NO995313L - Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen - Google Patents

Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen

Info

Publication number
NO995313L
NO995313L NO995313A NO995313A NO995313L NO 995313 L NO995313 L NO 995313L NO 995313 A NO995313 A NO 995313A NO 995313 A NO995313 A NO 995313A NO 995313 L NO995313 L NO 995313L
Authority
NO
Norway
Prior art keywords
delivery
microarticles
bloodstream
drugs
useful
Prior art date
Application number
NO995313A
Other languages
English (en)
Other versions
NO995313D0 (no
Inventor
Thomas B Ottoboni
Robert E Short
Ronald K Yamamoto
Original Assignee
Point Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Point Biomedical Corp filed Critical Point Biomedical Corp
Publication of NO995313D0 publication Critical patent/NO995313D0/no
Publication of NO995313L publication Critical patent/NO995313L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
NO995313A 1997-04-30 1999-10-29 Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen NO995313L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84715397A 1997-04-30 1997-04-30
PCT/US1998/008827 WO1998048783A1 (en) 1997-04-30 1998-04-30 Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream

Publications (2)

Publication Number Publication Date
NO995313D0 NO995313D0 (no) 1999-10-29
NO995313L true NO995313L (no) 1999-12-29

Family

ID=25299908

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995313A NO995313L (no) 1997-04-30 1999-10-29 Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen

Country Status (11)

Country Link
US (4) US6193951B1 (no)
EP (1) EP0979071B1 (no)
JP (1) JP2001527547A (no)
AT (1) ATE377414T1 (no)
AU (1) AU739919B2 (no)
CA (1) CA2289088C (no)
DE (2) DE19882362T1 (no)
ES (1) ES2296332T3 (no)
GB (1) GB2340040B (no)
NO (1) NO995313L (no)
WO (1) WO1998048783A1 (no)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6524802B1 (en) * 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
ES2296332T3 (es) * 1997-04-30 2008-04-16 Point Biomedical Corporation Microparticulas que son utilizadas como agentes de contraste para la liberacion de medicamentos en el flujo sanguineo.
US20020159951A1 (en) * 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6896659B2 (en) 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
ATE355856T1 (de) 1998-07-30 2007-03-15 Point Biomedical Corp Neuer wirkstoffträger für die gefriertrocknung von wässrigen suspensionen von mikropartikeln
EP1202670A4 (en) * 1999-08-13 2004-11-10 Point Biomedical Corp HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE
EP1202671A4 (en) * 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
US6527718B1 (en) 1999-08-20 2003-03-04 Brian G Connor Ultrasound system for continuous imaging and delivery of an encapsulated agent
US6740039B1 (en) 1999-08-20 2004-05-25 Koninklijke Philips Electronics N.V. Methods and apparatus for displaying information relating to delivery and activation of a therapeutic agent using ultrasound energy
US6479145B1 (en) 1999-09-09 2002-11-12 Regents Of The University Of Minnesota Biopolymers and biopolymer blends, and method for producing same
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7892854B2 (en) * 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP2004537401A (ja) * 2001-08-08 2004-12-16 ブラウン ユニバーシティ リサーチ ファウンデーション 疎水性薬物の微粉砕方法
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
WO2003049701A2 (en) * 2001-12-10 2003-06-19 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
CA2532324A1 (en) * 2002-07-11 2004-01-22 Targeson, Llc Microbubble compositions, and methods for preparing and using same
FR2842737B1 (fr) * 2002-07-25 2006-01-27 Centre Nat Rech Scient Particules revetues en surface de hyaluronane ou d'un de ses derives et leur utilisation a titre de vecteurs biologiques pour des matieres actives
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
GB0228826D0 (en) * 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
FR2850385B1 (fr) * 2003-01-29 2007-04-20 Inst Gustave Roussy Igr Microparticules echogenes, servant notamment comme agent de contraste pour l'exploration ultrasonique et/ou comme emboles pour le detections ultrasoniques
JP4684991B2 (ja) 2003-01-31 2011-05-18 ボストン サイエンティフィック リミテッド 薬物添加ナノカプセルを用いる局所的薬物デリバリー
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
US20040228800A1 (en) * 2003-05-15 2004-11-18 Scicotec Gmbh Non-invasive identification of patients at increased risk for myocardial infarction
GB0311664D0 (en) * 2003-05-21 2003-06-25 Univ Manchester Polymeric hollow nanospheres
US7537788B2 (en) * 2003-07-25 2009-05-26 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US7744852B2 (en) 2003-07-25 2010-06-29 Rubicor Medical, Llc Methods and systems for marking post biopsy cavity sites
US20050020899A1 (en) * 2003-07-25 2005-01-27 Rubicor Medical, Inc. Post-biopsy cavity treatmetn implants and methods
EP1673108A4 (en) * 2003-09-09 2009-06-03 Point Biomedical Corp METHOD AND COMPOSITIONS FOR THE ULTRASONIC IMAGING OF APOPTOSIS
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) * 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
US20050074406A1 (en) * 2003-10-03 2005-04-07 Scimed Life Systems, Inc. Ultrasound coating for enhancing visualization of medical device in ultrasound images
US7563569B2 (en) * 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004286253A1 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
EP1677738A2 (en) * 2003-10-31 2006-07-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
CN1984708B (zh) * 2004-06-29 2014-01-29 皇家飞利浦电子股份有限公司 微球体
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8119153B2 (en) * 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
EP1817098A1 (en) * 2004-10-29 2007-08-15 Koninklijke Philips Electronics N.V. Method and apparatus for the preparation of dispersions of particles for use as contrast agents in ultrasound imaging
US9039273B2 (en) * 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20090042284A1 (en) * 2005-07-04 2009-02-12 Shunro Tachibana Method for labeling/separation of cells and agent for labeling/separation of cells
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
EP1963805A4 (en) * 2005-12-09 2010-01-06 Univ Columbia SYSTEMS AND METHODS FOR ELASTOGRAPHIC IMAGING
EP1978945A1 (en) * 2006-01-24 2008-10-15 Koninklijke Philips Electronics N.V. Method for producing a particle comprising a gas core and a shell and particles thus obtained
AU2007226258A1 (en) * 2006-03-10 2007-09-20 Mcgill University Ultrasound molecular sensors and uses thereof
US20080305175A1 (en) * 2006-11-30 2008-12-11 Agency For Science, Technology And Research Micro-Container
JP5475683B2 (ja) * 2007-12-18 2014-04-16 コーニンクレッカ フィリップス エヌ ヴェ デンタルバイオフィルムの処理のための超音波場における抗菌剤充填カプセル
EP2103313A1 (en) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Method for the synthesis of hollow spheres
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
WO2010014977A1 (en) 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US8940277B2 (en) * 2008-11-06 2015-01-27 University of Pittsburgh—of the Commonwealth System of Higher Education Intracellular microbubble for imaging an anatomical site
WO2011013032A2 (en) * 2009-07-31 2011-02-03 Koninklijke Philips Electronics N.V. Method for the preparation of microparticles with efficient bioactive molecule incorporation
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
EP2493458A2 (en) * 2009-10-30 2012-09-05 The Ohio State University Multi-functional biodegradable particles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders
BR112012023441A2 (pt) * 2010-03-17 2016-05-24 Basf Se emulsificação por fusão
EP2566459A1 (en) * 2010-05-01 2013-03-13 The Trustees of Columbia University in the City of New York Methods devices and systems of preparing targeted microbubble shells
GB201102148D0 (en) * 2011-02-08 2011-03-23 Ucl Business Plc Layered bodies, compositions containing them and processes for producing them
WO2012148265A1 (en) 2011-04-26 2012-11-01 Encapson B.V. Coating for improving the ultrasound visibility
JP6122843B2 (ja) 2011-05-23 2017-04-26 プレジデント アンド フェローズ オブ ハーバード カレッジ 多重エマルジョンを含むエマルジョンの制御
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
US20140220350A1 (en) 2011-07-06 2014-08-07 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8927529B2 (en) 2012-01-30 2015-01-06 SpineThera Treatment of back pain by injection of microparticles of dexamethasone acetate and a polymer
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
AU2013338772B2 (en) 2012-10-31 2016-09-29 Encapson B.V. Medical devices with coatings for enhanced echogenicity
KR101446681B1 (ko) 2012-11-21 2014-10-07 한국과학기술연구원 간 종양 표적화 초음파 조영제 및 그 제조방법
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
US10052394B2 (en) 2014-11-21 2018-08-21 General Electric Company Microbubble tether for diagnostic and therapeutic applications
WO2016115133A1 (en) * 2015-01-12 2016-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Polymer microbubbles as x-ray dark field contrast agents
US20160361443A1 (en) * 2015-06-12 2016-12-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ultrasound Molecular Imaging With Targeted Biocompatible Microbubbles
JP6712003B2 (ja) 2016-10-28 2020-06-17 スパインセラSpinethera 医薬組成物及びその使用
US12383246B2 (en) 2020-10-12 2025-08-12 Abbott Cardiovascular Systems, Inc. Vessel closure device with improved safety and tract hemostasis
WO2022192361A2 (en) * 2021-03-09 2022-09-15 Board Of Regents Of The University Of Nebraska Microparticle compositions and methods use thereof
DE102022102770A1 (de) 2022-02-07 2023-08-10 Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts Oberflächenmodifizierung von Mikrobläschen und Nanopartikeln auf Poly(alkylcyanacrylat)-Basis

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900865A1 (de) 1969-01-09 1970-08-27 Bayer Ag Verfahren zur Herstellung von Mikrokapseln
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
KR0133132B1 (ko) * 1988-02-05 1998-04-17 쉐링 아게, 베를린 운트 베르크카멘 초음파 조영제, 이의 제법 및 이의 진단제로서의 용도
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
WO1991006287A1 (en) * 1989-11-06 1991-05-16 Enzytech, Inc. Protein microspheres and methods of using them
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB9003821D0 (en) 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
GB2256183B (en) 1990-02-20 1994-03-09 Delta Biotechnology Ltd Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use
US6120805A (en) * 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5948387A (en) * 1990-06-01 1999-09-07 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
EP0504340B1 (en) 1990-10-05 1995-06-21 BRACCO International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
DK166600B1 (da) * 1991-01-17 1993-06-21 Therkel Bisgaard Vaerktoejssaet til brug ved suturering i dybe operationsaabninger eller legemshulrum
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
HUT72323A (en) * 1993-01-25 1996-04-29 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
ATE197124T1 (de) * 1993-09-09 2000-11-15 Schering Ag Wirkstoffe und gas enthaltende mikropartikel
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5620883A (en) 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
DE19510690A1 (de) * 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
ES2296332T3 (es) * 1997-04-30 2008-04-16 Point Biomedical Corporation Microparticulas que son utilizadas como agentes de contraste para la liberacion de medicamentos en el flujo sanguineo.
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
US6205352B1 (en) * 1997-11-19 2001-03-20 Oncology Innovations, Inc. Sentinel node identification using non-isotope means
US6444192B1 (en) * 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
US6224554B1 (en) * 1999-03-31 2001-05-01 Point Biomedical Corporation Method to measure ambient fluid pressure
EP1202671A4 (en) * 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
US20030118649A1 (en) * 2001-10-04 2003-06-26 Jinming Gao Drug delivery devices and methods

Also Published As

Publication number Publication date
ATE377414T1 (de) 2007-11-15
WO1998048783A1 (en) 1998-11-05
CA2289088A1 (en) 1998-11-05
DE69838669T2 (de) 2008-10-30
EP0979071B1 (en) 2007-11-07
NO995313D0 (no) 1999-10-29
EP0979071A1 (en) 2000-02-16
GB2340040B (en) 2001-11-28
ES2296332T3 (es) 2008-04-16
US20090081130A1 (en) 2009-03-26
CA2289088C (en) 2007-08-07
EP0979071A4 (en) 2004-03-10
DE19882362T1 (de) 2000-05-18
JP2001527547A (ja) 2001-12-25
GB2340040A (en) 2000-02-16
DE69838669D1 (de) 2007-12-20
AU7173098A (en) 1998-11-24
AU739919B2 (en) 2001-10-25
GB9925661D0 (en) 1999-12-29
US6193951B1 (en) 2001-02-27
US20040086459A1 (en) 2004-05-06
US20010012522A1 (en) 2001-08-09

Similar Documents

Publication Publication Date Title
NO995313D0 (no) Mikroartikler nyttige som ultrasoniske kontrastmidler og til levering av legemidler i blodbanen
ATE269709T1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
DE69811278D1 (de) Gegen magensaft geschützte omeprazol-mikrogranülen, herstellungsverfahren und pharmazeutische zubereitungen
ES2104522T1 (es) Un nuevo sistema de suministro de farmacos.
DE60237372D1 (de) Magenretentionssystem mit kontrollierter arzneimittelfreisetzung
DE60016920D1 (de) Arzneistoffverabreichungsystem zur verzögerten, völlstandigen wirkstoffabgabe im verdauungstrakt
BRPI0013439B1 (pt) composiÇço compreendendo tramadol e um fÁrmaco anticonvulsivante.
PT1183014E (pt) Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor
ATE362522T1 (de) Wasserlösliches abgabeprodukt
HK1047537A1 (zh) 多元藥物劑型
ATE314054T1 (de) Osmotisches verabreichungssystem für lösliche dosen
EE05506B1 (et) Ravimi manustamise vahend eriti progestiinide ja”strogeenide manustamiseks
CA2396152A1 (en) Osmotic device within an osmotic device
ID28275A (id) Penghantaran kolon dan enterik yang menggunakan kapsul-kapsul hpmc
PT1140012E (pt) Conversao de capsulas de gelatina cheias com liquido em sistemas de libertacao controlada por camadas multiplas
EP1334732A4 (en) PHARMACEUTICAL PREPARATION WITH COPOLYVIDONE
IT1303242B1 (it) Procedimento e sistema per l'erogazione controllata di servizinumerici quali, ad esempio, servizi telematici multimediali.
ATE247981T1 (de) Proteinenthaltende pharmazeutische zubereitung
BR9806303A (pt) Sistema de distrituição de droga termoformado, e, unidade de dosagem
AU1789301A (en) Osmotic dosage form comprising first and second
AR033862A1 (es) Formulacion de medicamento que contiene un agente agonista muscarinico
DK0918543T3 (da) Polymerpræparater til oral indgivelse af peptider og proteiner
WO2003026555A3 (en) Floating osmotic device for controlled release drug delivery
IT1269638B (it) Dispositivo di conservazione e di trasporto di organi umani, sostanze medicinali, vaccini e simili.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application