NO996316L - Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe - Google Patents

Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe

Info

Publication number
NO996316L
NO996316L NO996316A NO996316A NO996316L NO 996316 L NO996316 L NO 996316L NO 996316 A NO996316 A NO 996316A NO 996316 A NO996316 A NO 996316A NO 996316 L NO996316 L NO 996316L
Authority
NO
Norway
Prior art keywords
inhibitors
factor
specificity group
neutral
somewhat neutral
Prior art date
Application number
NO996316A
Other languages
English (en)
Other versions
NO996316D0 (no
Inventor
Robert Anthony Galemmo Jr
Celia Dominguez
John Matthew Fevig
Qi Han
Patrick Yuk-Sun Lam
Donald Joseph-Phillip Pinto
James Russell Pruitt
Mimi Lifen Quan
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26758382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO996316(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NO996316D0 publication Critical patent/NO996316D0/no
Publication of NO996316L publication Critical patent/NO996316L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Faktor Xa-inhibitorer med en noytral p! spesifisitetsgruppe med formel (1), der R og E kan være grupper som metoksy og halogen, samt farmassiytisk akseptable saltformer derav.
NO996316A 1997-06-19 1999-12-17 Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe NO996316L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87888597A 1997-06-19 1997-06-19
US7669198P 1998-02-27 1998-02-27
PCT/US1998/012681 WO1998057937A2 (en) 1997-06-19 1998-06-18 Inhibitors of factor xa with a neutral p1 specificity group

Publications (2)

Publication Number Publication Date
NO996316D0 NO996316D0 (no) 1999-12-17
NO996316L true NO996316L (no) 1999-12-17

Family

ID=26758382

Family Applications (1)

Application Number Title Priority Date Filing Date
NO996316A NO996316L (no) 1997-06-19 1999-12-17 Faktor Xa-inhibitorer med en noeytral P1-spesifisitetsgruppe

Country Status (22)

Country Link
EP (1) EP0991625B1 (no)
JP (1) JP2002507968A (no)
KR (1) KR20010013977A (no)
AR (1) AR015906A1 (no)
AT (1) ATE296805T1 (no)
AU (1) AU8150398A (no)
BR (1) BR9810151A (no)
CA (1) CA2290982A1 (no)
DE (1) DE69830403T2 (no)
EA (1) EA200000048A1 (no)
EE (1) EE9900584A (no)
ES (1) ES2239806T3 (no)
HR (1) HRP980334A2 (no)
HU (1) HUP0003906A2 (no)
IL (1) IL133526A0 (no)
LV (1) LV12516B (no)
NO (1) NO996316L (no)
PL (1) PL337831A1 (no)
PT (1) PT991625E (no)
SI (1) SI20208A (no)
SK (1) SK174699A3 (no)
WO (1) WO1998057937A2 (no)

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IL133526A0 (en) 2001-04-30
CA2290982A1 (en) 1998-12-23
EA200000048A1 (ru) 2000-08-28
EP0991625B1 (en) 2005-06-01
JP2002507968A (ja) 2002-03-12
NO996316D0 (no) 1999-12-17
HUP0003906A2 (hu) 2001-05-28
DE69830403D1 (de) 2005-07-07
LV12516A (en) 2000-07-20
PL337831A1 (en) 2000-09-11
PT991625E (pt) 2005-10-31
AR015906A1 (es) 2001-05-30
WO1998057937A2 (en) 1998-12-23
HRP980334A2 (en) 1999-04-30
DE69830403T2 (de) 2006-02-02
ES2239806T3 (es) 2005-10-01
ATE296805T1 (de) 2005-06-15
SK174699A3 (en) 2000-08-14
EE9900584A (et) 2000-08-15
SI20208A (sl) 2000-10-31
WO1998057937A3 (en) 1999-03-18
LV12516B (en) 2001-03-20

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