NO993151L - Fremgangsmåte for fremstilling av renset dimer av benavledet faktor - Google Patents
Fremgangsmåte for fremstilling av renset dimer av benavledet faktorInfo
- Publication number
- NO993151L NO993151L NO993151A NO993151A NO993151L NO 993151 L NO993151 L NO 993151L NO 993151 A NO993151 A NO 993151A NO 993151 A NO993151 A NO 993151A NO 993151 L NO993151 L NO 993151L
- Authority
- NO
- Norway
- Prior art keywords
- dimer
- derived factor
- subjecting
- bone
- preparation
- Prior art date
Links
- 239000000539 dimer Substances 0.000 title abstract 6
- 210000000988 bone and bone Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 210000003000 inclusion body Anatomy 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Fremgangsmåte for fremstilling av en renset dimer av en benavledet faktor, som omfatter underkastelse av et inklusjonslegeme av en benavledet faktor fremstilt ved hjelp av genetisk konstruksjon for følgende trinn a) til. e) i rekkefølge; a) trinnet med behandling av et inklusjonslegeme av en benavledet faktor med et denaturerende middel for å fremstille en oppløst monomer; b) trinnet med behandling av den oppløste monomer med en refoldende oppløsning for å fremstille en dimer; c) trinnet med underkastelse av den refoldende dimer for ultrafiltrering og utbytting av oppløsningsmiddel; d) trinnet med underkastelse av dimeroppløsningen fremstilt ovenfor for isoelektrisk utfelling; og e) trinnet med underkastelse av den isoelektrisk utfelte dimer for revers-fasekromatografi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35581296 | 1996-12-25 | ||
| PCT/JP1997/004784 WO1998029559A1 (fr) | 1996-12-25 | 1997-12-24 | Procede de preparation de dimeres purifies a partir de facteur derive de l'os |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO993151L true NO993151L (no) | 1999-06-24 |
| NO993151D0 NO993151D0 (no) | 1999-06-24 |
Family
ID=18445882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO993151A NO993151D0 (no) | 1996-12-25 | 1999-06-24 | FremgangsmÕte for fremstilling av renset dimer av benavledet faktor |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6551801B1 (no) |
| EP (1) | EP0949335B2 (no) |
| KR (1) | KR20000062328A (no) |
| AP (1) | AP9901539A0 (no) |
| AT (1) | ATE266095T1 (no) |
| AU (1) | AU5339598A (no) |
| BR (1) | BR9714183A (no) |
| CA (1) | CA2275464A1 (no) |
| DE (1) | DE69728997T3 (no) |
| DK (1) | DK0949335T4 (no) |
| EA (1) | EA199900596A1 (no) |
| ES (1) | ES2216181T5 (no) |
| HU (1) | HUP0002573A2 (no) |
| IL (1) | IL130641A0 (no) |
| NO (1) | NO993151D0 (no) |
| PL (1) | PL334303A1 (no) |
| PT (1) | PT949335E (no) |
| SI (1) | SI0949335T2 (no) |
| TR (1) | TR199901479T2 (no) |
| WO (1) | WO1998029559A1 (no) |
| ZA (1) | ZA9711580B (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040019185A1 (en) * | 1996-12-25 | 2004-01-29 | Hidetoshi Andou | Process for preparing purified active monomer of bone-derived factor |
| US7811793B2 (en) * | 1996-12-25 | 2010-10-12 | Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Process for preparing purified active monomer of bone-derived factor |
| AU2001244647A1 (en) * | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Process for producing recombinant protein |
| JP4614661B2 (ja) * | 2002-02-08 | 2011-01-19 | ワイス | 生体活性因子を含有する処方物およびそれを使用する方法 |
| AU2003259765B2 (en) | 2002-08-13 | 2009-01-22 | Wyeth | Peptides as solubilizing excipients for transforming growth factor Beta proteins |
| JP4800739B2 (ja) * | 2005-10-20 | 2011-10-26 | デンカ生研株式会社 | アッセイ用媒体及びアッセイ方法 |
| WO2008031020A2 (en) * | 2006-09-08 | 2008-03-13 | Wyeth | Arginine wash in protein purification using affinity chromatography |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| BRPI0911048A2 (pt) * | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2522568B2 (ja) * | 1988-04-08 | 1996-08-07 | ストライカー・コーポレーション | 骨形成デバイス |
| ATE287949T1 (de) * | 1992-07-31 | 2005-02-15 | Stryker Corp | Löslicher komplex morphogener proteine und zusammensetzungen davon |
| JP3570558B2 (ja) * | 1993-05-01 | 2004-09-29 | 持田製薬株式会社 | Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法 |
| US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| DE69636728T4 (de) * | 1995-04-19 | 2007-06-28 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Neues protein und verfahren zu dessen herstellung |
| US5702637A (en) * | 1995-04-19 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Liquid crystal compounds having a chiral fluorinated terminal portion |
-
1997
- 1997-12-23 ZA ZA9711580A patent/ZA9711580B/xx unknown
- 1997-12-24 SI SI9730664T patent/SI0949335T2/sl unknown
- 1997-12-24 KR KR1019997005776A patent/KR20000062328A/ko not_active Withdrawn
- 1997-12-24 PL PL97334303A patent/PL334303A1/xx unknown
- 1997-12-24 DK DK97950371T patent/DK0949335T4/da active
- 1997-12-24 WO PCT/JP1997/004784 patent/WO1998029559A1/ja not_active Ceased
- 1997-12-24 EA EA199900596A patent/EA199900596A1/ru unknown
- 1997-12-24 BR BR9714183-6A patent/BR9714183A/pt not_active IP Right Cessation
- 1997-12-24 TR TR1999/01479T patent/TR199901479T2/xx unknown
- 1997-12-24 ES ES97950371T patent/ES2216181T5/es not_active Expired - Lifetime
- 1997-12-24 DE DE69728997T patent/DE69728997T3/de not_active Expired - Lifetime
- 1997-12-24 HU HU0002573A patent/HUP0002573A2/hu unknown
- 1997-12-24 IL IL13064197A patent/IL130641A0/xx unknown
- 1997-12-24 US US09/331,948 patent/US6551801B1/en not_active Expired - Fee Related
- 1997-12-24 PT PT97950371T patent/PT949335E/pt unknown
- 1997-12-24 AT AT97950371T patent/ATE266095T1/de active
- 1997-12-24 EP EP97950371A patent/EP0949335B2/en not_active Expired - Lifetime
- 1997-12-24 CA CA002275464A patent/CA2275464A1/en not_active Abandoned
- 1997-12-24 AP APAP/P/1999/001539A patent/AP9901539A0/en unknown
- 1997-12-24 AU AU53395/98A patent/AU5339598A/en not_active Abandoned
-
1999
- 1999-06-24 NO NO993151A patent/NO993151D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2275464A1 (en) | 1998-07-09 |
| EP0949335A1 (en) | 1999-10-13 |
| US6551801B1 (en) | 2003-04-22 |
| SI0949335T2 (sl) | 2009-04-30 |
| DK0949335T4 (da) | 2009-03-23 |
| ES2216181T5 (es) | 2009-03-01 |
| DK0949335T3 (da) | 2004-08-30 |
| ES2216181T3 (es) | 2004-10-16 |
| EP0949335B1 (en) | 2004-05-06 |
| HUP0002573A2 (hu) | 2000-12-28 |
| KR20000062328A (ko) | 2000-10-25 |
| DE69728997D1 (de) | 2004-06-09 |
| DE69728997T3 (de) | 2009-07-09 |
| ATE266095T1 (de) | 2004-05-15 |
| WO1998029559A1 (fr) | 1998-07-09 |
| SI0949335T1 (en) | 2004-10-31 |
| TR199901479T2 (xx) | 1999-09-21 |
| ZA9711580B (en) | 1999-09-23 |
| NO993151D0 (no) | 1999-06-24 |
| IL130641A0 (en) | 2000-06-01 |
| EP0949335B2 (en) | 2008-11-19 |
| BR9714183A (pt) | 2000-02-29 |
| PT949335E (pt) | 2004-09-30 |
| AU5339598A (en) | 1998-07-31 |
| PL334303A1 (en) | 2000-02-14 |
| EA199900596A1 (ru) | 2000-02-28 |
| AP9901539A0 (en) | 1999-06-30 |
| DE69728997T2 (de) | 2004-09-02 |
| EP0949335A4 (en) | 2003-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |