SK33199A3 - Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases - Google Patents

Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases Download PDF

Info

Publication number: SK33199A3
Authority: SK; Slovakia
Prior art keywords: alkyl; group; aryl; tumor cells; mixture
Prior art date: 1996-09-13

Application number

SK331-99A

Other languages

English (en)

Slovak (sk)

Inventor

Dinanath F Rane

Alan K Mallams

Arthur G Taveras

F George Njoroge

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-13

Filing date

1997-09-11

Publication date

1999-12-10

1997-09-11 Application filed by Schering Corp filed Critical Schering Corp

1999-12-10 Publication of SK33199A3 publication Critical patent/SK33199A3/sk

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK331-99A 1996-09-13 1997-09-11 Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases SK33199A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71332696A	1996-09-13	1996-09-13
PCT/US1997/015900 WO1998011096A1 (fr)	1996-09-13	1997-09-11	Composes tricycliques inhibant la fonction de la proteine g et traitant les maladies proliferantes

Publications (1)

Publication Number	Publication Date
SK33199A3 true SK33199A3 (en)	1999-12-10

Family

ID=24865700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK331-99A SK33199A3 (en)	1996-09-13	1997-09-11	Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Country Status (20)

Country	Link
EP (1)	EP0927178B1 (fr)
JP (1)	JP3152438B2 (fr)
KR (1)	KR20000036059A (fr)
CN (1)	CN1237169A (fr)
AT (1)	ATE213736T1 (fr)
AU (1)	AU729810B2 (fr)
BR (1)	BR9712819A (fr)
CA (1)	CA2264569C (fr)
CZ (1)	CZ83499A3 (fr)
DE (1)	DE69710741T2 (fr)
ES (1)	ES2169420T3 (fr)
HU (1)	HUP9904067A2 (fr)
ID (1)	ID22045A (fr)
IL (1)	IL128949A0 (fr)
NO (1)	NO991230L (fr)
NZ (1)	NZ334340A (fr)
PL (1)	PL332240A1 (fr)
SK (1)	SK33199A3 (fr)
TR (1)	TR199900561T2 (fr)
WO (1)	WO1998011096A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (fr)	1998-01-21	1999-07-29	Yoshisuke Nakasato	Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
AU2331999A (en)	1998-01-21	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en)	1998-09-04	2001-09-11	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en)	1998-09-04	2003-01-07	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en)	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en)	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
WO2005017160A2 (fr)	2003-08-13	2005-02-24	Children's Hospital Medical Center	Mobilisation de cellules hematopoietques
WO2007002254A2 (fr)	2005-06-23	2007-01-04	Merck & Co., Inc.	Benzocycloheptapyridines utilises comme inhibiteurs de la tyrosine kinase receptrice met
TW200813021A (en)	2006-07-10	2008-03-16	Merck & Co Inc	Tyrosine kinase inhibitors
TW201024283A (en)	2008-12-01	2010-07-01	Targacept Inc	Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
US11014912B2 (en)	2016-09-27	2021-05-25	Mission Therapeutics Limited	Cyanopyrrolidine derivatives with activity as inhibitors of USP30

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111235A (en) *	1993-10-15	2001-03-19	Schering Plough Corp	Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (fr) *	1993-10-15	2002-02-12	W. Robert Bishop	Composes carbamates tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
IL111257A0 (en) *	1993-10-15	1994-12-29	Schering Corp	Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

1997
- 1997-09-11 BR BR9712819-8A patent/BR9712819A/pt unknown
- 1997-09-11 CN CN97199586A patent/CN1237169A/zh active Pending
- 1997-09-11 HU HU9904067A patent/HUP9904067A2/hu unknown
- 1997-09-11 CA CA002264569A patent/CA2264569C/fr not_active Expired - Fee Related
- 1997-09-11 SK SK331-99A patent/SK33199A3/sk unknown
- 1997-09-11 WO PCT/US1997/015900 patent/WO1998011096A1/fr not_active Ceased
- 1997-09-11 AT AT97941474T patent/ATE213736T1/de not_active IP Right Cessation
- 1997-09-11 ID IDW990090D patent/ID22045A/id unknown
- 1997-09-11 DE DE69710741T patent/DE69710741T2/de not_active Expired - Fee Related
- 1997-09-11 AU AU43373/97A patent/AU729810B2/en not_active Ceased
- 1997-09-11 JP JP51375998A patent/JP3152438B2/ja not_active Expired - Fee Related
- 1997-09-11 PL PL97332240A patent/PL332240A1/xx unknown
- 1997-09-11 KR KR1019997002062A patent/KR20000036059A/ko not_active Withdrawn
- 1997-09-11 EP EP97941474A patent/EP0927178B1/fr not_active Expired - Lifetime
- 1997-09-11 TR TR1999/00561T patent/TR199900561T2/xx unknown
- 1997-09-11 CZ CZ99834A patent/CZ83499A3/cs unknown
- 1997-09-11 ES ES97941474T patent/ES2169420T3/es not_active Expired - Lifetime
- 1997-09-11 IL IL12894997A patent/IL128949A0/xx unknown
- 1997-09-11 NZ NZ334340A patent/NZ334340A/xx unknown
1999
- 1999-03-12 NO NO991230A patent/NO991230L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20000036059A (ko)	2000-06-26
ID22045A (id)	1999-08-26
HUP9904067A2 (hu)	2000-05-28
DE69710741T2 (de)	2002-10-24
JP3152438B2 (ja)	2001-04-03
JP2000502727A (ja)	2000-03-07
DE69710741D1 (de)	2002-04-04
WO1998011096A1 (fr)	1998-03-19
PL332240A1 (en)	1999-08-30
CA2264569A1 (fr)	1998-03-19
NO991230D0 (no)	1999-03-12
EP0927178A1 (fr)	1999-07-07
CA2264569C (fr)	2003-11-11
NZ334340A (en)	2000-09-29
CN1237169A (zh)	1999-12-01
NO991230L (no)	1999-05-14
EP0927178B1 (fr)	2002-02-27
HK1018267A1 (en)	1999-12-17
IL128949A0 (en)	2000-02-17
ATE213736T1 (de)	2002-03-15
TR199900561T2 (xx)	1999-06-21
BR9712819A (pt)	1999-11-23
AU729810B2 (en)	2001-02-08
ES2169420T3 (es)	2002-07-01
CZ83499A3 (cs)	1999-07-14
AU4337397A (en)	1998-04-02

Publication	Publication Date	Title
ES2235252T3 (es)	2005-07-01	Inhibidores triciclicos de la farnesil proteina transferasa.
SK33199A3 (en)	1999-12-10	Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1998057946A1 (fr)	1998-12-23	Composes tricycliques de carboxy piperidylacetamide utilises pour inhiber une fonction g-proteine et traiter des maladies proliferatives (inhibiteurs de farnesyl proteine transferase)
EP0934303B1 (fr)	2004-12-29	Composes servant a inhiber la farnesyl proteine transferase
CA2293712C (fr)	2004-01-06	Urees cycliques benzo(5,6)cycloheptapyridine et lactames utiles comme inhibiteurs de farnesyl proteine transferase
SK33599A3 (en)	2000-03-13	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
WO1998057947A1 (fr)	1998-12-23	Derives tricycliques de ceto-amides s'utilisant comme inhibiteurs de la transferase de proteine de farnesyl
US5958890A (en)	1999-09-28	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
CA2293373C (fr)	2008-09-23	Derives de benzo(5,6)cyclohepta(1,2b)pyridine s'utilisant comme inhibiteurs de transferase de proteine de farnesyl
ES2205255T3 (es)	2004-05-01	Derivados de benzocicloheptapiridina sustituida utiles para inhibir la farnesil-protein-transferasa.
CA2293549C (fr)	2008-08-05	Composes tricycliques substitues de phenyle servant a inhiber la farnesyl-proteine transferase
CA2264511C (fr)	2003-08-05	Composes utiles pour inhiber la farnesyl-proteine transferase
HK1018267B (en)	2002-07-05	Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
MXPA99012066A (en)	2000-09-04	Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors