NO995088L - Alkyl, alkenyl og alkynyl krysamin G derivater for foer-doeden- diagnose av Alzheimers sykdom og in vivo avbildning og hindring av amyloidavsetning - Google Patents

Alkyl, alkenyl og alkynyl krysamin G derivater for foer-doeden- diagnose av Alzheimers sykdom og in vivo avbildning og hindring av amyloidavsetning

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Publication number
NO995088L
NO995088L NO995088A NO995088A NO995088L NO 995088 L NO995088 L NO 995088L NO 995088 A NO995088 A NO 995088A NO 995088 A NO995088 A NO 995088A NO 995088 L NO995088 L NO 995088L
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derivatives
chrysamine
methods
alzheimer
azo
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NO995088A
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English (en)
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NO995088D0 (no
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William E Klunk
Jay W Pettegrew
Jr Chester A Mathis
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Univ Pittsburgh
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Publication of NO995088D0 publication Critical patent/NO995088D0/no
Publication of NO995088L publication Critical patent/NO995088L/no

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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D221/04—Ortho- or peri-condensed ring systems
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    • C09B23/14—Styryl dyes
    • C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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Abstract

Amyloidbindende forbindelser som er ikke-azo derivater av Krysamin G, farmasøytiske blandinger som inneholder og metoder som bruker slike forbindelser for å identifisere Alzheimers hjerne in vivo, og for å diagnostisere andre patologiske tilstander karakterisert ved amyloidose, slik som Downs syndrom, er beskrevet. Farmasøytiske blandinger som inneholder ikke-azo derivater av Krysamin G og metoder som bruker slike forbindelser for å hindre celledegenerering og amyloidindusert toksisitet i amyloidoseassosierte tilstander er også beskrevet. Metoder som bruker ikke- azo Krysamin G derivater for å farge eller detektere amyloidavleiringer i biopsi eller post-mortem vev er også beskrevet. Metoder som bruker ikke-azo Krysamin G derivater for å måle amyloidavleiringer i homogenater av biopsi eller post-mortem vev er også beskrevet.
NO995088A 1997-04-18 1999-10-18 Alkyl, alkenyl og alkynyl krysamin G derivater for foer-doeden- diagnose av Alzheimers sykdom og in vivo avbildning og hindring av amyloidavsetning NO995088L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/837,494 US6168776B1 (en) 1994-07-19 1997-04-18 Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PCT/US1998/007889 WO1998047969A1 (en) 1997-04-18 1998-04-20 Alkyl, alkenyl and alkynyl chrysamine g derivatives for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition

Publications (2)

Publication Number Publication Date
NO995088D0 NO995088D0 (no) 1999-10-18
NO995088L true NO995088L (no) 1999-12-17

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NO995088A NO995088L (no) 1997-04-18 1999-10-18 Alkyl, alkenyl og alkynyl krysamin G derivater for foer-doeden- diagnose av Alzheimers sykdom og in vivo avbildning og hindring av amyloidavsetning

Country Status (19)

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US (3) US6168776B1 (no)
EP (1) EP0977815A1 (no)
JP (1) JP2002500634A (no)
KR (1) KR20010006552A (no)
CN (1) CN1261906A (no)
AR (1) AR012845A1 (no)
AU (1) AU7136998A (no)
BR (1) BR9809580A (no)
CA (1) CA2286607A1 (no)
EE (1) EE9900503A (no)
HU (1) HUP0003804A3 (no)
IL (1) IL132426A0 (no)
NO (1) NO995088L (no)
NZ (1) NZ500714A (no)
PL (1) PL336321A1 (no)
SK (1) SK144099A3 (no)
TR (1) TR199903115T2 (no)
WO (1) WO1998047969A1 (no)
ZA (1) ZA983301B (no)

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