NO992903D0 - Anvendelse av 7-(2-oksa-5,8-diazabicyklo/4.3.0/non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer - Google Patents

Anvendelse av 7-(2-oksa-5,8-diazabicyklo/4.3.0/non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer

Info

Publication number: NO992903D0
Authority: NO; Norway
Prior art keywords: carboxylic acid; oxa; diazabicyclo; helicobacter pylori; treatment
Prior art date: 1996-12-16

Application number

NO992903A

Other languages

English (en)

Other versions

NO992903L (no

NO325617B1 (no

Inventor

Michael Matzke

Uwe Petersen

Thomas Jaetsch

Stephan Bartel

Thomas Schenke

Thomas Himmler

Bernd Baasner

Hans-Otto Werling

Klaus Schaller

Harald Labischinski

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-16

Filing date

1999-06-14

Publication date

1999-06-14

1999-06-14 Application filed by Bayer Ag filed Critical Bayer Ag

1999-06-14 Publication of NO992903L publication Critical patent/NO992903L/no

1999-06-14 Publication of NO992903D0 publication Critical patent/NO992903D0/no

2008-06-30 Publication of NO325617B1 publication Critical patent/NO325617B1/no

Links

206010019375 Helicobacter infections Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
-1 naphthyridone carboxylic acid derivatives Chemical class 0.000 title abstract 2
XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
239000002253 acid Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO19992903A 1996-12-16 1999-06-14 Anvendelse av 7-(2-oksa-5,8-diazabicyklo[4.3.0]non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for fremstilling av legemidler for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer, diastereomerrene og enantiomerrene forbindelser, anvendelse derav samt legemiddel inneholdende disse. NO325617B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19652239A DE19652239A1 (de)	1996-12-16	1996-12-16	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
PCT/EP1997/006781 WO1998026779A1 (de)	1996-12-16	1997-12-04	Verwendung von 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen

Publications (3)

Publication Number	Publication Date
NO992903L NO992903L (no)	1999-06-14
NO992903D0 true NO992903D0 (no)	1999-06-14
NO325617B1 NO325617B1 (no)	2008-06-30

Family

ID=7814837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19992903A NO325617B1 (no)	1996-12-16	1999-06-14	Anvendelse av 7-(2-oksa-5,8-diazabicyklo[4.3.0]non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for fremstilling av legemidler for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer, diastereomerrene og enantiomerrene forbindelser, anvendelse derav samt legemiddel inneholdende disse.

Country Status (27)

Country	Link
US (2)	US6133260A (no)
EP (1)	EP0946176B1 (no)
JP (3)	JP3463939B2 (no)
KR (1)	KR100536153B1 (no)
CN (1)	CN100335054C (no)
AT (1)	ATE214929T1 (no)
AU (1)	AU717751B2 (no)
BG (1)	BG64615B1 (no)
BR (1)	BR9714032A (no)
CA (1)	CA2274894C (no)
CZ (2)	CZ297363B6 (no)
DE (2)	DE19652239A1 (no)
DK (1)	DK0946176T3 (no)
EA (1)	EA002477B1 (no)
EE (1)	EE04090B1 (no)
ES (1)	ES2175519T3 (no)
HU (1)	HU226523B1 (no)
IL (1)	IL130311A (no)
NO (1)	NO325617B1 (no)
NZ (2)	NZ336228A (no)
PL (1)	PL191193B1 (no)
PT (1)	PT946176E (no)
RS (1)	RS49684B (no)
SK (2)	SK283224B6 (no)
TR (1)	TR199901754T2 (no)
UA (1)	UA57055C2 (no)
WO (1)	WO1998026779A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19633805A1 (de) *	1996-02-23	1997-08-28	Bayer Ag	Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
ATE245140T1 (de) *	1998-11-18	2003-08-15	Asahi Glass Co Ltd	Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
DE19917617A1 (de) *	1999-04-19	2000-10-26	Bayer Ag	-(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions
IL147043A0 (en) *	1999-07-01	2002-08-14	Wakunaga Pharma Co Ltd	Quinolinecarboxylic acid derivative or salts thereof
ATE285821T1 (de) *	1999-10-08	2005-01-15	Affinium Pharm Inc	Fab i inhibitoren
CA2444597A1 (en) *	2001-04-06	2002-10-06	Affinium Pharmaceuticals, Inc.	Fab i inhibitors
EP1575951B1 (en)	2002-12-06	2014-06-25	Debiopharm International SA	Heterocyclic compounds, methods of making them and their use in therapy
DE602004016831D1 (de)	2003-03-17	2008-11-13	Affinium Pharm Inc	Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
EP1669354B1 (en)	2003-09-29	2013-03-20	Daiichi Sankyo Company, Limited	8-cyanoquinolonecarboxylic acid derivative
CN1244582C (zh) *	2004-04-21	2006-03-08	中国医学科学院医药生物技术研究所	喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en)	2004-04-21	2010-07-20	Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences	Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
EP2848614A3 (en)	2004-06-04	2015-07-29	Debiopharm International SA	Acrylamide derivatives as antibiotic agents
EP1973902A2 (en) *	2005-12-05	2008-10-01	Affinium Pharmaceuticals, Inc.	3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (en)	2006-07-20	2017-07-19	Debiopharm International SA	Acrylamide derivatives as FAB I inhibitors
WO2008098374A1 (en)	2007-02-16	2008-08-21	Affinium Pharmaceuticals, Inc.	Salts, prodrugs and polymorphs of fab i inhibitors
WO2011003091A1 (en)	2009-07-02	2011-01-06	Alcon Research, Ltd.	Compositions comprising finafloxacin and methods for treating ophthalmic, otic, or nasal infections
RU2449805C1 (ru)	2011-01-27	2012-05-10	Общество С Ограниченной Ответственностью "Гармония"	Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
SI2861608T1 (sl)	2012-06-19	2019-08-30	Debiopharm International Sa	Derivati predzdravila (E)-N-metil-N-((3-metilbenzofuran-2-IL)metil)- 3-(7-okso-5,6,7,8-tetrahidro-1 ,8-nafthiridin-3-il)akrilamid
US9504691B2 (en) *	2012-12-06	2016-11-29	Alcon Research, Ltd.	Finafloxacin suspension compositions
CA2916535A1 (en)	2013-08-12	2015-02-19	Novartis Ag	Method for treating otic infections after tympanostomy tube placement
DE102014115951A1 (de) *	2014-11-03	2016-05-04	Merlion Pharmaceuticals Pte Ltd.	Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de)	2015-01-06	2016-07-07	Merlion Pharmaceuticals Pte Ltd.	Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
BR122023021456A2 (pt)	2016-02-26	2024-02-20	Debiopharm International S.A.	Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
CN107987074B (zh) *	2017-10-27	2020-12-29	浙江美诺华药物化学有限公司	一种普拉沙星的合成方法
CA3098060A1 (en) *	2018-04-25	2019-10-31	Bayer Animal Health Gmbh	Process for the hydrolysis of quinolone carboxylic esters
LT3923914T (lt)	2019-02-14	2023-07-25	Debiopharm International S.A.	Afabicino kompozicija, jos gamybos būdas
CN113939306B (zh)	2019-06-14	2024-07-19	德彪药业国际股份公司	用于治疗涉及生物膜的细菌感染的药物及其用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4822801A (en) *	1984-07-20	1989-04-18	Warner-Lambert Company	4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
JPS62205060A (ja) *	1986-03-04	1987-09-09	Kyorin Pharmaceut Co Ltd	８位置換キノロンカルボン酸誘導体
DE3702393A1 (de) *	1987-01-28	1988-08-11	Bayer Ag	8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5563138A (en) *	1987-04-16	1996-10-08	Otsuka Pharmaceutical Company, Limited	Benzoheterocyclic compounds
US4889857A (en) *	1987-10-12	1989-12-26	Yoshitomi Pharmaceutical Industries, Ltd.	Quinolonecarboxylic acid compounds and pharmaceutical use thereof
WO1989005643A1 (en) *	1987-12-18	1989-06-29	Pfizer Inc.	Heterocyclic-substituted quinoline-carboxylic acids
JP2844079B2 (ja) *	1988-05-23	1999-01-06	塩野義製薬株式会社	ピリドンカルボン酸系抗菌剤
DE3906365A1 (de) *	1988-07-15	1990-01-18	Bayer Ag	7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
US5147873A (en) *	1988-08-23	1992-09-15	Pfizer Inc.	Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
CA2001203C (en) *	1988-10-24	2001-02-13	Thomas P. Demuth, Jr.	Novel antimicrobial dithiocarbamoyl quinolones
US5262417A (en) *	1988-12-06	1993-11-16	The Upjohn Company	Antibacterial quinolone compounds
US5407932A (en) *	1989-03-31	1995-04-18	Wakunaga Seiyaku Kabushiki Kaisha	Quinolone derivatives and antibacterial agents containing the same
US5140033A (en) *	1989-04-03	1992-08-18	Bayer Aktiengesellschaft	Antibacterial 5-alkylquinolonecarboxylic acids
DE3910663A1 (de) *	1989-04-03	1990-10-04	Bayer Ag	5-alkylchinoloncarbonsaeuren
US5252734A (en) *	1989-04-03	1993-10-12	Bayer Aktiengesellschaft	Antibacterial 5-alkylquinolonecarboxylic acids
US5164402A (en) *	1989-08-16	1992-11-17	Pfizer Inc	Azabicyclo quinolone and naphthyridinone carboxylic acids
KR910009330B1 (ko) *	1989-10-23	1991-11-11	재단법인 한국화학연구소	항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
TW209865B (no) *	1992-01-10	1993-07-21	Bayer Ag
DE4200415A1 (de)	1992-01-10	1993-07-15	Bayer Ag	Enantiomerenreine 2-oxa-5,8-diazabicyclo(4.3.0)nonane sowie verfahren zu ihrer herstellung
NO301165B1 (no) *	1992-12-25	1997-09-22	Daiichi Seiyaku Co	Bicykliske aminderivater og antibakterielle midler inneholdende disse
DE4309964A1 (de)	1993-03-26	1994-09-29	Bayer Ag	Verfahren zur Herstellung enantiomerenreiner trans-2-Oxa-5,8-diazabicyclo[4.3.0]nonane
WO1994025464A1 (en) *	1993-04-24	1994-11-10	Korea Research Institute Of Chemical Technology	Novel quinolone carboxylic acid derivatives and process for preparing the same
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
DE4329600A1 (de) *	1993-09-02	1995-03-09	Bayer Ag	Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
DE69504392T2 (de) *	1994-04-07	1999-02-11	Pfizer Inc., New York, N.Y.	Verwendung von Trovafloxacin oder dessen Derivaten zur Herstellung eines Arzneimittels zur Behandlung von H.Pylori Infektionen
GB2289674A (en) *	1994-05-23	1995-11-29	Pfizer	Antibacterial naphthyridine
JPH0848629A (ja) *	1994-08-08	1996-02-20	Dainippon Pharmaceut Co Ltd	ピリドンカルボン酸誘導体およびそれを有効成分とする抗ピロリ菌剤

1996
- 1996-12-16 DE DE19652239A patent/DE19652239A1/de not_active Withdrawn
1997
- 1997-04-12 UA UA99074093A patent/UA57055C2/uk unknown
- 1997-12-04 SK SK1496-2000A patent/SK283224B6/sk not_active IP Right Cessation
- 1997-12-04 HU HU0000450A patent/HU226523B1/hu unknown
- 1997-12-04 WO PCT/EP1997/006781 patent/WO1998026779A1/de not_active Ceased
- 1997-12-04 IL IL13031197A patent/IL130311A/en not_active IP Right Cessation
- 1997-12-04 KR KR10-1999-7005330A patent/KR100536153B1/ko not_active Expired - Lifetime
- 1997-12-04 DK DK97954354T patent/DK0946176T3/da active
- 1997-12-04 CA CA002274894A patent/CA2274894C/en not_active Expired - Lifetime
- 1997-12-04 AT AT97954354T patent/ATE214929T1/de active
- 1997-12-04 CZ CZ0216899A patent/CZ297363B6/cs not_active IP Right Cessation
- 1997-12-04 JP JP52725098A patent/JP3463939B2/ja not_active Expired - Lifetime
- 1997-12-04 EA EA199900526A patent/EA002477B1/ru not_active IP Right Cessation
- 1997-12-04 DE DE59706808T patent/DE59706808D1/de not_active Expired - Lifetime
- 1997-12-04 PL PL333928A patent/PL191193B1/pl unknown
- 1997-12-04 CN CNB971817200A patent/CN100335054C/zh not_active Expired - Lifetime
- 1997-12-04 BR BR9714032-5A patent/BR9714032A/pt not_active IP Right Cessation
- 1997-12-04 SK SK795-99A patent/SK283223B6/sk not_active IP Right Cessation
- 1997-12-04 CZ CZ20003148A patent/CZ297364B6/cs not_active IP Right Cessation
- 1997-12-04 PT PT97954354T patent/PT946176E/pt unknown
- 1997-12-04 RS YUP-274/99A patent/RS49684B/sr unknown
- 1997-12-04 TR TR1999/01754T patent/TR199901754T2/xx unknown
- 1997-12-04 ES ES97954354T patent/ES2175519T3/es not_active Expired - Lifetime
- 1997-12-04 US US09/319,888 patent/US6133260A/en not_active Expired - Lifetime
- 1997-12-04 AU AU58541/98A patent/AU717751B2/en not_active Expired
- 1997-12-04 NZ NZ336228A patent/NZ336228A/xx not_active IP Right Cessation
- 1997-12-04 EE EEP199900248A patent/EE04090B1/xx unknown
- 1997-12-04 EP EP97954354A patent/EP0946176B1/de not_active Expired - Lifetime
1999
- 1999-06-08 BG BG103474A patent/BG64615B1/bg unknown
- 1999-06-14 NO NO19992903A patent/NO325617B1/no not_active IP Right Cessation
- 1999-11-08 US US09/436,316 patent/US6432948B1/en not_active Expired - Lifetime
2000
- 2000-05-25 JP JP2000154543A patent/JP4463380B2/ja not_active Expired - Lifetime
- 2000-08-04 NZ NZ506162A patent/NZ506162A/en not_active IP Right Cessation
2009
- 2009-07-22 JP JP2009171127A patent/JP5112395B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU717751B2 (en)	2000-03-30
IL130311A (en)	2004-01-04
JP4463380B2 (ja)	2010-05-19
CZ297363B6 (cs)	2006-11-15
WO1998026779A1 (de)	1998-06-25
EE04090B1 (et)	2003-08-15
HUP0000450A2 (hu)	2000-10-28
PL333928A1 (en)	2000-01-31
KR100536153B1 (ko)	2005-12-14
JP5112395B2 (ja)	2013-01-09
DE19652239A1 (de)	1998-06-18
CA2274894C (en)	2009-04-07
PT946176E (pt)	2002-08-30
CA2274894A1 (en)	1998-06-25
HU226523B1 (en)	2009-03-30
US6133260A (en)	2000-10-17
CZ216899A3 (cs)	2000-02-16
CN100335054C (zh)	2007-09-05
ATE214929T1 (de)	2002-04-15
SK79599A3 (en)	2001-01-18
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2013-06-17	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE
2017-12-11	MK1K	Patent expired

Publication	Publication Date	Title
NO992903L (no)	1999-06-14	Anvendelse av 7-(2-oksa-5,8-diazabicyklo/4.3.0/non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer
TNSN03144A1 (en)	2005-12-23	Pyrrolopyrimidines as protein kinase inhibitors
IS6865A (is)	2003-07-03	Setnar alkýlamínafleiður og aðferðir við notkun þeirra
EE200100172A (et)	2002-06-17	Tetrahüdropüridoeetrid, nende kasutamine ja ravim
MA27566A1 (fr)	2005-10-03	Inhibiteurs de 4-oxo-1-(3-phenyle substitue -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4
MXPA03011998A (es)	2005-07-01	Pirrolopirimidinas como inhibidores de protein cinasa.
PL328123A1 (en)	1999-01-18	Derivatives of banzo[c]quinolysine and method of obtaining them
WO1998026768A3 (de)	1998-08-06	Verwendung von 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen
BR0014052A (pt)	2002-05-21	Derivados de aminas
DE69924105D1 (de)	2005-04-14	Iga produktionsinhibitoren
DK0704443T3 (da)	2001-01-29	Quinolon- og naphthyridoncarboxylsyrederivater
MX8232A (es)	1993-12-01	Derivados de triazolopirimidina.
NO20053612L (no)	2005-09-23	1,2,4-triaminobenzenderivater nyttige for behandling av forstyrrelser i sentralnervesystemet