ATE213736T1 - Tricyclische verbindungen zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen - Google Patents

Tricyclische verbindungen zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen

Info

Publication number
ATE213736T1
ATE213736T1 AT97941474T AT97941474T ATE213736T1 AT E213736 T1 ATE213736 T1 AT E213736T1 AT 97941474 T AT97941474 T AT 97941474T AT 97941474 T AT97941474 T AT 97941474T AT E213736 T1 ATE213736 T1 AT E213736T1
Authority
AT
Austria
Prior art keywords
inhibiting
proliferative diseases
protein function
tricyclic compounds
treating proliferative
Prior art date
Application number
AT97941474T
Other languages
German (de)
English (en)
Inventor
Dinanath F Rane
Alan K Mallams
Arthur G Taveras
F George Njoroge
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE213736T1 publication Critical patent/ATE213736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97941474T 1996-09-13 1997-09-11 Tricyclische verbindungen zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen ATE213736T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332696A 1996-09-13 1996-09-13
PCT/US1997/015900 WO1998011096A1 (fr) 1996-09-13 1997-09-11 Composes tricycliques inhibant la fonction de la proteine g et traitant les maladies proliferantes

Publications (1)

Publication Number Publication Date
ATE213736T1 true ATE213736T1 (de) 2002-03-15

Family

ID=24865700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97941474T ATE213736T1 (de) 1996-09-13 1997-09-11 Tricyclische verbindungen zur inhibierung der g- protein funktion und für die behandlung von proliferativen erkrankungen

Country Status (20)

Country Link
EP (1) EP0927178B1 (fr)
JP (1) JP3152438B2 (fr)
KR (1) KR20000036059A (fr)
CN (1) CN1237169A (fr)
AT (1) ATE213736T1 (fr)
AU (1) AU729810B2 (fr)
BR (1) BR9712819A (fr)
CA (1) CA2264569C (fr)
CZ (1) CZ83499A3 (fr)
DE (1) DE69710741T2 (fr)
ES (1) ES2169420T3 (fr)
HU (1) HUP9904067A2 (fr)
ID (1) ID22045A (fr)
IL (1) IL128949A0 (fr)
NO (1) NO991230L (fr)
NZ (1) NZ334340A (fr)
PL (1) PL332240A1 (fr)
SK (1) SK33199A3 (fr)
TR (1) TR199900561T2 (fr)
WO (1) WO1998011096A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (fr) 1998-01-21 1999-07-29 Yoshisuke Nakasato Antagonistes du recepteur de la chemokine et procedes d'emploi desdits antagonistes
AU2331999A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2005017160A2 (fr) 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilisation de cellules hematopoietques
WO2007002254A2 (fr) 2005-06-23 2007-01-04 Merck & Co., Inc. Benzocycloheptapyridines utilises comme inhibiteurs de la tyrosine kinase receptrice met
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
TW201024283A (en) 2008-12-01 2010-07-01 Targacept Inc Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
US11014912B2 (en) 2016-09-27 2021-05-25 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of USP30

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (fr) * 1993-10-15 2002-02-12 W. Robert Bishop Composes carbamates tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
KR20000036059A (ko) 2000-06-26
ID22045A (id) 1999-08-26
HUP9904067A2 (hu) 2000-05-28
SK33199A3 (en) 1999-12-10
DE69710741T2 (de) 2002-10-24
JP3152438B2 (ja) 2001-04-03
JP2000502727A (ja) 2000-03-07
DE69710741D1 (de) 2002-04-04
WO1998011096A1 (fr) 1998-03-19
PL332240A1 (en) 1999-08-30
CA2264569A1 (fr) 1998-03-19
NO991230D0 (no) 1999-03-12
EP0927178A1 (fr) 1999-07-07
CA2264569C (fr) 2003-11-11
NZ334340A (en) 2000-09-29
CN1237169A (zh) 1999-12-01
NO991230L (no) 1999-05-14
EP0927178B1 (fr) 2002-02-27
HK1018267A1 (en) 1999-12-17
IL128949A0 (en) 2000-02-17
TR199900561T2 (xx) 1999-06-21
BR9712819A (pt) 1999-11-23
AU729810B2 (en) 2001-02-08
ES2169420T3 (es) 2002-07-01
CZ83499A3 (cs) 1999-07-14
AU4337397A (en) 1998-04-02

Similar Documents

Publication Publication Date Title
ATE210652T1 (de) Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
DE69710741D1 (de) Tricyclische verbindungen zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
MX9804956A (es) Amidas triciclicas utiles para la inhibicion de la funcion de la proteina -g y para el tratamiento de las enfermedades proliferativas.
ATE221781T1 (de) Angiostatische verbindungen und zusammensetzungen zur behandlung des glc1a glaukoms
DE69429440D1 (de) Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen
ATE286046T1 (de) Trizyklische inhibitoren der farnesyl protein transferase
MX9705273A (es) Inhibidores de prenil transferasas.
DE69634691D1 (de) Tricyclische amid-derivate verwendbar als g-protein funktion inhibitoren und für die behandlung von proliferativen erkrankungen
BG101841A (bg) Инхибитори на клетъчна адхезия
DE69434397D1 (de) Tricyclische Amide und Harnstoffderivate zur Inhibierung der G-Protein Funktion und für die Behandlung von proliferativen Behandlungen
WO1994026723A3 (fr) INHIBITEURS DE LA ras FARNESYL-TRANSFERASE
ATE177420T1 (de) Cyclobutan-derivate als inhibitoren der squalen- synthetase und der protein-farnesyltransferase
MX9707562A (es) Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
DE69725171D1 (de) Substituierte pyrrolylverbindungen zur behandlung von entzündungen
ATE83149T1 (de) Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen.
NZ312840A (en) Ketoheterocyclic inhibitors of factor Xa
IL128931A0 (en) Tricylic antitumor compounds being farnesyl protein transferase inhibitors
ATE323474T1 (de) Farnesyl protein transferase inhibitoren zur behandlung von brustkrebs
BG102553A (en) Thiol derivatives having metallopeptidase inhibitor activity
IL128951A0 (en) Tricyclic compounds useful for inhibition of farnesyl protein transferase
DE69503635D1 (de) Pyrrolidinderivate zur behandlung von cck und gastrin-abhängigen erkrankungen
BR9712035A (pt) Compostos Úteis para inibi-Æo de transferase de prote¡na farnesila
HUP0000126A2 (hu) Farnezil-protein-transzferáz inhibitorként alkalmazható szubsztituált benzo-ciklohepta-piridin-származékok

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties