 (fr)
ID (1)	ID22045A (fr)
IL (1)	IL128949A0 (fr)
NO (1)	NO991230L (fr)
NZ (1)	NZ334340A (fr)
PL (1)	PL332240A1 (fr)
SK (1)	SK33199A3 (fr)
TR (1)	TR199900561T2 (fr)
WO (1)	WO1998011096A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (fr)	1998-01-21	1999-07-29	Yoshisuke Nakasato	Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
AU2331999A (en)	1998-01-21	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
WO2005017160A2 (fr)	2003-08-13	2005-02-24	Children's Hospital Medical Center	Mobilisation de cellules hematopoietques
WO2007002254A2 (fr)	2005-06-23	2007-01-04	Merck & Co., Inc.	Benzocycloheptapyridines utilises comme inhibiteurs de la tyrosine kinase receptrice met
TW200813021A (en)	2006-07-10	2008-03-16	Merck & Co Inc	Tyrosine kinase inhibitors
TW201024283A (en)	2008-12-01	2010-07-01	Targacept Inc	Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
US11014912B2 (en)	2016-09-27	2021-05-25	Mission Therapeutics Limited	Cyanopyrrolidine derivatives with activity as inhibitors of USP30

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (fr) *	1993-10-15	2002-02-12	W. Robert Bishop	Composes carbamates tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
IL111257A0 (en) *	1993-10-15	1994-12-29	Schering Corp	Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-09-11 BR BR9712819-8A patent/BR9712819A/pt unknown
- 1997-09-11 CN CN97199586A patent/CN1237169A/zh active Pending
- 1997-09-11 HU HU9904067A patent/HUP9904067A2/hu unknown
- 1997-09-11 CA CA002264569A patent/CA2264569C/fr not_active Expired - Fee Related
- 1997-09-11 SK SK331-99A patent/SK33199A3/sk unknown
- 1997-09-11 WO PCT/US1997/015900 patent/WO1998011096A1/fr not_active Ceased
- 1997-09-11 AT AT97941474T patent/ATE213736T1/de not_active IP Right Cessation
- 1997-09-11 ID IDW990090D patent/ID22045A/id unknown
- 1997-09-11 DE DE69710741T patent/DE69710741T2/de not_active Expired - Fee Related
- 1997-09-11 AU AU43373/97A patent/AU729810B2/en not_active Ceased
- 1997-09-11 JP JP51375998A patent/JP3152438B2/ja not_active Expired - Fee Related
- 1997-09-11 PL PL97332240A patent/PL332240A1/xx unknown
- 1997-09-11 KR KR1019997002062A patent/KR20000036059A/ko not_active Withdrawn
- 1997-09-11 EP EP97941474A patent/EP0927178B1/fr not_active Expired - Lifetime
- 1997-09-11 TR TR1999/00561T patent/TR199900561T2/xx unknown
- 1997-09-11 CZ CZ99834A patent/CZ83499A3/cs unknown
- 1997-09-11 ES ES97941474T patent/ES2169420T3/es not_active Expired - Lifetime
- 1997-09-11 IL IL12894997A patent/IL128949A0/xx unknown
- 1997-09-11 NZ NZ334340A patent/NZ334340A/xx unknown
1999
- 1999-03-12 NO NO991230A patent/NO991230L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20000036059A (ko)	2000-06-26
ID22045A (id)	1999-08-26
HUP9904067A2 (hu)	2000-05-28
SK33199A3 (en)	1999-12-10
DE69710741T2 (de)	2002-10-24
JP3152438B2 (ja)	2001-04-03
JP2000502727A (ja)	2000-03-07
DE69710741D1 (de)	2002-04-04
WO1998011096A1 (fr)	1998-03-19
PL332240A1 (en)	1999-08-30
CA2264569A1 (fr)	1998-03-19
NO991230D0 (no)	1999-03-12
EP0927178A1 (fr)	1999-07-07
CA2264569C (fr)	2003-11-11
NZ334340A (en)	2000-09-29
CN1237169A (zh)	1999-12-01
EP0927178B1 (fr)	2002-02-27
HK1018267A1 (en)	1999-12-17
IL128949A0 (en)	2000-02-17
ATE213736T1 (de)	2002-03-15
TR199900561T2 (xx)	1999-06-21
BR9712819A (pt)	1999-11-23
AU729810B2 (en)	2001-02-08
ES2169420T3 (es)	2002-07-01
CZ83499A3 (cs)	1999-07-14
AU4337397A (en)	1998-04-02

Legal Events

Date	Code	Title	Description
2002-06-10	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO992492L (no)	1999-05-25	Benzamidoaldehyder og deres anvendelse som cystein-protease-inhibitorer
ES2193362T3 (es)	2003-11-01	Derivados de 2-pirimidinamina y su procedimiento de preparacion de los mismos.
DK0657458T3 (da)	2001-10-29	Inhibitorer af proteinkinase-C
NO20075066L (no)	1999-02-26	Farmasoytisk sammensetning som inneholder isoflavoner
TR199800759T2 (xx)	2001-01-22	Protein Kinaz C �nhibit�r�.
NO990667D0 (no)	1999-02-12	Depeptid-benzamidin som kinogenase-inhibitor
DK0767800T3 (da)	2001-06-18	Histidin- og homohistidinderivater som inhibitorer af protein farnesyltransferase
ATE200677T1 (de)	2001-05-15	Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase
NO996269L (no)	2000-02-16	Kinolin-indol antimikrobielle midler, samt anvendelse og blandinger derav
NO20025821L (no)	2003-02-04	2-aminokarbonyl-9H-purinderivater
NO992821L (no)	1999-06-11	Ketobenzamider som calpain-inhibitorer
NO991230L (no)	1999-05-14	Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer
GEP20032896B (en)	2003-02-25	4-Aminothiazole Derivatives, Containing Them Pharmaceutical Compositions Inhibiting Cyclin-Dependent Kinases and Methods for Treatment
IL127574A0 (en)	1999-10-28	Inhibitors of prenyl transferases
CA2244777A1 (fr)	1997-08-07	Derives de 2,3-benzodiazepine et leur utilisation comme inhibiteurs de recepteurs d'ampa
WO2000040583A3 (fr)	2000-09-21	Derives d'imidazo[4,5-c]pyridine-4-one
MXPA04005809A (es)	2004-09-13	Inhibidores de proteinas quinasas.
PL326554A1 (en)	1998-09-28	Derivatives of amine and thiourea and inhibitors of nitrogen oxide synthase
BG103271A (en)	2000-05-31	Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
NO973242L (no)	1997-07-11	Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av idiopatisk eller fysiologisk gynekomasti
AU2001230180A1 (en)	2001-07-24	Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
DK0982308T3 (da)	2003-05-12	Derivater af 8H-[2,3-b]pyrrolizin-8-on, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, som indeholder disse
HUP0000126A2 (hu)	2001-04-28	Farnezil-protein-transzferáz inhibitorként alkalmazható szubsztituált benzo-ciklohepta-piridin-származékok