NO992502L - 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister - Google Patents

2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister

Info

Publication number: NO992502L
Authority: NO; Norway
Prior art keywords: hydrogen; unsubstituted; compounds; imidazolinylaminoindazole; alfa
Prior art date: 1996-11-25

Application number

NO992502A

Other languages

English (en)

Norwegian (no)

Other versions

NO992502D0 (no

Inventor

Thomas Lee Cupps

Sophie Eva Bogdan

Raymond Todd Henry

Russell James Sheldon

William Lee Seibel

Jeffrey Joseph Ares

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-25

Filing date

1999-05-25

Publication date

1999-07-26

1999-05-25 Application filed by Procter & Gamble filed Critical Procter & Gamble

1999-05-25 Publication of NO992502D0 publication Critical patent/NO992502D0/no

1999-07-26 Publication of NO992502L publication Critical patent/NO992502L/no

Links

239000000048 adrenergic agonist Substances 0.000 title 1
229940126157 adrenergic receptor agonist Drugs 0.000 title 1
RGVBAADKKPKGQR-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-1h-indazol-3-amine Chemical class C1=NCCN1NC1=NNC2=CC=CC=C12 RGVBAADKKPKGQR-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000006559 (C1-C3) alkylamino group Chemical group 0.000 abstract 1
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
KYEXVVKKHWFWLT-UHFFFAOYSA-N 7-bromo-n-(4,5-dihydroimidazol-1-yl)-1h-indazol-6-amine Chemical compound C1=CC=2C=NNC=2C(Br)=C1NN1CCN=C1 KYEXVVKKHWFWLT-UHFFFAOYSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
102000017910 Adrenergic receptor Human genes 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
-1 amino, hydroxy, mercapto Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Resins (AREA)

NO992502A 1996-11-25 1999-05-25 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister NO992502L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3174096P	1996-11-25	1996-11-25
PCT/US1997/020551 WO1998023609A1 (en)	1996-11-25	1997-11-21	2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number	Publication Date
NO992502D0 NO992502D0 (no)	1999-05-25
NO992502L true NO992502L (no)	1999-07-26

Family

ID=21861136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO992502A NO992502L (no)	1996-11-25	1999-05-25	2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister

Country Status (20)

Country	Link
EP (1)	EP0944620A1 (id)
JP (1)	JP2001506599A (id)
KR (1)	KR20000069104A (id)
CN (1)	CN1244864A (id)
AR (1)	AR010643A1 (id)
AU (1)	AU5433998A (id)
BR (1)	BR9713535A (id)
CA (1)	CA2272644A1 (id)
CO (1)	CO4910166A1 (id)
CZ (1)	CZ183999A3 (id)
HU (1)	HUP9904660A3 (id)
ID (1)	ID22676A (id)
IL (1)	IL130067A0 (id)
NO (1)	NO992502L (id)
NZ (1)	NZ335882A (id)
PE (1)	PE47099A1 (id)
SK (1)	SK69699A3 (id)
TR (1)	TR199901542T2 (id)
WO (1)	WO1998023609A1 (id)
ZA (1)	ZA9710576B (id)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9908175D0 (en) *	1999-04-09	1999-06-02	Lilly Co Eli	Method of treating neurological disorders
US6433186B1 (en)	2000-08-16	2002-08-13	Astrazeneca Ab	Amidino derivatives and their use as thormbin inhibitors
EP2226315A4 (en)	2007-12-28	2012-01-25	Carna Biosciences Inc	2-aminoquinazoline DERIVATIVE
WO2010074753A1 (en)	2008-12-23	2010-07-01	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
CN112538074A (zh) *	2020-12-24	2021-03-23	艾希尔（深圳）药物研发有限公司	一种溴莫尼定脱溴杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH641782A5 (en) *	1978-12-07	1984-03-15	Siegfried Ag	1H- and 2H-indazole derivatives
US4526898A (en) *	1980-09-05	1985-07-02	Siegfried Aktiengesselschaft	Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole
US5478858A (en) *	1993-12-17	1995-12-26	The Procter & Gamble Company	5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
SG44628A1 (en) *	1993-12-17	1997-12-19	Procter & Gamble	6-(2-imidazolinylamino) Quinoxaline compounds useful as alpha-2 adrenoceptor agonists

1997
- 1997-11-21 ID IDW990412A patent/ID22676A/id unknown
- 1997-11-21 CZ CZ991839A patent/CZ183999A3/cs unknown
- 1997-11-21 BR BR9713535A patent/BR9713535A/pt unknown
- 1997-11-21 CA CA002272644A patent/CA2272644A1/en not_active Abandoned
- 1997-11-21 CN CN97181453A patent/CN1244864A/zh active Pending
- 1997-11-21 TR TR1999/01542T patent/TR199901542T2/xx unknown
- 1997-11-21 NZ NZ335882A patent/NZ335882A/xx unknown
- 1997-11-21 JP JP52468698A patent/JP2001506599A/ja active Pending
- 1997-11-21 WO PCT/US1997/020551 patent/WO1998023609A1/en not_active Ceased
- 1997-11-21 HU HU9904660A patent/HUP9904660A3/hu unknown
- 1997-11-21 KR KR1019997004569A patent/KR20000069104A/ko not_active Ceased
- 1997-11-21 EP EP97948238A patent/EP0944620A1/en not_active Withdrawn
- 1997-11-21 AU AU54339/98A patent/AU5433998A/en not_active Abandoned
- 1997-11-21 IL IL13006797A patent/IL130067A0/xx unknown
- 1997-11-24 CO CO97068615A patent/CO4910166A1/es unknown
- 1997-11-25 PE PE1997001067A patent/PE47099A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710576A patent/ZA9710576B/xx unknown
- 1997-11-25 AR ARP970105524A patent/AR010643A1/es unknown
1999
- 1999-05-25 NO NO992502A patent/NO992502L/no not_active Application Discontinuation
- 1999-05-25 SK SK696-99A patent/SK69699A3/sk unknown

Also Published As

Publication number	Publication date
IL130067A0 (en)	2000-02-29
WO1998023609A1 (en)	1998-06-04
SK69699A3 (en)	2000-06-12
CZ183999A3 (cs)	1999-11-17
CA2272644A1 (en)	1998-06-04
AR010643A1 (es)	2000-06-28
HUP9904660A3 (en)	2002-02-28
CO4910166A1 (es)	2000-04-24
BR9713535A (pt)	2000-03-21
CN1244864A (zh)	2000-02-16
NZ335882A (en)	2000-12-22
ID22676A (id)	1999-12-09
PE47099A1 (es)	1999-06-12
ZA9710576B (en)	1998-09-16
TR199901542T2 (xx)	2000-01-21
NO992502D0 (no)	1999-05-25
HUP9904660A2 (hu)	2000-06-28
JP2001506599A (ja)	2001-05-22
KR20000069104A (ko)	2000-11-25
EP0944620A1 (en)	1999-09-29
AU5433998A (en)	1998-06-22

Legal Events

Date	Code	Title	Description
2002-07-22	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
CO4910149A1 (es)	2000-04-24	Compuestos de 2-imidazolinilaminoindol utiles como agonistas de alfa-2 adrenoceptores
AU747521C (en)	1999-09-27	Cycloalkene derivatives, process for producing the same, and use
FI942881A0 (fi)	1994-06-16	2-piperatsinoniyhdisteet ja niiden käyttö
TR200000671T2 (tr)	2000-07-21	FP agonistleri olarak yararlı aromatik C16-C20-ikameli tetrahidro prostaglandinler.
TR200000673T2 (tr)	2000-11-21	FP agonistleri olarak yararlı aromatik C16-C20- ikameli tetrahidro prostaglandinler.
ATE178065T1 (de)	1999-04-15	Kondensierte imidazol- und triazolderivate als 5- hta rezeptoragonisten
TR199901468T2 (xx)	1999-10-21	Alfa-2 adrenosept�r agonistleri olarak yararl� guanidinil heterosikl bile�ikleri.
ATE196293T1 (de)	2000-09-15	Triazole enthaltende antifungizide mittel
NO992502L (no)	1999-07-26	2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister
IL67457A0 (en)	1983-05-15	Herbicidal cyclohexane-1,2-dione derivatives
DK0425209T3 (da)	1995-10-09	Naphtyloxazolidon Derivater
ES2091899T3 (es)	1996-11-16	Procedimiento para la obtencion de derivados de nitroguanidina.
BR9915950A (pt)	2001-08-21	Benzoilpirazol substituìdo por 3-heterociclila, processo para preparar benzoilpirazóis substituìdos por 3-heterociclila, éster de ácido benzóico, derivado de 3-(heterociclila) benzeno, composição, processos para preparar composições e para controlar vegetação indesejável, uso dos benzoilpirazóis substituìdos por 3-heterociclila
PT1234818E (pt)	2005-01-31	Sais de calcio de derivados de 1,5-benzodiazepina, processo para producao dos sais e drogas que os contem
ZA91288B (en)	1991-10-30	Coating compound,process for its production as well as use thereof
PE16199A1 (es)	1999-03-12	Compuestos de 2-imidazolinilaminobenzotiazol utiles como agonistas de alfa-2 adrenoreceptores
GR3033333T3 (en)	2000-09-29	Carbamoyl carboxylic acid amides
CA2272098A1 (en)	1998-06-04	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
ES2148800T3 (es)	2000-10-16	Derivados del acido benzoilpropionico sustituidos por fluoro.
DE69806411D1 (de)	2002-08-08	Neue antiarrythmische verbindungen
AU1617683A (en)	1984-01-05	Imidazole and triazole pesticides
DK0661275T3 (da)	1997-08-04	1-( alfa-Cyclopropyl-alfa-(substitueret oxy)-otolyl sulfamoyl) -3-(4,6-dimethoxy-2-pyrimidinyl) urinstoffer som herbicide midler.
DE3362868D1 (en)	1986-05-15	Microbicidal and plant-growth regulating agents
ATE52501T1 (de)	1990-05-15	Cyclohexan-1,3-dionderivate, diese enthaltende zusammensetzungen, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren.
MX9705971A (es)	1997-11-29	Producto fungicida.