NO991271L - Benmorfogenetiske Protein-16-sammensetninger (BMP-16) - Google Patents

Benmorfogenetiske Protein-16-sammensetninger (BMP-16)

Info

Publication number
NO991271L
NO991271L NO991271A NO991271A NO991271L NO 991271 L NO991271 L NO 991271L NO 991271 A NO991271 A NO 991271A NO 991271 A NO991271 A NO 991271A NO 991271 L NO991271 L NO 991271L
Authority
NO
Norway
Prior art keywords
proteins
bmp
compositions
disorders
treatment
Prior art date
Application number
NO991271A
Other languages
English (en)
Other versions
NO991271D0 (no
Inventor
Anthony J Celeste
Beth L Murray
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of NO991271L publication Critical patent/NO991271L/no
Publication of NO991271D0 publication Critical patent/NO991271D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)

Abstract

Renset BMP-16 proteiner og metoder for å produsere dem er beskrevet. DNA molekyler som koder for BMP-16 proteiner er også beskrevet. Proteinene kan bli brukt i behandling av ben, brusk, andre bindevevsdefekter og forstyrrelser, inklusiv sene, ligament og meniscus, i sårheling og relatert vevsreparasjon, såvel som for behandling av forstyrrelser og defekter hos vev som inkluderer epidermisk, nerve, muskel, inklusiv hjertemuskel, og andre vev og sår, og organer slike som lever, lunge, hjerte, bukspyttkjertelen og nyrevev. Proteinene kan også være nyttige for induksjon av vekst og/eller differensiering av udifferensiert embryonale og stamceller.
NO991271A 1996-09-18 1999-03-16 Benmorfogenetiske Protein-16-sammensetninger (BMP-16) NO991271D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/715,202 US5965403A (en) 1996-09-18 1996-09-18 Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
PCT/US1997/011954 WO1998012322A1 (en) 1996-09-18 1997-07-09 Bone morphogenetic protein-16 (bmp-16) compositions

Publications (2)

Publication Number Publication Date
NO991271L true NO991271L (no) 1999-03-16
NO991271D0 NO991271D0 (no) 1999-03-16

Family

ID=24873057

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991271A NO991271D0 (no) 1996-09-18 1999-03-16 Benmorfogenetiske Protein-16-sammensetninger (BMP-16)

Country Status (9)

Country Link
US (3) US5965403A (no)
EP (1) EP0941323A1 (no)
JP (1) JP2001500737A (no)
KR (1) KR20000036012A (no)
CA (1) CA2265508C (no)
FI (1) FI990596L (no)
NO (1) NO991271D0 (no)
OA (1) OA10997A (no)
WO (1) WO1998012322A1 (no)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US8106001B2 (en) * 1996-08-27 2012-01-31 University Of South Florida Diagnostic markers of human female infertility
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
CA2279575A1 (en) * 1997-02-06 1998-08-13 Genetics Institute, Inc. Human sdf-5 protein and compositions
EP1001964A4 (en) * 1997-08-04 2003-04-23 Millennium Pharm Inc TANGO-78, TANGO-79 AND TANGO-81 NUCLEIC ACID MOLECULES
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
US6992066B2 (en) 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
AU4676600A (en) * 1999-04-30 2000-11-17 Curis, Inc. Morphogen-induced enhancement of fertility
CA2379663A1 (en) * 1999-07-28 2001-02-08 Jamie M. Grooms Cartilage or bone matrix as a nucleic acid delivery vehicle
DK1223990T3 (da) 1999-10-15 2004-11-29 Inst Genetics Llc Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
CN1331248A (zh) * 2000-06-30 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人软骨连接蛋白10.67和编码这种多肽的多核苷酸
US6482936B1 (en) * 2001-04-17 2002-11-19 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
DE602004015064D1 (de) * 2003-01-06 2008-08-28 Wyeth Corp Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs
WO2004070062A2 (en) * 2003-02-04 2004-08-19 Wyeth Compositions and methods for diagnosing and treating cancers
US20050119210A1 (en) * 2003-05-20 2005-06-02 Xiaobing Be Compositions and methods for diagnosing and treating cancers
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
DE10361075A1 (de) * 2003-12-22 2005-07-28 Pac Tech - Packaging Technologies Gmbh Verfahren und Vorichtung zur Trocknung von Schaltungssubstraten
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
EP1740609A2 (en) * 2004-04-27 2007-01-10 Research Development Foundation Antagonism of tgf-beta superfamily receptor signaling
WO2005113585A2 (en) * 2004-05-20 2005-12-01 Acceleron Pharma Inc. Modified tgf-beta superfamily polypeptides
AU2005250441A1 (en) * 2004-05-27 2005-12-15 Acceleron Pharma Inc. TGF derepressors and uses related thereto
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
WO2006081379A1 (en) * 2005-01-26 2006-08-03 Wyeth Use of sfrps as markers of bmp activity
EP1863518A2 (en) * 2005-03-30 2007-12-12 Wyeth Methods for stimulating hair growth by administering bmps
US20060247790A1 (en) * 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
KR20080084808A (ko) 2005-11-17 2008-09-19 바이오미메틱 세라퓨틱스, 인크. rhPDGF-BB 및 생체적합성 매트릭스를 사용하는상악안면골 보강
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7659999B2 (en) * 2005-12-23 2010-02-09 Xerox Corporation UIdesign: N-up calculator user interface
ES2443581T3 (es) 2006-02-09 2014-02-19 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
WO2008073628A2 (en) 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
AU2009212151C1 (en) 2008-02-07 2015-09-17 Stryker Corporation Compositions and methods for distraction osteogenesis
US20100004175A1 (en) * 2008-06-09 2010-01-07 Tanya Shang Novel bmp-12-related proteins and methods of their manufacture
BR122020000059B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
CN105198981B (zh) 2010-08-20 2019-07-16 惠氏有限责任公司 经设计的成骨蛋白
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
WO2014012101A1 (en) 2012-07-13 2014-01-16 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
EP3821880A1 (en) 2015-10-26 2021-05-19 President and Fellows of Harvard College Oxidized polysaccharides and methods of use thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
WO1991018098A1 (en) * 1990-05-16 1991-11-28 Genetics Institute, Inc. Bone and cartilage inductive proteins
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
EP0592562B1 (en) * 1991-06-25 1999-01-07 Genetics Institute, Inc. Bmp-9 compositions
DK0625989T3 (da) * 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
EP0690871A4 (en) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med GROWTH DIFFERENTIATION FACTOR-5
US5808007A (en) * 1993-01-12 1998-09-15 The Johns Hopkins University School Of Medicine Growth differentiation factor-3
DK0690873T3 (da) * 1993-03-19 2003-09-29 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-8
WO1994026892A1 (en) * 1993-05-12 1994-11-24 Genetics Institute, Inc. Bmp-11 compositions
JPH09501305A (ja) * 1993-05-12 1997-02-10 ジェネティックス・インスティテュート・インコーポレイテッド Bmp−10組成物
EP0626451A3 (en) * 1993-05-27 1997-11-05 Takeda Chemical Industries, Ltd. Heterodimers of a TGF-beta superfamily
AU688779B2 (en) * 1993-07-09 1998-03-19 Johns Hopkins University School Of Medicine, The Growth differentiation factor-7
WO1995001801A1 (en) * 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
US6204047B1 (en) * 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
AU689184B2 (en) * 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
EP1574577A3 (en) * 1994-07-08 2006-06-14 The Johns Hopkins University School Of Medicine Growth differentiation factor-11
DK0770089T3 (da) * 1994-07-13 2000-10-23 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-12
US5693779A (en) * 1994-11-08 1997-12-02 The United States Of America As Represented By The Department Of Health And Human Services Production and use of anti-dorsalizing morphogenetic protein
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)

Also Published As

Publication number Publication date
JP2001500737A (ja) 2001-01-23
KR20000036012A (ko) 2000-06-26
US20030158379A1 (en) 2003-08-21
CA2265508C (en) 2003-11-18
US6623934B2 (en) 2003-09-23
FI990596L (fi) 1999-05-03
US5965403A (en) 1999-10-12
FI990596A0 (fi) 1999-03-17
FI990596A7 (fi) 1999-03-17
WO1998012322A1 (en) 1998-03-26
US6331612B1 (en) 2001-12-18
EP0941323A1 (en) 1999-09-15
OA10997A (en) 2003-03-04
CA2265508A1 (en) 1998-03-26
NO991271D0 (no) 1999-03-16

Similar Documents

Publication Publication Date Title
NO991271L (no) Benmorfogenetiske Protein-16-sammensetninger (BMP-16)
WO1999029718A3 (en) Bone morphogenetic protein (bmp)-17 and bmp-18 and compositions thereof
Reddi Collagen and cell differentiation
ATE265529T1 (de) Bmp-10 zusammensetzungen
DE69636764D1 (de) Zusammensetzungen zur behandlung von ischamischem gewebe
DE69733292D1 (de) Verfahren zur in vitro Herstellung von Knochen
DK0429570T3 (da) Osteoinducerende præparater
ATE469654T1 (de) Verwendung des erythropoietins zur regeneration von lebergewebe
DK0831884T3 (da) Anvendelse af knoglemorfogenetiske proteiner til heling og reparation af bindevævsbinding
ATE541594T1 (de) Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln
DE69528058D1 (de) Bmp-9 zusammensetzungen
EP0701563A4 (en) GEN TRANSFER FOR TREATING CONSTRUCTIVE TISSUE OF A MAMMAL HOST
CN1471412B8 (zh) 用于修复和再生软骨和其它组织的组合物以及该组合物的用途
DK1019082T3 (da) Fremgangsmåde til moduleringen af neovaskularisering og/eller væksten af kollaterale arterier og/eller andre arterier fra forudeksisterende arteriolære forbindelser
DE60238416D1 (de) Plasmaprotein-matritzes und verfahren zu ihrer herstellung
ATE256740T1 (de) Menschliches sdf-5 protein und diesbezügliche zusammensetzungen
WO1998020029A3 (en) Hnf3-delta compositions
DE69635305D1 (de) Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma
ATE255920T1 (de) Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln
BR0212757A (pt) Composição, método para produzir uma composição de fator de crescimento, e, método para tratar um defeito de osso, tendão ou cartilagem
ATE192495T1 (de) Carboxypeptidase-ähnliches protein aus knochen und verfahren zur dessen herstellung
Fitzgerald Enhanced cartilage repair in ‘healer’mice—New leads in the search for better clinical options for cartilage repair
US20070056597A1 (en) Transplantation of human lipid cells and other tissue regenerative cells and methods of use ancillary to sports/entertainment/celebrity/performance employment contracts and policies insuring those contracts
DE69424153D1 (de) Methode zur verbesserten herstellung einer produzierende zellinie durch verwendung eines fusionsprotokolls
Emami et al. Bone marrow transplantation and autogenic cancellous bone grafting in healing of segmental radial defects: an animal study

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application