NO995590L - 20-Aryl-5<alfa>-pregnan-derivater - Google Patents
20-Aryl-5<alfa>-pregnan-derivaterInfo
- Publication number
- NO995590L NO995590L NO995590A NO995590A NO995590L NO 995590 L NO995590 L NO 995590L NO 995590 A NO995590 A NO 995590A NO 995590 A NO995590 A NO 995590A NO 995590 L NO995590 L NO 995590L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- halogen
- independently hydrogen
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- YYQGUWHFXVXQOO-GFCCVEGCSA-N 2-chloro-4-[[3-[(2R)-2-hydroxybutyl]-1-methyl-2-oxobenzimidazol-5-yl]amino]pyridine-3-carbonitrile Chemical compound ClC1=C(C#N)C(=CC=N1)NC1=CC2=C(N(C(N2C[C@@H](CC)O)=O)C)C=C1 YYQGUWHFXVXQOO-GFCCVEGCSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Oppfinnelsen angår et 20-aralkyl-5a-pregnan derivat med den generelle formel eller et av dets farmasøytisk godtagbare salter, Formel hvor R, er (H.OR), (H,OS03H) eller NOR; R er H, (C^alkyl eller (C1.6)acyl; hver av R2 og R3er uavhengig av hverandre hydrogen eller (C,.6)alkyl; X er en lineær divalent C^ hydrokarbonrest, eventuelt omfattende en dobbelt- eller en trippelbinding; eller X er -(CH2)m-CR7R8-; m = 0-4; minst en av R7 og R9 er (CM)alkyl, hydroksy, (C^alkoksy eller halogen; den andre, om til stede, er hydrogen; eller R7 og R8 sammen representerer O eller NOR'; R1 er H, (C1Jalkyl eller (C, Jacyl; hver av R4, R5 og R$ er uavhengig .av hverandre hydrogen, hydroksy, (CM)alkoksy, halogen, NRg,R,0 eller (C1j()alkyl, eventuelt substituert med hydroksy, alkoksy, halogen eller okso; hver av R9 og R10 er uavhengig av hverandre hydrogen eller (C, Jalkyl; og de stiplede linjer indikerer en A7 eller en A8 dobbeltbinding eller et par konjugerte dobbeltbindinger valgt fra A7'14, A8'14 og A6'8'14'; Forbindelsene ifølge foreliggende oppfinnelse har meioseaktiverende aktivitet og kan anvendes for kontroll av fruktbarhet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201474 | 1997-05-16 | ||
| PCT/EP1998/002989 WO1998052965A1 (en) | 1997-05-16 | 1998-05-11 | 20-ARALKYL-5α-PREGNANE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO995590D0 NO995590D0 (no) | 1999-11-15 |
| NO995590L true NO995590L (no) | 2000-01-11 |
Family
ID=8228325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO995590A NO995590L (no) | 1997-05-16 | 1999-11-15 | 20-Aryl-5<alfa>-pregnan-derivater |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6177420B1 (no) |
| EP (1) | EP0984980B1 (no) |
| JP (1) | JP2001526673A (no) |
| KR (1) | KR20010012643A (no) |
| CN (1) | CN1260802A (no) |
| AT (1) | ATE229032T1 (no) |
| AU (1) | AU726016B2 (no) |
| BR (1) | BR9808803A (no) |
| CA (1) | CA2289675A1 (no) |
| DE (1) | DE69809905T2 (no) |
| DK (1) | DK0984980T3 (no) |
| ES (1) | ES2189173T3 (no) |
| HU (1) | HUP0002331A3 (no) |
| NO (1) | NO995590L (no) |
| PL (1) | PL337008A1 (no) |
| TR (1) | TR199902793T2 (no) |
| WO (1) | WO1998052965A1 (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001526293A (ja) * | 1997-12-18 | 2001-12-18 | アクゾ・ノベル・エヌ・ベー | １７β−アリール（アリールメチル）オキシ（チオ）アルキル−アンドロスタン誘導体 |
| WO1999058549A1 (en) * | 1998-05-13 | 1999-11-18 | Novo Nordisk A/S | Meiosis regulating compounds |
| IL140216A0 (en) * | 1998-06-19 | 2002-02-10 | Novo Nordisk As | Meiosis regulating compounds |
| US6552011B1 (en) | 1999-03-02 | 2003-04-22 | Akzo Nobel Nv | (Androst-5-en-17beta -yl)alkyl sulfoxides and sulfones and their use for control of fertility |
| EP1212345B1 (en) * | 1999-04-06 | 2003-08-06 | Akzo Nobel N.V. | Orally active 7-alpha-alkyl androgens |
| EP1127890A1 (en) | 2000-02-22 | 2001-08-29 | Schering Aktiengesellschaft | Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments |
| US6988613B2 (en) * | 2001-02-06 | 2006-01-24 | Novo Nordisk A/S | Composition for IVF |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| JP2007517877A (ja) | 2004-01-15 | 2007-07-05 | ワーナー・チルコット・カンパニー・インコーポレーテッド | エストラジオールのジ−ステロイド型プロドラッグ |
| WO2005070950A1 (en) | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| CN101218245B (zh) | 2005-07-12 | 2011-08-17 | 沃纳奇尔科特有限责任公司 | 炔雌醇的3-酯前药 |
| CA2643732C (en) | 2006-02-27 | 2012-08-21 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| CN101951915A (zh) | 2007-12-03 | 2011-01-19 | 加利福尼亚大学董事会 | 用于刺猬蛋白信号、骨诱导、抗脂肪形成和wnt信号的激活的氧固醇 |
| CA2872751A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| JP2016517888A (ja) | 2013-05-02 | 2016-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 骨選択的骨形成のオキシステロール骨標的薬剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716777A (en) * | 1994-06-23 | 1998-02-10 | Novo Nordisk A/S | Regulation of meiosis using sterols |
| HUP9800731A3 (en) | 1995-03-06 | 2000-03-28 | Novo Nordisk As | Stimulation of meiosis |
| CA2224866A1 (en) | 1995-06-23 | 1997-01-09 | Novo Nordisk A/S | Meiosis regulating compounds |
-
1998
- 1998-05-11 WO PCT/EP1998/002989 patent/WO1998052965A1/en not_active Ceased
- 1998-05-11 HU HU0002331A patent/HUP0002331A3/hu unknown
- 1998-05-11 CN CN98806290A patent/CN1260802A/zh active Pending
- 1998-05-11 DE DE69809905T patent/DE69809905T2/de not_active Expired - Fee Related
- 1998-05-11 EP EP98924316A patent/EP0984980B1/en not_active Expired - Lifetime
- 1998-05-11 ES ES98924316T patent/ES2189173T3/es not_active Expired - Lifetime
- 1998-05-11 PL PL98337008A patent/PL337008A1/xx unknown
- 1998-05-11 BR BR9808803-3A patent/BR9808803A/pt not_active Application Discontinuation
- 1998-05-11 DK DK98924316T patent/DK0984980T3/da active
- 1998-05-11 TR TR1999/02793T patent/TR199902793T2/xx unknown
- 1998-05-11 JP JP54995898A patent/JP2001526673A/ja not_active Ceased
- 1998-05-11 AT AT98924316T patent/ATE229032T1/de not_active IP Right Cessation
- 1998-05-11 KR KR1019997010604A patent/KR20010012643A/ko not_active Withdrawn
- 1998-05-11 AU AU76549/98A patent/AU726016B2/en not_active Ceased
- 1998-05-11 US US09/423,743 patent/US6177420B1/en not_active Expired - Fee Related
- 1998-05-11 CA CA002289675A patent/CA2289675A1/en not_active Abandoned
-
1999
- 1999-11-15 NO NO995590A patent/NO995590L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902793T2 (xx) | 2000-06-21 |
| BR9808803A (pt) | 2000-07-18 |
| CN1260802A (zh) | 2000-07-19 |
| JP2001526673A (ja) | 2001-12-18 |
| KR20010012643A (ko) | 2001-02-26 |
| HUP0002331A3 (en) | 2001-05-28 |
| DK0984980T3 (da) | 2003-03-17 |
| EP0984980A1 (en) | 2000-03-15 |
| EP0984980B1 (en) | 2002-12-04 |
| PL337008A1 (en) | 2000-07-31 |
| ATE229032T1 (de) | 2002-12-15 |
| WO1998052965A1 (en) | 1998-11-26 |
| ES2189173T3 (es) | 2003-07-01 |
| NO995590D0 (no) | 1999-11-15 |
| HUP0002331A2 (hu) | 2000-12-28 |
| DE69809905T2 (de) | 2003-08-28 |
| AU7654998A (en) | 1998-12-11 |
| US6177420B1 (en) | 2001-01-23 |
| CA2289675A1 (en) | 1998-11-26 |
| AU726016B2 (en) | 2000-10-26 |
| DE69809905D1 (de) | 2003-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |