NZ332035A - Modified pectin material with a rhamnogalacturan backbone - Google Patents
Modified pectin material with a rhamnogalacturan backboneInfo
- Publication number
- NZ332035A NZ332035A NZ332035A NZ33203597A NZ332035A NZ 332035 A NZ332035 A NZ 332035A NZ 332035 A NZ332035 A NZ 332035A NZ 33203597 A NZ33203597 A NZ 33203597A NZ 332035 A NZ332035 A NZ 332035A
- Authority
- NZ
- New Zealand
- Prior art keywords
- modified pectin
- side chains
- units
- chains
- group
- Prior art date
Links
- 229920001277 pectin Polymers 0.000 title claims abstract description 53
- 239000001814 pectin Substances 0.000 title claims abstract description 53
- 235000010987 pectin Nutrition 0.000 title claims abstract description 53
- 239000000463 material Substances 0.000 title claims abstract description 42
- 230000007935 neutral effect Effects 0.000 claims abstract description 31
- 235000000346 sugar Nutrition 0.000 claims abstract description 30
- 150000008163 sugars Chemical class 0.000 claims abstract description 29
- 229930182830 galactose Natural products 0.000 claims abstract description 17
- 230000001419 dependent effect Effects 0.000 claims abstract description 7
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical group C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 24
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims description 19
- 150000002772 monosaccharides Chemical group 0.000 claims description 12
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 9
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims description 8
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 8
- 125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- -1 feruloyl groups Chemical compound 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 5
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 3
- 108091092195 Intron Proteins 0.000 claims description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 3
- 235000011468 Albizia julibrissin Nutrition 0.000 description 7
- 241001070944 Mimosa Species 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000139306 Platt Species 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229940040387 citrus pectin Drugs 0.000 description 1
- 239000009194 citrus pectin Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 208000037819 metastatic cancer Diseases 0.000 description 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1383696P | 1996-03-21 | 1996-03-21 | |
| PCT/US1997/004205 WO1997034907A1 (fr) | 1996-03-21 | 1997-03-18 | Matiere pectique modifiee |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ332035A true NZ332035A (en) | 1999-04-29 |
Family
ID=21762028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ332035A NZ332035A (en) | 1996-03-21 | 1997-03-18 | Modified pectin material with a rhamnogalacturan backbone |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0888366B1 (fr) |
| JP (1) | JP2001500171A (fr) |
| AT (1) | ATE268780T1 (fr) |
| AU (1) | AU714164B2 (fr) |
| BR (1) | BR9708122A (fr) |
| CA (1) | CA2249215C (fr) |
| CZ (1) | CZ295423B6 (fr) |
| DE (1) | DE69729443T2 (fr) |
| ES (1) | ES2222509T3 (fr) |
| IL (1) | IL126282A0 (fr) |
| NZ (1) | NZ332035A (fr) |
| WO (1) | WO1997034907A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1765874A1 (fr) | 2004-03-26 | 2007-03-28 | Glycogenesys, Inc. | Pectines modifiees, compositions associees et procedes correspondants |
| WO2006020027A1 (fr) * | 2004-07-14 | 2006-02-23 | Glycogenesys, Inc. | Composition et procédé pour traiter les maladies hyperproliférantes |
| KR100656877B1 (ko) * | 2005-05-03 | 2006-12-20 | 한양대학교 산학협력단 | 펙틴 유도체 및 이의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI943242L (fi) * | 1993-07-15 | 1995-01-16 | Jcr Pharmaceutical Co Ltd | Lääke munuais- ja maksatauteihin |
| US5834442A (en) * | 1994-07-07 | 1998-11-10 | Barbara Ann Karmanos Cancer Institute | Method for inhibiting cancer metastasis by oral administration of soluble modified citrus pectin |
-
1997
- 1997-03-18 ES ES97916793T patent/ES2222509T3/es not_active Expired - Lifetime
- 1997-03-18 CZ CZ19983009A patent/CZ295423B6/cs not_active IP Right Cessation
- 1997-03-18 AU AU25321/97A patent/AU714164B2/en not_active Ceased
- 1997-03-18 WO PCT/US1997/004205 patent/WO1997034907A1/fr not_active Ceased
- 1997-03-18 EP EP97916793A patent/EP0888366B1/fr not_active Revoked
- 1997-03-18 CA CA002249215A patent/CA2249215C/fr not_active Expired - Fee Related
- 1997-03-18 IL IL12628297A patent/IL126282A0/xx not_active IP Right Cessation
- 1997-03-18 NZ NZ332035A patent/NZ332035A/en not_active IP Right Cessation
- 1997-03-18 DE DE69729443T patent/DE69729443T2/de not_active Revoked
- 1997-03-18 AT AT97916793T patent/ATE268780T1/de not_active IP Right Cessation
- 1997-03-18 JP JP09533589A patent/JP2001500171A/ja not_active Ceased
- 1997-03-18 BR BR9708122-1A patent/BR9708122A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ295423B6 (cs) | 2005-08-17 |
| JP2001500171A (ja) | 2001-01-09 |
| ES2222509T3 (es) | 2005-02-01 |
| EP0888366A4 (fr) | 1999-11-17 |
| DE69729443D1 (de) | 2004-07-15 |
| EP0888366B1 (fr) | 2004-06-09 |
| AU2532197A (en) | 1997-10-10 |
| CA2249215A1 (fr) | 1997-09-25 |
| CA2249215C (fr) | 2004-09-21 |
| WO1997034907A1 (fr) | 1997-09-25 |
| CZ300998A3 (cs) | 1999-02-17 |
| DE69729443T2 (de) | 2005-09-15 |
| AU714164B2 (en) | 1999-12-23 |
| IL126282A0 (en) | 1999-05-09 |
| BR9708122A (pt) | 2000-01-18 |
| EP0888366A1 (fr) | 1999-01-07 |
| ATE268780T1 (de) | 2004-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |